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The map label for this gene is nagB

Identifier: 23098066

GI number: 23098066

Start: 639057

End: 639809

Strand: Reverse

Name: nagB

Synonym: OB0611

Alternate gene names: 23098066

Gene position: 639809-639057 (Counterclockwise)

Preceding gene: 23098072

Following gene: 23098063

Centisome position: 17.62

GC content: 34.13

Gene sequence:

>753_bases
ATGAAAATAATTCAAACAGAAAATTATCAGTCAATGAGTAAGCTTGCTAGCCAACATGTAATTAATACCATAAAGCAGTT
AAATAAACCAGTTCTTGGGTTAGCGACTGGTTCAACTCCTGAAGGTCTTTACCAACATTTAATTAAAGCTTATCGTATGC
ATCAAATTTCCTTTGCAAATGTATCTACATTTAATTTAGATGAATATGTTGGTTTACACAAGGAAGATAAAAATAGTTAT
CATTATTACATGCAAAAATTTCTATTTAATCATGTTGATATTCCATATAAAAATATCCATTTACCTAATGGAATAGCAAA
AGATTTATCCGTTGAATGTACATCTTATGAAGATCGCATTCAACAAGCAGGCGGTATTCATATTCAGGTTCTAGGAATCG
GACGAAATGGGCATATCGGTTTTAATGAACCTGGTACTTCCTTTGAAAGTCAAACGCATGTCGTGGACTTGGATGAATCT
ACAAGAAATGCAAATGCACGTTTCTTTGACTCGATCGACGAAGTACCAAATCAGGCAATTACAATGGGAATTCAGTCGAT
CATGCGAGCAAAGGAAATACTCTTACTTGTTTCTGGGAGTGAAAAAGCAGAGGCGTTAGAAAAACTGGTCAATGGTAATG
TAAGTGAAGAGTTTCCGGCATCTATTCTTCAAACACATCAGAATGTCAAGATTATTGCTGATAAAGCAGCCTTACAAGAT
ATTTCTTATCATCACTTTTCAGAAACTATGTAA

Upstream 100 bases:

>100_bases
ATAATTATTAAAAATAGCTTATCAGAATTAACTTTCAATGTACATTAACATGTATAGACAACTGTATATGTTCAATTTTA
AAAAAGAAGGTCGGATGAAA

Downstream 100 bases:

>100_bases
TGATAGTTATTAATAACCTAAGGAATAAAAGGTCCAACCATAGTTAGACATCACAAATTATGAAATCAAATCATTTAAAA
AATCGGTTCTAAGTCAAATG

Product: N-acetylglucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKIIQTENYQSMSKLASQHVINTIKQLNKPVLGLATGSTPEGLYQHLIKAYRMHQISFANVSTFNLDEYVGLHKEDKNSY
HYYMQKFLFNHVDIPYKNIHLPNGIAKDLSVECTSYEDRIQQAGGIHIQVLGIGRNGHIGFNEPGTSFESQTHVVDLDES
TRNANARFFDSIDEVPNQAITMGIQSIMRAKEILLLVSGSEKAEALEKLVNGNVSEEFPASILQTHQNVKIIADKAALQD
ISYHHFSETM

Sequences:

>Translated_250_residues
MKIIQTENYQSMSKLASQHVINTIKQLNKPVLGLATGSTPEGLYQHLIKAYRMHQISFANVSTFNLDEYVGLHKEDKNSY
HYYMQKFLFNHVDIPYKNIHLPNGIAKDLSVECTSYEDRIQQAGGIHIQVLGIGRNGHIGFNEPGTSFESQTHVVDLDES
TRNANARFFDSIDEVPNQAITMGIQSIMRAKEILLLVSGSEKAEALEKLVNGNVSEEFPASILQTHQNVKIIADKAALQD
ISYHHFSETM
>Mature_250_residues
MKIIQTENYQSMSKLASQHVINTIKQLNKPVLGLATGSTPEGLYQHLIKAYRMHQISFANVSTFNLDEYVGLHKEDKNSY
HYYMQKFLFNHVDIPYKNIHLPNGIAKDLSVECTSYEDRIQQAGGIHIQVLGIGRNGHIGFNEPGTSFESQTHVVDLDES
TRNANARFFDSIDEVPNQAITMGIQSIMRAKEILLLVSGSEKAEALEKLVNGNVSEEFPASILQTHQNVKIIADKAALQD
ISYHHFSETM

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=247, Percent_Identity=42.1052631578947, Blast_Score=200, Evalue=9e-52,
Organism=Homo sapiens, GI19923881, Length=244, Percent_Identity=40.9836065573771, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1786893, Length=257, Percent_Identity=40.0778210116732, Blast_Score=207, Evalue=5e-55,
Organism=Escherichia coli, GI1789530, Length=225, Percent_Identity=30.2222222222222, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI48994958, Length=241, Percent_Identity=30.7053941908714, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17554876, Length=242, Percent_Identity=43.3884297520661, Blast_Score=203, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24581960, Length=243, Percent_Identity=42.798353909465, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI19920764, Length=243, Percent_Identity=42.798353909465, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_OCEIH (Q8ESL6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691532.1
- ProteinModelPortal:   Q8ESL6
- SMR:   Q8ESL6
- GeneID:   1015994
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0611
- NMPDR:   fig|221109.1.peg.615
- HOGENOM:   HBG725991
- OMA:   HLSITMG
- ProtClustDB:   CLSK238298
- BioCyc:   OIHE221109:OB0611-MONOMER
- BRENDA:   3.5.99.6
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 28118; Mature: 28118

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 67-67 ACT_SITE 136-136 ACT_SITE 138-138 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIQTENYQSMSKLASQHVINTIKQLNKPVLGLATGSTPEGLYQHLIKAYRMHQISFAN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCEECC
VSTFNLDEYVGLHKEDKNSYHYYMQKFLFNHVDIPYKNIHLPNGIAKDLSVECTSYEDRI
CEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCHHHHH
QQAGGIHIQVLGIGRNGHIGFNEPGTSFESQTHVVDLDESTRNANARFFDSIDEVPNQAI
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCHHHH
TMGIQSIMRAKEILLLVSGSEKAEALEKLVNGNVSEEFPASILQTHQNVKIIADKAALQD
HHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHH
ISYHHFSETM
HHHHHHHCCC
>Mature Secondary Structure
MKIIQTENYQSMSKLASQHVINTIKQLNKPVLGLATGSTPEGLYQHLIKAYRMHQISFAN
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCEECC
VSTFNLDEYVGLHKEDKNSYHYYMQKFLFNHVDIPYKNIHLPNGIAKDLSVECTSYEDRI
CEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCHHHHH
QQAGGIHIQVLGIGRNGHIGFNEPGTSFESQTHVVDLDESTRNANARFFDSIDEVPNQAI
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCHHHH
TMGIQSIMRAKEILLLVSGSEKAEALEKLVNGNVSEEFPASILQTHQNVKIIADKAALQD
HHHHHHHHHHHHEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHHHH
ISYHHFSETM
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376