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The map label for this gene is serA [H]

Identifier: 229916352

GI number: 229916352

Start: 574502

End: 575665

Strand: Reverse

Name: serA [H]

Synonym: EAT1b_0622

Alternate gene names: 229916352

Gene position: 575665-574502 (Counterclockwise)

Preceding gene: 229916353

Following gene: 229916351

Centisome position: 19.19

GC content: 49.4

Gene sequence:

>1164_bases
ATGTATCACATCAAAACATTTAATCAAATCGCTGCCGCTGGTCTGAAACGATTCGAGCCAAGCGAGTACGTCATCAATGC
ATCGGATCAAGCCGATGCTTGGGTACTGAGAAGTCATCAAGTCCATGAAGAGGACATCCCTCCCTATCTTCTCGCCATCG
CCAGAGCTGGGGCCGGTGTCAACAACCTTCCGCTCGATCAACTTGCGAAACGAGGAATCGTCGCGTTTCATACACCTGGC
GCGAATGCGAATGCGGTGAAAGAGCTCGTCCTTGCGAGTATGATCCTCTCAGTACGACCTATTGTGAAAGGTTTCAATTG
GGTGAATGAACAGACTACCGCATCGCAATCTCAATTAGAAGAAGCGATGGAATTGCAAAAACGACAATTCCTCGGAGCGG
AGTTGCGGGGTAAAAAAGTGGGGATTATCGGTCTAGGAGCCATCGGTGCGTCGCTAGCCAACGATCTTCTCCAACTCGGG
GTCGATGTCATCGGATACGACCCTCATCTCTCGGTTGATGCCGCTTGGAATATTTCGAAACATGTCACGCGTGCCAAACA
TTTAAGTGAAGTACTGGGCAACGTTGATTTACTGTCGATCCATATGCCTTTGACTGAGGAGACTCGATTCAGCATCGACC
GGAGTTGGTTTGAGCGGATGAAACCGGGGATGACTGTTTTGAACTTTGCGCGAGGAGAGCTCGTGAAAGATGATGACTTA
CTAAAGGCATTCCATCATCATGTGGGACTGTATGTGACCGACTTCCCCCGTCACACGCTGATCGGTCATCCGCAAGTCAT
GGCATTGCCTCACCTCGGTGCATCGACTAAAGAATCGGAAGTCAACTGTGCCATTCAAGCCGTGGAGACGCTGAAATTGT
ATCTCGAGACAGGGAATATTCGTTCGTCCGCTAATTTTCCGAACGTCGAGCTTCCATACACGGGTAAACGCCGTCTTGGG
ATTTTGCATCGAAACGTCCCGAACATGGTCGGTCAAATCACGGGAGAACTTGCCTCACATGGATTGAATATCGATAACAT
GGTCAATCGTAGCCGCGGGGAGATGGCGTATACGTTGATTGATTTAGACAACAGCGAGCATGAACCGTTATCGATTCATG
CGCTGTATGAAATACAGGGCGTCATTCGCGTCCGGGAATTTTAA

Upstream 100 bases:

>100_bases
CGTTCGGTAGGGGGCTTACGTGCAAGTCTATATAATGCGATGCCGCTAGAAGGGGCAGAACGCCTCGTCGACGTCATGAG
AGCATTCGAGGAGGAGACCC

Downstream 100 bases:

>100_bases
GGAGGATCCTTATGGTCGTATTTAAACCGTTCAGCCCTTATATGCCAACGCATCCGGAACGTGTCGCCGCAGACCCGTAT
GATGTCGTATCGATTGAAGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MYHIKTFNQIAAAGLKRFEPSEYVINASDQADAWVLRSHQVHEEDIPPYLLAIARAGAGVNNLPLDQLAKRGIVAFHTPG
ANANAVKELVLASMILSVRPIVKGFNWVNEQTTASQSQLEEAMELQKRQFLGAELRGKKVGIIGLGAIGASLANDLLQLG
VDVIGYDPHLSVDAAWNISKHVTRAKHLSEVLGNVDLLSIHMPLTEETRFSIDRSWFERMKPGMTVLNFARGELVKDDDL
LKAFHHHVGLYVTDFPRHTLIGHPQVMALPHLGASTKESEVNCAIQAVETLKLYLETGNIRSSANFPNVELPYTGKRRLG
ILHRNVPNMVGQITGELASHGLNIDNMVNRSRGEMAYTLIDLDNSEHEPLSIHALYEIQGVIRVREF

Sequences:

>Translated_387_residues
MYHIKTFNQIAAAGLKRFEPSEYVINASDQADAWVLRSHQVHEEDIPPYLLAIARAGAGVNNLPLDQLAKRGIVAFHTPG
ANANAVKELVLASMILSVRPIVKGFNWVNEQTTASQSQLEEAMELQKRQFLGAELRGKKVGIIGLGAIGASLANDLLQLG
VDVIGYDPHLSVDAAWNISKHVTRAKHLSEVLGNVDLLSIHMPLTEETRFSIDRSWFERMKPGMTVLNFARGELVKDDDL
LKAFHHHVGLYVTDFPRHTLIGHPQVMALPHLGASTKESEVNCAIQAVETLKLYLETGNIRSSANFPNVELPYTGKRRLG
ILHRNVPNMVGQITGELASHGLNIDNMVNRSRGEMAYTLIDLDNSEHEPLSIHALYEIQGVIRVREF
>Mature_387_residues
MYHIKTFNQIAAAGLKRFEPSEYVINASDQADAWVLRSHQVHEEDIPPYLLAIARAGAGVNNLPLDQLAKRGIVAFHTPG
ANANAVKELVLASMILSVRPIVKGFNWVNEQTTASQSQLEEAMELQKRQFLGAELRGKKVGIIGLGAIGASLANDLLQLG
VDVIGYDPHLSVDAAWNISKHVTRAKHLSEVLGNVDLLSIHMPLTEETRFSIDRSWFERMKPGMTVLNFARGELVKDDDL
LKAFHHHVGLYVTDFPRHTLIGHPQVMALPHLGASTKESEVNCAIQAVETLKLYLETGNIRSSANFPNVELPYTGKRRLG
ILHRNVPNMVGQITGELASHGLNIDNMVNRSRGEMAYTLIDLDNSEHEPLSIHALYEIQGVIRVREF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=293, Percent_Identity=31.740614334471, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=26.8774703557312, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI145580578, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557499, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1789279, Length=366, Percent_Identity=30.8743169398907, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87082289, Length=277, Percent_Identity=26.7148014440433, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787645, Length=195, Percent_Identity=27.6923076923077, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=285, Percent_Identity=29.4736842105263, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=25.1824817518248, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320925, Length=359, Percent_Identity=28.4122562674095, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=359, Percent_Identity=28.133704735376, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=287, Percent_Identity=24.7386759581882, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921140, Length=287, Percent_Identity=29.9651567944251, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=252, Percent_Identity=26.984126984127, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574286, Length=246, Percent_Identity=27.2357723577236, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=28.1746031746032, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646446, Length=231, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646448, Length=231, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646452, Length=231, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646450, Length=231, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=28.7610619469027, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 42898; Mature: 42898

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHIKTFNQIAAAGLKRFEPSEYVINASDQADAWVLRSHQVHEEDIPPYLLAIARAGAGV
CCEECHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCC
NNLPLDQLAKRGIVAFHTPGANANAVKELVLASMILSVRPIVKGFNWVNEQTTASQSQLE
CCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EAMELQKRQFLGAELRGKKVGIIGLGAIGASLANDLLQLGVDVIGYDPHLSVDAAWNISK
HHHHHHHHHHCCHHCCCCEEEEEEEHHHHHHHHHHHHHHCCHHCCCCCCCCEEECCCHHH
HVTRAKHLSEVLGNVDLLSIHMPLTEETRFSIDRSWFERMKPGMTVLNFARGELVKDDDL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCHHH
LKAFHHHVGLYVTDFPRHTLIGHPQVMALPHLGASTKESEVNCAIQAVETLKLYLETGNI
HHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHEEEECCCC
RSSANFPNVELPYTGKRRLGILHRNVPNMVGQITGELASHGLNIDNMVNRSRGEMAYTLI
CCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEE
DLDNSEHEPLSIHALYEIQGVIRVREF
ECCCCCCCCEEEEEEEEEHHHEEEECC
>Mature Secondary Structure
MYHIKTFNQIAAAGLKRFEPSEYVINASDQADAWVLRSHQVHEEDIPPYLLAIARAGAGV
CCEECHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCC
NNLPLDQLAKRGIVAFHTPGANANAVKELVLASMILSVRPIVKGFNWVNEQTTASQSQLE
CCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
EAMELQKRQFLGAELRGKKVGIIGLGAIGASLANDLLQLGVDVIGYDPHLSVDAAWNISK
HHHHHHHHHHCCHHCCCCEEEEEEEHHHHHHHHHHHHHHCCHHCCCCCCCCEEECCCHHH
HVTRAKHLSEVLGNVDLLSIHMPLTEETRFSIDRSWFERMKPGMTVLNFARGELVKDDDL
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCHHH
LKAFHHHVGLYVTDFPRHTLIGHPQVMALPHLGASTKESEVNCAIQAVETLKLYLETGNI
HHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHEEEECCCC
RSSANFPNVELPYTGKRRLGILHRNVPNMVGQITGELASHGLNIDNMVNRSRGEMAYTLI
CCCCCCCCEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEE
DLDNSEHEPLSIHALYEIQGVIRVREF
ECCCCCCCCEEEEEEEEEHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]