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The map label for this gene is nuoL1 [H]

Identifier: 229587154

GI number: 229587154

Start: 1138703

End: 1140685

Strand: Direct

Name: nuoL1 [H]

Synonym: RAF_ORF1117

Alternate gene names: 229587154

Gene position: 1138703-1140685 (Clockwise)

Preceding gene: 229587153

Following gene: 229587155

Centisome position: 89.06

GC content: 34.95

Gene sequence:

>1983_bases
GTGGGGATAATGATGTATCAAAATATTTGCATAATGATCATCATGTTACCGCTTGCATCTAGCATAATAAACGGGTTATT
CGTAAGGGTAATAGACAAAAAATTAGCGCAAGTAATTGCAACCGGCTTTTTATCTTTATCTGCCTTATTCTCATTAATAA
TATTTTGCGATGCAGGCTTAGACGGGAATATAATCCATATTAAATTATTACCATGGATTGAGGTTGGAAATTTTAAAGTA
AATTGGTCGATTTATATCGATCAGCTAACTAGCATAATGTTTATAGCCGTAACATGGGTGTCAAGCATCGTGCATATCTA
CTCGCTTGGCTATATGGCCAAAGATAAGGGGATTATACGCTTCTTGTCTTTTCTTTCTTTATTCACTTTTTTTATGTTAA
TACTAGTATCTAGCGATAATTTCTTACAGTTATTTTTCGGTTGGGAGGGCGTCGGCGTTTGCTCATATTTACTAATAGGT
TTTTGGTATTCAAAAGAATCAGCCAATAAAGCAGCGATTAAAGCTTTTATAATAAATAGAGCCAGCGATTTTGCTTTTAT
CTTAGGCGTAATGACGATTATTGTTTATTGTGGCTCAGCAAATTACAAAGATGTATTGTCATCTGCAGAATTATTATCTA
ATATAAAAATATTTGTACATTTTTCTATTCTAGACATTATTTGTTTATTATTATTCATCGGTTGTATGGGTAAATCTGCA
CAGATCGGTTTACATGTATGGCTTCCTGATGCGATGGAAGGACCGACTCCGGTATCTGCACTTATTCATGCAGCAACCAT
GGTAACGGCAGGAGTATTCTTAGTAGCACGCTGCTCGTATTTATTTGAATATAGCCCTTTAATTCTACAATTTATTACGA
TTATCGGCGGTGTTACTTGTCTTTTTGCTGCAAGCATTGCTATTATGCACAGCGATATCAAGAAGATTATTGCTTACTCA
ACTTGCAGTCAGCTTGGTTATATGTTCATGGCGTGCGGAGTATCTGCCTATAATAGCGGAATATTTCACTTAGTAACTCA
TGCCTTTTTTAAGGCCTTATTATTCTTATCAGCCGGCAGCGTAATACATGCCGTTCACGAGCAGGATATTTTTAAAATGG
GTGATTTAAGAAATAAAATGCCGGTAACTTATGGCAACTTCTTAATCGGCTCACTTGCACTAATAGGGATTTATCCTTTG
GCAGGATTTTACTCTAAAGACTCGATTTTAGAAGCGGCTTATAGTAGCGGCTCGTTTATGTTTATTTTTGGAATAGCAGC
AGCAATACTTACCGCTATTTATTCAATGAAGATTATTATGTTGGTATTTCATGGCAAAACTAAGCTAGAAAAAGATGTTT
TTGAGCATGCTCACGAACCGGCTAAAGTAATGAATAATCCACTTATATTACTTGTCGCCGGAAGCTTTTTTAGTGGTATG
ATCGGCTATTATTTACTTGCTATGGACAAACCAAACGGTTATTTCCATGCAAGCCTATTTAATTTACATATTTATAAATT
ACTAATTAGCCACCCGCCTTTATATATTAAGCTACTACCTATGGCAGTCGGTATAGTGGGAATTGTTACTGGGATTTACT
TATATAAGTCAAGTACTGTTATGTCATTCCCGCAAAAGCGGGAATCCAGTAAAAATATTAAAAACGCCTGGATCCTACGG
TCAAGCCGCGGGATGACACCCCTTGTATTAATTTCCAACATATTACGCAATAAATATTACTTCGATGAAATATATAATTG
CTTAATTGTGAAACCTATTAACTGTTTAGCTTCTTTATTTTATCTTGGCGATCAGCAAATAATCGATCGTTTTGGACCAA
ACGGTTTTTCACGAGTCGTTAATTGCTTTAGCGTTCTTACCGGCAAAATACAAACAGGATATGTTTTTAATTATGCTTTG
TATATAGTATCATTTATTGTTGTAACAATTAGTTATTTTGTTTGGAAAAACATAATGTACTGA

Upstream 100 bases:

>100_bases
TCTTAACCGTAGCAGCTGCCGAAACCTCAATCGGACTTGCAATATTACTAATATATTTCCGTAATAAAGGCTCCATTGAA
ATTACTGACATTAATCAGAT

Downstream 100 bases:

>100_bases
TGTTATTTGCGTTAAAAACTAAAACCGTCATTGCGAGCGAACGTAAAGAGCGTGGCAATCTCATAAAATAATAACAAATT
CCTGAGATTGCTTTGTCAAT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MGIMMYQNICIMIIMLPLASSIINGLFVRVIDKKLAQVIATGFLSLSALFSLIIFCDAGLDGNIIHIKLLPWIEVGNFKV
NWSIYIDQLTSIMFIAVTWVSSIVHIYSLGYMAKDKGIIRFLSFLSLFTFFMLILVSSDNFLQLFFGWEGVGVCSYLLIG
FWYSKESANKAAIKAFIINRASDFAFILGVMTIIVYCGSANYKDVLSSAELLSNIKIFVHFSILDIICLLLFIGCMGKSA
QIGLHVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYLFEYSPLILQFITIIGGVTCLFAASIAIMHSDIKKIIAYS
TCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKMGDLRNKMPVTYGNFLIGSLALIGIYPL
AGFYSKDSILEAAYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLEKDVFEHAHEPAKVMNNPLILLVAGSFFSGM
IGYYLLAMDKPNGYFHASLFNLHIYKLLISHPPLYIKLLPMAVGIVGIVTGIYLYKSSTVMSFPQKRESSKNIKNAWILR
SSRGMTPLVLISNILRNKYYFDEIYNCLIVKPINCLASLFYLGDQQIIDRFGPNGFSRVVNCFSVLTGKIQTGYVFNYAL
YIVSFIVVTISYFVWKNIMY

Sequences:

>Translated_660_residues
MGIMMYQNICIMIIMLPLASSIINGLFVRVIDKKLAQVIATGFLSLSALFSLIIFCDAGLDGNIIHIKLLPWIEVGNFKV
NWSIYIDQLTSIMFIAVTWVSSIVHIYSLGYMAKDKGIIRFLSFLSLFTFFMLILVSSDNFLQLFFGWEGVGVCSYLLIG
FWYSKESANKAAIKAFIINRASDFAFILGVMTIIVYCGSANYKDVLSSAELLSNIKIFVHFSILDIICLLLFIGCMGKSA
QIGLHVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYLFEYSPLILQFITIIGGVTCLFAASIAIMHSDIKKIIAYS
TCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKMGDLRNKMPVTYGNFLIGSLALIGIYPL
AGFYSKDSILEAAYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLEKDVFEHAHEPAKVMNNPLILLVAGSFFSGM
IGYYLLAMDKPNGYFHASLFNLHIYKLLISHPPLYIKLLPMAVGIVGIVTGIYLYKSSTVMSFPQKRESSKNIKNAWILR
SSRGMTPLVLISNILRNKYYFDEIYNCLIVKPINCLASLFYLGDQQIIDRFGPNGFSRVVNCFSVLTGKIQTGYVFNYAL
YIVSFIVVTISYFVWKNIMY
>Mature_659_residues
GIMMYQNICIMIIMLPLASSIINGLFVRVIDKKLAQVIATGFLSLSALFSLIIFCDAGLDGNIIHIKLLPWIEVGNFKVN
WSIYIDQLTSIMFIAVTWVSSIVHIYSLGYMAKDKGIIRFLSFLSLFTFFMLILVSSDNFLQLFFGWEGVGVCSYLLIGF
WYSKESANKAAIKAFIINRASDFAFILGVMTIIVYCGSANYKDVLSSAELLSNIKIFVHFSILDIICLLLFIGCMGKSAQ
IGLHVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYLFEYSPLILQFITIIGGVTCLFAASIAIMHSDIKKIIAYST
CSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGSVIHAVHEQDIFKMGDLRNKMPVTYGNFLIGSLALIGIYPLA
GFYSKDSILEAAYSSGSFMFIFGIAAAILTAIYSMKIIMLVFHGKTKLEKDVFEHAHEPAKVMNNPLILLVAGSFFSGMI
GYYLLAMDKPNGYFHASLFNLHIYKLLISHPPLYIKLLPMAVGIVGIVTGIYLYKSSTVMSFPQKRESSKNIKNAWILRS
SRGMTPLVLISNILRNKYYFDEIYNCLIVKPINCLASLFYLGDQQIIDRFGPNGFSRVVNCFSVLTGKIQTGYVFNYALY
IVSFIVVTISYFVWKNIMY

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=526, Percent_Identity=39.5437262357414, Blast_Score=304, Evalue=2e-82,
Organism=Escherichia coli, GI1788614, Length=634, Percent_Identity=36.1198738170347, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1788829, Length=423, Percent_Identity=28.3687943262411, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1788827, Length=411, Percent_Identity=27.4939172749392, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=28.6931818181818, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788613, Length=403, Percent_Identity=24.317617866005, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI2367154, Length=220, Percent_Identity=25.4545454545455, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73557; Mature: 73426

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMMYQNICIMIIMLPLASSIINGLFVRVIDKKLAQVIATGFLSLSALFSLIIFCDAGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGNIIHIKLLPWIEVGNFKVNWSIYIDQLTSIMFIAVTWVSSIVHIYSLGYMAKDKGIIR
CCCEEEEEEECEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
FLSFLSLFTFFMLILVSSDNFLQLFFGWEGVGVCSYLLIGFWYSKESANKAAIKAFIINR
HHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
ASDFAFILGVMTIIVYCGSANYKDVLSSAELLSNIKIFVHFSILDIICLLLFIGCMGKSA
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHCCCCCC
QIGLHVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYLFEYSPLILQFITIIGGVTC
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LFAASIAIMHSDIKKIIAYSTCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCH
VIHAVHEQDIFKMGDLRNKMPVTYGNFLIGSLALIGIYPLAGFYSKDSILEAAYSSGSFM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEE
FIFGIAAAILTAIYSMKIIMLVFHGKTKLEKDVFEHAHEPAKVMNNPLILLVAGSFFSGM
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHH
IGYYLLAMDKPNGYFHASLFNLHIYKLLISHPPLYIKLLPMAVGIVGIVTGIYLYKSSTV
HHHEEEEEECCCCEEEHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCH
MSFPQKRESSKNIKNAWILRSSRGMTPLVLISNILRNKYYFDEIYNCLIVKPINCLASLF
HCCCHHHCCCCCCCHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHEECHHHHHHHHH
YLGDQQIIDRFGPNGFSRVVNCFSVLTGKIQTGYVFNYALYIVSFIVVTISYFVWKNIMY
HCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIMMYQNICIMIIMLPLASSIINGLFVRVIDKKLAQVIATGFLSLSALFSLIIFCDAGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGNIIHIKLLPWIEVGNFKVNWSIYIDQLTSIMFIAVTWVSSIVHIYSLGYMAKDKGIIR
CCCEEEEEEECEEEECCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHH
FLSFLSLFTFFMLILVSSDNFLQLFFGWEGVGVCSYLLIGFWYSKESANKAAIKAFIINR
HHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
ASDFAFILGVMTIIVYCGSANYKDVLSSAELLSNIKIFVHFSILDIICLLLFIGCMGKSA
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHHCCCCCC
QIGLHVWLPDAMEGPTPVSALIHAATMVTAGVFLVARCSYLFEYSPLILQFITIIGGVTC
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LFAASIAIMHSDIKKIIAYSTCSQLGYMFMACGVSAYNSGIFHLVTHAFFKALLFLSAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHCCH
VIHAVHEQDIFKMGDLRNKMPVTYGNFLIGSLALIGIYPLAGFYSKDSILEAAYSSGSFM
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEE
FIFGIAAAILTAIYSMKIIMLVFHGKTKLEKDVFEHAHEPAKVMNNPLILLVAGSFFSGM
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCHHHHCCCEEEEEECHHHHHH
IGYYLLAMDKPNGYFHASLFNLHIYKLLISHPPLYIKLLPMAVGIVGIVTGIYLYKSSTV
HHHEEEEEECCCCEEEHHHHHHHHHHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHCCCCH
MSFPQKRESSKNIKNAWILRSSRGMTPLVLISNILRNKYYFDEIYNCLIVKPINCLASLF
HCCCHHHCCCCCCCHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHEECHHHHHHHHH
YLGDQQIIDRFGPNGFSRVVNCFSVLTGKIQTGYVFNYALYIVSFIVVTISYFVWKNIMY
HCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]