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The map label for this gene is goaG [C]

Identifier: 23098716

GI number: 23098716

Start: 1307154

End: 1308458

Strand: Reverse

Name: goaG [C]

Synonym: OB1261

Alternate gene names: 23098716

Gene position: 1308458-1307154 (Counterclockwise)

Preceding gene: 23098728

Following gene: 23098715

Centisome position: 36.04

GC content: 38.47

Gene sequence:

>1305_bases
ATGAATAAATCAGATCAACATTGGCAAGAACTTGTAAACTCAATCGGAAATTTCTTAGCACCTAGTATGGCAAAAGATCA
TCCGAATCTTCCGGTAGTAAAAGCAGAAGGTTGTTACTACTATGGAACGGATGGAAAAGAATATTTAGATTTCACTTCTG
GAATTGCCGTTGAAAATGTCGGACATCGTCATCCTAAAGTAGTACAAGCGATAAAAGATAGTGCAGATCACCTTGTACAC
GGTCCATCAGGAGTAATTATCTATGAATCTATCTTAAAATTAGCACAAGAACTTCAAGAGATTATGCCACCAAAACTAGA
TAATTTCTTCTTTGCTAATAGTGGTACAGAAGCAATTGAAGGTGGATTAAAGTTAGCTAAGCATGTGACAAAACGTCCAT
ATGTCATTTCATTTACCGGAAACTTCCATGGTCGCTCGATTGGTTCATTAAGTGTATCTACCTCAAAAAGTAAATATCGT
AAGTATCAACAACCATCATGGTTAACGTATCAATTACCATACGCTCTGCCAGAATACTTACCAGAAGGACAAGACCCAGA
AGTATTCTTTGCAGAAAAGCTAGAGAAAGATGCAGAATCCCTTTTCAAACATCAGGTAGACCCTGAAGAAGTAGCATGTA
TGATACTGGAACCAATTATGGGCGAAGGTGGTTACATCATCCCACCTAAATCATGGTTACAAAAAGTACGTGAAATCTGT
GATCGTCATGGTATTTTACTCATTTTTGATGAAGTACAAACTGGATTTGGACGTACCGGTGATTGGTTTGCAGCACAAAC
CTTTGGTGTTACACCTGACATTATGGCAATTGCAAAAGGAATCGCAGCAGGAATGCCATTAAGTGCCACTGTTGCATCTA
AAGAACTCATGGATCAATGGCCATTAGGTTCACACGGAACAACTTTTGGTGGTAACCCGATTGCTTGTGCAGCAGCACGC
GCTTCTCTTTCTATAATGAAAGAAGAAAAACTCCTTAACAATGCCAAGACAATGGGAGATTATGCATTAACCAAACTAAG
CGGTCTAAAAGATAAATATGAGATTGTCCACGAAGTACGCGGAATTGGCTTAATGCTAGGGATAGAACTGAGAGATCCTG
AAACAGGTGAACCAGATGGTGAAGCAGTAATGAAAGCTTTAAACGGCTGTTTAGATGAAGGAGTTTTATTCTATCTATGT
GGAAATGCAGGAGAAGTTATTCGAATGATTCCACCACTAACCATTAATAAAGAACAAATTGATCAAGGAATCGATGTACT
AGACAAAGTTCTAGCACAAATGTAA

Upstream 100 bases:

>100_bases
CCCTTCATAATTCGACAAATCTATTATATAATTTTTATGCAATCAAATTTATATTTATACATTTATTATACTATCATGAC
AATAAAGGAGCTTTTTTCTT

Downstream 100 bases:

>100_bases
AGGACGTGCCAATATGAGCAATCAAGTAGAAAATCTATCAAACAATACTCCACAATCAGAAGAAAAAATAGATAAAAATG
GTCTAATGAAGTTTCTACTT

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNKSDQHWQELVNSIGNFLAPSMAKDHPNLPVVKAEGCYYYGTDGKEYLDFTSGIAVENVGHRHPKVVQAIKDSADHLVH
GPSGVIIYESILKLAQELQEIMPPKLDNFFFANSGTEAIEGGLKLAKHVTKRPYVISFTGNFHGRSIGSLSVSTSKSKYR
KYQQPSWLTYQLPYALPEYLPEGQDPEVFFAEKLEKDAESLFKHQVDPEEVACMILEPIMGEGGYIIPPKSWLQKVREIC
DRHGILLIFDEVQTGFGRTGDWFAAQTFGVTPDIMAIAKGIAAGMPLSATVASKELMDQWPLGSHGTTFGGNPIACAAAR
ASLSIMKEEKLLNNAKTMGDYALTKLSGLKDKYEIVHEVRGIGLMLGIELRDPETGEPDGEAVMKALNGCLDEGVLFYLC
GNAGEVIRMIPPLTINKEQIDQGIDVLDKVLAQM

Sequences:

