Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 229587155

GI number: 229587155

Start: 1140839

End: 1142320

Strand: Direct

Name: nuoM [H]

Synonym: RAF_ORF1118

Alternate gene names: 229587155

Gene position: 1140839-1142320 (Clockwise)

Preceding gene: 229587154

Following gene: 229587156

Centisome position: 89.23

GC content: 33.54

Gene sequence:

>1482_bases
ATGTTAGAATTACCTATTATATCTATCAGTATTTTTCTGCCACTAATAAGCGTGCTATATATTTTGCTGTTTATTAGTCA
AAGTAAAAAAGCAGATAAACCGATATATGTAATGTATGTTGCAGTGCTTAGTTCTGTTTTAACATTCATCTCAACTATCT
ATATTTTAATAGAGTTTGACTCCTCAAACCCCGCTTATCAATTCGTTGAACGCTACGCTTGGCTTGATAAGATCGGGCTT
GAATTCCATGTAGGCGTTGACGGTATATCAATATTTTTTGTGGTTCTAACTTCTTTTCTTACTCTTATTTGTATAATTGG
AAGCTTATTTACCGTTAAAAAATATATTAAAGAATATTTGGTATGTTTCTTATTAATGGAATCTTTTTGTATAGGGGCAT
TTACCTCGGTAAATTTACTATTATTTTATCTGTTTTTTGAAGCAATATTAGTGCCGATGTATATTATTATCGGCGTATGG
GGTGGCAAGAATAGAATATATGCGGCTCTTAAATTCTTCTTATACACGTTCTTTGGTTCTGTATTTTTCCTACTTTCATT
AATTTATATTTATAGCAAAATGCATAGCTTTGATTTAACCTATATCTTTCAGCTTACCGATAATATTCCATTATTTGCTC
AGCAAATTTTATGGTGGGCTATCTTTATTGCTTTTGCCGTTAAAATCCCTATTATTCCTTTTCATACTTGGCTACCAGAT
GCACACGTACAAGCTCCAACCAGCGGCTCGGTTATTCTTGCCGGTATTTTGCTAAAACTCGGCGGTTACGGTTTTTTAAG
AGTATTACTACCTCTATGTCCGAGTGTATCACAAGAATTTGCAATTTACGTAATTTACCTTAGCATTATTGCTATAATAT
ATGCATCACTCGTTGCGCTTGCTCAAAAAGATATGAAGAAGATGATAGCATATTCATCTATTGCACATATGGGATATGTT
ACGATAGGTATTTTTAGCTTTACTAAAGCCGGAGTTAGCGGAGCAATATTTCAGATGCTTAGCCACGGTGTGATTTCTTC
ATGTCTATTCTTAATAGTCGGTACTTTGTACGAAAGATTACATACAAAAGAAATAGCTAAATATGGTGGTGTAGCAAGTA
AAATGCCGGTGCTTGCCGCATTTTTTATGATTGCAATGCTCGGCTCTGTCGGGTTACCCGGAACTAGTGGATTTATTGGA
GAATTTTTAAGCCTGCTTGGGATTTATAAGGTAAATGTAGTAGCAACCTTTATAGCAGCTCTCGGCATAATCTTCGGGGC
GGTTTATATGCTGAAATTATACAAAGAAGTAATGCTCGGTGAAATTACCAATAAAGAAATTATGCATTTCAGAGATTTAT
ATAAATACGAAATAATCTCAATAGCTCCTTTAATATTATTAATTATTTACTTTGGTCTAATGCCGAGTTCTATTTTAAAT
GTATTTAGCTTATCGGTGGGAAATTTGCTGGTAAAATTTTAA

Upstream 100 bases:

>100_bases
GGCAATCTCATAAAATAATAACAAATTCCTGAGATTGCTTTGTCAATTACTGCGTAATTTGCTTCGCCATGACGGAAAAA
AACTCATAAAATCTTAAAGA

Downstream 100 bases:

>100_bases
TTGCTTACAAAAAATATAAATGCTACTTTAATTATAGAACTTAAAAGTGAGATTTATATAAAAAATAGCAAAAGAACCTA
AAAAATAAACCATGAATTAA

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MLELPIISISIFLPLISVLYILLFISQSKKADKPIYVMYVAVLSSVLTFISTIYILIEFDSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVVLTSFLTLICIIGSLFTVKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGKNRIYAALKFFLYTFFGSVFFLLSLIYIYSKMHSFDLTYIFQLTDNIPLFAQQILWWAIFIAFAVKIPIIPFHTWLPD
AHVQAPTSGSVILAGILLKLGGYGFLRVLLPLCPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTKAGVSGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMPVLAAFFMIAMLGSVGLPGTSGFIG
EFLSLLGIYKVNVVATFIAALGIIFGAVYMLKLYKEVMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSLSVGNLLVKF

Sequences:

>Translated_493_residues
MLELPIISISIFLPLISVLYILLFISQSKKADKPIYVMYVAVLSSVLTFISTIYILIEFDSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVVLTSFLTLICIIGSLFTVKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGKNRIYAALKFFLYTFFGSVFFLLSLIYIYSKMHSFDLTYIFQLTDNIPLFAQQILWWAIFIAFAVKIPIIPFHTWLPD
AHVQAPTSGSVILAGILLKLGGYGFLRVLLPLCPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTKAGVSGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMPVLAAFFMIAMLGSVGLPGTSGFIG
EFLSLLGIYKVNVVATFIAALGIIFGAVYMLKLYKEVMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSLSVGNLLVKF
>Mature_493_residues
MLELPIISISIFLPLISVLYILLFISQSKKADKPIYVMYVAVLSSVLTFISTIYILIEFDSSNPAYQFVERYAWLDKIGL
EFHVGVDGISIFFVVLTSFLTLICIIGSLFTVKKYIKEYLVCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVW
GGKNRIYAALKFFLYTFFGSVFFLLSLIYIYSKMHSFDLTYIFQLTDNIPLFAQQILWWAIFIAFAVKIPIIPFHTWLPD
AHVQAPTSGSVILAGILLKLGGYGFLRVLLPLCPSVSQEFAIYVIYLSIIAIIYASLVALAQKDMKKMIAYSSIAHMGYV
TIGIFSFTKAGVSGAIFQMLSHGVISSCLFLIVGTLYERLHTKEIAKYGGVASKMPVLAAFFMIAMLGSVGLPGTSGFIG
EFLSLLGIYKVNVVATFIAALGIIFGAVYMLKLYKEVMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
VFSLSVGNLLVKF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=359, Percent_Identity=33.983286908078, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI251831117, Length=387, Percent_Identity=23.7726098191214, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1788613, Length=444, Percent_Identity=37.8378378378378, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1788827, Length=354, Percent_Identity=26.8361581920904, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788831, Length=280, Percent_Identity=24.6428571428571, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693160, Length=371, Percent_Identity=28.3018867924528, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788614, Length=411, Percent_Identity=25.3041362530414, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788829, Length=272, Percent_Identity=27.2058823529412, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI2367154, Length=317, Percent_Identity=23.6593059936909, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55180; Mature: 55180

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELPIISISIFLPLISVLYILLFISQSKKADKPIYVMYVAVLSSVLTFISTIYILIEFD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEC
SSNPAYQFVERYAWLDKIGLEFHVGVDGISIFFVVLTSFLTLICIIGSLFTVKKYIKEYL
CCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVWGGKNRIYAALKFFLYTFFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VFFLLSLIYIYSKMHSFDLTYIFQLTDNIPLFAQQILWWAIFIAFAVKIPIIPFHTWLPD
HHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECHHCCCC
AHVQAPTSGSVILAGILLKLGGYGFLRVLLPLCPSVSQEFAIYVIYLSIIAIIYASLVAL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQKDMKKMIAYSSIAHMGYVTIGIFSFTKAGVSGAIFQMLSHGVISSCLFLIVGTLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTKEIAKYGGVASKMPVLAAFFMIAMLGSVGLPGTSGFIGEFLSLLGIYKVNVVATFIAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGIIFGAVYMLKLYKEVMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VFSLSVGNLLVKF
HHHHHHHHHHHCC
>Mature Secondary Structure
MLELPIISISIFLPLISVLYILLFISQSKKADKPIYVMYVAVLSSVLTFISTIYILIEFD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEC
SSNPAYQFVERYAWLDKIGLEFHVGVDGISIFFVVLTSFLTLICIIGSLFTVKKYIKEYL
CCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCFLLMESFCIGAFTSVNLLLFYLFFEAILVPMYIIIGVWGGKNRIYAALKFFLYTFFGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VFFLLSLIYIYSKMHSFDLTYIFQLTDNIPLFAQQILWWAIFIAFAVKIPIIPFHTWLPD
HHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECHHCCCC
AHVQAPTSGSVILAGILLKLGGYGFLRVLLPLCPSVSQEFAIYVIYLSIIAIIYASLVAL
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AQKDMKKMIAYSSIAHMGYVTIGIFSFTKAGVSGAIFQMLSHGVISSCLFLIVGTLYERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HTKEIAKYGGVASKMPVLAAFFMIAMLGSVGLPGTSGFIGEFLSLLGIYKVNVVATFIAA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGIIFGAVYMLKLYKEVMLGEITNKEIMHFRDLYKYEIISIAPLILLIIYFGLMPSSILN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VFSLSVGNLLVKF
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA