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The map label for this gene is glcD [H]

Identifier: 23098812

GI number: 23098812

Start: 1404145

End: 1405518

Strand: Reverse

Name: glcD [H]

Synonym: OB1357

Alternate gene names: 23098812

Gene position: 1405518-1404145 (Counterclockwise)

Preceding gene: 23098814

Following gene: 23098809

Centisome position: 38.71

GC content: 40.39

Gene sequence:

>1374_bases
ATGGAAACAACCATTACTTCCTTGATAGAAGAATTAAGCAAATATTTAGAAACAGCACAAATCACTCAAAACGAAACGCT
GTTAGAACAACATAGTAAAGACGAATCTTACCACGCACCTCATAAGCCATTAGCTGTCATATTTCCTAAAGATACGACAG
ATGTCCAACACATAACGAGATGTTGCTCACAGTTTAAAGTACCAATCTACCCTTTTGGTGTCGGAACTAGTTTAGAAGGA
CATGTGATTCCAAATCAGCCAGGAATTTCGGTAGATTTCTCGCTAATGAACAACATCGTGGAGATTAATCCAGAGGATTT
AATTGTAAGAGTGCAACCAGGTGTTACCCGTACGCAACTAGAAAAGGAACTGAAAAAGTATGGTTTATTCTTTCCTGTTG
ATCCAGGAGCGGATGCAACACTTGGAGGAATGGCCGCTACAAATGCCAGTGGTACACTAACTGTAAAATATGGAACGATG
CGAGATAATGTACGGACAATGGAAGTGGTCCTCGCAAACGGCACCACGATTCAAACAGGTACAAAAGCTGCAAAATCTTC
TTCTGGATATCATTTAAATGGATTATTTGTTGGCTCCGAAGGGACATTAGGATGCATCACGGAACTAACCTTAAAAGTTT
TTGGTATTCCAGAACATATTGCTGCTGGAAGAGCTACCTTCCCTACCGTTCATCAAGCTATTGAAGCAGTAGTTTCCGTA
CTTCAAGCAGGTATTCCAATCGCGCGAATGGAGATCGTCGACGAAGATTCTATTTTGCAGGTCAATCAGTATAGCGAGTT
AGATCTTTCGATAGAACCAACCTTATTTATTGAATTTCATGGGAATAAATCGGGTCTTGCAGAAGATATGGCATTCACAG
AACAACTATTTTCAGATTTTGACTGTACAAATATCACCTTTGAGTCTGATACTGCAGCTAGAAACCAACTATGGGAAGCT
AGACATAATCTCGCATATGCATATGTACATGGTTATAAAGGTAGAAAAATGATGATCACGGATGTTTGCTTACCGATTTC
ATATCTAGCTGATGCGATATCTCATGCTAGATTAATGCTAGATATCTACGGGCTTCCTGGTGGCATTACGGGACATGTCG
GCGATGGGAATTTCCATATCGTCCTAATGTTTGATCCACACGATGAACAAGAGATCCAATTCGCTCAAGAACTAAATGAA
AAAGTTGTAGCTTATGCTTTAGAACGCGGCGGAACCTGTACCGGTGAGCATGGAGTCGGGACCGGCAAGAAAAAGTATCA
GCAACAAGAACACGGAGAGGCACTAACTGTAATGAGACAATTAAAACAAGCTCTTGACCCAGACCAGATTATGAATCCGA
ATAAAATATTTTAA

Upstream 100 bases:

>100_bases
GTCCATATTATAAACCTTTTTTCAATATTTTTAAACACTTTGCTATACATTTAAAAAGTCAGACATAAAATTTTATAACT
ACTAAAAAGGAGTGCTCCAC

Downstream 100 bases:

>100_bases
AAGCGTTTAACAATGAAAAAATGTGAGTCGCTTCCCAAAGGCATGTCAACAACTAACTTGAGAATATTGTTTCAAGTTAG
TTATTGACCTCTGCTCTTTT

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
METTITSLIEELSKYLETAQITQNETLLEQHSKDESYHAPHKPLAVIFPKDTTDVQHITRCCSQFKVPIYPFGVGTSLEG
HVIPNQPGISVDFSLMNNIVEINPEDLIVRVQPGVTRTQLEKELKKYGLFFPVDPGADATLGGMAATNASGTLTVKYGTM
RDNVRTMEVVLANGTTIQTGTKAAKSSSGYHLNGLFVGSEGTLGCITELTLKVFGIPEHIAAGRATFPTVHQAIEAVVSV
LQAGIPIARMEIVDEDSILQVNQYSELDLSIEPTLFIEFHGNKSGLAEDMAFTEQLFSDFDCTNITFESDTAARNQLWEA
RHNLAYAYVHGYKGRKMMITDVCLPISYLADAISHARLMLDIYGLPGGITGHVGDGNFHIVLMFDPHDEQEIQFAQELNE
KVVAYALERGGTCTGEHGVGTGKKKYQQQEHGEALTVMRQLKQALDPDQIMNPNKIF

Sequences:

>Translated_457_residues
METTITSLIEELSKYLETAQITQNETLLEQHSKDESYHAPHKPLAVIFPKDTTDVQHITRCCSQFKVPIYPFGVGTSLEG
HVIPNQPGISVDFSLMNNIVEINPEDLIVRVQPGVTRTQLEKELKKYGLFFPVDPGADATLGGMAATNASGTLTVKYGTM
RDNVRTMEVVLANGTTIQTGTKAAKSSSGYHLNGLFVGSEGTLGCITELTLKVFGIPEHIAAGRATFPTVHQAIEAVVSV
LQAGIPIARMEIVDEDSILQVNQYSELDLSIEPTLFIEFHGNKSGLAEDMAFTEQLFSDFDCTNITFESDTAARNQLWEA
RHNLAYAYVHGYKGRKMMITDVCLPISYLADAISHARLMLDIYGLPGGITGHVGDGNFHIVLMFDPHDEQEIQFAQELNE
KVVAYALERGGTCTGEHGVGTGKKKYQQQEHGEALTVMRQLKQALDPDQIMNPNKIF
>Mature_457_residues
METTITSLIEELSKYLETAQITQNETLLEQHSKDESYHAPHKPLAVIFPKDTTDVQHITRCCSQFKVPIYPFGVGTSLEG
HVIPNQPGISVDFSLMNNIVEINPEDLIVRVQPGVTRTQLEKELKKYGLFFPVDPGADATLGGMAATNASGTLTVKYGTM
RDNVRTMEVVLANGTTIQTGTKAAKSSSGYHLNGLFVGSEGTLGCITELTLKVFGIPEHIAAGRATFPTVHQAIEAVVSV
LQAGIPIARMEIVDEDSILQVNQYSELDLSIEPTLFIEFHGNKSGLAEDMAFTEQLFSDFDCTNITFESDTAARNQLWEA
RHNLAYAYVHGYKGRKMMITDVCLPISYLADAISHARLMLDIYGLPGGITGHVGDGNFHIVLMFDPHDEQEIQFAQELNE
KVVAYALERGGTCTGEHGVGTGKKKYQQQEHGEALTVMRQLKQALDPDQIMNPNKIF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=454, Percent_Identity=44.0528634361233, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI37595754, Length=477, Percent_Identity=41.9287211740042, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI119964728, Length=431, Percent_Identity=28.538283062645, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4501993, Length=218, Percent_Identity=30.7339449541284, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789351, Length=455, Percent_Identity=29.010989010989, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787977, Length=497, Percent_Identity=29.3762575452716, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994907, Length=227, Percent_Identity=26.8722466960352, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994914, Length=170, Percent_Identity=27.6470588235294, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=462, Percent_Identity=42.2077922077922, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71992381, Length=462, Percent_Identity=41.1255411255411, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71992392, Length=361, Percent_Identity=46.814404432133, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17534361, Length=424, Percent_Identity=25.2358490566038, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=457, Percent_Identity=24.507658643326, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320027, Length=473, Percent_Identity=35.5179704016913, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6320023, Length=469, Percent_Identity=25.5863539445629, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320764, Length=433, Percent_Identity=27.4826789838337, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=25.4117647058824, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=25.4117647058824, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=25.4117647058824, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24653753, Length=223, Percent_Identity=31.390134529148, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 50264; Mature: 50264

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTITSLIEELSKYLETAQITQNETLLEQHSKDESYHAPHKPLAVIFPKDTTDVQHITR
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
CCSQFKVPIYPFGVGTSLEGHVIPNQPGISVDFSLMNNIVEINPEDLIVRVQPGVTRTQL
HHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCEEEECCCCEEEEECCCCCHHHH
EKELKKYGLFFPVDPGADATLGGMAATNASGTLTVKYGTMRDNVRTMEVVLANGTTIQTG
HHHHHHCCCEEECCCCCCCCCCCEEECCCCCEEEEEECCCCCCCEEEEEEEECCCEEECC
TKAAKSSSGYHLNGLFVGSEGTLGCITELTLKVFGIPEHIAAGRATFPTVHQAIEAVVSV
CHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHEECCCHHHHCCCCCCHHHHHHHHHHHHH
LQAGIPIARMEIVDEDSILQVNQYSELDLSIEPTLFIEFHGNKSGLAEDMAFTEQLFSDF
HHCCCCEEEEEEECCCCEEEECCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHCCC
DCTNITFESDTAARNQLWEARHNLAYAYVHGYKGRKMMITDVCLPISYLADAISHARLML
CCCEEEECCCCHHHHHHHHHHHCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHEEEE
DIYGLPGGITGHVGDGNFHIVLMFDPHDEQEIQFAQELNEKVVAYALERGGTCTGEHGVG
EEECCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TGKKKYQQQEHGEALTVMRQLKQALDPDQIMNPNKIF
CCHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCC
>Mature Secondary Structure
METTITSLIEELSKYLETAQITQNETLLEQHSKDESYHAPHKPLAVIFPKDTTDVQHITR
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHH
CCSQFKVPIYPFGVGTSLEGHVIPNQPGISVDFSLMNNIVEINPEDLIVRVQPGVTRTQL
HHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHHCCEEEECCCCEEEEECCCCCHHHH
EKELKKYGLFFPVDPGADATLGGMAATNASGTLTVKYGTMRDNVRTMEVVLANGTTIQTG
HHHHHHCCCEEECCCCCCCCCCCEEECCCCCEEEEEECCCCCCCEEEEEEEECCCEEECC
TKAAKSSSGYHLNGLFVGSEGTLGCITELTLKVFGIPEHIAAGRATFPTVHQAIEAVVSV
CHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHEECCCHHHHCCCCCCHHHHHHHHHHHHH
LQAGIPIARMEIVDEDSILQVNQYSELDLSIEPTLFIEFHGNKSGLAEDMAFTEQLFSDF
HHCCCCEEEEEEECCCCEEEECCCCCCCEEECCEEEEEECCCCCCCHHHHHHHHHHHCCC
DCTNITFESDTAARNQLWEARHNLAYAYVHGYKGRKMMITDVCLPISYLADAISHARLML
CCCEEEECCCCHHHHHHHHHHHCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHEEEE
DIYGLPGGITGHVGDGNFHIVLMFDPHDEQEIQFAQELNEKVVAYALERGGTCTGEHGVG
EEECCCCCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
TGKKKYQQQEHGEALTVMRQLKQALDPDQIMNPNKIF
CCHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]