>Translated_434_residues
MNKSDQHWQELVNSIGNFLAPSMAKDHPNLPVVKAEGCYYYGTDGKEYLDFTSGIAVENVGHRHPKVVQAIKDSADHLVH
GPSGVIIYESILKLAQELQEIMPPKLDNFFFANSGTEAIEGGLKLAKHVTKRPYVISFTGNFHGRSIGSLSVSTSKSKYR
KYQQPSWLTYQLPYALPEYLPEGQDPEVFFAEKLEKDAESLFKHQVDPEEVACMILEPIMGEGGYIIPPKSWLQKVREIC
DRHGILLIFDEVQTGFGRTGDWFAAQTFGVTPDIMAIAKGIAAGMPLSATVASKELMDQWPLGSHGTTFGGNPIACAAAR
ASLSIMKEEKLLNNAKTMGDYALTKLSGLKDKYEIVHEVRGIGLMLGIELRDPETGEPDGEAVMKALNGCLDEGVLFYLC
GNAGEVIRMIPPLTINKEQIDQGIDVLDKVLAQM
>Mature_434_residues
MNKSDQHWQELVNSIGNFLAPSMAKDHPNLPVVKAEGCYYYGTDGKEYLDFTSGIAVENVGHRHPKVVQAIKDSADHLVH
GPSGVIIYESILKLAQELQEIMPPKLDNFFFANSGTEAIEGGLKLAKHVTKRPYVISFTGNFHGRSIGSLSVSTSKSKYR
KYQQPSWLTYQLPYALPEYLPEGQDPEVFFAEKLEKDAESLFKHQVDPEEVACMILEPIMGEGGYIIPPKSWLQKVREIC
DRHGILLIFDEVQTGFGRTGDWFAAQTFGVTPDIMAIAKGIAAGMPLSATVASKELMDQWPLGSHGTTFGGNPIACAAAR
ASLSIMKEEKLLNNAKTMGDYALTKLSGLKDKYEIVHEVRGIGLMLGIELRDPETGEPDGEAVMKALNGCLDEGVLFYLC
GNAGEVIRMIPPLTINKEQIDQGIDVLDKVLAQM

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=422, Percent_Identity=33.4123222748815, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI13994255, Length=417, Percent_Identity=33.5731414868106, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=30.4556354916067, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=30.166270783848, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=29.4536817102138, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=30.1790281329923, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI284507298, Length=328, Percent_Identity=33.2317073170732, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI188536080, Length=436, Percent_Identity=26.605504587156, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI38679950, Length=436, Percent_Identity=26.605504587156, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI38679946, Length=436, Percent_Identity=26.605504587156, Blast_Score=129, Evalue=8e-30,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=37.0098039215686, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=35.0746268656716, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=37.8109452736318, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=34.4827586206897, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=34.390243902439, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=31.2206572769953, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1786349, Length=414, Percent_Identity=30.1932367149758, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564660, Length=443, Percent_Identity=33.4085778781038, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI25144271, Length=420, Percent_Identity=32.8571428571429, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=421, Percent_Identity=32.0665083135392, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=33.7704918032787, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17541228, Length=443, Percent_Identity=25.0564334085779, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=147, Percent_Identity=30.6122448979592, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=31.7241379310345, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6324432, Length=407, Percent_Identity=33.1695331695332, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324386, Length=344, Percent_Identity=27.0348837209302, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=445, Percent_Identity=26.2921348314607, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI161085790, Length=450, Percent_Identity=31.5555555555556, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574759, Length=446, Percent_Identity=32.0627802690583, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21356575, Length=412, Percent_Identity=32.2815533980583, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21357415, Length=421, Percent_Identity=32.7790973871734, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281366494, Length=439, Percent_Identity=25.0569476082005, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667139, Length=439, Percent_Identity=25.0569476082005, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667143, Length=439, Percent_Identity=25.0569476082005, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 47734; Mature: 47734

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSDQHWQELVNSIGNFLAPSMAKDHPNLPVVKAEGCYYYGTDGKEYLDFTSGIAVENV
CCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEECCEEEECCCCHHHHHHHCCCCCCCC
GHRHPKVVQAIKDSADHLVHGPSGVIIYESILKLAQELQEIMPPKLDNFFFANSGTEAIE
CCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
GGLKLAKHVTKRPYVISFTGNFHGRSIGSLSVSTSKSKYRKYQQPSWLTYQLPYALPEYL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHCCCCCEEEECCHHHHHHC
PEGQDPEVFFAEKLEKDAESLFKHQVDPEEVACMILEPIMGEGGYIIPPKSWLQKVREIC
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DRHGILLIFDEVQTGFGRTGDWFAAQTFGVTPDIMAIAKGIAAGMPLSATVASKELMDQW
HHCCEEEEEECHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PLGSHGTTFGGNPIACAAARASLSIMKEEKLLNNAKTMGDYALTKLSGLKDKYEIVHEVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GIGLMLGIELRDPETGEPDGEAVMKALNGCLDEGVLFYLCGNAGEVIRMIPPLTINKEQI
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHEECCCCCCCHHHH
DQGIDVLDKVLAQM
HHHHHHHHHHHHCC
>Mature Secondary Structure
MNKSDQHWQELVNSIGNFLAPSMAKDHPNLPVVKAEGCYYYGTDGKEYLDFTSGIAVENV
CCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEECCEEEECCCCHHHHHHHCCCCCCCC
GHRHPKVVQAIKDSADHLVHGPSGVIIYESILKLAQELQEIMPPKLDNFFFANSGTEAIE
CCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHH
GGLKLAKHVTKRPYVISFTGNFHGRSIGSLSVSTSKSKYRKYQQPSWLTYQLPYALPEYL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHCCCCCEEEECCHHHHHHC
PEGQDPEVFFAEKLEKDAESLFKHQVDPEEVACMILEPIMGEGGYIIPPKSWLQKVREIC
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHH
DRHGILLIFDEVQTGFGRTGDWFAAQTFGVTPDIMAIAKGIAAGMPLSATVASKELMDQW
HHCCEEEEEECHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PLGSHGTTFGGNPIACAAARASLSIMKEEKLLNNAKTMGDYALTKLSGLKDKYEIVHEVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GIGLMLGIELRDPETGEPDGEAVMKALNGCLDEGVLFYLCGNAGEVIRMIPPLTINKEQI
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCHHEECCCCCCCHHHH
DQGIDVLDKVLAQM
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA