Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 229918183

GI number: 229918183

Start: 2417901

End: 2418950

Strand: Direct

Name: hemE [H]

Synonym: EAT1b_2463

Alternate gene names: 229918183

Gene position: 2417901-2418950 (Clockwise)

Preceding gene: 229918182

Following gene: 229918184

Centisome position: 80.6

GC content: 49.33

Gene sequence:

>1050_bases
ATGACGCGACGTATGAACGATACTATTTTAAAAGCGTTTAAAGGAGAGGCGACAGACTATGTACCTGTGTGGTATATGCG
CCAAGCCGGACGCTACCAACCGGAATATCGAGAGATTAAAAAGACGAGGTCACTATTCGAGATCACGCATGATCCTGAAC
TTTGTGCATATGTCACGGAACTTCCGGTGAAACAACTCGGAGTCGACGCGGCCATTCTATATAAGGACATTATGACGCCA
CTTCCGTCTATGGGAGTCGATGTCGAGATCAAGAGCGGGATTGGACCGGTCATCGACAATCCGTATCGAACGATGGAAGA
TGTGGAACGTTTGAAACCGTTAAACCCGGAAGATATCTCATACGTCTTTGACACGATTCGTCTACTACGGGAACGATTAG
AAGTTCCGCTTATCGGCTTCTCAGGCGCACCGTTCACATTGGCGAGCTATATGATCGAAGGGGGACCGTCGCGGAACTAC
CATCGTACGAAAGCACTCATGTATGCAGAACCGGATGTATGGAATGCATTGATGGAAAAACTCGGCGACATGGTCATCAC
GTATGCGAAGGCGCAAGCGGATGCCGGCATTCAAGCGTTCCAATTGTTTGATTCGTGGGTCGGGACGCTCAGCCGCAAAG
ATTATGCACGTTACATCAAACCGACGACGGAGCGTATCTTTAAAGAACTACGTTCACTCGACATTCCACTCATCATGCAT
GGTGTCGGAGCGAGCCATCAAATCGAAGAATGGCACGACCTTCCACTTGATGTGGTCGGGCTTGACTGGCGCCTGTCGGT
ACAGGAAGCACGGGACCGTGGTATTACAAAGGCGGTTCAAGGAAATTTAGACCCGTCGTTCTTGTTAGCTCCATGGCCGG
TCATCGAAGAGAAGGTTAAGGAAATTTTAGATGAAGGAATGAAACAGCCAGGATACGTCTTCAACTTGGGACATGGGGTG
TTCCCTGAAGTCGACCCGGCCGTACTCGTCAAATTGACGGCATTCATTCACGACTACTCACGCGAAAAAATGGGAGGCAA
CGAATCATGA

Upstream 100 bases:

>100_bases
TGAAAATGCTTCACATTAGCATAATTCTAATTAATTTCTGTATAATGTTTTTGAGTTCACAAACACGAGAATAAAGAGTG
TAGGAGAAATTTAGAGGGGA

Downstream 100 bases:

>100_bases
AAACAGTCGGACTACTTGTCATGGCGTACGGCACACCGTACAAACCAGAAGATATCGAGCGGTATTACACGCACATTCGC
TACGGACGCAAACCGTCACC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTRRMNDTILKAFKGEATDYVPVWYMRQAGRYQPEYREIKKTRSLFEITHDPELCAYVTELPVKQLGVDAAILYKDIMTP
LPSMGVDVEIKSGIGPVIDNPYRTMEDVERLKPLNPEDISYVFDTIRLLRERLEVPLIGFSGAPFTLASYMIEGGPSRNY
HRTKALMYAEPDVWNALMEKLGDMVITYAKAQADAGIQAFQLFDSWVGTLSRKDYARYIKPTTERIFKELRSLDIPLIMH
GVGASHQIEEWHDLPLDVVGLDWRLSVQEARDRGITKAVQGNLDPSFLLAPWPVIEEKVKEILDEGMKQPGYVFNLGHGV
FPEVDPAVLVKLTAFIHDYSREKMGGNES

Sequences:

>Translated_349_residues
MTRRMNDTILKAFKGEATDYVPVWYMRQAGRYQPEYREIKKTRSLFEITHDPELCAYVTELPVKQLGVDAAILYKDIMTP
LPSMGVDVEIKSGIGPVIDNPYRTMEDVERLKPLNPEDISYVFDTIRLLRERLEVPLIGFSGAPFTLASYMIEGGPSRNY
HRTKALMYAEPDVWNALMEKLGDMVITYAKAQADAGIQAFQLFDSWVGTLSRKDYARYIKPTTERIFKELRSLDIPLIMH
GVGASHQIEEWHDLPLDVVGLDWRLSVQEARDRGITKAVQGNLDPSFLLAPWPVIEEKVKEILDEGMKQPGYVFNLGHGV
FPEVDPAVLVKLTAFIHDYSREKMGGNES
>Mature_348_residues
TRRMNDTILKAFKGEATDYVPVWYMRQAGRYQPEYREIKKTRSLFEITHDPELCAYVTELPVKQLGVDAAILYKDIMTPL
PSMGVDVEIKSGIGPVIDNPYRTMEDVERLKPLNPEDISYVFDTIRLLRERLEVPLIGFSGAPFTLASYMIEGGPSRNYH
RTKALMYAEPDVWNALMEKLGDMVITYAKAQADAGIQAFQLFDSWVGTLSRKDYARYIKPTTERIFKELRSLDIPLIMHG
VGASHQIEEWHDLPLDVVGLDWRLSVQEARDRGITKAVQGNLDPSFLLAPWPVIEEKVKEILDEGMKQPGYVFNLGHGVF
PEVDPAVLVKLTAFIHDYSREKMGGNES

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=38, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=38.7464387464387, Blast_Score=241, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=341, Percent_Identity=36.3636363636364, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330099, Length=343, Percent_Identity=36.734693877551, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI19921920, Length=343, Percent_Identity=36.734693877551, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39744; Mature: 39613

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRMNDTILKAFKGEATDYVPVWYMRQAGRYQPEYREIKKTRSLFEITHDPELCAYVTE
CCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
LPVKQLGVDAAILYKDIMTPLPSMGVDVEIKSGIGPVIDNPYRTMEDVERLKPLNPEDIS
CCHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
YVFDTIRLLRERLEVPLIGFSGAPFTLASYMIEGGPSRNYHRTKALMYAEPDVWNALMEK
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHEEEEECCHHHHHHHHH
LGDMVITYAKAQADAGIQAFQLFDSWVGTLSRKDYARYIKPTTERIFKELRSLDIPLIMH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GVGASHQIEEWHDLPLDVVGLDWRLSVQEARDRGITKAVQGNLDPSFLLAPWPVIEEKVK
CCCCCCCHHHHHCCCCEEECCCEEEEHHHHHCCCCHHHHHCCCCCCEEECCCHHHHHHHH
EILDEGMKQPGYVFNLGHGVFPEVDPAVLVKLTAFIHDYSREKMGGNES
HHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TRRMNDTILKAFKGEATDYVPVWYMRQAGRYQPEYREIKKTRSLFEITHDPELCAYVTE
CCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
LPVKQLGVDAAILYKDIMTPLPSMGVDVEIKSGIGPVIDNPYRTMEDVERLKPLNPEDIS
CCHHHHCCCHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHH
YVFDTIRLLRERLEVPLIGFSGAPFTLASYMIEGGPSRNYHRTKALMYAEPDVWNALMEK
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHEEEEECCHHHHHHHHH
LGDMVITYAKAQADAGIQAFQLFDSWVGTLSRKDYARYIKPTTERIFKELRSLDIPLIMH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GVGASHQIEEWHDLPLDVVGLDWRLSVQEARDRGITKAVQGNLDPSFLLAPWPVIEEKVK
CCCCCCCHHHHHCCCCEEECCCEEEEHHHHHCCCCHHHHHCCCCCCEEECCCHHHHHHHH
EILDEGMKQPGYVFNLGHGVFPEVDPAVLVKLTAFIHDYSREKMGGNES
HHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA