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The map label for this gene is tlc1 [H]

Identifier: 229586293

GI number: 229586293

Start: 73752

End: 75257

Strand: Direct

Name: tlc1 [H]

Synonym: RAF_ORF0076

Alternate gene names: 229586293

Gene position: 73752-75257 (Clockwise)

Preceding gene: 229586291

Following gene: 229586294

Centisome position: 5.77

GC content: 31.54

Gene sequence:

>1506_bases
ATGAATACTCCCAAAAATGACAATTATCTCTCGGAACTAAGCAAGGTAATTTGGCCTATAGAAAGATATGAAAATAAGAA
GTTTCTTCCTATGGCGTTTATGATGTTCTGTATTTTATTAAACTACTCAACGCTTCGTTCAATTAAAGACGGGTTTGTAG
TAACGGATATAGGAGCAGAAGCAATAAGTTTCTTAAAAACATATATAGTACTACCTTCTGCTGTAATCGCTATGGTAATT
TATGTTAAGCTCTGCGATATTTTAAAGCAAGAAAACGTGTTTTATGTTATTACTTCATTTTTCTTAGGGTATTTTGCATT
ATTTGCGTTTGTTCTTTACCCTTACCCTGATTTAGTTCATCCTGATCCTGAAACCATAGAATCTTGGAGTGTAGCTTATC
CTAATTTCAAATGGTTTATAAGAATAGTTGGGAAATGGAGTTTTGCATCTTTTTATACTATGGCAGAGCTTTGGGGAACA
ATGATGCTTAGTTTATTATTTTGGCAATTTGCTAACCAAATTACTAAAACCGATGAAGCTAAACGTTTTTACTCAATGTT
TGGTTTACTTGCTAATTTAGCATTGCCTGTAACATCCGTAATTATTGGATATTGCTTGCATGAAAAAACTCAAATAGTTG
CAGAACATCTAAAATTTGTGCCTTTATTTGTTATAATGATAACAAGTAGCTTTTTGGTAATATTAACATATAGATGGATG
AATAAAAACGTTCTAACCGATCCTAGACTTTATGATCCGGCATTAGTAAAAGAAAAGAAAGCTAAAGCTAAAATGTCATT
AATAGACAGTTTTAAAATGATCTTTACTTCTAAGTATGTAGGTTATATTGCATTGTTACTTATTGCTTACGGTGTTTCAG
TAAATTTAGTTGAAGGTGTTTGGAAATCCAAAGTAAAAGAATTATATCCGACGAAAGAGGCTTACACTATATATATGGGG
AAGTTCCAATTTTATCAGGGTTGGGTTGCAATTGCTTTCATGCTTATAGGTAGTAATATTTTAAGAAAAGTATCATGGCT
AACTGCAGCTATGATAACTCCATTAATGATGTTAATTACCGGTGCAGCGTTTTTTGTATTTATCTTTTTTGATAGTGTTA
TTGCTATGCATTTAACAGGTATTCTTGCTTCAGGTCCTTTAGCACTTGCTGTTATGATCGGTATGATTCAAAATGTTTTA
AGTAAAGGTGTAAAATATTCTTTATTTGATGCCACTAAAAACATGGCGTATATTCCGCTTGATAAGGATTTACGAGTAAA
AGGGCAAGCTGCTGTTGAAGTTATTGGAGGAAGATTTGGTAAATCAGGCGGTGCTATTATTCAATCTACATTCTTTATTT
TATTTCCTGCATTTGGTTTTGTAGAGGCAACTCCTTATTTTGCTTCTATATTCTTTGTAATAGTAATATTATGGATATAT
GCCGTTAAAGGTTTAAATAAAGAGTATAAAGTTTTGGTAAATAAAACCGAAAATAGAATTTGTTAA

Upstream 100 bases:

>100_bases
AATTTTATTTAATTTCTTTTGAGAAAAATCAATAAGTTTGACTTTTCTAACATATTCTAGTATAATATTCATCTTCACAA
CAAATAGAAAAATTTAATTT

Downstream 100 bases:

>100_bases
AATTTATTTACTGCTAGACTCTTAAACTTGCTTTTTTTATACTCGGAGAGTTTATAATATGACAAATACAAGATCCAAAA
TTAAAATTCCAAGATCGCCA

Product: ATP/ADP translocase

Products: NA

Alternate protein names: ADP/ATP translocase 1 [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNTPKNDNYLSELSKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVIAMVI
YVKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPDLVHPDPETIESWSVAYPNFKWFIRIVGKWSFASFYTMAELWGT
MMLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYCLHEKTQIVAEHLKFVPLFVIMITSSFLVILTYRWM
NKNVLTDPRLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMG
KFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFVFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVL
SKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
AVKGLNKEYKVLVNKTENRIC

Sequences:

>Translated_501_residues
MNTPKNDNYLSELSKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVIAMVI
YVKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPDLVHPDPETIESWSVAYPNFKWFIRIVGKWSFASFYTMAELWGT
MMLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYCLHEKTQIVAEHLKFVPLFVIMITSSFLVILTYRWM
NKNVLTDPRLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMG
KFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFVFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVL
SKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
AVKGLNKEYKVLVNKTENRIC
>Mature_501_residues
MNTPKNDNYLSELSKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAEAISFLKTYIVLPSAVIAMVI
YVKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPDLVHPDPETIESWSVAYPNFKWFIRIVGKWSFASFYTMAELWGT
MMLSLLFWQFANQITKTDEAKRFYSMFGLLANLALPVTSVIIGYCLHEKTQIVAEHLKFVPLFVIMITSSFLVILTYRWM
NKNVLTDPRLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMG
KFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLITGAAFFVFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVL
SKGVKYSLFDATKNMAYIPLDKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
AVKGLNKEYKVLVNKTENRIC

Specific function: Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism [H]

COG id: COG3202

COG function: function code C; ATP/ADP translocase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ADP/ATP translocase tlc family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004667 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 57084; Mature: 57084

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCHHEEEECCCCCCC
>Mature Secondary Structure
MNTPKNDNYLSELSKVIWPIERYENKKFLPMAFMMFCILLNYSTLRSIKDGFVVTDIGAE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHH
AISFLKTYIVLPSAVIAMVIYVKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPDLVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PDPETIESWSVAYPNFKWFIRIVGKWSFASFYTMAELWGTMMLSLLFWQFANQITKTDEA
CCHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
KRFYSMFGLLANLALPVTSVIIGYCLHEKTQIVAEHLKFVPLFVIMITSSFLVILTYRWM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKNVLTDPRLYDPALVKEKKAKAKMSLIDSFKMIFTSKYVGYIALLLIAYGVSVNLVEGV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
WKSKVKELYPTKEAYTIYMGKFQFYQGWVAIAFMLIGSNILRKVSWLTAAMITPLMMLIT
HHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAAFFVFIFFDSVIAMHLTGILASGPLALAVMIGMIQNVLSKGVKYSLFDATKNMAYIPL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCEEECC
DKDLRVKGQAAVEVIGGRFGKSGGAIIQSTFFILFPAFGFVEATPYFASIFFVIVILWIY
CCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AVKGLNKEYKVLVNKTENRIC
HHHCCCCCHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2555259; 9823893; 1904433; 2165754; 9917392 [H]