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The map label for this gene is cks

Identifier: 42522383

GI number: 42522383

Start: 756879

End: 757622

Strand: Direct

Name: cks

Synonym: Bd0807

Alternate gene names: 42522383

Gene position: 756879-757622 (Clockwise)

Preceding gene: 42522382

Following gene: 229221137

Centisome position: 20.01

GC content: 52.15

Gene sequence:

>744_bases
ATGAAAATTGTCGGTGTGATCCCCGCTCGTTTTGGCTCTACACGCTTCCCCGGAAAACCCCTGGTGAACTTGAAAGGCCG
CCCCCTGATTCAGTGGACGGTTGAAGGAGCCAAGAAGTCGAAACTTCTGAGCGAGGTGATTGTCGCCACCGATCACGAAG
GCATCAAAGCCGCCGCCGAAGCTGTCGGTGTTAAAGTCGTCATGACGGACAGCGATCTTCCCACCGGAAGCGACCGAATC
AATGCTGCCATTAAAGATGTTGCCTGTGATGTCGTTGTCAATATCCAGGGGGATGAACCGCTGGTGACCGGCGAGTTGAT
TGACCGCCTGGCGCAGGTGTTTGTCGATGATCCGAAAATGGACATGGCCACGCTGGCTCATCCGATCAGTGCTGAAGAGC
TGCAATCCATGAACTCGGTGAAAGTTGTTGTGAACTGCCGTGACGAGGCTCTTTATTTCAGCCGCTATCCAATGCCTTAT
TCCCGTATGTCGGCACAAGAGGCCGGCAGCATGGATGGTTGTCTGAAACACATCGGCATGTATGCCTATTCCAGAAATTT
TTTAAAACAGTTCTGCGAAGCTCCTCCGGCCCTCATTGAAAAAGCCGAGAGTCTGGAGCAGCTGCGCGCTCTGTATTTAG
GTGCAAAAATCAAAGTAATCAGAGTCAAGGAAGCCAGTGTCGGGGTGGATACTCCCGAAGATCTGGCGCGACTCGAAAAA
CTCTTAAGCTCACAGGGGATGTAA

Upstream 100 bases:

>100_bases
AGAAGGCCTCGGGCCTGAGTGCCGTGTTTGGTGTGTCTGCCCTGAAAAAAGAGGGCCAGGACGCGGTTGAAGACTACATC
TATGAAAATTGGATAAAAGA

Downstream 100 bases:

>100_bases
TGGCAAAGAGAAAGACCACCACAAAGAAGGTGTCGACAGCGAAGTCGACCAAGAAAACGTTGAAGCAAAAATTTATTTTT
GTCACCGGGGGCGTTGTTTC

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAEAVGVKVVMTDSDLPTGSDRI
NAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKMDMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPY
SRMSAQEAGSMDGCLKHIGMYAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEK
LLSSQGM

Sequences:

>Translated_247_residues
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAEAVGVKVVMTDSDLPTGSDRI
NAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKMDMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPY
SRMSAQEAGSMDGCLKHIGMYAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEK
LLSSQGM
>Mature_247_residues
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAEAVGVKVVMTDSDLPTGSDRI
NAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKMDMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPY
SRMSAQEAGSMDGCLKHIGMYAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEK
LLSSQGM

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=245, Percent_Identity=42.0408163265306, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_BDEBA (Q6MPP1)

Other databases:

- EMBL:   BX842648
- RefSeq:   NP_967763.1
- HSSP:   P04951
- ProteinModelPortal:   Q6MPP1
- SMR:   Q6MPP1
- GeneID:   2734035
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0807
- NMPDR:   fig|264462.1.peg.733
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- PhylomeDB:   Q6MPP1
- ProtClustDB:   PRK05450
- BioCyc:   BBAC264462:BD0807-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 26922; Mature: 26922

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAE
CCEEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHH
AVGVKVVMTDSDLPTGSDRINAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKM
HHCEEEEEECCCCCCCCHHHHHHHHHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
DMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPYSRMSAQEAGSMDGCLKHIGM
CHHHHHCCCCHHHHHCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHH
YAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHH
LLSSQGM
HHHHCCC
>Mature Secondary Structure
MKIVGVIPARFGSTRFPGKPLVNLKGRPLIQWTVEGAKKSKLLSEVIVATDHEGIKAAAE
CCEEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHH
AVGVKVVMTDSDLPTGSDRINAAIKDVACDVVVNIQGDEPLVTGELIDRLAQVFVDDPKM
HHCEEEEEECCCCCCCCHHHHHHHHHHEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCC
DMATLAHPISAEELQSMNSVKVVVNCRDEALYFSRYPMPYSRMSAQEAGSMDGCLKHIGM
CHHHHHCCCCHHHHHCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHH
YAYSRNFLKQFCEAPPALIEKAESLEQLRALYLGAKIKVIRVKEASVGVDTPEDLARLEK
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHH
LLSSQGM
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA