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The map label for this gene is yacD [H]

Identifier: 23097538

GI number: 23097538

Start: 85418

End: 86329

Strand: Direct

Name: yacD [H]

Synonym: OB0083

Alternate gene names: 23097538

Gene position: 85418-86329 (Clockwise)

Preceding gene: 23097537

Following gene: 23097539

Centisome position: 2.35

GC content: 36.51

Gene sequence:

>912_bases
ATGTCAAAAAAATTGTTGCTCGGAATCGTTGTGGTACTGCTGATTACGAATATTGCAACTCTATTGTTTGTGGGAGATAG
CAATGACTCAGAAGTAGTGTCGGACGGTAAAGGGGAAAAAGAGATCAATCGTAATGAAGCAGTAGCAACAGTAGCTGGCG
AAGAAATATCTTATGATGAATGGATGACAGGCTTAAGAAATATGCAAGGGCAAAAACATTTAAAACAGATGATTGATAAG
GAAGTCGTTAATACGCTAGCAGAGCAAGAGGGTATTGAAGTAAGTGAAAAAATCATCGACAGAGAAGTTTCTTTCTTATA
TACCATGCAAGGGATTTTAACAGAAGATGATGCTGTTGAAGAAGAAGAAAGATGGAGAGAAGAAATAAAATACCGTTATC
AGTTGGAACAGTTACTAACTAAAAATATTGAGATCCCTGAAGAGGAATTAAGGTCATATTATGATACATATGGTAATCAA
TATGATTTTTCATCTTCTGTTAAGCTCTCGCATATCTTAGTGGAAGATATGGAAACGGCTGAACAGGTATACCAAGAATT
AGAAGATGGTGCTTCTTTTAGATTATTAGCTAGAGAATATAGCATTGACGATGAGACAAGACAAAATGGTGGATACATGG
GAAGTATCTACACATCAAGTCAATTCTTGTTGGATAGTTACGAAACACAGGCAGCAAATATGGAAAATCACACATATAGT
GAACCTTTTCAAGCGGAAAATGGTGTAGCGATTATGTATTTGCATCGTAAACTTCCGGCGATTAAATTTACCTACGACGA
AGTACAACCGTATGTCCATAGTGAAGTTGCCATGCATGAAGAAGGACTGACGTTAGAAGCTGACCAATTATGGGAAGAAG
TAGATATAGAGTGGATTTACGAAAATGAATAA

Upstream 100 bases:

>100_bases
TGCAGAGGCAACTTGTCATTTTTGTAATGAAAAGTATCATTTTACTGAGGAAGAATTAGAAGACCTTAAACAGTAGAGAG
AAGAAAGGAAGTTACACTTC

Downstream 100 bases:

>100_bases
TATGAAATTATCAGACAAATTAGTTGACATTTTAGGATAAAGGAACTACATTAGATGTAAATCTTATAAAAATACTTGGA
ATTAGAGGAGGAAGTCAGAT

Product: protein secretion protein

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSKKLLLGIVVVLLITNIATLLFVGDSNDSEVVSDGKGEKEINRNEAVATVAGEEISYDEWMTGLRNMQGQKHLKQMIDK
EVVNTLAEQEGIEVSEKIIDREVSFLYTMQGILTEDDAVEEEERWREEIKYRYQLEQLLTKNIEIPEEELRSYYDTYGNQ
YDFSSSVKLSHILVEDMETAEQVYQELEDGASFRLLAREYSIDDETRQNGGYMGSIYTSSQFLLDSYETQAANMENHTYS
EPFQAENGVAIMYLHRKLPAIKFTYDEVQPYVHSEVAMHEEGLTLEADQLWEEVDIEWIYENE

Sequences:

>Translated_303_residues
MSKKLLLGIVVVLLITNIATLLFVGDSNDSEVVSDGKGEKEINRNEAVATVAGEEISYDEWMTGLRNMQGQKHLKQMIDK
EVVNTLAEQEGIEVSEKIIDREVSFLYTMQGILTEDDAVEEEERWREEIKYRYQLEQLLTKNIEIPEEELRSYYDTYGNQ
YDFSSSVKLSHILVEDMETAEQVYQELEDGASFRLLAREYSIDDETRQNGGYMGSIYTSSQFLLDSYETQAANMENHTYS
EPFQAENGVAIMYLHRKLPAIKFTYDEVQPYVHSEVAMHEEGLTLEADQLWEEVDIEWIYENE
>Mature_302_residues
SKKLLLGIVVVLLITNIATLLFVGDSNDSEVVSDGKGEKEINRNEAVATVAGEEISYDEWMTGLRNMQGQKHLKQMIDKE
VVNTLAEQEGIEVSEKIIDREVSFLYTMQGILTEDDAVEEEERWREEIKYRYQLEQLLTKNIEIPEEELRSYYDTYGNQY
DFSSSVKLSHILVEDMETAEQVYQELEDGASFRLLAREYSIDDETRQNGGYMGSIYTSSQFLLDSYETQAANMENHTYSE
PFQAENGVAIMYLHRKLPAIKFTYDEVQPYVHSEVAMHEEGLTLEADQLWEEVDIEWIYENE

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 35105; Mature: 34974

Theoretical pI: Translated: 4.00; Mature: 4.00

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLLLGIVVVLLITNIATLLFVGDSNDSEVVSDGKGEKEINRNEAVATVAGEEISYDE
CCCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCCCCCCCCCCHHEEEECCCCCCHHH
WMTGLRNMQGQKHLKQMIDKEVVNTLAEQEGIEVSEKIIDREVSFLYTMQGILTEDDAVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEERWREEIKYRYQLEQLLTKNIEIPEEELRSYYDTYGNQYDFSSSVKLSHILVEDMETA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EQVYQELEDGASFRLLAREYSIDDETRQNGGYMGSIYTSSQFLLDSYETQAANMENHTYS
HHHHHHHHCCCCEEEEHHHCCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCC
EPFQAENGVAIMYLHRKLPAIKFTYDEVQPYVHSEVAMHEEGLTLEADQLWEEVDIEWIY
CCCCCCCCEEEEEEECCCCCEEEEHHHHCHHHHHHHHHHCCCCEECHHHHHHHCCEEEEE
ENE
CCC
>Mature Secondary Structure 
SKKLLLGIVVVLLITNIATLLFVGDSNDSEVVSDGKGEKEINRNEAVATVAGEEISYDE
CCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCCCCCCCCCCHHEEEECCCCCCHHH
WMTGLRNMQGQKHLKQMIDKEVVNTLAEQEGIEVSEKIIDREVSFLYTMQGILTEDDAVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EEERWREEIKYRYQLEQLLTKNIEIPEEELRSYYDTYGNQYDFSSSVKLSHILVEDMETA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
EQVYQELEDGASFRLLAREYSIDDETRQNGGYMGSIYTSSQFLLDSYETQAANMENHTYS
HHHHHHHHCCCCEEEEHHHCCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCC
EPFQAENGVAIMYLHRKLPAIKFTYDEVQPYVHSEVAMHEEGLTLEADQLWEEVDIEWIY
CCCCCCCCEEEEEEECCCCCEEEEHHHHCHHHHHHHHHHCCCCEECHHHHHHHCCEEEEE
ENE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]