Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 23099833

GI number: 23099833

Start: 2430349

End: 2431572

Strand: Reverse

Name: csd [H]

Synonym: OB2378

Alternate gene names: 23099833

Gene position: 2431572-2430349 (Counterclockwise)

Preceding gene: 23099834

Following gene: 23099832

Centisome position: 66.98

GC content: 37.91

Gene sequence:

>1224_bases
ATGGATGTAAATGCCATTAAACAACAATTTCCGATTTTAAATCAAGAAGTAAATGGACATCCACTTGTATACTTGGATTC
CTCTGCAACATCTCAAAAACCGCTTTCGGTTATTGAAGCGGTAAATGCGTACTACAGAGAGAATAATTCCAATGTACACC
GTGGTGTTCATACTCTTGGTACAAGAGCAACAGATCAATATGAGGGATCAAGAGAAAAGGTTCGATCATTTATTAATGCG
AACAGTACAAAAGAGATTATTTTTACAAGAGGGACTACTACTTCCATTAATATCGTAGCATCAAGCTATGCTAGAATGAA
TGTTGGTCCTGGTGATGAAATAGTTATCACCCAAATGGAGCACCATAGTAATCTAATTCCTTGGCAACAAGTTGCTAAAG
CAACAGGAGCATCGTTGGTGTACTTACCTCTTCAAGAGGATGGTACTATTACAATTGAAGATGCGAAGAAGACGATTACA
GATCAGACAAAAATTGTTGCCATGGCACATGTTTCTAATGTGCTAGGTTCAATTAATCCTATTAAAGAAATTGCTGCTAT
TGCGCATCAACATGATGCAATTATGGTAGTCGATGGTGCGCAAGGTGCACCTCATATGAAAGTGGATGTTGAAGATCTAG
ATTGTGACTTTTATGCATTCTCTGGTCATAAAATGTGTGGTCCTACTGGAATCGGAGTATTATATGGAAAGCAGCATTTA
TTAGAAAACATGGAGCCTATTGAATTTGGCGGAGAAATGATTGATTTTGTAAATCTTTATGACTCTACATGGAAAGAACT
TCCTTGGAAATTCGAAGGCGGGACACCAATAATTGCTGGAGCAATTGGACTCGGTGCTGCAATTGATTTCCTAGAAAATA
TAGGATATCAAGAAATTGTCAATCATGAAAATGAATTGGCAGCACACGCTTTAAAGCAAATGCGTACAATTGATGGAATT
TCCATATATGGACCTGAACAAAGGGCTGGGCTAGTAACATTTAATCTAGATGATGTACATCCACACGATACTGCTACTGT
ACTAGATGCAGAAGGAATCGCAGTACGTGCTGGCCATCATTGTGCTCAACCATTAATGAAGTGGTTGAATGTTTCAGCGA
CGGCTAGAGCAAGTTTCTACCTTTATAATTCAAAAGAAGATGTAGATCGATTGGTAGAAGGACTGTTAAAAACAAAGGAG
TATTTTGGGAATGTCTTTGAATAA

Upstream 100 bases:

>100_bases
GTCTTGTTATTCATGGTTTCCTTGCACCAGTAGTATCACAGATCCCGATTGAATCTGTTCGTAAACAATTAACGCAAGTA
ATTGAAAGGAAAGTTTATTA

Downstream 100 bases:

>100_bases
CCTCGATACACTTTACCGACAAGTAATAATGGATCATTATAAGAATCCTAGAAATCGTGGTAGTCTTGAAGGAGACTCTG
TTACAGTAGATATGAATAAC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MDVNAIKQQFPILNQEVNGHPLVYLDSSATSQKPLSVIEAVNAYYRENNSNVHRGVHTLGTRATDQYEGSREKVRSFINA
NSTKEIIFTRGTTTSINIVASSYARMNVGPGDEIVITQMEHHSNLIPWQQVAKATGASLVYLPLQEDGTITIEDAKKTIT
DQTKIVAMAHVSNVLGSINPIKEIAAIAHQHDAIMVVDGAQGAPHMKVDVEDLDCDFYAFSGHKMCGPTGIGVLYGKQHL
LENMEPIEFGGEMIDFVNLYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLENIGYQEIVNHENELAAHALKQMRTIDGI
SIYGPEQRAGLVTFNLDDVHPHDTATVLDAEGIAVRAGHHCAQPLMKWLNVSATARASFYLYNSKEDVDRLVEGLLKTKE
YFGNVFE

Sequences:

>Translated_407_residues
MDVNAIKQQFPILNQEVNGHPLVYLDSSATSQKPLSVIEAVNAYYRENNSNVHRGVHTLGTRATDQYEGSREKVRSFINA
NSTKEIIFTRGTTTSINIVASSYARMNVGPGDEIVITQMEHHSNLIPWQQVAKATGASLVYLPLQEDGTITIEDAKKTIT
DQTKIVAMAHVSNVLGSINPIKEIAAIAHQHDAIMVVDGAQGAPHMKVDVEDLDCDFYAFSGHKMCGPTGIGVLYGKQHL
LENMEPIEFGGEMIDFVNLYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLENIGYQEIVNHENELAAHALKQMRTIDGI
SIYGPEQRAGLVTFNLDDVHPHDTATVLDAEGIAVRAGHHCAQPLMKWLNVSATARASFYLYNSKEDVDRLVEGLLKTKE
YFGNVFE
>Mature_407_residues
MDVNAIKQQFPILNQEVNGHPLVYLDSSATSQKPLSVIEAVNAYYRENNSNVHRGVHTLGTRATDQYEGSREKVRSFINA
NSTKEIIFTRGTTTSINIVASSYARMNVGPGDEIVITQMEHHSNLIPWQQVAKATGASLVYLPLQEDGTITIEDAKKTIT
DQTKIVAMAHVSNVLGSINPIKEIAAIAHQHDAIMVVDGAQGAPHMKVDVEDLDCDFYAFSGHKMCGPTGIGVLYGKQHL
LENMEPIEFGGEMIDFVNLYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLENIGYQEIVNHENELAAHALKQMRTIDGI
SIYGPEQRAGLVTFNLDDVHPHDTATVLDAEGIAVRAGHHCAQPLMKWLNVSATARASFYLYNSKEDVDRLVEGLLKTKE
YFGNVFE

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=250, Percent_Identity=31.2, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156713448, Length=308, Percent_Identity=26.9480519480519, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=48.5148514851485, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=44.080604534005, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI48994898, Length=231, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193211090, Length=378, Percent_Identity=28.3068783068783, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=229, Percent_Identity=29.2576419213974, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319831, Length=229, Percent_Identity=31.4410480349345, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=243, Percent_Identity=32.9218106995885, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44777; Mature: 44777

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVNAIKQQFPILNQEVNGHPLVYLDSSATSQKPLSVIEAVNAYYRENNSNVHRGVHTLG
CCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHC
TRATDQYEGSREKVRSFINANSTKEIIFTRGTTTSINIVASSYARMNVGPGDEIVITQME
CCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCEEEEEEC
HHSNLIPWQQVAKATGASLVYLPLQEDGTITIEDAKKTITDQTKIVAMAHVSNVLGSINP
CCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHCCCHHEEHHHHHHHHHHCCCH
IKEIAAIAHQHDAIMVVDGAQGAPHMKVDVEDLDCDFYAFSGHKMCGPTGIGVLYGKQHL
HHHHHHHHHCCCEEEEEECCCCCCCEEEEHHHCCCEEEEECCCCCCCCCCCCHHHCHHHH
LENMEPIEFGGEMIDFVNLYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLENIGYQEIV
HCCCCCHHHCCHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHHHHHHCCHHHHH
NHENELAAHALKQMRTIDGISIYGPEQRAGLVTFNLDDVHPHDTATVLDAEGIAVRAGHH
CCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCHH
CAQPLMKWLNVSATARASFYLYNSKEDVDRLVEGLLKTKEYFGNVFE
HHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDVNAIKQQFPILNQEVNGHPLVYLDSSATSQKPLSVIEAVNAYYRENNSNVHRGVHTLG
CCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHC
TRATDQYEGSREKVRSFINANSTKEIIFTRGTTTSINIVASSYARMNVGPGDEIVITQME
CCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCEEEEEEC
HHSNLIPWQQVAKATGASLVYLPLQEDGTITIEDAKKTITDQTKIVAMAHVSNVLGSINP
CCCCCCCHHHHHHHCCCEEEEEEECCCCEEEEECCHHHHCCCHHEEHHHHHHHHHHCCCH
IKEIAAIAHQHDAIMVVDGAQGAPHMKVDVEDLDCDFYAFSGHKMCGPTGIGVLYGKQHL
HHHHHHHHHCCCEEEEEECCCCCCCEEEEHHHCCCEEEEECCCCCCCCCCCCHHHCHHHH
LENMEPIEFGGEMIDFVNLYDSTWKELPWKFEGGTPIIAGAIGLGAAIDFLENIGYQEIV
HCCCCCHHHCCHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHHHHHHCCHHHHH
NHENELAAHALKQMRTIDGISIYGPEQRAGLVTFNLDDVHPHDTATVLDAEGIAVRAGHH
CCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCHH
CAQPLMKWLNVSATARASFYLYNSKEDVDRLVEGLLKTKEYFGNVFE
HHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]