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The map label for this gene is mmgC [H]

Identifier: 23098143

GI number: 23098143

Start: 723777

End: 724931

Strand: Direct

Name: mmgC [H]

Synonym: OB0688

Alternate gene names: 23098143

Gene position: 723777-724931 (Clockwise)

Preceding gene: 23098142

Following gene: 23098144

Centisome position: 19.94

GC content: 36.97

Gene sequence:

>1155_bases
ATGAATTTTGAATTAGATGAAGATATTCAAATTATCAAGGATAACGTACGGAATTTTATTCAAACAGAGGTAGAGCAGGT
TGCTGATAATATTGAACGAAATAATAAAATACCTGATCGAATAATCGAATTATCAAAACAAATGGGATTATTTGGTTTAA
GTATACCCGAACAATATGGGGGATTAGGTATTGGAATGGTAGGAAAATGTGCATTATATGAAGAAATTGGAGTCACCCAT
AATGGGTATACAACACTCATTGGTGCTCATACTGGAATTGGTACTGTTGGAATAGTAGAGATGGGAAACGAACAACAAAA
ACAGAAATACTTACCTCTTATGGCAAGCGGAGAAAAAATTGGTGCATTTGCCCTTACAGAACCGGAAGCTGGATCAAATG
CAAGTGCTTTGAAAACATCGGCTATTAAAAAGAAAGATAAATATATATTAAATGGAACAAAACACTATATTACCAATGCC
ACTGAGGCAGAAGTGTTTACTGTGATGGCAGTTACCGATCCTGCCAAAGGTGCTAAAGGCATTTCTTCTTTTATTGTTGA
GAAAAGTAATTTGGGATTTCATGTAGGCGCAGTTGAAGAGAAGATGGGGCTAAAAGGTTCTCACTCTGCAGAAATAATTT
TAGATGATTGTGAAGTTTCAGTAGAGAATTTACTTGGTGAAGAAGGGCAAGGGTATGTGAATGCATTAAAAATTTTAACG
AATGGTCGAGCTGGTTTGGCGGCTCGAAATTTAGGGTCATGCCAGAAACTCTTAGATATGTCGACTACCTATGCAATTGA
AAGACAACAATTCGGGACATCGATTATTGACCATCAAGCAGTAGCACATATGTTAGCAGAAATGGCTGTGGAGATAGAGG
CATTGCGGGCCTTAACATATAAAGTGGCGTGGATGGTAGATAATGGAGAAAATGTCATTAAAGAAGCAGCGATGTTAAAA
CTATATGGTTCCGAAGTATACAACCGAGTGGCAGATAAAGCAGTTCAAGTGCATGGGGGAATTGGTTATATATCTGATTT
TCCAGTGGAACGATATTATAGAGATGCGCGTATTACTCGGATTTATGAAGGAACATCGGAAATTCAGAAGAATATTATTG
CAGGACAATTGAAAAAACACTATAGCAACAGATAA

Upstream 100 bases:

>100_bases
CATTTTTAAAACAATAAAACTTGGCATTTTTCACTGCCAAGTTTTACTTCTTTTTTCCATAAGAAGCAATGATTATGTAC
GGAACAGGAGGTAATCCGAT

Downstream 100 bases:

>100_bases
GAAGCAGGGAGGTATAAAGGTGGAGGATCCGATCGTTATTGTTAGTGCAATTAGAACGCCAATTGGAGCATATGGCCAAT
CATTGAAAAACATATCATCT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNFELDEDIQIIKDNVRNFIQTEVEQVADNIERNNKIPDRIIELSKQMGLFGLSIPEQYGGLGIGMVGKCALYEEIGVTH
NGYTTLIGAHTGIGTVGIVEMGNEQQKQKYLPLMASGEKIGAFALTEPEAGSNASALKTSAIKKKDKYILNGTKHYITNA
TEAEVFTVMAVTDPAKGAKGISSFIVEKSNLGFHVGAVEEKMGLKGSHSAEIILDDCEVSVENLLGEEGQGYVNALKILT
NGRAGLAARNLGSCQKLLDMSTTYAIERQQFGTSIIDHQAVAHMLAEMAVEIEALRALTYKVAWMVDNGENVIKEAAMLK
LYGSEVYNRVADKAVQVHGGIGYISDFPVERYYRDARITRIYEGTSEIQKNIIAGQLKKHYSNR

Sequences:

>Translated_384_residues
MNFELDEDIQIIKDNVRNFIQTEVEQVADNIERNNKIPDRIIELSKQMGLFGLSIPEQYGGLGIGMVGKCALYEEIGVTH
NGYTTLIGAHTGIGTVGIVEMGNEQQKQKYLPLMASGEKIGAFALTEPEAGSNASALKTSAIKKKDKYILNGTKHYITNA
TEAEVFTVMAVTDPAKGAKGISSFIVEKSNLGFHVGAVEEKMGLKGSHSAEIILDDCEVSVENLLGEEGQGYVNALKILT
NGRAGLAARNLGSCQKLLDMSTTYAIERQQFGTSIIDHQAVAHMLAEMAVEIEALRALTYKVAWMVDNGENVIKEAAMLK
LYGSEVYNRVADKAVQVHGGIGYISDFPVERYYRDARITRIYEGTSEIQKNIIAGQLKKHYSNR
>Mature_384_residues
MNFELDEDIQIIKDNVRNFIQTEVEQVADNIERNNKIPDRIIELSKQMGLFGLSIPEQYGGLGIGMVGKCALYEEIGVTH
NGYTTLIGAHTGIGTVGIVEMGNEQQKQKYLPLMASGEKIGAFALTEPEAGSNASALKTSAIKKKDKYILNGTKHYITNA
TEAEVFTVMAVTDPAKGAKGISSFIVEKSNLGFHVGAVEEKMGLKGSHSAEIILDDCEVSVENLLGEEGQGYVNALKILT
NGRAGLAARNLGSCQKLLDMSTTYAIERQQFGTSIIDHQAVAHMLAEMAVEIEALRALTYKVAWMVDNGENVIKEAAMLK
LYGSEVYNRVADKAVQVHGGIGYISDFPVERYYRDARITRIYEGTSEIQKNIIAGQLKKHYSNR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=39.0625, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=38.2978723404255, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=36.7875647668394, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=36.7875647668394, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI21361497, Length=382, Percent_Identity=39.2670157068063, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=37.4331550802139, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557235, Length=383, Percent_Identity=37.3368146214099, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=37.3368146214099, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=39.2857142857143, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=34.0482573726542, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=30.7486631016043, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI4503943, Length=373, Percent_Identity=29.7587131367292, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=29.4765840220386, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI38505218, Length=348, Percent_Identity=27.0114942528736, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI48976061, Length=353, Percent_Identity=27.1954674220963, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI211971008, Length=353, Percent_Identity=27.1954674220963, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=28.7958115183246, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=30.1546391752577, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87081702, Length=387, Percent_Identity=24.5478036175711, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=25.7352941176471, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=381, Percent_Identity=37.5328083989501, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=37.1352785145889, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=37.8947368421053, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=36.71875, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=37.0466321243523, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71985184, Length=360, Percent_Identity=38.3333333333333, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=34.2857142857143, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=39.1156462585034, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=29.8666666666667, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=294, Percent_Identity=37.7551020408163, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=37.3913043478261, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=382, Percent_Identity=28.2722513089005, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=373, Percent_Identity=30.0268096514745, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=27.7628032345013, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=32.2344322344322, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=32.258064516129, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562446, Length=352, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=186, Percent_Identity=30.1075268817204, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=359, Percent_Identity=25.0696378830084, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=27.0676691729323, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=27.0676691729323, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356377, Length=379, Percent_Identity=39.3139841688654, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=37.3015873015873, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24646207, Length=370, Percent_Identity=35.9459459459459, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281363737, Length=361, Percent_Identity=38.781163434903, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=36.436170212766, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=34.8051948051948, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI19920834, Length=374, Percent_Identity=28.3422459893048, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24652780, Length=331, Percent_Identity=23.5649546827795, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42047; Mature: 42047

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELDEDIQIIKDNVRNFIQTEVEQVADNIERNNKIPDRIIELSKQMGLFGLSIPEQYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCHHHC
GLGIGMVGKCALYEEIGVTHNGYTTLIGAHTGIGTVGIVEMGNEQQKQKYLPLMASGEKI
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHCCCEEECCCCC
GAFALTEPEAGSNASALKTSAIKKKDKYILNGTKHYITNATEAEVFTVMAVTDPAKGAKG
CEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCHHEECCCCCCEEEEEEEECCCCCCHHH
ISSFIVEKSNLGFHVGAVEEKMGLKGSHSAEIILDDCEVSVENLLGEEGQGYVNALKILT
HHHHHEECCCCCEEEECHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHH
NGRAGLAARNLGSCQKLLDMSTTYAIERQQFGTSIIDHQAVAHMLAEMAVEIEALRALTY
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHE
KVAWMVDNGENVIKEAAMLKLYGSEVYNRVADKAVQVHGGIGYISDFPVERYYRDARITR
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHEE
IYEGTSEIQKNIIAGQLKKHYSNR
EECCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFELDEDIQIIKDNVRNFIQTEVEQVADNIERNNKIPDRIIELSKQMGLFGLSIPEQYG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCHHHC
GLGIGMVGKCALYEEIGVTHNGYTTLIGAHTGIGTVGIVEMGNEQQKQKYLPLMASGEKI
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHCCCEEECCCCC
GAFALTEPEAGSNASALKTSAIKKKDKYILNGTKHYITNATEAEVFTVMAVTDPAKGAKG
CEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCHHEECCCCCCEEEEEEEECCCCCCHHH
ISSFIVEKSNLGFHVGAVEEKMGLKGSHSAEIILDDCEVSVENLLGEEGQGYVNALKILT
HHHHHEECCCCCEEEECHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCCCCHHHHHHHHH
NGRAGLAARNLGSCQKLLDMSTTYAIERQQFGTSIIDHQAVAHMLAEMAVEIEALRALTY
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHE
KVAWMVDNGENVIKEAAMLKLYGSEVYNRVADKAVQVHGGIGYISDFPVERYYRDARITR
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHEE
IYEGTSEIQKNIIAGQLKKHYSNR
EECCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]