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The map label for this gene is cdr [H]

Identifier: 23098314

GI number: 23098314

Start: 909917

End: 911260

Strand: Reverse

Name: cdr [H]

Synonym: OB0859

Alternate gene names: 23098314

Gene position: 911260-909917 (Counterclockwise)

Preceding gene: 23098315

Following gene: 23098306

Centisome position: 25.1

GC content: 37.05

Gene sequence:

>1344_bases
ATGTCTAAAAAAATTATTATTGTCGGTGGTGTTGGGGGTGGAGCAACGGTTGCCGCACAAATTAGAAGAACGAATAAAAC
GGCAGAAATTCTTGTACTAGAACGAAATGGATATGTATCTTTTGCAAATTGCGGTATGCCATATTATCTGGGAGGTACAA
TTACTGATCGTCAAAAATTAATTTATCCTGAAGAAAAGTTTGCACAAAAATATGACCTAACCGTACAAACACATGCAAAT
GTTACCAAAATTAACCGGGAACAAAAAAGCGTTGTATATGAAAAGTATAAAACAGAACACAAAGCTGACTATGATATTCT
TATATTGTCCCCAGGAGCATCGCCTGTATTACCTGATATAGCTGGATTACAACAATCTAATACGTTTCCGTTAAGGACGA
TTGAAGATATGGATAATATAGAACAGTTTATTCAATCTAATAATCCGCAATCTGCTGCGATTATTGGCGGAGGTTTTATT
GGATTAGAAATGGCAGAAAGTCTGTGTCATCGAGGGTTCTCCTGTTCTCTAGTAGATCGTTCTGAGCATGTATTAAAACG
AATCGATAAAGAAATGGCAATACATATAGATGAACATTTACAAGAAAAAGGAATAGCTTTGTATGTCAATGATGGATTAA
AAAGCTTTTCAGATAATGGTACCACCTTACACCTTTCGAGTGATAAAACGATCCAAGCTGATATGACTATTATGGCAATA
GGAATAAAACCAAATACAGAGCTTGCCATTGATGCCGGATTGGAAATTGGAGAAACTGGTGGAATTAAAGTAAATCAATA
TATGCAAACTACCGACCCAACTATCTTTGCTCTCGGTGATGCAGTAGAAGTTACTGATTTCATAACTAGAGAACCTGCTC
ATATTGCCTTAGCTTGGCCAGCTCATAGGCAAGCATTCATTATCTCTTCGTTCTTAAGTGGCAATCCTATATCTGATGAT
GGAATAATTGGGTCATCAATTTTGCGTGTCTTTGATTTAACTGTTGCAGCTACTGGGCAAAACAAACAGACGTTAATCGA
TAATGAGATTGCATTCGAAGAAACGATAATGAAAGGTTATTCTCATGCAGCATATTACCCTGGCTCAAAGGAGCTTTGGA
TGCAAATTGTCTATGATAAAAATACCGGACAATTATTTGGTGGAAGCGTAATTGGATTTGACGGCGCAGATAAACGCATG
GCTGTTCTAGCTACAGCTATCAAAGGTAAGTTAACAGTAGCAGATTTGGCTTCATTAGAATTAGGTTATTCCCCCATTTA
TTCAGGCGCAAAAGATCCTTTAAATATACTAGGCTATAAAGCCATGGAACAGCTAGAGGATTAG

Upstream 100 bases:

>100_bases
AATAGATATTTTGTGCCTCTCATCTATTTGATGAGAGGTTTTTTATAACGAGCTTAAACTAGTCAACTGGTAAAAGTCTT
ACTAATTGGGAGTGAATAAT

Downstream 100 bases:

>100_bases
TCGAAGCAGTGTCTGCAAAAAGCGGTATCTGCAATGGATATACAGAATAAATGATGTAATGAATGTAAATAGAGATTTAA
CGCATTGGACATTAAACTCC

Product: NADH oxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSKKIIIVGGVGGGATVAAQIRRTNKTAEILVLERNGYVSFANCGMPYYLGGTITDRQKLIYPEEKFAQKYDLTVQTHAN
VTKINREQKSVVYEKYKTEHKADYDILILSPGASPVLPDIAGLQQSNTFPLRTIEDMDNIEQFIQSNNPQSAAIIGGGFI
GLEMAESLCHRGFSCSLVDRSEHVLKRIDKEMAIHIDEHLQEKGIALYVNDGLKSFSDNGTTLHLSSDKTIQADMTIMAI
GIKPNTELAIDAGLEIGETGGIKVNQYMQTTDPTIFALGDAVEVTDFITREPAHIALAWPAHRQAFIISSFLSGNPISDD
GIIGSSILRVFDLTVAATGQNKQTLIDNEIAFEETIMKGYSHAAYYPGSKELWMQIVYDKNTGQLFGGSVIGFDGADKRM
AVLATAIKGKLTVADLASLELGYSPIYSGAKDPLNILGYKAMEQLED

Sequences:

>Translated_447_residues
MSKKIIIVGGVGGGATVAAQIRRTNKTAEILVLERNGYVSFANCGMPYYLGGTITDRQKLIYPEEKFAQKYDLTVQTHAN
VTKINREQKSVVYEKYKTEHKADYDILILSPGASPVLPDIAGLQQSNTFPLRTIEDMDNIEQFIQSNNPQSAAIIGGGFI
GLEMAESLCHRGFSCSLVDRSEHVLKRIDKEMAIHIDEHLQEKGIALYVNDGLKSFSDNGTTLHLSSDKTIQADMTIMAI
GIKPNTELAIDAGLEIGETGGIKVNQYMQTTDPTIFALGDAVEVTDFITREPAHIALAWPAHRQAFIISSFLSGNPISDD
GIIGSSILRVFDLTVAATGQNKQTLIDNEIAFEETIMKGYSHAAYYPGSKELWMQIVYDKNTGQLFGGSVIGFDGADKRM
AVLATAIKGKLTVADLASLELGYSPIYSGAKDPLNILGYKAMEQLED
>Mature_446_residues
SKKIIIVGGVGGGATVAAQIRRTNKTAEILVLERNGYVSFANCGMPYYLGGTITDRQKLIYPEEKFAQKYDLTVQTHANV
TKINREQKSVVYEKYKTEHKADYDILILSPGASPVLPDIAGLQQSNTFPLRTIEDMDNIEQFIQSNNPQSAAIIGGGFIG
LEMAESLCHRGFSCSLVDRSEHVLKRIDKEMAIHIDEHLQEKGIALYVNDGLKSFSDNGTTLHLSSDKTIQADMTIMAIG
IKPNTELAIDAGLEIGETGGIKVNQYMQTTDPTIFALGDAVEVTDFITREPAHIALAWPAHRQAFIISSFLSGNPISDDG
IIGSSILRVFDLTVAATGQNKQTLIDNEIAFEETIMKGYSHAAYYPGSKELWMQIVYDKNTGQLFGGSVIGFDGADKRMA
VLATAIKGKLTVADLASLELGYSPIYSGAKDPLNILGYKAMEQLED

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=310, Percent_Identity=25.8064516129032, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI21389617, Length=310, Percent_Identity=25.8064516129032, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI65787454, Length=310, Percent_Identity=25.8064516129032, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=25.9375, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788892, Length=281, Percent_Identity=26.3345195729537, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789765, Length=340, Percent_Identity=21.1764705882353, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082354, Length=181, Percent_Identity=28.7292817679558, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789915, Length=189, Percent_Identity=28.042328042328, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=291, Percent_Identity=23.7113402061856, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=287, Percent_Identity=20.9059233449477, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639257, Length=284, Percent_Identity=22.1830985915493, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281359715, Length=282, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281359713, Length=282, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639250, Length=282, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18543267, Length=282, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639252, Length=282, Percent_Identity=22.3404255319149, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585130, Length=283, Percent_Identity=22.2614840989399, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 48785; Mature: 48654

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIIIVGGVGGGATVAAQIRRTNKTAEILVLERNGYVSFANCGMPYYLGGTITDRQKL
CCCEEEEEECCCCCHHEEEEHHHCCCCEEEEEEECCCEEEEECCCCCEEECCEEECCCEE
IYPEEKFAQKYDLTVQTHANVTKINREQKSVVYEKYKTEHKADYDILILSPGASPVLPDI
ECCHHHHHHHCCEEEEECCCCEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHH
AGLQQSNTFPLRTIEDMDNIEQFIQSNNPQSAAIIGGGFIGLEMAESLCHRGFSCSLVDR
HCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECC
SEHVLKRIDKEMAIHIDEHLQEKGIALYVNDGLKSFSDNGTTLHLSSDKTIQADMTIMAI
HHHHHHHHCHHHEEEEHHHHHHCCEEEEEECCCHHCCCCCCEEEECCCCEEEECEEEEEE
GIKPNTELAIDAGLEIGETGGIKVNQYMQTTDPTIFALGDAVEVTDFITREPAHIALAWP
ECCCCCCEEEECCCEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHCCCCCEEEEECC
AHRQAFIISSFLSGNPISDDGIIGSSILRVFDLTVAATGQNKQTLIDNEIAFEETIMKGY
CCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCEEECCHHHHHHHHHHCC
SHAAYYPGSKELWMQIVYDKNTGQLFGGSVIGFDGADKRMAVLATAIKGKLTVADLASLE
CCEEECCCCHHEEEEEEEECCCCCEECCEEEECCCCCCHHEEEEHHHCCCEEEEHHHHHH
LGYSPIYSGAKDPLNILGYKAMEQLED
CCCCHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKIIIVGGVGGGATVAAQIRRTNKTAEILVLERNGYVSFANCGMPYYLGGTITDRQKL
CCEEEEEECCCCCHHEEEEHHHCCCCEEEEEEECCCEEEEECCCCCEEECCEEECCCEE
IYPEEKFAQKYDLTVQTHANVTKINREQKSVVYEKYKTEHKADYDILILSPGASPVLPDI
ECCHHHHHHHCCEEEEECCCCEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHH
AGLQQSNTFPLRTIEDMDNIEQFIQSNNPQSAAIIGGGFIGLEMAESLCHRGFSCSLVDR
HCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECC
SEHVLKRIDKEMAIHIDEHLQEKGIALYVNDGLKSFSDNGTTLHLSSDKTIQADMTIMAI
HHHHHHHHCHHHEEEEHHHHHHCCEEEEEECCCHHCCCCCCEEEECCCCEEEECEEEEEE
GIKPNTELAIDAGLEIGETGGIKVNQYMQTTDPTIFALGDAVEVTDFITREPAHIALAWP
ECCCCCCEEEECCCEECCCCCEEEEEEEECCCCEEEEECCCHHHHHHHCCCCCEEEEECC
AHRQAFIISSFLSGNPISDDGIIGSSILRVFDLTVAATGQNKQTLIDNEIAFEETIMKGY
CCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCEEECCHHHHHHHHHHCC
SHAAYYPGSKELWMQIVYDKNTGQLFGGSVIGFDGADKRMAVLATAIKGKLTVADLASLE
CCEEECCCCHHEEEEEEEECCCCCEECCEEEECCCCCCHHEEEEHHHCCCEEEEHHHHHH
LGYSPIYSGAKDPLNILGYKAMEQLED
CCCCHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA