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The map label for this gene is pyrG

Identifier: 229221137

GI number: 229221137

Start: 757682

End: 759286

Strand: Direct

Name: pyrG

Synonym: Bd0808

Alternate gene names: 229221137

Gene position: 757682-759286 (Clockwise)

Preceding gene: 42522383

Following gene: 42522385

Centisome position: 20.03

GC content: 51.15

Gene sequence:

>1605_bases
TTGAAGCAAAAATTTATTTTTGTCACCGGGGGCGTTGTTTCCTCGATTGGCAAAGGACTGACAGCAGCCAGCCTTGGTGC
TTTGCTGGAAGGCCGCGGTCACAAAGTGACCATCATGAAATTTGATCCTTATTTGAACGTGGATCCTGGCACAATGTCGC
CATTGCAGCACGGTGAAGTTTATGTGACTGAAGATGGGGCGGAAACCGATCTGGATCTGGGGCACTATGAGCGTTTCACA
TCCGCTTTGATGAACCGCTCAAACTCTGTTTCCACCGGTCAGATCTATGACACGGTTTTGAACCGCGAGCGTCGCGGGGA
CTACCTGGGTGGCACTGTGCAGGTCATTCCGCACATCACGGAAGAAATCAAAGCTCGTATCTATGAAGCCGCTCAGGGCA
GTGAAATCATTCTGGTTGAAATCGGCGGGACAGTCGGGGATATCGAAAGTCAGCCGTTCCTGGAAGCCATTCGTCAGATG
CGTATCGATGTGGGTCAGGAAAACTCTGTGCTGGTGCATGTGACTTATGTGCCGTACATCGCGGCGGCGGGTGAATTGAA
ATCCAAGCCGACTCAGCACTCAGTGAAAGAGCTGCGTGAAATCGGTTTGCAACCCGACTTCCTGGTCTGCCGCAGTGAAA
AAGTCATTGATGACAATCTGAAGGCCAAAATCGGTCTGTTCTGTTCCGTGAAACCGGAAAATGTTATCGCCGCTCAGGAC
AGTCGTTTTATCTATGAAGTCCCTCTGGCTTTGCACAGAGAAAAGCTGGATGAACTGATCGTGGCACGTCTGGGCCTTTC
TGCTGGCAAGTTGAACATGAAAGGCTGGCAGAATCTGGTGAAGATTCTGGGGAACCCAAGTCATACTGTGAAAATCGGCG
TGGTTGGCAAGTATGTCGATTTGAAGGAATCCTACAAATCCCTGCATGAAGCCTTGGTTCACGGTGGCGTTGCCAACAAT
GCCCGCGTGGAAATCATTTACGTGGATTCCGAAAAGGTCACCGACAAGACTGTGCACTCTTTATTGGGCAAGGTCGACGG
CATTCTGGTGCCGGGGGGCTTCGGCACCCGTGGTGTGGAAGGCAAGATCACTGCCATCAAGTATGCCCGTGAAAAGCGGG
TTCCATTCTTCGGTATCTGTTTTGGTATGCAATTGTCGGCGATTGAGTTTGCGCGCAACGTGTGTGGTATCAAAGATGCC
ACCAGCCGTGAATTCCATGCTGAAAACAAACGCACTGGCAACTTCGTGATTGATTCCATGGCCGAGCAGCGCGGAGTGAT
CAACAAGGGTGGCACCATGCGCCTGGGCGCTTTCCCATGCGCTATTGCCTCCGGCTCGCGCGCCTATCAGGTGTACAAGG
CGTCGTCCATTATGGAACGTCACCGTCACCGTTTTGAGTTCAACAACAAGTATAAAGACTTGTTTGAAAAGAACGGCATG
ATGGCTTCCGGTATCTGCAAAGAACGTGACCTGGTCGAGATTGTGGAACTTCCTGATCACCCATGGTTTGTCGGCGTGCA
GTTCCATCCGGAATTCAAATCAAAGCCCTTGGCTCCGCACCCTCTCTTCGTGCATTTTGTTAAAGCAAGCCTGAAGAAGA
AGTAA

Upstream 100 bases:

>100_bases
TGGCGCGACTCGAAAAACTCTTAAGCTCACAGGGGATGTAATGGCAAAGAGAAAGACCACCACAAAGAAGGTGTCGACAG
CGAAGTCGACCAAGAAAACG

Downstream 100 bases:

>100_bases
GAAAGGTTCGTTAGAATATGTCCAAAGTTATTCAACAGGGTCTGAAAGTTCTAGAGGTTGAGGCCCAGGCCATTCTGGCA
TTGAAAGAGCGCCTTGGGGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MKQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEVYVTEDGAETDLDLGHYERFT
SALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHITEEIKARIYEAAQGSEIILVEIGGTVGDIESQPFLEAIRQM
RIDVGQENSVLVHVTYVPYIAAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQD
SRFIYEVPLALHREKLDELIVARLGLSAGKLNMKGWQNLVKILGNPSHTVKIGVVGKYVDLKESYKSLHEALVHGGVANN
ARVEIIYVDSEKVTDKTVHSLLGKVDGILVPGGFGTRGVEGKITAIKYAREKRVPFFGICFGMQLSAIEFARNVCGIKDA
TSREFHAENKRTGNFVIDSMAEQRGVINKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGM
MASGICKERDLVEIVELPDHPWFVGVQFHPEFKSKPLAPHPLFVHFVKASLKKK

Sequences:

>Translated_534_residues
MKQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEVYVTEDGAETDLDLGHYERFT
SALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHITEEIKARIYEAAQGSEIILVEIGGTVGDIESQPFLEAIRQM
RIDVGQENSVLVHVTYVPYIAAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQD
SRFIYEVPLALHREKLDELIVARLGLSAGKLNMKGWQNLVKILGNPSHTVKIGVVGKYVDLKESYKSLHEALVHGGVANN
ARVEIIYVDSEKVTDKTVHSLLGKVDGILVPGGFGTRGVEGKITAIKYAREKRVPFFGICFGMQLSAIEFARNVCGIKDA
TSREFHAENKRTGNFVIDSMAEQRGVINKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGM
MASGICKERDLVEIVELPDHPWFVGVQFHPEFKSKPLAPHPLFVHFVKASLKKK
>Mature_534_residues
MKQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEVYVTEDGAETDLDLGHYERFT
SALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHITEEIKARIYEAAQGSEIILVEIGGTVGDIESQPFLEAIRQM
RIDVGQENSVLVHVTYVPYIAAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQD
SRFIYEVPLALHREKLDELIVARLGLSAGKLNMKGWQNLVKILGNPSHTVKIGVVGKYVDLKESYKSLHEALVHGGVANN
ARVEIIYVDSEKVTDKTVHSLLGKVDGILVPGGFGTRGVEGKITAIKYAREKRVPFFGICFGMQLSAIEFARNVCGIKDA
TSREFHAENKRTGNFVIDSMAEQRGVINKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGM
MASGICKERDLVEIVELPDHPWFVGVQFHPEFKSKPLAPHPLFVHFVKASLKKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=44.6460980036298, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=44.6460980036298, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=44.6460980036298, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI148491070, Length=554, Percent_Identity=44.5848375451264, Blast_Score=460, Evalue=1e-129,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=53.4450651769088, Blast_Score=575, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=37.6026272577997, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=42.6287744227353, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=41.4590747330961, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24664469, Length=553, Percent_Identity=45.2079566003617, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21357815, Length=499, Percent_Identity=44.2885771543086, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_BDEBA (Q6MPP0)

Other databases:

- EMBL:   BX842648
- RefSeq:   NP_967764.2
- HSSP:   P17812
- ProteinModelPortal:   Q6MPP0
- SMR:   Q6MPP0
- GeneID:   2734036
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0808
- NMPDR:   fig|264462.1.peg.734
- HOGENOM:   HBG597806
- PhylomeDB:   Q6MPP0
- ProtClustDB:   PRK05380
- BioCyc:   BBAC264462:BD0808-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59099; Mature: 59099

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 380-380 ACT_SITE 509-509 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEV
CCCEEEEEECHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCCCCCCCEE
YVTEDGAETDLDLGHYERFTSALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHH
EEIKARIYEAAQGSEIILVEIGGTVGDIESQPFLEAIRQMRIDVGQENSVLVHVTYVPYI
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHH
AAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQD
HHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCEEEECC
SRFIYEVPLALHREKLDELIVARLGLSAGKLNMKGWQNLVKILGNPSHTVKIGVVGKYVD
CCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEC
LKESYKSLHEALVHGGVANNARVEIIYVDSEKVTDKTVHSLLGKVDGILVPGGFGTRGVE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCC
GKITAIKYAREKRVPFFGICFGMQLSAIEFARNVCGIKDATSREFHAENKRTGNFVIDSM
CEEEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHH
AEQRGVINKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGM
HHHCCCCCCCCCEEECCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
MASGICKERDLVEIVELPDHPWFVGVQFHPEFKSKPLAPHPLFVHFVKASLKKK
EEECCCCCCCHHHHEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQKFIFVTGGVVSSIGKGLTAASLGALLEGRGHKVTIMKFDPYLNVDPGTMSPLQHGEV
CCCEEEEEECHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCCCCCCCEE
YVTEDGAETDLDLGHYERFTSALMNRSNSVSTGQIYDTVLNRERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHH
EEIKARIYEAAQGSEIILVEIGGTVGDIESQPFLEAIRQMRIDVGQENSVLVHVTYVPYI
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCHH
AAAGELKSKPTQHSVKELREIGLQPDFLVCRSEKVIDDNLKAKIGLFCSVKPENVIAAQD
HHCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCEEEECC
SRFIYEVPLALHREKLDELIVARLGLSAGKLNMKGWQNLVKILGNPSHTVKIGVVGKYVD
CCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEC
LKESYKSLHEALVHGGVANNARVEIIYVDSEKVTDKTVHSLLGKVDGILVPGGFGTRGVE
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCC
GKITAIKYAREKRVPFFGICFGMQLSAIEFARNVCGIKDATSREFHAENKRTGNFVIDSM
CEEEEEEEHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHH
AEQRGVINKGGTMRLGAFPCAIASGSRAYQVYKASSIMERHRHRFEFNNKYKDLFEKNGM
HHHCCCCCCCCCEEECCCCEEECCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
MASGICKERDLVEIVELPDHPWFVGVQFHPEFKSKPLAPHPLFVHFVKASLKKK
EEECCCCCCCHHHHEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA