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The map label for this gene is hemH [H]

Identifier: 229918184

GI number: 229918184

Start: 2418947

End: 2419876

Strand: Direct

Name: hemH [H]

Synonym: EAT1b_2464

Alternate gene names: 229918184

Gene position: 2418947-2419876 (Clockwise)

Preceding gene: 229918183

Following gene: 229918185

Centisome position: 80.63

GC content: 49.14

Gene sequence:

>930_bases
ATGAAAACAGTCGGACTACTTGTCATGGCGTACGGCACACCGTACAAACCAGAAGATATCGAGCGGTATTACACGCACAT
TCGCTACGGACGCAAACCGTCACCGGAAGCACTCCAAGATTTGACGGAACGTTACGAAGCGATTGGTGGTGTATCTCCAC
TCGCAAAAATCACGATCGATCAAGCGGAGACGCTTCGTGACATCTTGAACGAGCGTCATGTAGGTGAAATCGAGTTCAAA
CTGTATATCGGATTGAAGCATATCGAACCGTTCGTAGAAGACGCGGTCGCGCAAATGGCGAACGACGGCATCAAAGAGGC
GGTATCGGTTGTCTTAGCACCTCATTACTCGTCATATAGCGTCAAATCATACAACGGACGTGCTCATGAAGAAGCAGCGA
AGTATGGCATCGACATTCGTTCGGTAGAGTCGTGGTATGATGAGCCGAAGTTTATCAAATGGTGGGCGAATGCGATTAAC
GATACGTATGCGTCATTGCCAGTACCGGCTGAAAAGACATGTCTCATCGTTTCAGCGCATAGTCTTCCTGAGAAAATCTT
GGCTGGTGGCGACCCGTATCCGGATCAGTTGAAAGAAACAGCTGATAAAATTGCCATTGAAACAGGCGTCCCGCATTATG
AGATTGGTTGGCAGTCAGAAGGAAACACGCCGGACCCATGGATTGGACCGGATGTTCAAGATTTGACGGCTGAACTTTAT
GAAAAGTACGGCTACGAGGCGTTCGTCTATACGCCGGTCGGCTTTGTTGCAGACCATCTCGAAGTATTGTTCGATAACGA
CGTCGAGTGTAAAGTTGTCTGTGACCGCCTCGGTGTTCACTACGCACGTCCAGCTATGCCAAATGCAGAGCGAAGCTTCA
TCGAAGCCATCGCGGATCGAATGGAAAGCGTGATTGTGCATCATGCGTAA

Upstream 100 bases:

>100_bases
TGGGACATGGGGTGTTCCCTGAAGTCGACCCGGCCGTACTCGTCAAATTGACGGCATTCATTCACGACTACTCACGCGAA
AAAATGGGAGGCAACGAATC

Downstream 100 bases:

>100_bases
ATTCACGATTGTCGGTGGTGGGATCACAGGTCTCACCGCCGCTTTTTATGCAGAGCGTTATTTGCCGGAAGACGTGACCA
TCACGTTGCTTGAGGCGACG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKTVGLLVMAYGTPYKPEDIERYYTHIRYGRKPSPEALQDLTERYEAIGGVSPLAKITIDQAETLRDILNERHVGEIEFK
LYIGLKHIEPFVEDAVAQMANDGIKEAVSVVLAPHYSSYSVKSYNGRAHEEAAKYGIDIRSVESWYDEPKFIKWWANAIN
DTYASLPVPAEKTCLIVSAHSLPEKILAGGDPYPDQLKETADKIAIETGVPHYEIGWQSEGNTPDPWIGPDVQDLTAELY
EKYGYEAFVYTPVGFVADHLEVLFDNDVECKVVCDRLGVHYARPAMPNAERSFIEAIADRMESVIVHHA

Sequences:

>Translated_309_residues
MKTVGLLVMAYGTPYKPEDIERYYTHIRYGRKPSPEALQDLTERYEAIGGVSPLAKITIDQAETLRDILNERHVGEIEFK
LYIGLKHIEPFVEDAVAQMANDGIKEAVSVVLAPHYSSYSVKSYNGRAHEEAAKYGIDIRSVESWYDEPKFIKWWANAIN
DTYASLPVPAEKTCLIVSAHSLPEKILAGGDPYPDQLKETADKIAIETGVPHYEIGWQSEGNTPDPWIGPDVQDLTAELY
EKYGYEAFVYTPVGFVADHLEVLFDNDVECKVVCDRLGVHYARPAMPNAERSFIEAIADRMESVIVHHA
>Mature_309_residues
MKTVGLLVMAYGTPYKPEDIERYYTHIRYGRKPSPEALQDLTERYEAIGGVSPLAKITIDQAETLRDILNERHVGEIEFK
LYIGLKHIEPFVEDAVAQMANDGIKEAVSVVLAPHYSSYSVKSYNGRAHEEAAKYGIDIRSVESWYDEPKFIKWWANAIN
DTYASLPVPAEKTCLIVSAHSLPEKILAGGDPYPDQLKETADKIAIETGVPHYEIGWQSEGNTPDPWIGPDVQDLTAELY
EKYGYEAFVYTPVGFVADHLEVLFDNDVECKVVCDRLGVHYARPAMPNAERSFIEAIADRMESVIVHHA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=278, Percent_Identity=29.8561151079137, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI60499021, Length=278, Percent_Identity=29.8561151079137, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324750, Length=271, Percent_Identity=28.4132841328413, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=27.0769230769231, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=31.7647058823529, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651774, Length=201, Percent_Identity=27.8606965174129, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 34750; Mature: 34750

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGLLVMAYGTPYKPEDIERYYTHIRYGRKPSPEALQDLTERYEAIGGVSPLAKITID
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHEEHH
QAETLRDILNERHVGEIEFKLYIGLKHIEPFVEDAVAQMANDGIKEAVSVVLAPHYSSYS
HHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VKSYNGRAHEEAAKYGIDIRSVESWYDEPKFIKWWANAINDTYASLPVPAEKTCLIVSAH
EECCCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
SLPEKILAGGDPYPDQLKETADKIAIETGVPHYEIGWQSEGNTPDPWIGPDVQDLTAELY
CCHHHHHCCCCCCHHHHHHHHHHEEHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHH
EKYGYEAFVYTPVGFVADHLEVLFDNDVECKVVCDRLGVHYARPAMPNAERSFIEAIADR
HHHCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHH
MESVIVHHA
HHHHHHCCC
>Mature Secondary Structure
MKTVGLLVMAYGTPYKPEDIERYYTHIRYGRKPSPEALQDLTERYEAIGGVSPLAKITID
CCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHEEHH
QAETLRDILNERHVGEIEFKLYIGLKHIEPFVEDAVAQMANDGIKEAVSVVLAPHYSSYS
HHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCE
VKSYNGRAHEEAAKYGIDIRSVESWYDEPKFIKWWANAINDTYASLPVPAEKTCLIVSAH
EECCCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
SLPEKILAGGDPYPDQLKETADKIAIETGVPHYEIGWQSEGNTPDPWIGPDVQDLTAELY
CCHHHHHCCCCCCHHHHHHHHHHEEHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHH
EKYGYEAFVYTPVGFVADHLEVLFDNDVECKVVCDRLGVHYARPAMPNAERSFIEAIADR
HHHCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHH
MESVIVHHA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA