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The map label for this gene is nupC [H]

Identifier: 23098546

GI number: 23098546

Start: 1141162

End: 1142361

Strand: Direct

Name: nupC [H]

Synonym: OB1091

Alternate gene names: 23098546

Gene position: 1141162-1142361 (Clockwise)

Preceding gene: 23098545

Following gene: 23098548

Centisome position: 31.43

GC content: 34.33

Gene sequence:

>1200_bases
GTGAGTATACTTCTCGGTATATTAGCAATTATTATTACATTAGGACTTGCCTTCCTCATGTCGAACAAAAAGAAAAAAAT
AAACCTTAAAGGCATAGGAATAATGTTAGTTCTTCAGTTACTAATTACGTGGTTTATGTTCTCAACCACTATTGGTGCTT
CTATAATTAAGGGTATATCAGCTGTGTTTAATAAGCTGATTGAATTTGGTACAGAAGGCGTCAATTTTGTACTTGGAGGA
TTTGAAGTTGCAGAAGGTGGAGTTTTCTTCTTCAACGTATTATTACTTATTATATTCTTTGCAACATTACTGTCTGTGTT
AACGTATTTAAAAATACTACCGGCTATTATTAAGTATGTTGGAGCAGCAATCTCAAAAGTTACTGGATTACCACGAATTG
AATCATTTAACGGAGTAAATAGTATATTTTTTGGACAATCGGAAGCACTAATCGCAATTCGGTCTCAATTCCATCATTTA
AATGAAAATCGTCTTTATATTGTGAGTGCTTCAGCGATGGGGTCAGTATCTGCTTCCATTGTAGGTGCATATATTCAAAT
ATTACCACCTGAATATATATTAGTCGCATTGCCTTTAAACATGTTTAGTGCGTTAATGATTGCATCAATTATTGCTCCTG
TCGAAGTTCCAAAAGAAGAAGACAAAGTTGATATTTCTGATGTTAGTCAAGATAAGAGTATTTTCGAAGCAATGGGAAAT
GGAGCTTTAGAAGGTGGAAAAATTGCATTAATCGTAGCTGCAATGTTAATTGCATTTATTGCGTCTTTAGAGCTTGTAAA
CTGGATAATTCAGTTTGTATTTTCTGGCTTCAGTGCAGACATCACTTTAGAAACAATCTTAGGATATATTCTTGCTCCTA
TTGGAATCTTAATGGGGATTGCACCTAGTGAAGTTATTGAGGCAGGATCTATAATGGGTACAAAGATTGTTACAAATGAA
TTTGTAGCGATGACGCAATTCCAACCTCTATTAGATGAAATGTCTGAGAAAACAATTGGTATTGTTACTGTATTCCTAAC
AAGTTTTGCTAACTTCTCTTCCATTGGTATCATTGCTGGTACGGTTAAAGGAATTGATAGCAAGAAAGCTGTGTCAGTAT
CCCAATTTGGAATGAAGCTTTTAATAGGGTCCATATTAGCTTCCATCTTATCAGCAACAATTGTAGGATTGTTCTTGTAA

Upstream 100 bases:

>100_bases
AAAATGGTAATATATTTTTTGTTTCTTTAACTTGTCATACGTCATACATGTTAATAGATAAAATGGTATTTATACCTAAA
ACGAATAAAGGAGGCTAACC

Downstream 100 bases:

>100_bases
AAAATTTAATTTATCTTAATACCATAGGATTATATTATATTCTTAAGAAGTTGGGACAAAAATATTTGTTTTGTCCCAAC
TTCTTTATTTATATCTAGGA

Product: pyrimidine nucleoside transporter

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSILLGILAIIITLGLAFLMSNKKKKINLKGIGIMLVLQLLITWFMFSTTIGASIIKGISAVFNKLIEFGTEGVNFVLGG
FEVAEGGVFFFNVLLLIIFFATLLSVLTYLKILPAIIKYVGAAISKVTGLPRIESFNGVNSIFFGQSEALIAIRSQFHHL
NENRLYIVSASAMGSVSASIVGAYIQILPPEYILVALPLNMFSALMIASIIAPVEVPKEEDKVDISDVSQDKSIFEAMGN
GALEGGKIALIVAAMLIAFIASLELVNWIIQFVFSGFSADITLETILGYILAPIGILMGIAPSEVIEAGSIMGTKIVTNE
FVAMTQFQPLLDEMSEKTIGIVTVFLTSFANFSSIGIIAGTVKGIDSKKAVSVSQFGMKLLIGSILASILSATIVGLFL

Sequences:

