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The map label for this gene is pyrH

Identifier: 23099043

GI number: 23099043

Start: 1624482

End: 1625204

Strand: Direct

Name: pyrH

Synonym: OB1588

Alternate gene names: 23099043

Gene position: 1624482-1625204 (Clockwise)

Preceding gene: 23099042

Following gene: 23099044

Centisome position: 44.75

GC content: 38.04

Gene sequence:

>723_bases
ATGACGACAGCACGTTACAATAGAGTTGTGTTAAAATTAAGTGGAGAAGCTTTAAGTGGTGATCAAGGATATGGAATCGA
CCCAAAAGTAATCCAATCCATTTCAAAGCAAGTAAAAGAGGTTGCTGACCTTGGTGTTGAAGTAGCCATTGTTGTAGGTG
GAGGTAATATTTGGAGAGGTAAAGTCGGTAGTGAGATGGGAATGGATCGTGCATCTGCTGATTATATGGGGATGCTTGCT
ACGATTATGAACTCTCTTGCATTACAAGATGGCTTAGAAACAATTGATGTTGAGACAAGAGTACAGACGTCCATTGAGAT
GAGACAAGTAGCAGAACCTTACATAAGAAGAAAAGCTATTCGCCATCTAGAGAAGAAACGTGTTGTCATTTTTGCAGCAG
GAACGGGTAATCCATATTTCTCTACAGACACTACTGCCGCATTAAGAGCAGCTGAAATTGAAGCTGAAGTAATTTTAATG
GCAAAGAATAATGTTGATGGAGTATACACTGATGACCCTAAGTTAAACAAGTCAGCTAAGAAATACGAATCGTTAACATA
TCTTGAGATGTTAAATGAAGGATTAGGTGTAATGGATTCAACAGCATCTTCATTATGTATGGATAATAACATTCCATTAA
TTGTATTCTCAATTATGGAAGAAGGAAACATTAAACGGGTCGTTCAAGGTGAGACGATCGGAACTACAATAAGGGGGAAA
TAA

Upstream 100 bases:

>100_bases
ATGATTATTACCGAATACTTTTATCGTTTGGTTGGTTGATAAACCGATTTTAAAAAGTTGAAATCATATATATAGTAAAA
ACTTTTCTCTGGAGGTTATT

Downstream 100 bases:

>100_bases
AAATGTCAGCTTCTGAATTAAAAGAAATGGAACAAAAGATGGAACAAGCGGTACAAGCTCTTTCTAAGAATTTAGCTTCC
GTAAGAGCAGGACGTGCTAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTTARYNRVVLKLSGEALSGDQGYGIDPKVIQSISKQVKEVADLGVEVAIVVGGGNIWRGKVGSEMGMDRASADYMGMLA
TIMNSLALQDGLETIDVETRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILM
AKNNVDGVYTDDPKLNKSAKKYESLTYLEMLNEGLGVMDSTASSLCMDNNIPLIVFSIMEEGNIKRVVQGETIGTTIRGK

Sequences:

>Translated_240_residues
MTTARYNRVVLKLSGEALSGDQGYGIDPKVIQSISKQVKEVADLGVEVAIVVGGGNIWRGKVGSEMGMDRASADYMGMLA
TIMNSLALQDGLETIDVETRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILM
AKNNVDGVYTDDPKLNKSAKKYESLTYLEMLNEGLGVMDSTASSLCMDNNIPLIVFSIMEEGNIKRVVQGETIGTTIRGK
>Mature_239_residues
TTARYNRVVLKLSGEALSGDQGYGIDPKVIQSISKQVKEVADLGVEVAIVVGGGNIWRGKVGSEMGMDRASADYMGMLAT
IMNSLALQDGLETIDVETRVQTSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMA
KNNVDGVYTDDPKLNKSAKKYESLTYLEMLNEGLGVMDSTASSLCMDNNIPLIVFSIMEEGNIKRVVQGETIGTTIRGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=46.551724137931, Blast_Score=220, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_OCEIH (Q8EQV1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692509.1
- ProteinModelPortal:   Q8EQV1
- SMR:   Q8EQV1
- GeneID:   1017976
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1588
- NMPDR:   fig|221109.1.peg.1590
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   OIHE221109:OB1588-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26145; Mature: 26014

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTARYNRVVLKLSGEALSGDQGYGIDPKVIQSISKQVKEVADLGVEVAIVVGGGNIWRG
CCCCCCEEEEEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEC
KVGSEMGMDRASADYMGMLATIMNSLALQDGLETIDVETRVQTSIEMRQVAEPYIRRKAI
CCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKNNVDGVYTDDPKLNKSAK
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCEECCCCCCCCHHH
KYESLTYLEMLNEGLGVMDSTASSLCMDNNIPLIVFSIMEEGNIKRVVQGETIGTTIRGK
HHHHHHHHHHHHCCCCCHHCCHHHHEECCCCCEEEEEEECCCCEEEEEECCEECEEECCC
>Mature Secondary Structure 
TTARYNRVVLKLSGEALSGDQGYGIDPKVIQSISKQVKEVADLGVEVAIVVGGGNIWRG
CCCCCEEEEEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEC
KVGSEMGMDRASADYMGMLATIMNSLALQDGLETIDVETRVQTSIEMRQVAEPYIRRKAI
CCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
RHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKNNVDGVYTDDPKLNKSAK
HHHHHCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCEECCCCCCCCHHH
KYESLTYLEMLNEGLGVMDSTASSLCMDNNIPLIVFSIMEEGNIKRVVQGETIGTTIRGK
HHHHHHHHHHHHCCCCCHHCCHHHHEECCCCCEEEEEEECCCCEEEEEECCEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376