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The map label for this gene is murC [H]

Identifier: 229586496

GI number: 229586496

Start: 334159

End: 335616

Strand: Direct

Name: murC [H]

Synonym: RAF_ORF0308

Alternate gene names: 229586496

Gene position: 334159-335616 (Clockwise)

Preceding gene: 229586495

Following gene: 229586497

Centisome position: 26.14

GC content: 34.16

Gene sequence:

>1458_bases
ATGCTGTTACTTGAATTAAAAAAAACTAATCAAACCTTAGAAACTATACATTTTATAGGTATCGGCGGCGTTGGCATGAG
CGGTATTGCCGAGATATTATATAATCTAGGTTATAAAGTACAAGGTTCCGATTTAGTAGAAAATTATAATACTAAAAGGC
TTGAGTCATACGGTATTAAAATATTTTTAGGACACGCCGAGCAGAACATTACCAATGTGTCGTATGTTGTTATTTCATCG
GCAATTAATCCAAAGAATCCTGAAATAAAAGAAGCTTTGGAGCGTAAAATTCCAATTATTAGACGTGCGGACATGCTTGC
TGAACTTATGAGATTAAAATGTTCAGTAGCAGTTTCGGGATCGCACGGTAAAACCACTACTACTTCTTTAGTTGCTTGTT
TATTTGAGGCAGCTGGTTTATGTCCTACGGTTATTAACGGTGGGATCATCAATAATAAATCGACTAATGCATATCTTGGT
TCAAGTAATTATTTAATTGCGGAGGCCGATGAATCGGATGCAACGTTTATTCATATTCCATCAACTATTGCGATAATAAC
TAACATTGATCCTGAACATTTAGATTATTATAGAGATTTTGAAACATTAATTGGTGCTTTTAGAAGCTTTATTACTAATT
TGCCGTTTTACGGTTTTGCCGTTTGTTGTATCGATCATAAAATAGTTCGTAAGTTAGTAGACGATATTACTGAAAGGAAG
ATTGTTACTTATGGCATCGATTCGGAAGATGCTCATATTATAGCGTTTAATATTAACACTGATATTGCCTCCTCTACTTT
TGACGTAAAAATTAGTCTACCAAATGTACTAGGTACAACGATTATTGAAAAAATTACTATTCCAACGCCCGGAAGACATA
ATATTTTAAATAGTCTTGCTGCAATTGCCGTTGGGATAGAATTAGATTTCGGTATTAAAGCTATTAAAAACGGTTTTAAT
AATTTTAAAGGAGTGAAGAGGAGATTTACTAAAGTAGCTGAATATAATAACGCTTCAATTATCGATGATTACGCTCATCA
CCCTGAGGAAATCAAAGCAACGCTTGCGACGGCTAAAAATATAGCAAATAAACAAAACGGTAAAGTTATTGCTATTTTTC
AGCCTCACAGATATTCAAGAATGCAGTATTTATTTGATGATTTTATGTTTTGCTTTGCTGATGCCGATATACTCTATATT
ACTGATATATATGCTGCAGGTGAAAACCCTATAGAGGGAATTACAGGACGAAATTTAGTTGATAAGATTACTAAGCGTAA
ACATCACGATAAAGCAAATTTTCTAGCAGAGCTAGATGATGCGGTTGGAGTTATTATAGATAATGCAGCTTCTGGTGATA
TGATAATTATGATGGGAGCAGGTAATATTTCAAGTTTTGCTAATGAATTAGAGGGGAGATTGTCATCCCGTGGCTTTAGT
TGTCATACCGTGGTTTGA

Upstream 100 bases:

>100_bases
AACTGGATACCGCGATCAAGTCGCGATATGACACAGTTAGTGCTTGACAATGTTACTTAAAACCTATATGCAGAACTCAA
TTTTAAATGATTAAACTTAA

Downstream 100 bases:

>100_bases
CTGGTATTGTTGCATAGCTCTTATGTCATTCCCGCGAAAGCGGGAATGACATCTGTTCGTATAACATAGGGTCAAGCGAA
CTAAGGGACAAAAGAGTGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLLLELKKTNQTLETIHFIGIGGVGMSGIAEILYNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAEQNITNVSYVVISS
AINPKNPEIKEALERKIPIIRRADMLAELMRLKCSVAVSGSHGKTTTTSLVACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYRDFETLIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNASIIDDYAHHPEEIKATLATAKNIANKQNGKVIAIFQPHRYSRMQYLFDDFMFCFADADILYI
TDIYAAGENPIEGITGRNLVDKITKRKHHDKANFLAELDDAVGVIIDNAASGDMIIMMGAGNISSFANELEGRLSSRGFS
CHTVV

Sequences:

>Translated_485_residues
MLLLELKKTNQTLETIHFIGIGGVGMSGIAEILYNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAEQNITNVSYVVISS
AINPKNPEIKEALERKIPIIRRADMLAELMRLKCSVAVSGSHGKTTTTSLVACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYRDFETLIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNASIIDDYAHHPEEIKATLATAKNIANKQNGKVIAIFQPHRYSRMQYLFDDFMFCFADADILYI
TDIYAAGENPIEGITGRNLVDKITKRKHHDKANFLAELDDAVGVIIDNAASGDMIIMMGAGNISSFANELEGRLSSRGFS
CHTVV
>Mature_485_residues
MLLLELKKTNQTLETIHFIGIGGVGMSGIAEILYNLGYKVQGSDLVENYNTKRLESYGIKIFLGHAEQNITNVSYVVISS
AINPKNPEIKEALERKIPIIRRADMLAELMRLKCSVAVSGSHGKTTTTSLVACLFEAAGLCPTVINGGIINNKSTNAYLG
SSNYLIAEADESDATFIHIPSTIAIITNIDPEHLDYYRDFETLIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERK
IVTYGIDSEDAHIIAFNINTDIASSTFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFN
NFKGVKRRFTKVAEYNNASIIDDYAHHPEEIKATLATAKNIANKQNGKVIAIFQPHRYSRMQYLFDDFMFCFADADILYI
TDIYAAGENPIEGITGRNLVDKITKRKHHDKANFLAELDDAVGVIIDNAASGDMIIMMGAGNISSFANELEGRLSSRGFS
CHTVV

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=41.2017167381974, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1790680, Length=479, Percent_Identity=25.8872651356994, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53372; Mature: 53372

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLELKKTNQTLETIHFIGIGGVGMSGIAEILYNLGYKVQGSDLVENYNTKRLESYGIK
CEEEEEECCCCHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHCCCCHHHHHCCEE
IFLGHAEQNITNVSYVVISSAINPKNPEIKEALERKIPIIRRADMLAELMRLKCSVAVSG
EEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEC
SHGKTTTTSLVACLFEAAGLCPTVINGGIINNKSTNAYLGSSNYLIAEADESDATFIHIP
CCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCEEECCCCEEEEECCCCCCEEEECC
STIAIITNIDPEHLDYYRDFETLIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCE
IVTYGIDSEDAHIIAFNINTDIASSTFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLA
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCCHHHHHHHHH
AIAVGIELDFGIKAIKNGFNNFKGVKRRFTKVAEYNNASIIDDYAHHPEEIKATLATAKN
HHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHCCHHHHHHHHHHHHH
IANKQNGKVIAIFQPHRYSRMQYLFDDFMFCFADADILYITDIYAAGENPIEGITGRNLV
HCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHH
DKITKRKHHDKANFLAELDDAVGVIIDNAASGDMIIMMGAGNISSFANELEGRLSSRGFS
HHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCE
CHTVV
EEECC
>Mature Secondary Structure
MLLLELKKTNQTLETIHFIGIGGVGMSGIAEILYNLGYKVQGSDLVENYNTKRLESYGIK
CEEEEEECCCCHHHEEEEEEECCCCHHHHHHHHHHCCCEECCCHHHHCCCCHHHHHCCEE
IFLGHAEQNITNVSYVVISSAINPKNPEIKEALERKIPIIRRADMLAELMRLKCSVAVSG
EEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEC
SHGKTTTTSLVACLFEAAGLCPTVINGGIINNKSTNAYLGSSNYLIAEADESDATFIHIP
CCCCHHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCEEECCCCEEEEECCCCCCEEEECC
STIAIITNIDPEHLDYYRDFETLIGAFRSFITNLPFYGFAVCCIDHKIVRKLVDDITERK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCE
IVTYGIDSEDAHIIAFNINTDIASSTFDVKISLPNVLGTTIIEKITIPTPGRHNILNSLA
EEEEECCCCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCCHHHHHHHHH
AIAVGIELDFGIKAIKNGFNNFKGVKRRFTKVAEYNNASIIDDYAHHPEEIKATLATAKN
HHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHCCHHHHHHHHHHHHH
IANKQNGKVIAIFQPHRYSRMQYLFDDFMFCFADADILYITDIYAAGENPIEGITGRNLV
HCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHH
DKITKRKHHDKANFLAELDDAVGVIIDNAASGDMIIMMGAGNISSFANELEGRLSSRGFS
HHHHHHHCCCHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCE
CHTVV
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA