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The map label for this gene is murQ

Identifier: 23098069

GI number: 23098069

Start: 642516

End: 643400

Strand: Direct

Name: murQ

Synonym: OB0614

Alternate gene names: 23098069

Gene position: 642516-643400 (Clockwise)

Preceding gene: 23098068

Following gene: 23098070

Centisome position: 17.7

GC content: 37.29

Gene sequence:

>885_bases
TTGTTAGATAAATTACCGACTGAACAACGTAATCCCAAGACGATGGATATCGATACAAAATCTATAAAAGAGATTCTAGA
AATGATGAATCGAGAAGATTTTACAGTACCGCAAACGGTTCAAAAAGAAATTTCTTTTATTGAGGAAGCAGTTCACCGAA
CAATTCATTCGTTTAAAAGTAATGGTAGATTAATTTATATTGGAGCTGGAACTAGTGGTAGATTGGGAGTGTTAGATGCA
TCTGAATGCCCGCCAACGTTTGGGGTTTCATCAGAAATGGTGAAAGGATTGATTTCCGGAGGATTGGAAGCGATTACAAA
AGCGAAAGAGGGAGCGGAAGATTCTGAAGCAATGGCAAAACAAGATCTACTAGATATTAAGTTAACAGAGCACGATACTG
TAATTGGAATCGCTGCGAGTGGTAGAACCCCATATGTAAAAGGAGCGCTATCTTATGCAAATGAAATAGGAGCGTCTACT
GTTGCCATTAGTAATAACAAAAATTCAGAGATAGGTAAAATAGCTGAAATTGCCATCGAGGCGGAAACAGGACCTGAAGT
CATAACAGGATCCACAAGACTAAAAGCAGGAACGGCACAAAAATTGATCCTAAATATGATATCTACAGCTTCTATGATTG
GTGTAGGAAAAGTATATGAAAATCTAATGGTAGATCTCAAACCAACGAACAAGAAGCTAGTAGATCGTTCCAAGCGAATT
ATAATGGAAGCCACACAAGTGGATTATACTACTGCAGAAAACTACTTACAAAAAGCAAATAACTCCGTCAAGACAGCCAT
TGTAATGATTTTATTAAATTGTAATGTAGACGAAGCGATACAACATCTAGATCGGGCAGAAGGATTTATACGTAAAACGA
AATAG

Upstream 100 bases:

>100_bases
AGTTAATGAAATTAAATTTCATAATTTACTAAAATATTATTGACTAATAGTTTCGCTATTGTAAAATAAAATTAAGAATA
TTAGGAAAGGGAGTGGAGAT

Downstream 100 bases:

>100_bases
GGGGAGAGACAATGAAGAAGGAAGAGAGGATTGCAAGAGAGATATTAGAACATATCGGTGGAAAAGATAATATTCGTTCT
TTCACACATTGCATGACTAG

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLDKLPTEQRNPKTMDIDTKSIKEILEMMNREDFTVPQTVQKEISFIEEAVHRTIHSFKSNGRLIYIGAGTSGRLGVLDA
SECPPTFGVSSEMVKGLISGGLEAITKAKEGAEDSEAMAKQDLLDIKLTEHDTVIGIAASGRTPYVKGALSYANEIGAST
VAISNNKNSEIGKIAEIAIEAETGPEVITGSTRLKAGTAQKLILNMISTASMIGVGKVYENLMVDLKPTNKKLVDRSKRI
IMEATQVDYTTAENYLQKANNSVKTAIVMILLNCNVDEAIQHLDRAEGFIRKTK

Sequences:

>Translated_294_residues
MLDKLPTEQRNPKTMDIDTKSIKEILEMMNREDFTVPQTVQKEISFIEEAVHRTIHSFKSNGRLIYIGAGTSGRLGVLDA
SECPPTFGVSSEMVKGLISGGLEAITKAKEGAEDSEAMAKQDLLDIKLTEHDTVIGIAASGRTPYVKGALSYANEIGAST
VAISNNKNSEIGKIAEIAIEAETGPEVITGSTRLKAGTAQKLILNMISTASMIGVGKVYENLMVDLKPTNKKLVDRSKRI
IMEATQVDYTTAENYLQKANNSVKTAIVMILLNCNVDEAIQHLDRAEGFIRKTK
>Mature_294_residues
MLDKLPTEQRNPKTMDIDTKSIKEILEMMNREDFTVPQTVQKEISFIEEAVHRTIHSFKSNGRLIYIGAGTSGRLGVLDA
SECPPTFGVSSEMVKGLISGGLEAITKAKEGAEDSEAMAKQDLLDIKLTEHDTVIGIAASGRTPYVKGALSYANEIGAST
VAISNNKNSEIGKIAEIAIEAETGPEVITGSTRLKAGTAQKLILNMISTASMIGVGKVYENLMVDLKPTNKKLVDRSKRI
IMEATQVDYTTAENYLQKANNSVKTAIVMILLNCNVDEAIQHLDRAEGFIRKTK

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=291, Percent_Identity=50.1718213058419, Blast_Score=265, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_OCEIH (Q8ESL3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691535.1
- HSSP:   P44862
- ProteinModelPortal:   Q8ESL3
- SMR:   Q8ESL3
- GeneID:   1016000
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0614
- NMPDR:   fig|221109.1.peg.619
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK05441
- BioCyc:   OIHE221109:OB0614-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31976; Mature: 31976

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 82-82 ACT_SITE 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKLPTEQRNPKTMDIDTKSIKEILEMMNREDFTVPQTVQKEISFIEEAVHRTIHSFKS
CCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NGRLIYIGAGTSGRLGVLDASECPPTFGVSSEMVKGLISGGLEAITKAKEGAEDSEAMAK
CCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QDLLDIKLTEHDTVIGIAASGRTPYVKGALSYANEIGASTVAISNNKNSEIGKIAEIAIE
HHHHEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHEEEEEEE
AETGPEVITGSTRLKAGTAQKLILNMISTASMIGVGKVYENLMVDLKPTNKKLVDRSKRI
CCCCCCEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHH
IMEATQVDYTTAENYLQKANNSVKTAIVMILLNCNVDEAIQHLDRAEGFIRKTK
HHHHHHCCHHHHHHHHHHHCCHHHHEEEEHEECCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDKLPTEQRNPKTMDIDTKSIKEILEMMNREDFTVPQTVQKEISFIEEAVHRTIHSFKS
CCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
NGRLIYIGAGTSGRLGVLDASECPPTFGVSSEMVKGLISGGLEAITKAKEGAEDSEAMAK
CCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QDLLDIKLTEHDTVIGIAASGRTPYVKGALSYANEIGASTVAISNNKNSEIGKIAEIAIE
HHHHEEEEECCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHEEEEEEE
AETGPEVITGSTRLKAGTAQKLILNMISTASMIGVGKVYENLMVDLKPTNKKLVDRSKRI
CCCCCCEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHH
IMEATQVDYTTAENYLQKANNSVKTAIVMILLNCNVDEAIQHLDRAEGFIRKTK
HHHHHHCCHHHHHHHHHHHCCHHHHEEEEHEECCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376