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The map label for this gene is serC

Identifier: 229916353

GI number: 229916353

Start: 575643

End: 576713

Strand: Reverse

Name: serC

Synonym: EAT1b_0623

Alternate gene names: 229916353

Gene position: 576713-575643 (Counterclockwise)

Preceding gene: 229916354

Following gene: 229916352

Centisome position: 19.22

GC content: 47.81

Gene sequence:

>1071_bases
GTGTCGACGTATACATACTCTGCGGGTCCCGGCATGCTACCGACAGAAGTGATGCAAGAGATTCAACAACATCTTCTGAC
GTTTGAATATGAAGGCGTTTCGATTATCGAAACGAGTCATCGCTCCGCGTCTTTCCAACGTGTGGTCGACTCTCTTGAAT
GGAGACTGAGAAGACTCATGCATATCCCTGAGAATTATGCCGTACTTTGGCTACAGGGCGGGGCGACGTTACAATTTTCC
ATGATTCCGATGAATTTACGGAAACAGAATCGATTCGCTTATGTGGATACAGGCATTTGGTCTAAAAAAGCGATGGAAGA
TGCGAAACACTTTGGAGAGGTCGATGTCATTCATCCGTTGGTAGATGCGACGGGAGGGATGTCGTTTGAATCGAGCCTTG
TCCAAGAGGTGGACTATCTCCATGTGACACTGAACAACACGATTGAAGGGACTCGATTTACACATATCCCTGAAATCGAT
GTTCCGTTGATTGCAGATGCTTCCTCGAATATTCTAGCCGAGCAGATCGATGTGGAGCGCTTCGGGGTGATCTATGCCGG
AGCCCAGAAGAATATTGGACCTGCAGGACTGACGGTCGTCATCATCCGTCGAGATTTGATTCAGTCGCTTCAGTTGCCGA
GTTATCTTCAATATGCATCACATGTCGATACGTTATTCAATACACCGTCGACGTTTAGTATGTATGCAGCCGAGCGTGTA
TTGAAGTGGGTGGAAGACTGCGGAGGCGTCGAAGCGATGGAACGATTGAATCGTCAAAAAAGTGACAGAATCTATTCCTA
TCTTGAAGAGTCGACCTGTTTTTCTCCAATTGTAACGGGGGAACGTCGTTCATTGACGAACATCCCATTTTCAACGGGAA
ATCAAGAGCTGGATCAGCGCTTTGAGCGATACGCGTTAGAACGTGGCTTGCTCGAACTCGGTGGACATCGTTCGGTAGGG
GGCTTACGTGCAAGTCTATATAATGCGATGCCGCTAGAAGGGGCAGAACGCCTCGTCGACGTCATGAGAGCATTCGAGGA
GGAGACCCATGTATCACATCAAAACATTTAA

Upstream 100 bases:

>100_bases
CCTGATTTTCGAATCAGGGCGATTTTGTATTTTAGGCAGGAAATGCCACTTCCTATAAGGAAGAGTACACCCTTAGACAG
ACTATAGAGGAGGAAACACC

Downstream 100 bases:

>100_bases
TCAAATCGCTGCCGCTGGTCTGAAACGATTCGAGCCAAGCGAGTACGTCATCAATGCATCGGATCAAGCCGATGCTTGGG
TACTGAGAAGTCATCAAGTC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSTYTYSAGPGMLPTEVMQEIQQHLLTFEYEGVSIIETSHRSASFQRVVDSLEWRLRRLMHIPENYAVLWLQGGATLQFS
MIPMNLRKQNRFAYVDTGIWSKKAMEDAKHFGEVDVIHPLVDATGGMSFESSLVQEVDYLHVTLNNTIEGTRFTHIPEID
VPLIADASSNILAEQIDVERFGVIYAGAQKNIGPAGLTVVIIRRDLIQSLQLPSYLQYASHVDTLFNTPSTFSMYAAERV
LKWVEDCGGVEAMERLNRQKSDRIYSYLEESTCFSPIVTGERRSLTNIPFSTGNQELDQRFERYALERGLLELGGHRSVG
GLRASLYNAMPLEGAERLVDVMRAFEEETHVSHQNI

Sequences:

>Translated_356_residues
MSTYTYSAGPGMLPTEVMQEIQQHLLTFEYEGVSIIETSHRSASFQRVVDSLEWRLRRLMHIPENYAVLWLQGGATLQFS
MIPMNLRKQNRFAYVDTGIWSKKAMEDAKHFGEVDVIHPLVDATGGMSFESSLVQEVDYLHVTLNNTIEGTRFTHIPEID
VPLIADASSNILAEQIDVERFGVIYAGAQKNIGPAGLTVVIIRRDLIQSLQLPSYLQYASHVDTLFNTPSTFSMYAAERV
LKWVEDCGGVEAMERLNRQKSDRIYSYLEESTCFSPIVTGERRSLTNIPFSTGNQELDQRFERYALERGLLELGGHRSVG
GLRASLYNAMPLEGAERLVDVMRAFEEETHVSHQNI
>Mature_355_residues
STYTYSAGPGMLPTEVMQEIQQHLLTFEYEGVSIIETSHRSASFQRVVDSLEWRLRRLMHIPENYAVLWLQGGATLQFSM
IPMNLRKQNRFAYVDTGIWSKKAMEDAKHFGEVDVIHPLVDATGGMSFESSLVQEVDYLHVTLNNTIEGTRFTHIPEIDV
PLIADASSNILAEQIDVERFGVIYAGAQKNIGPAGLTVVIIRRDLIQSLQLPSYLQYASHVDTLFNTPSTFSMYAAERVL
KWVEDCGGVEAMERLNRQKSDRIYSYLEESTCFSPIVTGERRSLTNIPFSTGNQELDQRFERYALERGLLELGGHRSVGG
LRASLYNAMPLEGAERLVDVMRAFEEETHVSHQNI

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=359, Percent_Identity=42.6183844011142, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI10863955, Length=293, Percent_Identity=41.6382252559727, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1787136, Length=354, Percent_Identity=41.2429378531073, Blast_Score=274, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI17506897, Length=357, Percent_Identity=39.4957983193277, Blast_Score=255, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=32.987012987013, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI21356589, Length=356, Percent_Identity=40.7303370786517, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_EXISA (C4L432)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002884999.1
- GeneID:   7871362
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_0623
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40289; Mature: 40158

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 100-100 BINDING 147-147 BINDING 166-166 BINDING 189-189

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYTYSAGPGMLPTEVMQEIQQHLLTFEYEGVSIIETSHRSASFQRVVDSLEWRLRRLM
CCCEECCCCCCCCHHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
HIPENYAVLWLQGGATLQFSMIPMNLRKQNRFAYVDTGIWSKKAMEDAKHFGEVDVIHPL
HCCCCCEEEEEECCCEEEEEEECCCHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHH
VDATGGMSFESSLVQEVDYLHVTLNNTIEGTRFTHIPEIDVPLIADASSNILAEQIDVER
HHCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEECCCCCCCCEEECCCCCHHHHHHHHHH
FGVIYAGAQKNIGPAGLTVVIIRRDLIQSLQLPSYLQYASHVDTLFNTPSTFSMYAAERV
HCEEEECCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LKWVEDCGGVEAMERLNRQKSDRIYSYLEESTCFSPIVTGERRSLTNIPFSTGNQELDQR
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FERYALERGLLELGGHRSVGGLRASLYNAMPLEGAERLVDVMRAFEEETHVSHQNI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STYTYSAGPGMLPTEVMQEIQQHLLTFEYEGVSIIETSHRSASFQRVVDSLEWRLRRLM
CCEECCCCCCCCHHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
HIPENYAVLWLQGGATLQFSMIPMNLRKQNRFAYVDTGIWSKKAMEDAKHFGEVDVIHPL
HCCCCCEEEEEECCCEEEEEEECCCHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHH
VDATGGMSFESSLVQEVDYLHVTLNNTIEGTRFTHIPEIDVPLIADASSNILAEQIDVER
HHCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEECCCCCCCCEEECCCCCHHHHHHHHHH
FGVIYAGAQKNIGPAGLTVVIIRRDLIQSLQLPSYLQYASHVDTLFNTPSTFSMYAAERV
HCEEEECCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LKWVEDCGGVEAMERLNRQKSDRIYSYLEESTCFSPIVTGERRSLTNIPFSTGNQELDQR
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FERYALERGLLELGGHRSVGGLRASLYNAMPLEGAERLVDVMRAFEEETHVSHQNI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA