Click here to switch to the map view.

The map label for this gene is opuE [H]

Identifier: 23100283

GI number: 23100283

Start: 2906766

End: 2908193

Strand: Direct

Name: opuE [H]

Synonym: OB2828

Alternate gene names: 23100283

Gene position: 2906766-2908193 (Clockwise)

Preceding gene: 23100282

Following gene: 23100284

Centisome position: 80.06

GC content: 34.52

Gene sequence:

>1428_bases
TTGGGATTAGAATACAATAATAGTTTTCTTTGGTTCGTAATAGGATATGGGTTAATCATCTTAATGATGGGTGCATTTTA
TTCAAAAAAAGTAACCTCAAGTGAGGATTTTATACTCGCTGGTAAATCTCTTGGACCAATTGTATTAATGGGAACATTGT
TAGCAACATGGGTTGGCAGTGGAACTGTAACAGGCGGACCTAATTCTATCGCATATTCCAATGGTTTATGGCCAGCAATT
GGTTATGTTATCCCCAGTTTAATTGGTATTACGATTCTGTTATTAATATCAGCTAAAATTCGAAACTATGGAAAATATAC
TGTGTCAGAAATACTCGAGATTAAATATGGTTCTTTTGCTAGAATCCTATCTTTAATTATCATTGTGCTTGCCTTTGTTG
GTATAGTTTCTTATCAATATCAGGGACTTGGCTTTATACTACACGTGTCCACCGGTATCTCTGTTGAAACAGGCACTATT
ATAGGAGCAGTATTAATTATCTTCTTGGCAACAATAGGGGGATTAATGTCTGTCGCTCCAACTGATACGTTAAGTGCATT
AATTATTTTTTTGGGCTTAATTATTGGAGTACCTGTTATTTTAGGGGATATTGGAGGGTTCGACCATCTAGTGAGTAGTG
TCGAGACTGAAAGGTTAAATCTATTTGGAAATTTAAACTTACTACAAGTAATGGGTTTCTATATTCCTGTTTTATTCCTA
CTCTTAGGTGACCAAAATATGTATCAAAGAATTTCAGCATCCAGTAGTGATAAAACAACTAAACTAGGTATCTCTGGTTG
GATTATAGGAATGTTAATCTCTACTCCTTTAGTTGCTGTATTAGCATTTTCTGCTAGGTACTACTTTCCTGATCTAGATC
CTGGAATGGCATTGATATCAACTTCGTTGGTCTTACCAACTGCTATTGGTGGCTTACTAATTGCGGCAGTCACTTCTTTT
ATTGTCACTACAGGAAATTCTTATTTATTATCTTCAGCAACAAATATAACTTATGATATTTATGGTAAATACATTAATCC
AAAAGCTACAGATAAGCAGAAATTAGTTTTTACTAGAGTATTGATCCCAGTGCTAGGATTAATTGCATATCTACTAACCA
CTTATTTTCCAACTGTCCTCACCGTTCAAATGTATGCTTATACAGTCTACGGTGCCGGGATTACACCTGCTTTACTAGGC
GTATTCCTTTGGAAACGTGTAACAAAACAAGCAGGTATTTCTTCGATGTTAGCTGGTGTTGTGTCCACGTTAATTTGGGA
GTTTTTCGATACACCATTTAATATCAATAGTTCCTTGATTTCTATTCCTATCGCGATATTAGTATTAGTTATTGTAACTT
TACTTACTTCAAAAAAACAAGAATTATTCGACTATAGAAAGGATGATTTAATTGCAAACCAAAAATAG

Upstream 100 bases:

>100_bases
ATTAACATTTAAACTAACAATTTTCACTTTTGTATGGGAAAGGAGGATTTTAGTAAAAGTTAGCTATACCTTTAAATAGA
ATGAAGGAGGCATAGGAATC

Downstream 100 bases:

>100_bases
AGTTGATAACTTAAGAGCAATTATGGAGGAAAGTAATATTGATTTGTCCATCATTATGAACGTTGAAAATCAATATTATC
TAAACGGTTTAAAGGCTATT

Product: sodium:proline symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MGLEYNNSFLWFVIGYGLIILMMGAFYSKKVTSSEDFILAGKSLGPIVLMGTLLATWVGSGTVTGGPNSIAYSNGLWPAI
GYVIPSLIGITILLLISAKIRNYGKYTVSEILEIKYGSFARILSLIIIVLAFVGIVSYQYQGLGFILHVSTGISVETGTI
IGAVLIIFLATIGGLMSVAPTDTLSALIIFLGLIIGVPVILGDIGGFDHLVSSVETERLNLFGNLNLLQVMGFYIPVLFL
LLGDQNMYQRISASSSDKTTKLGISGWIIGMLISTPLVAVLAFSARYYFPDLDPGMALISTSLVLPTAIGGLLIAAVTSF
IVTTGNSYLLSSATNITYDIYGKYINPKATDKQKLVFTRVLIPVLGLIAYLLTTYFPTVLTVQMYAYTVYGAGITPALLG
VFLWKRVTKQAGISSMLAGVVSTLIWEFFDTPFNINSSLISIPIAILVLVIVTLLTSKKQELFDYRKDDLIANQK

