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The map label for this gene is hisD2

Identifier: 229259632

GI number: 229259632

Start: 5446777

End: 5448087

Strand: Direct

Name: hisD2

Synonym: mlr6649

Alternate gene names: 229259632

Gene position: 5446777-5448087 (Clockwise)

Preceding gene: 13475549

Following gene: 13475551

Centisome position: 77.41

GC content: 64.07

Gene sequence:

>1311_bases
ATGATACGCACCATCAAGTCGGCTCGAGGCAGCGTTGTAAACGGCGGCAACGGTGCCATGACGAGCGCGGTCCAGACACT
CCTCGACCAAGTCGAGCAGGGGGGCGACAGGGCAGTCCGCGAACTGTCGATCCGTTTCGACAAGTTCGACCGGGACTCCT
ATCGCCTGACCAAGGCCGAGATCGACGCTTGCATCAACTCGCTGACCGGGCGTGAACGCGAAGACCTTGATTTCGCGCAG
GACCAGATCCGCAACTTCGCCGAGGCGCAGCGCGCAACACTGCTCGATCTTGAGATCGAGACGCTGCCGGGCGTCGTCCT
TGGGCACCGCAACGTGCCGATCCAGAATGTCGGCTGCTACGTGCCGGGCGGAAAGTATCCACTGCTGGCCTCGGCGCATA
TGACGGTGCTCACGGCAAGGGTTGCCGGTTGCGAGCGCATCATCACGTGCGCACCGCCCTTCCAGGGCAAGGTCGCCGAA
AAGATCGTGGCCGCCCAGGCCCTGGCCGGGGCCGACGAGATCTACTGTCTCGGCGGCGTCCAGGCGATCGCGGCCATGGC
GTACGGGACCGAAACGATCGCCCCGGTCGACATGGTGGCGGGGCCAGGCAATGCCTATGTGGCCGAAGCCAAGCGCCTTC
TGTTCGGTAAGGTCGGCATCGATCTCTTTGCCGGTCCAACCGAGACTCTGGTGATCGCCGACGACAGCGTCGATGGCGAG
CTGGTTGCGACCGACCTGCTCGGCCAGGCCGAGCATGGCGTGAACTCGCCGGCGGTGCTGATCACCAACTCCGAAAAGCT
GGCACTGGACACAGTCGCCGAAATCGGGCGCCTGCTGACGATCCTCCCAACGGCGGCCATCGCGGCAAAGGCCTGGGAGG
ATTTCGGCGAGATCATCCTGTGCGAGACGACCAAAGAGATGGTGGCCGAGGCCGATCGTCTCGCTTCCGAACATGTCCAG
GTGATGACGCGCGACCCCGACCACTTCCTCAACTCCATGAGGAACTATGGCGCGCTGTTCCTGGGGGCTCGCACGAACGT
TTCGTTCGGCGACAAGGTCATAGGCACCAACCACACGCTGCCGACCAACAAGGCCGCCCGCTATACCGGCGGGCTCTGGG
TAGGCAAGTTCCTCAAGACCTGCACCTATCAGCGCATCCTGACGGACGAGGCCTCCGCGCTCATCGGAGAGTACGGCTCG
CGTCTCTCCCTCATGGAGGGCTTCGTCGGCCACGCCGAGCAATCCAACATCCGGGTCCGCCGCTACGGGGGGCGAAACGT
CGGCTATGCCATGCCGGTCGATCCACGCTGA

Upstream 100 bases:

>100_bases
TAGCCGTACCTGGGGCGAGCAGCCCTGGCTGCTCGCGCTTCATTCCATTGATTCAGACCGCAATGCGGGGCGTAGGCCCT
GCAAACGAAGAGCCATTGCC

Downstream 100 bases:

>100_bases
CTGCCACCGCCCGATAACAGCCGAATAGGCGACCGGGCATTTCAACATCAACCAAGGGGAATGACGATGACTGAACTCAA
GAAAATTCTGTTGGCCACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIRTIKSARGSVVNGGNGAMTSAVQTLLDQVEQGGDRAVRELSIRFDKFDRDSYRLTKAEIDACINSLTGREREDLDFAQ
DQIRNFAEAQRATLLDLEIETLPGVVLGHRNVPIQNVGCYVPGGKYPLLASAHMTVLTARVAGCERIITCAPPFQGKVAE
KIVAAQALAGADEIYCLGGVQAIAAMAYGTETIAPVDMVAGPGNAYVAEAKRLLFGKVGIDLFAGPTETLVIADDSVDGE
LVATDLLGQAEHGVNSPAVLITNSEKLALDTVAEIGRLLTILPTAAIAAKAWEDFGEIILCETTKEMVAEADRLASEHVQ
VMTRDPDHFLNSMRNYGALFLGARTNVSFGDKVIGTNHTLPTNKAARYTGGLWVGKFLKTCTYQRILTDEASALIGEYGS
RLSLMEGFVGHAEQSNIRVRRYGGRNVGYAMPVDPR

Sequences:

>Translated_436_residues
MIRTIKSARGSVVNGGNGAMTSAVQTLLDQVEQGGDRAVRELSIRFDKFDRDSYRLTKAEIDACINSLTGREREDLDFAQ
DQIRNFAEAQRATLLDLEIETLPGVVLGHRNVPIQNVGCYVPGGKYPLLASAHMTVLTARVAGCERIITCAPPFQGKVAE
KIVAAQALAGADEIYCLGGVQAIAAMAYGTETIAPVDMVAGPGNAYVAEAKRLLFGKVGIDLFAGPTETLVIADDSVDGE
LVATDLLGQAEHGVNSPAVLITNSEKLALDTVAEIGRLLTILPTAAIAAKAWEDFGEIILCETTKEMVAEADRLASEHVQ
VMTRDPDHFLNSMRNYGALFLGARTNVSFGDKVIGTNHTLPTNKAARYTGGLWVGKFLKTCTYQRILTDEASALIGEYGS
RLSLMEGFVGHAEQSNIRVRRYGGRNVGYAMPVDPR
>Mature_436_residues
MIRTIKSARGSVVNGGNGAMTSAVQTLLDQVEQGGDRAVRELSIRFDKFDRDSYRLTKAEIDACINSLTGREREDLDFAQ
DQIRNFAEAQRATLLDLEIETLPGVVLGHRNVPIQNVGCYVPGGKYPLLASAHMTVLTARVAGCERIITCAPPFQGKVAE
KIVAAQALAGADEIYCLGGVQAIAAMAYGTETIAPVDMVAGPGNAYVAEAKRLLFGKVGIDLFAGPTETLVIADDSVDGE
LVATDLLGQAEHGVNSPAVLITNSEKLALDTVAEIGRLLTILPTAAIAAKAWEDFGEIILCETTKEMVAEADRLASEHVQ
VMTRDPDHFLNSMRNYGALFLGARTNVSFGDKVIGTNHTLPTNKAARYTGGLWVGKFLKTCTYQRILTDEASALIGEYGS
RLSLMEGFVGHAEQSNIRVRRYGGRNVGYAMPVDPR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=404, Percent_Identity=34.6534653465347, Blast_Score=235, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319819, Length=408, Percent_Identity=36.0294117647059, Blast_Score=217, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX2_RHILO (Q988P7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_107114.2
- ProteinModelPortal:   Q988P7
- SMR:   Q988P7
- GeneID:   1229769
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr6649
- NMPDR:   fig|266835.1.peg.5215
- HOGENOM:   HBG329596
- OMA:   FLGARTN
- ProtClustDB:   PRK12447
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46849; Mature: 46849

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 381-381 ACT_SITE 382-382 BINDING 184-184 BINDING 245-245 BINDING 268-268 BINDING 291-291 BINDING 313-313 BINDING 316-316 BINDING 382-382 BINDING 415-415 BINDING 470-470 BINDING 475-475

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTIKSARGSVVNGGNGAMTSAVQTLLDQVEQGGDRAVRELSIRFDKFDRDSYRLTKAE
CCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEHHHH
IDACINSLTGREREDLDFAQDQIRNFAEAQRATLLDLEIETLPGVVLGHRNVPIQNVGCY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEHHHCCCEEECCCCCCCCCCCEE
VPGGKYPLLASAHMTVLTARVAGCERIITCAPPFQGKVAEKIVAAQALAGADEIYCLGGV
CCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEHHH
QAIAAMAYGTETIAPVDMVAGPGNAYVAEAKRLLFGKVGIDLFAGPTETLVIADDSVDGE
HHHHHHHHCCCCCCCHHEECCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCC
LVATDLLGQAEHGVNSPAVLITNSEKLALDTVAEIGRLLTILPTAAIAAKAWEDFGEIIL
EEHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
CETTKEMVAEADRLASEHVQVMTRDPDHFLNSMRNYGALFLGARTNVSFGDKVIGTNHTL
EECHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCC
PTNKAARYTGGLWVGKFLKTCTYQRILTDEASALIGEYGSRLSLMEGFVGHAEQSNIRVR
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEE
RYGGRNVGYAMPVDPR
EECCCCCCEECCCCCC
>Mature Secondary Structure
MIRTIKSARGSVVNGGNGAMTSAVQTLLDQVEQGGDRAVRELSIRFDKFDRDSYRLTKAE
CCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEHHHH
IDACINSLTGREREDLDFAQDQIRNFAEAQRATLLDLEIETLPGVVLGHRNVPIQNVGCY
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEHHHCCCEEECCCCCCCCCCCEE
VPGGKYPLLASAHMTVLTARVAGCERIITCAPPFQGKVAEKIVAAQALAGADEIYCLGGV
CCCCCCCEEEHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEHHH
QAIAAMAYGTETIAPVDMVAGPGNAYVAEAKRLLFGKVGIDLFAGPTETLVIADDSVDGE
HHHHHHHHCCCCCCCHHEECCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCC
LVATDLLGQAEHGVNSPAVLITNSEKLALDTVAEIGRLLTILPTAAIAAKAWEDFGEIIL
EEHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
CETTKEMVAEADRLASEHVQVMTRDPDHFLNSMRNYGALFLGARTNVSFGDKVIGTNHTL
EECHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCCCC
PTNKAARYTGGLWVGKFLKTCTYQRILTDEASALIGEYGSRLSLMEGFVGHAEQSNIRVR
CCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEE
RYGGRNVGYAMPVDPR
EECCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968