Click here to switch to the map view.

The map label for this gene is trpF

Identifier: 23097978

GI number: 23097978

Start: 555689

End: 556303

Strand: Reverse

Name: trpF

Synonym: OB0523

Alternate gene names: 23097978

Gene position: 556303-555689 (Counterclockwise)

Preceding gene: 23097979

Following gene: 23097977

Centisome position: 15.32

GC content: 38.54

Gene sequence:

>615_bases
ATGTTTGTAAAAATATGCGGAATAACTTCCATTGATACTGCTCAAGCAGTTGTAGATGCTAACGCTGATATGATTGGATT
TGTATTTGCACCGAGTAAGCGACAACTATCCACCTCTCTAGCTGAGGAAATAGCAAATACACTTCCTCAGACCATTCAAA
AAGTTGGGGTATTTGTAGATGAGCCTTTAGAGAATATCCTATCCATCATCGAGAGGGTGAATCTTGATATTGTCCAGTTA
CACGGCGATGAGTCTATCGACTATCAAAAGAGGATTCCAATTCCGATAATCAAAGCATTTCCAGCTACTACAGAGGGATT
AAACCAAGCAAATCAATCATCTGCAAAATATATATTAATCGACAGTCCCCCTCTGCAATCATCGCGCGGAGGAAACGGGG
TAACATTTAATTGGAATATCCTTAAAGACCAACCTTTTACTAGCAAATTAATATTGGCTGGTGGGTTGAATACAGAGAAT
ATACGTGAAGCTATAAAAACTGTAAATCCCGCTGGTGTTGATGTTTCAAGTGGAGTAGAAACAAATGGAAAAAAGGACGC
AAAGAAGATCCAGCAATTTATTACTAACGTACAAAGAAAGGATGTATTGCGATGA

Upstream 100 bases:

>100_bases
AGCAAAAGCGATTTTAGTTGGAGAAACATTTATGAGGTCGAATCAATTAGAAACTGATTTTAATAATCTACGCGTTCCTC
TTGTGGAAAGGAGTATATAG

Downstream 100 bases:

>100_bases
CTACTTATTCATTTCCAAATACAAAAGGAAAATATGGAGAGTTTGGCGGAAGATTTGTTCCAGAACTATTAATGCCTGCA
GTACTTGAATTAGAAAAAGC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVDEPLENILSIIERVNLDIVQL
HGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILIDSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTEN
IREAIKTVNPAGVDVSSGVETNGKKDAKKIQQFITNVQRKDVLR

Sequences:

>Translated_204_residues
MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVDEPLENILSIIERVNLDIVQL
HGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILIDSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTEN
IREAIKTVNPAGVDVSSGVETNGKKDAKKIQQFITNVQRKDVLR
>Mature_204_residues
MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVDEPLENILSIIERVNLDIVQL
HGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILIDSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTEN
IREAIKTVNPAGVDVSSGVETNGKKDAKKIQQFITNVQRKDVLR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=193, Percent_Identity=33.160621761658, Blast_Score=84, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=216, Percent_Identity=35.1851851851852, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_OCEIH (Q8ESU3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691444.1
- ProteinModelPortal:   Q8ESU3
- SMR:   Q8ESU3
- GeneID:   1015793
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0523
- NMPDR:   fig|221109.1.peg.526
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- BioCyc:   OIHE221109:OB0523-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22233; Mature: 22233

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVD
CEEEEECCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EPLENILSIIERVNLDIVQLHGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILI
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHEECCCCCHHHHHHCCCCCCCEEEE
DSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTENIREAIKTVNPAGVDVSSGVE
ECCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
TNGKKDAKKIQQFITNVQRKDVLR
CCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFVKICGITSIDTAQAVVDANADMIGFVFAPSKRQLSTSLAEEIANTLPQTIQKVGVFVD
CEEEEECCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EPLENILSIIERVNLDIVQLHGDESIDYQKRIPIPIIKAFPATTEGLNQANQSSAKYILI
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHEECCCCCHHHHHHCCCCCCCEEEE
DSPPLQSSRGGNGVTFNWNILKDQPFTSKLILAGGLNTENIREAIKTVNPAGVDVSSGVE
ECCCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
TNGKKDAKKIQQFITNVQRKDVLR
CCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376