Sequences:

>Translated_475_residues
MGLEYNNSFLWFVIGYGLIILMMGAFYSKKVTSSEDFILAGKSLGPIVLMGTLLATWVGSGTVTGGPNSIAYSNGLWPAI
GYVIPSLIGITILLLISAKIRNYGKYTVSEILEIKYGSFARILSLIIIVLAFVGIVSYQYQGLGFILHVSTGISVETGTI
IGAVLIIFLATIGGLMSVAPTDTLSALIIFLGLIIGVPVILGDIGGFDHLVSSVETERLNLFGNLNLLQVMGFYIPVLFL
LLGDQNMYQRISASSSDKTTKLGISGWIIGMLISTPLVAVLAFSARYYFPDLDPGMALISTSLVLPTAIGGLLIAAVTSF
IVTTGNSYLLSSATNITYDIYGKYINPKATDKQKLVFTRVLIPVLGLIAYLLTTYFPTVLTVQMYAYTVYGAGITPALLG
VFLWKRVTKQAGISSMLAGVVSTLIWEFFDTPFNINSSLISIPIAILVLVIVTLLTSKKQELFDYRKDDLIANQK
>Mature_474_residues
GLEYNNSFLWFVIGYGLIILMMGAFYSKKVTSSEDFILAGKSLGPIVLMGTLLATWVGSGTVTGGPNSIAYSNGLWPAIG
YVIPSLIGITILLLISAKIRNYGKYTVSEILEIKYGSFARILSLIIIVLAFVGIVSYQYQGLGFILHVSTGISVETGTII
GAVLIIFLATIGGLMSVAPTDTLSALIIFLGLIIGVPVILGDIGGFDHLVSSVETERLNLFGNLNLLQVMGFYIPVLFLL
LGDQNMYQRISASSSDKTTKLGISGWIIGMLISTPLVAVLAFSARYYFPDLDPGMALISTSLVLPTAIGGLLIAAVTSFI
VTTGNSYLLSSATNITYDIYGKYINPKATDKQKLVFTRVLIPVLGLIAYLLTTYFPTVLTVQMYAYTVYGAGITPALLGV
FLWKRVTKQAGISSMLAGVVSTLIWEFFDTPFNINSSLISIPIAILVLVIVTLLTSKKQELFDYRKDDLIANQK

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=493, Percent_Identity=22.920892494929, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI11141885, Length=386, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1787251, Length=445, Percent_Identity=24.7191011235955, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87082237, Length=421, Percent_Identity=25.1781472684086, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17539284, Length=411, Percent_Identity=24.0875912408759, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648033, Length=391, Percent_Identity=25.8312020460358, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356865, Length=391, Percent_Identity=25.8312020460358, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51248; Mature: 51116

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLEYNNSFLWFVIGYGLIILMMGAFYSKKVTSSEDFILAGKSLGPIVLMGTLLATWVGS
CCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
GTVTGGPNSIAYSNGLWPAIGYVIPSLIGITILLLISAKIRNYGKYTVSEILEIKYGSFA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
RILSLIIIVLAFVGIVSYQYQGLGFILHVSTGISVETGTIIGAVLIIFLATIGGLMSVAP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECHHHHHHHHHHHHHHHHHHHHHCCC
TDTLSALIIFLGLIIGVPVILGDIGGFDHLVSSVETERLNLFGNLNLLQVMGFYIPVLFL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LLGDQNMYQRISASSSDKTTKLGISGWIIGMLISTPLVAVLAFSARYYFPDLDPGMALIS
HHCCCHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
TSLVLPTAIGGLLIAAVTSFIVTTGNSYLLSSATNITYDIYGKYINPKATDKQKLVFTRV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHH
LIPVLGLIAYLLTTYFPTVLTVQMYAYTVYGAGITPALLGVFLWKRVTKQAGISSMLAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSTLIWEFFDTPFNINSSLISIPIAILVLVIVTLLTSKKQELFDYRKDDLIANQK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
GLEYNNSFLWFVIGYGLIILMMGAFYSKKVTSSEDFILAGKSLGPIVLMGTLLATWVGS
CCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
GTVTGGPNSIAYSNGLWPAIGYVIPSLIGITILLLISAKIRNYGKYTVSEILEIKYGSFA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
RILSLIIIVLAFVGIVSYQYQGLGFILHVSTGISVETGTIIGAVLIIFLATIGGLMSVAP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECHHHHHHHHHHHHHHHHHHHHHCCC
TDTLSALIIFLGLIIGVPVILGDIGGFDHLVSSVETERLNLFGNLNLLQVMGFYIPVLFL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LLGDQNMYQRISASSSDKTTKLGISGWIIGMLISTPLVAVLAFSARYYFPDLDPGMALIS
HHCCCHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
TSLVLPTAIGGLLIAAVTSFIVTTGNSYLLSSATNITYDIYGKYINPKATDKQKLVFTRV
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHH
LIPVLGLIAYLLTTYFPTVLTVQMYAYTVYGAGITPALLGVFLWKRVTKQAGISSMLAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSTLIWEFFDTPFNINSSLISIPIAILVLVIVTLLTSKKQELFDYRKDDLIANQK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]