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The map label for this gene is hisC1

Identifier: 23098000

GI number: 23098000

Start: 578314

End: 579378

Strand: Reverse

Name: hisC1

Synonym: OB0545

Alternate gene names: 23098000

Gene position: 579378-578314 (Counterclockwise)

Preceding gene: 23098001

Following gene: 23097991

Centisome position: 15.96

GC content: 34.08

Gene sequence:

>1065_bases
GTGAGTAAATTCTGGAGCTCCTTAGCTAAACAAGTAGATCCATACATTCCTGGAGAACAATTGAATGATGATACGATTAT
TAAACTAAATACAAATGAAAATCCGTATCCCCCGTCTAACCAGGTAATTCAGGCTATAGACGAGGCATCAAAGAATTTGA
GGTTATACCCCTCTCCAACTGTTGATGAATTACGAAGCGAAATTGGAGAAATGTATGGGCTAAGTCAAGATCATATATTC
ATTGGAAATGGATCCGACGAGGTGCTTGCTTTCAGTTTCATGTCATTCTTTGAACCGGGAAATAGGATTAAATATCCGGA
AATCACTTATAGTTTCTACCCAGTTTATGCTAAGTTATTTAATATATCTACGGATGTAATTCCGTTAAATGACGACTATA
CAATACCTGTAGAACATTTTTATAATTCAGAAGGTGGAGTGATTTTCCCTAATCCTAATGCTCCGACTGGTATTTTCTTA
GAGATAGACCAAATTAAACGCATACTTGAAAATAATCCTAACCAAGTGGTGATTATTGATGAAGCATATATCGATTTCGC
ATTGGAAAGTGCAGTAACATTAGTCGAAGCATTTCCAAATTTGCTTGTTATTCAAACCATGTCAAAGTCTCGATCACTAG
CAGGGCTGCGTATTGGATTTGCTATCGGTAATCCTGAATTAATAATTGGATTAGAAAGAATAAAAAATTCATTTAATTCT
TATACCGTTGATCGATTAGCTATTGCAGGTGCTATAGAGGCAATAAGAGATAAGGATTATTTCCTGCAAACTACTACTAA
AATTATTGAATCTAGATCCTATTTAAAAGAGCAATTAGAAACTAGACATTTTGATATTCTCCCATCCCAAGCTAATTTCT
TGCTTGTATCTCATAAAGAGGTAAATGCTGAAGTGTTATATCAAGAGTTAAAAAAACAAGGAATTCTTGTAAGGTATTTT
CAAAAACCTGGACTAGAAAATTTCTTGCGTATTTCAATTGGAACACCAGCACAAATAGAAAAACTCTTAAAGAAAATTGA
CCACATAATAAAACCATCGCCATAA

Upstream 100 bases:

>100_bases
CTGTATCACTCACTAGTACTCATGGAACAACAAGGAGTTACGTTAGAGGATATCAAAAAAGAGCTATATAAACGTCACGT
CGAGAAAGAAGGCCAACAAC

Downstream 100 bases:

>100_bases
TGTTGGCGATGGTTTTATTGGGCGCATAGGCCTTTGTTCATAGATAGGATATTGTAAGATTTGTGTGCTGTGAATAACTA
AATAATAAACCAGCCACGTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSKFWSSLAKQVDPYIPGEQLNDDTIIKLNTNENPYPPSNQVIQAIDEASKNLRLYPSPTVDELRSEIGEMYGLSQDHIF
IGNGSDEVLAFSFMSFFEPGNRIKYPEITYSFYPVYAKLFNISTDVIPLNDDYTIPVEHFYNSEGGVIFPNPNAPTGIFL
EIDQIKRILENNPNQVVIIDEAYIDFALESAVTLVEAFPNLLVIQTMSKSRSLAGLRIGFAIGNPELIIGLERIKNSFNS
YTVDRLAIAGAIEAIRDKDYFLQTTTKIIESRSYLKEQLETRHFDILPSQANFLLVSHKEVNAEVLYQELKKQGILVRYF
QKPGLENFLRISIGTPAQIEKLLKKIDHIIKPSP

Sequences:

>Translated_354_residues
MSKFWSSLAKQVDPYIPGEQLNDDTIIKLNTNENPYPPSNQVIQAIDEASKNLRLYPSPTVDELRSEIGEMYGLSQDHIF
IGNGSDEVLAFSFMSFFEPGNRIKYPEITYSFYPVYAKLFNISTDVIPLNDDYTIPVEHFYNSEGGVIFPNPNAPTGIFL
EIDQIKRILENNPNQVVIIDEAYIDFALESAVTLVEAFPNLLVIQTMSKSRSLAGLRIGFAIGNPELIIGLERIKNSFNS
YTVDRLAIAGAIEAIRDKDYFLQTTTKIIESRSYLKEQLETRHFDILPSQANFLLVSHKEVNAEVLYQELKKQGILVRYF
QKPGLENFLRISIGTPAQIEKLLKKIDHIIKPSP
>Mature_353_residues
SKFWSSLAKQVDPYIPGEQLNDDTIIKLNTNENPYPPSNQVIQAIDEASKNLRLYPSPTVDELRSEIGEMYGLSQDHIFI
GNGSDEVLAFSFMSFFEPGNRIKYPEITYSFYPVYAKLFNISTDVIPLNDDYTIPVEHFYNSEGGVIFPNPNAPTGIFLE
IDQIKRILENNPNQVVIIDEAYIDFALESAVTLVEAFPNLLVIQTMSKSRSLAGLRIGFAIGNPELIIGLERIKNSFNSY
TVDRLAIAGAIEAIRDKDYFLQTTTKIIESRSYLKEQLETRHFDILPSQANFLLVSHKEVNAEVLYQELKKQGILVRYFQ
KPGLENFLRISIGTPAQIEKLLKKIDHIIKPSP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=26.2108262108262, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=357, Percent_Identity=30.2521008403361, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_OCEIH (Q8ESS3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691466.1
- ProteinModelPortal:   Q8ESS3
- SMR:   Q8ESS3
- GeneID:   1015834
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0545
- NMPDR:   fig|221109.1.peg.548
- HOGENOM:   HBG646350
- OMA:   MQAELND
- ProtClustDB:   PRK05387
- BioCyc:   OIHE221109:OB0545-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40160; Mature: 40029

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFWSSLAKQVDPYIPGEQLNDDTIIKLNTNENPYPPSNQVIQAIDEASKNLRLYPSPT
CCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEECCCCC
VDELRSEIGEMYGLSQDHIFIGNGSDEVLAFSFMSFFEPGNRIKYPEITYSFYPVYAKLF
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
NISTDVIPLNDDYTIPVEHFYNSEGGVIFPNPNAPTGIFLEIDQIKRILENNPNQVVIID
CCCCCEEECCCCCEEEHHHEECCCCCEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEEE
EAYIDFALESAVTLVEAFPNLLVIQTMSKSRSLAGLRIGFAIGNPELIIGLERIKNSFNS
HHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCEEEEEEEECCCCEEEEHHHHHCCCCC
YTVDRLAIAGAIEAIRDKDYFLQTTTKIIESRSYLKEQLETRHFDILPSQANFLLVSHKE
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCC
VNAEVLYQELKKQGILVRYFQKPGLENFLRISIGTPAQIEKLLKKIDHIIKPSP
CCHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKFWSSLAKQVDPYIPGEQLNDDTIIKLNTNENPYPPSNQVIQAIDEASKNLRLYPSPT
CHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEECCCCC
VDELRSEIGEMYGLSQDHIFIGNGSDEVLAFSFMSFFEPGNRIKYPEITYSFYPVYAKLF
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
NISTDVIPLNDDYTIPVEHFYNSEGGVIFPNPNAPTGIFLEIDQIKRILENNPNQVVIID
CCCCCEEECCCCCEEEHHHEECCCCCEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEEE
EAYIDFALESAVTLVEAFPNLLVIQTMSKSRSLAGLRIGFAIGNPELIIGLERIKNSFNS
HHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCEEEEEEEECCCCEEEEHHHHHCCCCC
YTVDRLAIAGAIEAIRDKDYFLQTTTKIIESRSYLKEQLETRHFDILPSQANFLLVSHKE
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCC
VNAEVLYQELKKQGILVRYFQKPGLENFLRISIGTPAQIEKLLKKIDHIIKPSP
CCHHHHHHHHHHCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376