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The map label for this gene is csd [H]

Identifier: 229916532

GI number: 229916532

Start: 756498

End: 757718

Strand: Reverse

Name: csd [H]

Synonym: EAT1b_0803

Alternate gene names: 229916532

Gene position: 757718-756498 (Counterclockwise)

Preceding gene: 229916533

Following gene: 229916531

Centisome position: 25.26

GC content: 52.83

Gene sequence:

>1221_bases
ATGTTGAACGCCTCGATTCGTGAACAGTTTCCGATTTTAGATCAGGAAATCAATGGACACCCGCTCGTTTATCTTGATAG
CGCGGCGAGCTCACAAAAGCCGATCGCTGTCATCGAGGCGATCGAGGACTATTATCGTCGCAACCATTCGAACGTGCATC
GTGGCGTCCATACGCTCGGGACGCAAGCGACGGATGCGTATGAAGGAGCACGCGAACGCGTCCGCTCGTTCATCCATGCG
GCGGTTCCTGAAGAAATCATTTTCACTCGTGGAACGACGACGGCCATCAACTTGGTCGCATCGAGCTACGGAGATGCGAA
TGTCGGTGAAGGCGACGAAATCGTCCTCACCCCGATGGAACACCATGCGAACTTGATTCCGTGGCAACAACTCGCTAAAC
GTAAAGGCGCGACGCTTCGATACGTCGAGCTCACGCCGGACGGACGGGTCACACTGGATGCCGTTCAAGCGGTGTTATCG
GACCGGACGAAAATCGTCGCGATGAGCCACGTCTCGAACGTACTCGGGACGATTAACCCGATTGCCGAAGTCGCTCGACT
CGCGCATGAAAAAGGTGCTGTCATGGTCGTCGATGCCGCACAAAGTGCACCGCATCGAAAATTGGACGTCCAAGCACTCG
ACTGTGACTTCCTCGCCTTTTCTGGACATAAGATGCTCGGACCGACTGGAATCGGTGTCTTATATGGGAAGAAACAACTC
CTCAAAAACATGGAGCCGGTCGAGTTCGGTGGCGAGATGATCGACTATGTCGATTTGTATGAATCGACGTGGAAAGACAT
CCCGTACCGTTTCGAAGCGGGGACACCGATTATCGCCGGAGCGGTCGGACTTGCGGCTGCCATCGACTTTTTAGAAGAAA
TCGGTCTTGAGAACGTCGAAGCACACGAACGTGAACTCGCGTCTTACGCGATTGAACAGATGAAAACGATTGAAGGGATT
GAGATTTACGGTCCTGAAGATCGCGTTGGTCTCGTCACGTTCAACTTGAAGGACGTGCACGCGCACGACCTCGCGACCGT
TCTCGATATGCAAGGCATCGCGGTTCGTGCCGGTCACCACTGTGCACAACCACTCATGCGTCTTTTGAAGCAATCATCGA
CGGCACGGGCGAGCTTCTATTTGTACAACACAAAAGAAGAAGTCGACCGCTTCATCGAGGGATTACGTCAAACGAAGGAG
TATTTCAATTATGAGTTTTAA

Upstream 100 bases:

>100_bases
TTAATCATCCACGGATTCTTGACGCCTGTCGTCGAAGAACTCGCAATCGATTCGGTCAAAGACCGTCTCCGCGAAGTCAT
CGAAGGGAAAGTACGTTAAG

Downstream 100 bases:

>100_bases
TAATCTCGACATGTTGTACCGACAGGTCATCATGGATCACTATAAAAACCCAAGAAACCGTGGCGTCATCGAAGATGGCG
TGACGGTGGACTTGAACAAC

Product: cysteine desulfurase, SufS subfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLNASIREQFPILDQEINGHPLVYLDSAASSQKPIAVIEAIEDYYRRNHSNVHRGVHTLGTQATDAYEGARERVRSFIHA
AVPEEIIFTRGTTTAINLVASSYGDANVGEGDEIVLTPMEHHANLIPWQQLAKRKGATLRYVELTPDGRVTLDAVQAVLS
DRTKIVAMSHVSNVLGTINPIAEVARLAHEKGAVMVVDAAQSAPHRKLDVQALDCDFLAFSGHKMLGPTGIGVLYGKKQL
LKNMEPVEFGGEMIDYVDLYESTWKDIPYRFEAGTPIIAGAVGLAAAIDFLEEIGLENVEAHERELASYAIEQMKTIEGI
EIYGPEDRVGLVTFNLKDVHAHDLATVLDMQGIAVRAGHHCAQPLMRLLKQSSTARASFYLYNTKEEVDRFIEGLRQTKE
YFNYEF

Sequences:

>Translated_406_residues
MLNASIREQFPILDQEINGHPLVYLDSAASSQKPIAVIEAIEDYYRRNHSNVHRGVHTLGTQATDAYEGARERVRSFIHA
AVPEEIIFTRGTTTAINLVASSYGDANVGEGDEIVLTPMEHHANLIPWQQLAKRKGATLRYVELTPDGRVTLDAVQAVLS
DRTKIVAMSHVSNVLGTINPIAEVARLAHEKGAVMVVDAAQSAPHRKLDVQALDCDFLAFSGHKMLGPTGIGVLYGKKQL
LKNMEPVEFGGEMIDYVDLYESTWKDIPYRFEAGTPIIAGAVGLAAAIDFLEEIGLENVEAHERELASYAIEQMKTIEGI
EIYGPEDRVGLVTFNLKDVHAHDLATVLDMQGIAVRAGHHCAQPLMRLLKQSSTARASFYLYNTKEEVDRFIEGLRQTKE
YFNYEF
>Mature_406_residues
MLNASIREQFPILDQEINGHPLVYLDSAASSQKPIAVIEAIEDYYRRNHSNVHRGVHTLGTQATDAYEGARERVRSFIHA
AVPEEIIFTRGTTTAINLVASSYGDANVGEGDEIVLTPMEHHANLIPWQQLAKRKGATLRYVELTPDGRVTLDAVQAVLS
DRTKIVAMSHVSNVLGTINPIAEVARLAHEKGAVMVVDAAQSAPHRKLDVQALDCDFLAFSGHKMLGPTGIGVLYGKKQL
LKNMEPVEFGGEMIDYVDLYESTWKDIPYRFEAGTPIIAGAVGLAAAIDFLEEIGLENVEAHERELASYAIEQMKTIEGI
EIYGPEDRVGLVTFNLKDVHAHDLATVLDMQGIAVRAGHHCAQPLMRLLKQSSTARASFYLYNTKEEVDRFIEGLRQTKE
YFNYEF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=389, Percent_Identity=25.1928020565553, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=26.3975155279503, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1787970, Length=393, Percent_Identity=50.8905852417303, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=41.3098236775819, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI48994898, Length=389, Percent_Identity=26.2210796915167, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193211090, Length=418, Percent_Identity=27.2727272727273, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25143064, Length=229, Percent_Identity=27.9475982532751, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17533177, Length=334, Percent_Identity=23.6526946107784, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=394, Percent_Identity=24.6192893401015, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129463, Length=247, Percent_Identity=31.1740890688259, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45001; Mature: 45001

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNASIREQFPILDQEINGHPLVYLDSAASSQKPIAVIEAIEDYYRRNHSNVHRGVHTLG
CCCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
TQATDAYEGARERVRSFIHAAVPEEIIFTRGTTTAINLVASSYGDANVGEGDEIVLTPME
CCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHCCCCCCCCCCCEEEEEEHH
HHANLIPWQQLAKRKGATLRYVELTPDGRVTLDAVQAVLSDRTKIVAMSHVSNVLGTINP
HCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHCCCHHEEEHHHHHHHHHHHHH
IAEVARLAHEKGAVMVVDAAQSAPHRKLDVQALDCDFLAFSGHKMLGPTGIGVLYGKKQL
HHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCEEEECCCCEECCCCCCHHCCHHHH
LKNMEPVEFGGEMIDYVDLYESTWKDIPYRFEAGTPIIAGAVGLAAAIDFLEEIGLENVE
HCCCCCHHHCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AHERELASYAIEQMKTIEGIEIYGPEDRVGLVTFNLKDVHAHDLATVLDMQGIAVRAGHH
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCHH
CAQPLMRLLKQSSTARASFYLYNTKEEVDRFIEGLRQTKEYFNYEF
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNASIREQFPILDQEINGHPLVYLDSAASSQKPIAVIEAIEDYYRRNHSNVHRGVHTLG
CCCCCHHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
TQATDAYEGARERVRSFIHAAVPEEIIFTRGTTTAINLVASSYGDANVGEGDEIVLTPME
CCCHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHCCCCCCCCCCCEEEEEEHH
HHANLIPWQQLAKRKGATLRYVELTPDGRVTLDAVQAVLSDRTKIVAMSHVSNVLGTINP
HCCCCCCHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHCCCHHEEEHHHHHHHHHHHHH
IAEVARLAHEKGAVMVVDAAQSAPHRKLDVQALDCDFLAFSGHKMLGPTGIGVLYGKKQL
HHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCEEEECCCCEECCCCCCHHCCHHHH
LKNMEPVEFGGEMIDYVDLYESTWKDIPYRFEAGTPIIAGAVGLAAAIDFLEEIGLENVE
HCCCCCHHHCCHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCH
AHERELASYAIEQMKTIEGIEIYGPEDRVGLVTFNLKDVHAHDLATVLDMQGIAVRAGHH
HHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCHH
CAQPLMRLLKQSSTARASFYLYNTKEEVDRFIEGLRQTKEYFNYEF
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]