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The map label for this gene is mtlD

Identifier: 229917925

GI number: 229917925

Start: 2137896

End: 2139044

Strand: Direct

Name: mtlD

Synonym: EAT1b_2204

Alternate gene names: 229917925

Gene position: 2137896-2139044 (Clockwise)

Preceding gene: 229917924

Following gene: 229917927

Centisome position: 71.27

GC content: 50.65

Gene sequence:

>1149_bases
ATGAAAGCTGTTCACTTTGGGGCAGGGAACATCGGACGAGGCTTTATCGGATTATTGCTCAACCAAAGCGGTTACGAGGT
GACGTTTGTCGACATCAATGACACGGTCATCGAAGCGCTTGAGGTAAAACGTCATTATGAGGTCGGGTTCGCAGAAGACG
GCGTCGATCGTATCGTCGTCGACCGTGTTCGCGGTGTCAATAGTTTGAAAGAACCGGCTCGTGTCGTGGACTTGATTGCA
GAAGCAGATCTCGTGACGACGGCTGTCGGACCGTCACTTCTCTCAAAAGTGGCACCGTTGATCAGCGAAGGACTTCGTGC
TCGTGAAGTCGAGGATGCACCGGTCTATGTCATCGCATGTGAGAACATGATTGGTGGGAGTGCAATTCTTCGTCAAGAAG
TAGAGGCGTGTGGCGGTGTCGGGGAGGCGAATGTCTTCTTCCCGAACGCGGCTGTCGACCGCATCGTCCCGCTACAACAA
CATGAGGATCCACTTTACGTGGAAGTCGAGACGTTCCATGAATGGGTCATCGAGACACAAGGGCTCAACGAACAACCACC
GATTCAAGGCGTGACGTGGGTCGAGGAGATCGGACCGTATATCGAACGGAAATTATTCACGGTCAATACAGGACACGCCA
TCGCCTCTTATATCGGCTCGTTGTTCGGGAAGGCGACGATTGACGAGGCGCTGAAGGATCGTCGCGTGCGTCAAGTCGTC
CAAGGAGCATTATATGAGACAGGTTGGTTATTGCTTGAGAAATACGGATTCGAGGCGAAAGAGCATAGCCAATACATTCA
AAAAATCATCAAACGCTTTGAAAATCCGAAATTGAAGGATGAAGTGTCGCGTGTGGCCCGTTCACCGATTCGTAAACTTG
GACCGAGCGACCGTCTCGTCAAGCCGGCACGTGAATTGATGGATAACGGCATCGAGCCGAACGAACTCGCTTACGGGATT
GCAGCAGCCCTTCATTACTACAACCCGGAGGATTCGGAATCGTCGGAGCTGAACTTGTCGATCGAAGAACACGGCATCTC
GTCAACGATTGAAAAATACCTTCATCTTCATGAAGGGGACACGTTGACTCAGTTGATTCTCGATCAATATCATTTGATTC
GGGAAGAAGAAAAAGAACGTGTGTCTTAA

Upstream 100 bases:

>100_bases
AATCGCGATTCTATGCTCAGACGAAAGCAATGTGGAGCGTCTTGTTCAGGCGAAAACGAAGGAAGAAATCTTGGCGCTCT
TTATGGAAGAGGTGGCGTAA

Downstream 100 bases:

>100_bases
TCAAAAATCGCTTCTGTCACCTGACAGAAGCGATTTTTTAGTGTTTCCCGAATTCGAGATAGGTCGTTGTTTGTTTTACG
TGAAGTGGAACGTCTGTCTC

Product: Mannitol dehydrogenase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKAVHFGAGNIGRGFIGLLLNQSGYEVTFVDINDTVIEALEVKRHYEVGFAEDGVDRIVVDRVRGVNSLKEPARVVDLIA
EADLVTTAVGPSLLSKVAPLISEGLRAREVEDAPVYVIACENMIGGSAILRQEVEACGGVGEANVFFPNAAVDRIVPLQQ
HEDPLYVEVETFHEWVIETQGLNEQPPIQGVTWVEEIGPYIERKLFTVNTGHAIASYIGSLFGKATIDEALKDRRVRQVV
QGALYETGWLLLEKYGFEAKEHSQYIQKIIKRFENPKLKDEVSRVARSPIRKLGPSDRLVKPARELMDNGIEPNELAYGI
AAALHYYNPEDSESSELNLSIEEHGISSTIEKYLHLHEGDTLTQLILDQYHLIREEEKERVS

