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The map label for this gene is trpC

Identifier: 23097979

GI number: 23097979

Start: 556304

End: 557089

Strand: Reverse

Name: trpC

Synonym: OB0524

Alternate gene names: 23097979

Gene position: 557089-556304 (Counterclockwise)

Preceding gene: 23097980

Following gene: 23097978

Centisome position: 15.34

GC content: 35.24

Gene sequence:

>786_bases
ATGACTTTTCTAGCAAAAATCTTAGAGGAAAAGCAAACGGAAGTTAACAGTAGAAAACAAGAGAAAATCGATTTCGGAAG
TAGAAATATACCAGTGCACTCGTTTATTCAACTAATCAATCAAGCAAGCTCATTATCTATTATCGCCGAAATAAAACGCG
CCTCTCCATCAAAAGGAGAAATTCAAATGGACATTGATCCCGTCGAGCAAGCTATAAAGTATGAGCAAGCAGGTGCATCA
GCCATATCTGTATTAACAGATCAACGTTTTTTCAAAGGTTCATTAAACGATTTACAACAAGTAAGTGAAGCCGTTTCAAT
TCCAGTTCTTTGTAAAGATTTTATTATCGATGAAATTCAAATTGATGATGCAAAAGATGCAGGAGCTTCTATTATTCTGT
TAATTCTAGCAGCTTTACCATTAGAGAGATTCCAAGAATTATATAATTATGCTACAAAGCAAGGACTTGAGGTCATATGT
GAAGTGCATACAGCAGAAGAATTAAAAAATGCCTTAACGATATCCCCAGCAATCATTGGCATAAATAATCGTAACTTAAA
ATCTTTTGACGTTGATTTACAAACTACGAAACAATTGGCTCAACGAGTTGATACCAATAAAACGATTATCATCAGTGAAA
GCGGCATGAGAACTGCTAGTGATGCAACACTAGCTGCTGAATCTGGAGCAAAAGCGATTTTAGTTGGAGAAACATTTATG
AGGTCGAATCAATTAGAAACTGATTTTAATAATCTACGCGTTCCTCTTGTGGAAAGGAGTATATAG

Upstream 100 bases:

>100_bases
CGGTGTCGAACTTGCTCGGGAAAGTATTACATCTGGATCAGCATTAAGCAAACTCAATAACTTAATCACATTCAGTAAGA
AAGTTAGCGAGGTGGTTTAA

Downstream 100 bases:

>100_bases
ATGTTTGTAAAAATATGCGGAATAACTTCCATTGATACTGCTCAAGCAGTTGTAGATGCTAACGCTGATATGATTGGATT
TGTATTTGCACCGAGTAAGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGEIQMDIDPVEQAIKYEQAGAS
AISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQIDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVIC
EVHTAEELKNALTISPAIIGINNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFM
RSNQLETDFNNLRVPLVERSI

Sequences:

>Translated_261_residues
MTFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGEIQMDIDPVEQAIKYEQAGAS
AISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQIDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVIC
EVHTAEELKNALTISPAIIGINNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFM
RSNQLETDFNNLRVPLVERSI
>Mature_260_residues
TFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGEIQMDIDPVEQAIKYEQAGASA
ISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQIDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVICE
VHTAEELKNALTISPAIIGINNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFMR
SNQLETDFNNLRVPLVERSI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=248, Percent_Identity=37.5, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=225, Percent_Identity=39.5555555555556, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_OCEIH (Q8ESU2)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691445.1
- HSSP:   P00909
- ProteinModelPortal:   Q8ESU2
- SMR:   Q8ESU2
- GeneID:   1015794
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0524
- NMPDR:   fig|221109.1.peg.527
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   OIHE221109:OB0524-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28823; Mature: 28692

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGE
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
IQMDIDPVEQAIKYEQAGASAISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQ
EEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHEE
IDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVICEVHTAEELKNALTISPAIIG
ECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEE
INNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFM
CCCCCCCEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCCCEEEECHHHH
RSNQLETDFNNLRVPLVERSI
HCCCCCCCHHHCEECCCCCCC
>Mature Secondary Structure 
TFLAKILEEKQTEVNSRKQEKIDFGSRNIPVHSFIQLINQASSLSIIAEIKRASPSKGE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCC
IQMDIDPVEQAIKYEQAGASAISVLTDQRFFKGSLNDLQQVSEAVSIPVLCKDFIIDEIQ
EEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHEE
IDDAKDAGASIILLILAALPLERFQELYNYATKQGLEVICEVHTAEELKNALTISPAIIG
ECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEE
INNRNLKSFDVDLQTTKQLAQRVDTNKTIIISESGMRTASDATLAAESGAKAILVGETFM
CCCCCCCEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCCCEEEECHHHH
RSNQLETDFNNLRVPLVERSI
HCCCCCCCHHHCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376