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The map label for this gene is capD [H]

Identifier: 229917104

GI number: 229917104

Start: 1348610

End: 1350520

Strand: Reverse

Name: capD [H]

Synonym: EAT1b_1378

Alternate gene names: 229917104

Gene position: 1350520-1348610 (Counterclockwise)

Preceding gene: 229917106

Following gene: 229917103

Centisome position: 45.02

GC content: 47.41

Gene sequence:

>1911_bases
ATGAGTACTCCAACTGTTCGGTCTCCCATTGATCGAAAAAATGCGCTCTTGATGTTACTCGATATCACGATTGCAGGGCT
CGCGATTTTTGTGACGTTTGACCTATTCTTTGCGAATGATCCGACGGTAACGTCTGACCCGCTAGATTTGATCACGATCC
TCGGATTGAAGACGCTCGTTCTTCTCATTTTAGGATGGGTGACTCGGGTATACCGAATCGACTGGCGATACGGATCGATG
CGTGAGTTGCAATTACTGGCGATTGTGTTGGTCATGAGTGACACGTTCGTCTTATTCGCATCATACGTATTATTGGATGG
CTTTTCCTATCAAGCGATTTTTATTCAAAGCTTACTCGCATTTAACGGCATGTTATTTATCCGACTCGTCGCTAGGACAC
GATCGTTTTTCCAATTTCACGCACCGGTGTCGAATGGAAAAGCTACCTTGGTCATCGGTGGTGGCGAATCGGGTCAAAAA
ATCATTAAAGAACTGAAAGAACATCGAACGAATGTGCTACATGTGGTCGGGGTGTTGGATGATAATCCAATGCTTCACCG
TCTCTACATTCACGGGACACCGGTCATCGGTTCAATCGATTTACTGGAACGAAAAATTGAAGAATTGAATATCGAAGTGG
TCGTGTTGGCCATTCCTTCTCTTCCATATGGAGATCGAGTCCAACTATTGAAACGAATCGAAAAGACAGGCGTCGAATCT
CATGCACTGCCGATGCTTGCGGAACTCGCATCCGGAAAGGTGTCATTAAATGAGATTCGAGAAGTGGCCATCGAAGATTT
GCTCGGCCGTGAACCAGTTCAGCTCGACGTTTCGGAAATCTCTCAGACGTTGAGTGGATTGACCATTTTCATCTCGGGTG
CGGGAGGGTCGATTGGCTCAGAGCTTTGTCGTCAATTGATGAAATTCAATCCTGGCAAACTGATCCTGTTTGGACATGGC
GAGAATAGCATATATGCAATCGATCGGGAACTCCGCTTACTCGGATCTGATACAGAGATTTGTCCTGTCATCGGTGACGT
CCAAGACCGGGCACGGGTGACGGAAGTGTTTGATCAGTATCGACCGGACGTCGTCTATCATGCGGCAGCCCATAAGCACG
TTCCGCTCATGGAAGACAACCCGAGAGAGGCTGTGAAAAACAATATATACGGAACGAAGAACATGGTCGAAGCCGCCGAT
TTCTTTGAAGTGAAGCGCTTCGTCATGATCTCTACAGATAAGGCGGTCAATCCAACAAACGTGATGGGTGCAACGAAACG
AGTAGCAGAAATGATCGTCCAACAGCAGGCTCGCCACAGCGAAACGACATTCTCGGTCGTTCGTTTCGGCAACGTCTTAG
GAAGTCGTGGCTCCGTCGTTCCGCTCTTTAAAGAACAAATTCAACGGGGCGGACCGATTACGGTGACGCATCCAGAGATG
ACCCGATACTTTATGACCATCCCGGAAGCGAGTCGCCTCGTCATTCAAGCGAGCGTGCGCGCAAATGGGGGCGAAGTGTT
CGTACTAGATATGGGGAATCCCGTCAAAATTGTGGACTTGGCGAAACGGATGATTACACTGAGCGGTTTCACCCTCGAAC
AAATCCCGATTCATTTCAGTGGCATTCGTCCTGGTGAGAAGCTGTTCGAAGAACTGCTCGCAACGAGCGAACATACGAAT
CAAGTATATGAAAAGATTTTCGTCGGTTGTACAAGACCCTTTAAATCGGTTGATCCGATTTTGAAAACGATTGAATATCT
ACTCGATCAATCGAATGGACTCACTTCTTTCTTGTTGTTTGTCGCAAACAACGAACTGCCAGAAGAAGTGATGGAAAGTA
TTTTTGCGCCACAAATCGAACCGGTACGCATGCGAGTCAACGAGTCAACGCAAAGGAGGAAGTCGTTATGA

Upstream 100 bases:

>100_bases
TCGTATCAAAAAGCTATTCTTTTCTTTTGGATTGTGAATCTTGAACGGGTACTTATCTAGCATCAACTCGAAGCTGATTG
GGATGGAAGGTGGTGAAAGG

Downstream 100 bases:

>100_bases
AAAAAACAGTTCTCGTGACCGGAGTGGCCGGGTTCATTGGTTTTCATCTAGCTCGACGGTTGCTAAAAGAAGGACATCAT
GTCATCGGGATCGATGTGGT

Product: polysaccharide biosynthesis protein CapD

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MSTPTVRSPIDRKNALLMLLDITIAGLAIFVTFDLFFANDPTVTSDPLDLITILGLKTLVLLILGWVTRVYRIDWRYGSM
RELQLLAIVLVMSDTFVLFASYVLLDGFSYQAIFIQSLLAFNGMLFIRLVARTRSFFQFHAPVSNGKATLVIGGGESGQK
IIKELKEHRTNVLHVVGVLDDNPMLHRLYIHGTPVIGSIDLLERKIEELNIEVVVLAIPSLPYGDRVQLLKRIEKTGVES
HALPMLAELASGKVSLNEIREVAIEDLLGREPVQLDVSEISQTLSGLTIFISGAGGSIGSELCRQLMKFNPGKLILFGHG
ENSIYAIDRELRLLGSDTEICPVIGDVQDRARVTEVFDQYRPDVVYHAAAHKHVPLMEDNPREAVKNNIYGTKNMVEAAD
FFEVKRFVMISTDKAVNPTNVMGATKRVAEMIVQQQARHSETTFSVVRFGNVLGSRGSVVPLFKEQIQRGGPITVTHPEM
TRYFMTIPEASRLVIQASVRANGGEVFVLDMGNPVKIVDLAKRMITLSGFTLEQIPIHFSGIRPGEKLFEELLATSEHTN
QVYEKIFVGCTRPFKSVDPILKTIEYLLDQSNGLTSFLLFVANNELPEEVMESIFAPQIEPVRMRVNESTQRRKSL

Sequences:

>Translated_636_residues
MSTPTVRSPIDRKNALLMLLDITIAGLAIFVTFDLFFANDPTVTSDPLDLITILGLKTLVLLILGWVTRVYRIDWRYGSM
RELQLLAIVLVMSDTFVLFASYVLLDGFSYQAIFIQSLLAFNGMLFIRLVARTRSFFQFHAPVSNGKATLVIGGGESGQK
IIKELKEHRTNVLHVVGVLDDNPMLHRLYIHGTPVIGSIDLLERKIEELNIEVVVLAIPSLPYGDRVQLLKRIEKTGVES
HALPMLAELASGKVSLNEIREVAIEDLLGREPVQLDVSEISQTLSGLTIFISGAGGSIGSELCRQLMKFNPGKLILFGHG
ENSIYAIDRELRLLGSDTEICPVIGDVQDRARVTEVFDQYRPDVVYHAAAHKHVPLMEDNPREAVKNNIYGTKNMVEAAD
FFEVKRFVMISTDKAVNPTNVMGATKRVAEMIVQQQARHSETTFSVVRFGNVLGSRGSVVPLFKEQIQRGGPITVTHPEM
TRYFMTIPEASRLVIQASVRANGGEVFVLDMGNPVKIVDLAKRMITLSGFTLEQIPIHFSGIRPGEKLFEELLATSEHTN
QVYEKIFVGCTRPFKSVDPILKTIEYLLDQSNGLTSFLLFVANNELPEEVMESIFAPQIEPVRMRVNESTQRRKSL
>Mature_635_residues
STPTVRSPIDRKNALLMLLDITIAGLAIFVTFDLFFANDPTVTSDPLDLITILGLKTLVLLILGWVTRVYRIDWRYGSMR
ELQLLAIVLVMSDTFVLFASYVLLDGFSYQAIFIQSLLAFNGMLFIRLVARTRSFFQFHAPVSNGKATLVIGGGESGQKI
IKELKEHRTNVLHVVGVLDDNPMLHRLYIHGTPVIGSIDLLERKIEELNIEVVVLAIPSLPYGDRVQLLKRIEKTGVESH
ALPMLAELASGKVSLNEIREVAIEDLLGREPVQLDVSEISQTLSGLTIFISGAGGSIGSELCRQLMKFNPGKLILFGHGE
NSIYAIDRELRLLGSDTEICPVIGDVQDRARVTEVFDQYRPDVVYHAAAHKHVPLMEDNPREAVKNNIYGTKNMVEAADF
FEVKRFVMISTDKAVNPTNVMGATKRVAEMIVQQQARHSETTFSVVRFGNVLGSRGSVVPLFKEQIQRGGPITVTHPEMT
RYFMTIPEASRLVIQASVRANGGEVFVLDMGNPVKIVDLAKRMITLSGFTLEQIPIHFSGIRPGEKLFEELLATSEHTNQ
VYEKIFVGCTRPFKSVDPILKTIEYLLDQSNGLTSFLLFVANNELPEEVMESIFAPQIEPVRMRVNESTQRRKSL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=257, Percent_Identity=24.124513618677, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 70995; Mature: 70864

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTVRSPIDRKNALLMLLDITIAGLAIFVTFDLFFANDPTVTSDPLDLITILGLKTLV
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LLILGWVTRVYRIDWRYGSMRELQLLAIVLVMSDTFVLFASYVLLDGFSYQAIFIQSLLA
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FNGMLFIRLVARTRSFFQFHAPVSNGKATLVIGGGESGQKIIKELKEHRTNVLHVVGVLD
HCCHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEEC
DNPMLHRLYIHGTPVIGSIDLLERKIEELNIEVVVLAIPSLPYGDRVQLLKRIEKTGVES
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCH
HALPMLAELASGKVSLNEIREVAIEDLLGREPVQLDVSEISQTLSGLTIFISGAGGSIGS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCEEEEEECCCCCHHH
ELCRQLMKFNPGKLILFGHGENSIYAIDRELRLLGSDTEICPVIGDVQDRARVTEVFDQY
HHHHHHHHCCCCEEEEEECCCCCEEEECCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
RPDVVYHAAAHKHVPLMEDNPREAVKNNIYGTKNMVEAADFFEVKRFVMISTDKAVNPTN
CCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHH
VMGATKRVAEMIVQQQARHSETTFSVVRFGNVLGSRGSVVPLFKEQIQRGGPITVTHPEM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCEEEECHHH
TRYFMTIPEASRLVIQASVRANGGEVFVLDMGNPVKIVDLAKRMITLSGFTLEQIPIHFS
HHHEEECCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEC
GIRPGEKLFEELLATSEHTNQVYEKIFVGCTRPFKSVDPILKTIEYLLDQSNGLTSFLLF
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEE
VANNELPEEVMESIFAPQIEPVRMRVNESTQRRKSL
EECCCCHHHHHHHHHCCCCCHHHEECCCHHHHHHCC
>Mature Secondary Structure 
STPTVRSPIDRKNALLMLLDITIAGLAIFVTFDLFFANDPTVTSDPLDLITILGLKTLV
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LLILGWVTRVYRIDWRYGSMRELQLLAIVLVMSDTFVLFASYVLLDGFSYQAIFIQSLLA
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FNGMLFIRLVARTRSFFQFHAPVSNGKATLVIGGGESGQKIIKELKEHRTNVLHVVGVLD
HCCHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEEC
DNPMLHRLYIHGTPVIGSIDLLERKIEELNIEVVVLAIPSLPYGDRVQLLKRIEKTGVES
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCH
HALPMLAELASGKVSLNEIREVAIEDLLGREPVQLDVSEISQTLSGLTIFISGAGGSIGS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCEEEEEECCCCCHHH
ELCRQLMKFNPGKLILFGHGENSIYAIDRELRLLGSDTEICPVIGDVQDRARVTEVFDQY
HHHHHHHHCCCCEEEEEECCCCCEEEECCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHH
RPDVVYHAAAHKHVPLMEDNPREAVKNNIYGTKNMVEAADFFEVKRFVMISTDKAVNPTN
CCCEEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHH
VMGATKRVAEMIVQQQARHSETTFSVVRFGNVLGSRGSVVPLFKEQIQRGGPITVTHPEM
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCEEEECHHH
TRYFMTIPEASRLVIQASVRANGGEVFVLDMGNPVKIVDLAKRMITLSGFTLEQIPIHFS
HHHEEECCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCEEEC
GIRPGEKLFEELLATSEHTNQVYEKIFVGCTRPFKSVDPILKTIEYLLDQSNGLTSFLLF
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHEEEE
VANNELPEEVMESIFAPQIEPVRMRVNESTQRRKSL
EECCCCHHHHHHHHHCCCCCHHHEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]