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The map label for this gene is comC [H]

Identifier: 23098072

GI number: 23098072

Start: 645987

End: 646742

Strand: Reverse

Name: comC [H]

Synonym: OB0617

Alternate gene names: 23098072

Gene position: 646742-645987 (Counterclockwise)

Preceding gene: 23098073

Following gene: 23098066

Centisome position: 17.81

GC content: 33.47

Gene sequence:

>756_bases
ATGTTTAATATTCACCCTCTATTTTTCTTCATCCTCGGAGCTATTTTGGGCTCATTTTTTATGGTCGTGGGTTTACGACT
CCCCAAACAGATGCCCTTTGTTAATGCCCGATCATGTTGTGATCATTGTCAATATCAACTTCGTTGGTTCGATAATATTC
CTATTGTTTCTTATATTTATCTAAGGGGGAAGTGCAGAAAATGTAAAACAAGAATCCATCCGCTCCATGTTGTAGCAGAA
ATCATAACTGGGATTTTATTTACGGTAAGCTATTATCACATCGGTTTACAGTGGGAAATAATTATTTCCTTATTACTTAC
ATCTTTATTAGTTATAATTTGCATTTCAGATTTTATATACATGGTGATCCCAAACAAATTGTTACTTTTCTTTCTCCCCA
TCTTCATTATTTTACGACTTTTACTTCCATTAGATCCATGGTGGTCTATGTTTACAGGTGCTGCAATAGGCTTCGGTATT
ATATTTCTTATCATATTAATTAGTAGAGGCGGGATGGGGGCTGGTGATATGAAATTACTTGGCCTTGCAGGTATTGTTTT
AGGTGTTGAAAAAATTATTCTAGCATTTTTCTTAGCATGCATAATCGGTTCTGTCATCAGCATTGTTTTATTATCTGTCC
ATTTAATTCAACGTAATAAACCATTTCCATTTGGTCCCTTTATCGCGATTGGTATTCTCATATCCTATTTTTATGGAGAT
TCATTAATTAATTGGTATCTTCAATATTTTATTTAA

Upstream 100 bases:

>100_bases
AGTATTCCCTTAGAAAGAAACGTACATATTCCGTTCTTTACTTACTTGTACTTCTTCCCCCCTCATATTTTAGATAATAA
AATAGTCAGGAGCCTCGCTT

Downstream 100 bases:

>100_bases
ATACTAACTCTAAGATAATCATAAAATTGAAGTTATTTCTTCATTCGTCAAAAAGAAAAGTAAACCTCGCTCCAGCGTTC
ATATACTCTACAATAGATAT

Product: leader peptide processing enzyme

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MFNIHPLFFFILGAILGSFFMVVGLRLPKQMPFVNARSCCDHCQYQLRWFDNIPIVSYIYLRGKCRKCKTRIHPLHVVAE
IITGILFTVSYYHIGLQWEIIISLLLTSLLVIICISDFIYMVIPNKLLLFFLPIFIILRLLLPLDPWWSMFTGAAIGFGI
IFLIILISRGGMGAGDMKLLGLAGIVLGVEKIILAFFLACIIGSVISIVLLSVHLIQRNKPFPFGPFIAIGILISYFYGD
SLINWYLQYFI

Sequences:

>Translated_251_residues
MFNIHPLFFFILGAILGSFFMVVGLRLPKQMPFVNARSCCDHCQYQLRWFDNIPIVSYIYLRGKCRKCKTRIHPLHVVAE
IITGILFTVSYYHIGLQWEIIISLLLTSLLVIICISDFIYMVIPNKLLLFFLPIFIILRLLLPLDPWWSMFTGAAIGFGI
IFLIILISRGGMGAGDMKLLGLAGIVLGVEKIILAFFLACIIGSVISIVLLSVHLIQRNKPFPFGPFIAIGILISYFYGD
SLINWYLQYFI
>Mature_251_residues
MFNIHPLFFFILGAILGSFFMVVGLRLPKQMPFVNARSCCDHCQYQLRWFDNIPIVSYIYLRGKCRKCKTRIHPLHVVAE
IITGILFTVSYYHIGLQWEIIISLLLTSLLVIICISDFIYMVIPNKLLLFFLPIFIILRLLLPLDPWWSMFTGAAIGFGI
IFLIILISRGGMGAGDMKLLGLAGIVLGVEKIILAFFLACIIGSVISIVLLSVHLIQRNKPFPFGPFIAIGILISYFYGD
SLINWYLQYFI

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 28574; Mature: 28574

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHC
>Mature Secondary Structure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HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]