| Definition | Vibrio vulnificus YJ016 chromosome I, complete sequence. |
|---|---|
| Accession | NC_005139 |
| Length | 3,354,505 |
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The map label for this gene is thrA
Identifier: 229047217
GI number: 229047217
Start: 645104
End: 647563
Strand: Direct
Name: thrA
Synonym: VV0650
Alternate gene names: 229047217
Gene position: 645104-647563 (Clockwise)
Preceding gene: 37678832
Following gene: 161486660
Centisome position: 19.23
GC content: 48.05
Gene sequence:
>2460_bases ATGCGAGTATTAAAGTTTGGTGGCTCATCGTTAGCCGATGCAGACCGCTTTTTAAGAGCGGCGGACATTGTTGCTAACAA TGCCAAGCAGGAAGAAGTTTCTGTAGTGTTGTCGGCGCCAGGGAAAACAACCAATAAATTGGTCGCGGTCATTGAGTCTG CACTGAAAAATGGCGAAGCAGAACGACAAGTCGACGAGCTAGACACTGCGTTCAAACAACTGCTGAGTGATATTAAACAG CAGCTTCCTAGCCTTAACGGTGACGCGTATTTAAAGCAAGTCGCGGATTCACTTTCGCAACTGCGTCAATTTGTTCATGG TATCGGCTTGTTGGGGATGTGTCCTGACAACGTCAATGCTCGCATCATCAGTAAAGGTGAGCGTGTTTCCATCCAGTTGA TGAAGGCGGTGTTGGAAGCAAAAGGTCATCTCGTTAATCTTATTGACCCGGTTGACTACTTGCTTGCCCATGGTGATCAC TTAGAAGGGATGGTGGATGTCGATGTATCTACGCAAAACTTCCGTTCAAATCCTCTTCCTCAGGGGCACGTTCATATCAT GCCTGGCTTTACCGCGGGCAATAAGCATGGTGAGCTGGTCACTCTAGGTCGTAATGGTTCCGATTACTCAGCAGCCGTGT TGGCTGCATGTCTGCGCGCGGATTGTTGTGAGATCTGGACGGATGTGGATGGGGTGTACAACTGTGACCCTCGTTTAGTC GAAGATGCTCGCTTATTGAAGTCATTAAGCTATCAAGAGGCCATGGAGCTTTCATACTTTGGTGCATCCGTTTTGCATCC CAAAACCATTGCGCCAATTGCTCAATTTCATATCCCATGTTTGATTAAGAACAGCTTCAATCCTCAAGGTGCTGGTACGC TGATTGGTCAAGATACAGGCGAAGATAATCTAGCGATCAAAGGCATCACTACGCTCAATAACCTGACGATGGTCAACGTG TCTGGACCGGGAATGAAAGGCATGGTTGGTATGGCGAGCCGAGTATTTGGTGCGATGTCGGCCTCTGGCGTGTCAATCGT TCTGATTACTCAGTCTTCTTCTGAGTACAGTATCAGCTTCTGTATTGAAGCTGCCGACAGACCTTTAGCCGAACAGGCAC TCTCAGATGCTTTTGAGTTAGAACTGAAAGATGGTCTATTGGAGCCCGTCGAGTTCCTGACTAATGTCTCTATCATCACG CTGGTGGGTGATGGTATGCGCACTTCCAAAGGTGTCGCATCACAATTCTTTGCTTCTCTTGCGGAAGTGAGTGTCAATGT TATCGCTATTGCTCAAGGTTCGTCAGAGCGCGCTATTTCAGCGGTGATCCCAGAGGATAAGATCTCCCAAGCGATCAAAG CGTGTCATGAAAATCTCTTCAACTCGAAACATTACCTTGATGTGTTTGTTGTTGGTGTCGGTGGTGTTGGTGGTGAGTTG GTGGATCAGATCCAGCGTCAGCAAGCCAAACTGGCAGACAAAGGCATTGTCATCCGAGTGTGTGGTTTGGCTAATAGCAA AGGGCTGTTGTTAGACAGTAACGGCTTACCACTGGAACATTGGCGTGACCGCATGGCCAATGCATCTGAAGCGTTTAGCC TTGCCAGTTTGATTGCCACTGTGCAGCGTAACCATATCATCAACCCTGTGCTCGTCGATTGTACTTCTAGCGACGTGATT GCTAACCAATACGCAGAGTTTTTAGCCGCTGGTTTCCATGTTGTGACGCCAAATAAGAAAGCAAATACCGCGAGTATGGC GTATTACCATCAGCTACGCGATGTGGCACGCAGCTCTCGTCGTAAGTTGATGTATGAAACCACGGTTGGTGCAGGCTTGC CTGTGATCGAGAACTTGCAAAATCTGATTTCTGCCGGAGATGAGTTGGAGCGATTCAGCGGCATTCTCTCTGGTTCACTT TCCTTTATCTTCGGTAAGTTGGATGAAGGCATGACGTTGAGTGAGGCGACCAATATCGCCAAACAAAATGGCTTTACAGA GCCGGATCCTCGTGATGATCTGTCCGGAATGGATGTGGCGCGTAAACTGTTGATCTTGGCGCGTGAAGCGGGCATGGCAT TAGAGCTGGAAGATGTCGAAGTGGATCAAGCCTTGCCACCAAGTTTTGATGATTCAGGCAGTGTCGATGAATTTATGGCT CGACTACCGGAAGCTGATGCGTACTTCAAGCAACTTTCTGCGCAAGCGGCCGAAGAAGGCAAAGTACTGCGTTATGTCGG TGAAATCATCGATGGTAAGTGCAAAGTCTCGATCGCTGCGGTAGATGAAAATGATCCGATGTTCAAAATTAAAGATGGTG AAAATGCGTTAGCATTTTACAGCCGTTACTATCAGCCGATCCCGTTAGTATTGAGAGGTTACGGTGCCGGTACTCAAGTG ACTGCGGCAGGCGTGTTCTCAGATGTGATGCGTACTTTAGGCTGGAAATTAGGGGTTTAA
Upstream 100 bases:
>100_bases GCAGGCTGCTGAGCGAAAGAACAAATTTCAAAAAAAGGCCTGTATCCAACAAGATACAGGCCTTTTTTTATACAGATTAA AAATAATCCGGGAGGAAGGG
Downstream 100 bases:
>100_bases TCGATGAGTTCAAGCGATATGGCTGTGGTAGTGTACGCTCCCGCTTCTATTGGTAATGTCAGTGTTGGTTTTGATGTATT AGGGGCGGCAGTGTCGCCCA
Product: bifunctional aspartokinase I/homeserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVLKFGGSSLADADRFLRAADIVANNAKQEEVSVVLSAPGKTTNKLVAVIESALKNGEAERQVDELDTAFKQLLSDIKQ QLPSLNGDAYLKQVADSLSQLRQFVHGIGLLGMCPDNVNARIISKGERVSIQLMKAVLEAKGHLVNLIDPVDYLLAHGDH LEGMVDVDVSTQNFRSNPLPQGHVHIMPGFTAGNKHGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV EDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSASGVSIVLITQSSSEYSISFCIEAADRPLAEQALSDAFELELKDGLLEPVEFLTNVSIIT LVGDGMRTSKGVASQFFASLAEVSVNVIAIAQGSSERAISAVIPEDKISQAIKACHENLFNSKHYLDVFVVGVGGVGGEL VDQIQRQQAKLADKGIVIRVCGLANSKGLLLDSNGLPLEHWRDRMANASEAFSLASLIATVQRNHIINPVLVDCTSSDVI ANQYAEFLAAGFHVVTPNKKANTASMAYYHQLRDVARSSRRKLMYETTVGAGLPVIENLQNLISAGDELERFSGILSGSL SFIFGKLDEGMTLSEATNIAKQNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPSFDDSGSVDEFMA RLPEADAYFKQLSAQAAEEGKVLRYVGEIIDGKCKVSIAAVDENDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTQV TAAGVFSDVMRTLGWKLGV
Sequences:
>Translated_819_residues MRVLKFGGSSLADADRFLRAADIVANNAKQEEVSVVLSAPGKTTNKLVAVIESALKNGEAERQVDELDTAFKQLLSDIKQ QLPSLNGDAYLKQVADSLSQLRQFVHGIGLLGMCPDNVNARIISKGERVSIQLMKAVLEAKGHLVNLIDPVDYLLAHGDH LEGMVDVDVSTQNFRSNPLPQGHVHIMPGFTAGNKHGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV EDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSASGVSIVLITQSSSEYSISFCIEAADRPLAEQALSDAFELELKDGLLEPVEFLTNVSIIT LVGDGMRTSKGVASQFFASLAEVSVNVIAIAQGSSERAISAVIPEDKISQAIKACHENLFNSKHYLDVFVVGVGGVGGEL VDQIQRQQAKLADKGIVIRVCGLANSKGLLLDSNGLPLEHWRDRMANASEAFSLASLIATVQRNHIINPVLVDCTSSDVI ANQYAEFLAAGFHVVTPNKKANTASMAYYHQLRDVARSSRRKLMYETTVGAGLPVIENLQNLISAGDELERFSGILSGSL SFIFGKLDEGMTLSEATNIAKQNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPSFDDSGSVDEFMA RLPEADAYFKQLSAQAAEEGKVLRYVGEIIDGKCKVSIAAVDENDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTQV TAAGVFSDVMRTLGWKLGV >Mature_819_residues MRVLKFGGSSLADADRFLRAADIVANNAKQEEVSVVLSAPGKTTNKLVAVIESALKNGEAERQVDELDTAFKQLLSDIKQ QLPSLNGDAYLKQVADSLSQLRQFVHGIGLLGMCPDNVNARIISKGERVSIQLMKAVLEAKGHLVNLIDPVDYLLAHGDH LEGMVDVDVSTQNFRSNPLPQGHVHIMPGFTAGNKHGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV EDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSASGVSIVLITQSSSEYSISFCIEAADRPLAEQALSDAFELELKDGLLEPVEFLTNVSIIT LVGDGMRTSKGVASQFFASLAEVSVNVIAIAQGSSERAISAVIPEDKISQAIKACHENLFNSKHYLDVFVVGVGGVGGEL VDQIQRQQAKLADKGIVIRVCGLANSKGLLLDSNGLPLEHWRDRMANASEAFSLASLIATVQRNHIINPVLVDCTSSDVI ANQYAEFLAAGFHVVTPNKKANTASMAYYHQLRDVARSSRRKLMYETTVGAGLPVIENLQNLISAGDELERFSGILSGSL SFIFGKLDEGMTLSEATNIAKQNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPSFDDSGSVDEFMA RLPEADAYFKQLSAQAAEEGKVLRYVGEIIDGKCKVSIAAVDENDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTQV TAAGVFSDVMRTLGWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=821, Percent_Identity=61.63215590743, Blast_Score=1027, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=823, Percent_Identity=31.9562575941677, Blast_Score=350, Evalue=2e-97, Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=29.7413793103448, Blast_Score=154, Evalue=3e-38, Organism=Saccharomyces cerevisiae, GI6322599, Length=339, Percent_Identity=33.9233038348083, Blast_Score=178, Evalue=3e-45, Organism=Saccharomyces cerevisiae, GI6320893, Length=513, Percent_Identity=28.0701754385965, Blast_Score=154, Evalue=8e-38,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88110; Mature: 88110
Theoretical pI: Translated: 4.82; Mature: 4.82
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGSSLADADRFLRAADIVANNAKQEEVSVVLSAPGKTTNKLVAVIESALKNGEA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCH ERQVDELDTAFKQLLSDIKQQLPSLNGDAYLKQVADSLSQLRQFVHGIGLLGMCPDNVNA HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCE RIISKGERVSIQLMKAVLEAKGHLVNLIDPVDYLLAHGDHLEGMVDVDVSTQNFRSNPLP EEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC QGHVHIMPGFTAGNKHGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH EDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHHCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCC EDNLAIKGITTLNNLTMVNVSGPGMKGMVGMASRVFGAMSASGVSIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEE CIEAADRPLAEQALSDAFELELKDGLLEPVEFLTNVSIITLVGDGMRTSKGVASQFFASL EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH AEVSVNVIAIAQGSSERAISAVIPEDKISQAIKACHENLFNSKHYLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHH VDQIQRQQAKLADKGIVIRVCGLANSKGLLLDSNGLPLEHWRDRMANASEAFSLASLIAT HHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHH VQRNHIINPVLVDCTSSDVIANQYAEFLAAGFHVVTPNKKANTASMAYYHQLRDVARSSR HHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH RKLMYETTVGAGLPVIENLQNLISAGDELERFSGILSGSLSFIFGKLDEGMTLSEATNIA HHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH KQNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPSFDDSGSVDEFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH RLPEADAYFKQLSAQAAEEGKVLRYVGEIIDGKCKVSIAAVDENDPMFKIKDGENALAFY HCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTQVTAAGVFSDVMRTLGWKLGV HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCHHCCC >Mature Secondary Structure MRVLKFGGSSLADADRFLRAADIVANNAKQEEVSVVLSAPGKTTNKLVAVIESALKNGEA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCH ERQVDELDTAFKQLLSDIKQQLPSLNGDAYLKQVADSLSQLRQFVHGIGLLGMCPDNVNA HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCE RIISKGERVSIQLMKAVLEAKGHLVNLIDPVDYLLAHGDHLEGMVDVDVSTQNFRSNPLP EEECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCC QGHVHIMPGFTAGNKHGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH EDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHHCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCC EDNLAIKGITTLNNLTMVNVSGPGMKGMVGMASRVFGAMSASGVSIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEE CIEAADRPLAEQALSDAFELELKDGLLEPVEFLTNVSIITLVGDGMRTSKGVASQFFASL EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH AEVSVNVIAIAQGSSERAISAVIPEDKISQAIKACHENLFNSKHYLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHH VDQIQRQQAKLADKGIVIRVCGLANSKGLLLDSNGLPLEHWRDRMANASEAFSLASLIAT HHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHH VQRNHIINPVLVDCTSSDVIANQYAEFLAAGFHVVTPNKKANTASMAYYHQLRDVARSSR HHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH RKLMYETTVGAGLPVIENLQNLISAGDELERFSGILSGSLSFIFGKLDEGMTLSEATNIA HHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH KQNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPSFDDSGSVDEFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH RLPEADAYFKQLSAQAAEEGKVLRYVGEIIDGKCKVSIAAVDENDPMFKIKDGENALAFY HCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTQVTAAGVFSDVMRTLGWKLGV HHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]