>Translated_399_residues
MSILLGILAIIITLGLAFLMSNKKKKINLKGIGIMLVLQLLITWFMFSTTIGASIIKGISAVFNKLIEFGTEGVNFVLGG
FEVAEGGVFFFNVLLLIIFFATLLSVLTYLKILPAIIKYVGAAISKVTGLPRIESFNGVNSIFFGQSEALIAIRSQFHHL
NENRLYIVSASAMGSVSASIVGAYIQILPPEYILVALPLNMFSALMIASIIAPVEVPKEEDKVDISDVSQDKSIFEAMGN
GALEGGKIALIVAAMLIAFIASLELVNWIIQFVFSGFSADITLETILGYILAPIGILMGIAPSEVIEAGSIMGTKIVTNE
FVAMTQFQPLLDEMSEKTIGIVTVFLTSFANFSSIGIIAGTVKGIDSKKAVSVSQFGMKLLIGSILASILSATIVGLFL
>Mature_398_residues
SILLGILAIIITLGLAFLMSNKKKKINLKGIGIMLVLQLLITWFMFSTTIGASIIKGISAVFNKLIEFGTEGVNFVLGGF
EVAEGGVFFFNVLLLIIFFATLLSVLTYLKILPAIIKYVGAAISKVTGLPRIESFNGVNSIFFGQSEALIAIRSQFHHLN
ENRLYIVSASAMGSVSASIVGAYIQILPPEYILVALPLNMFSALMIASIIAPVEVPKEEDKVDISDVSQDKSIFEAMGNG
ALEGGKIALIVAAMLIAFIASLELVNWIIQFVFSGFSADITLETILGYILAPIGILMGIAPSEVIEAGSIMGTKIVTNEF
VAMTQFQPLLDEMSEKTIGIVTVFLTSFANFSSIGIIAGTVKGIDSKKAVSVSQFGMKLLIGSILASILSATIVGLFL

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=351, Percent_Identity=27.3504273504274, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI42542381, Length=416, Percent_Identity=25.2403846153846, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI227116277, Length=422, Percent_Identity=26.303317535545, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1788737, Length=393, Percent_Identity=43.765903307888, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1788485, Length=417, Percent_Identity=33.5731414868106, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788488, Length=414, Percent_Identity=33.0917874396135, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17560276, Length=395, Percent_Identity=23.7974683544304, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71991794, Length=408, Percent_Identity=23.5294117647059, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45552519, Length=410, Percent_Identity=23.9024390243902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552517, Length=410, Percent_Identity=23.9024390243902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19921868, Length=410, Percent_Identity=23.9024390243902, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281360430, Length=358, Percent_Identity=24.5810055865922, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42583; Mature: 42451

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILLGILAIIITLGLAFLMSNKKKKINLKGIGIMLVLQLLITWFMFSTTIGASIIKGIS
CHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFNKLIEFGTEGVNFVLGGFEVAEGGVFFFNVLLLIIFFATLLSVLTYLKILPAIIKYV
HHHHHHHHHCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAAISKVTGLPRIESFNGVNSIFFGQSEALIAIRSQFHHLNENRLYIVSASAMGSVSASI
HHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
VGAYIQILPPEYILVALPLNMFSALMIASIIAPVEVPKEEDKVDISDVSQDKSIFEAMGN
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GALEGGKIALIVAAMLIAFIASLELVNWIIQFVFSGFSADITLETILGYILAPIGILMGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCC
APSEVIEAGSIMGTKIVTNEFVAMTQFQPLLDEMSEKTIGIVTVFLTSFANFSSIGIIAG
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
TVKGIDSKKAVSVSQFGMKLLIGSILASILSATIVGLFL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILLGILAIIITLGLAFLMSNKKKKINLKGIGIMLVLQLLITWFMFSTTIGASIIKGIS
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFNKLIEFGTEGVNFVLGGFEVAEGGVFFFNVLLLIIFFATLLSVLTYLKILPAIIKYV
HHHHHHHHHCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAAISKVTGLPRIESFNGVNSIFFGQSEALIAIRSQFHHLNENRLYIVSASAMGSVSASI
HHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
VGAYIQILPPEYILVALPLNMFSALMIASIIAPVEVPKEEDKVDISDVSQDKSIFEAMGN
HHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GALEGGKIALIVAAMLIAFIASLELVNWIIQFVFSGFSADITLETILGYILAPIGILMGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCC
APSEVIEAGSIMGTKIVTNEFVAMTQFQPLLDEMSEKTIGIVTVFLTSFANFSSIGIIAG
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHH
TVKGIDSKKAVSVSQFGMKLLIGSILASILSATIVGLFL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]