Sequences:

>Translated_382_residues
MKAVHFGAGNIGRGFIGLLLNQSGYEVTFVDINDTVIEALEVKRHYEVGFAEDGVDRIVVDRVRGVNSLKEPARVVDLIA
EADLVTTAVGPSLLSKVAPLISEGLRAREVEDAPVYVIACENMIGGSAILRQEVEACGGVGEANVFFPNAAVDRIVPLQQ
HEDPLYVEVETFHEWVIETQGLNEQPPIQGVTWVEEIGPYIERKLFTVNTGHAIASYIGSLFGKATIDEALKDRRVRQVV
QGALYETGWLLLEKYGFEAKEHSQYIQKIIKRFENPKLKDEVSRVARSPIRKLGPSDRLVKPARELMDNGIEPNELAYGI
AAALHYYNPEDSESSELNLSIEEHGISSTIEKYLHLHEGDTLTQLILDQYHLIREEEKERVS
>Mature_382_residues
MKAVHFGAGNIGRGFIGLLLNQSGYEVTFVDINDTVIEALEVKRHYEVGFAEDGVDRIVVDRVRGVNSLKEPARVVDLIA
EADLVTTAVGPSLLSKVAPLISEGLRAREVEDAPVYVIACENMIGGSAILRQEVEACGGVGEANVFFPNAAVDRIVPLQQ
HEDPLYVEVETFHEWVIETQGLNEQPPIQGVTWVEEIGPYIERKLFTVNTGHAIASYIGSLFGKATIDEALKDRRVRQVV
QGALYETGWLLLEKYGFEAKEHSQYIQKIIKRFENPKLKDEVSRVARSPIRKLGPSDRLVKPARELMDNGIEPNELAYGI
AAALHYYNPEDSESSELNLSIEEHGISSTIEKYLHLHEGDTLTQLILDQYHLIREEEKERVS

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=366, Percent_Identity=45.0819672131148, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1788497, Length=257, Percent_Identity=27.2373540856031, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787823, Length=264, Percent_Identity=26.5151515151515, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790779, Length=212, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324401, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320765, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_EXISA (C4L274)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002886571.1
- ProteinModelPortal:   C4L274
- GeneID:   7869592
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2204
- OMA:   FTVNTGH
- ProtClustDB:   CLSK2489393
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 42640; Mature: 42640

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVHFGAGNIGRGFIGLLLNQSGYEVTFVDINDTVIEALEVKRHYEVGFAEDGVDRIVV
CCEEEECCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHH
DRVRGVNSLKEPARVVDLIAEADLVTTAVGPSLLSKVAPLISEGLRAREVEDAPVYVIAC
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEE
ENMIGGSAILRQEVEACGGVGEANVFFPNAAVDRIVPLQQHEDPLYVEVETFHEWVIETQ
CCCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHCCCHHCCCCCEEEEHHHHHHHHHHHC
GLNEQPPIQGVTWVEEIGPYIERKLFTVNTGHAIASYIGSLFGKATIDEALKDRRVRQVV
CCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALYETGWLLLEKYGFEAKEHSQYIQKIIKRFENPKLKDEVSRVARSPIRKLGPSDRLV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
KPARELMDNGIEPNELAYGIAAALHYYNPEDSESSELNLSIEEHGISSTIEKYLHLHEGD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCC
TLTQLILDQYHLIREEEKERVS
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAVHFGAGNIGRGFIGLLLNQSGYEVTFVDINDTVIEALEVKRHYEVGFAEDGVDRIVV
CCEEEECCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHH
DRVRGVNSLKEPARVVDLIAEADLVTTAVGPSLLSKVAPLISEGLRAREVEDAPVYVIAC
HHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEE
ENMIGGSAILRQEVEACGGVGEANVFFPNAAVDRIVPLQQHEDPLYVEVETFHEWVIETQ
CCCCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHCCCHHCCCCCEEEEHHHHHHHHHHHC
GLNEQPPIQGVTWVEEIGPYIERKLFTVNTGHAIASYIGSLFGKATIDEALKDRRVRQVV
CCCCCCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALYETGWLLLEKYGFEAKEHSQYIQKIIKRFENPKLKDEVSRVARSPIRKLGPSDRLV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHH
KPARELMDNGIEPNELAYGIAAALHYYNPEDSESSELNLSIEEHGISSTIEKYLHLHEGD
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCC
TLTQLILDQYHLIREEEKERVS
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA