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The map label for this gene is ywlC [H]

Identifier: 227827742

GI number: 227827742

Start: 1378483

End: 1379559

Strand: Direct

Name: ywlC [H]

Synonym: M1425_1473

Alternate gene names: 227827742

Gene position: 1378483-1379559 (Clockwise)

Preceding gene: 227827740

Following gene: 227827743

Centisome position: 52.84

GC content: 36.49

Gene sequence:

>1077_bases
ATGACTGAAGTACTTAAGGTGGATCCATTATATCCGGAATTGGATAAAATAAAAAAGGCTGCCAGTGTAATAAAAGCAGG
TGGCACTGTAGTCTTTCCTACAGAAACTGTTTATGGATTAGGCGCAAATGCATTAGATGCAGAAGCTGTTAAAAAGATAT
TTATCGCAAAAAATAGGCCTATGGATAATCCTCTCATAGTCCATATATCAAATATAGATCAGCTTTATGAGGTAGCTAAA
GATATACCAGAAAAAATAATTAATATAGTGAAGATAGTGTGGCCGGGACCATTAACATTTGTCTTAAAGAAAACTGATAA
AGTTCCTAAAGAGACTACTGGTGGATTAGATACAATAGCAGTAAGAATGCCAGCTCATCCAGTTGCTTTAGCTTTGATAA
ATGAAAGTGACGTACCAATAGCAGCACCAAGTGCTAATTTAGCGACAAAACCTAGCCCTACTAAGGCAGAGCATGTGATT
GATGATTTATTTGGAAAAGTAGATGTAGTATTAGATTCCGGAGAAACGTTTTTTGGCGTCGAATCAACTGTTATAAACGT
TACTGTCGACCCTCCAGTACTTTTAAGGCCTGGCCCATTTAGTGTCGAAGAGCTGGAAAGGATATTTGGAAAGATCATTA
TTCCAGAGCAAGCTAAAGGCACAGGTGAATTTAGTGTTGCCTTAGCTCCAGGGATGAAATATAAGCATTATGCACCTACA
AAAAAGTTCCTAGTAGTTGAGAACAGAGGTATATTACGCGATGTTATCAAAGAATTACGAGAAAAGGGTTATAGGGTAGT
TTTTTTATGTGCACATGAGGTCTGTAAGCAATTTCAAGAAGAAAAGATTGAAATAATAGAGCTTGGAAGTGAAAATAACC
TCTATGAGATCTCTAGAAACTTGTTTGACAGCTTTAGAAAGTTGGATAAGTCCAATGCAGATATTGGAATTATTCATAGT
GTTAGTGAGAGAGGAATAGGACTGGCGATAATGAATAGGACAAGAAAGGCATCTGGCTTCTCTTCAATTTATAGTATAGA
GGATGTGTGGAAATATGTTGGTAATAAGACTCAATAA

Upstream 100 bases:

>100_bases
ATAACTTTATTCAGAGATCACCTCACAAATCATCAAATCAATTTTCCCTATCTCATCATCGACAAGTATATTTTCTTGTT
AATCTTTAAAGTTAAAAATA

Downstream 100 bases:

>100_bases
GGTTACATCTACACAAGATTTCGCAGAGGCTATTAGTAATATGTTATATGAAGATTTTTTGATAATTGCAGAAGAGCAAA
CTAAAGCAAGAGGAAGATTA

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTEVLKVDPLYPELDKIKKAASVIKAGGTVVFPTETVYGLGANALDAEAVKKIFIAKNRPMDNPLIVHISNIDQLYEVAK
DIPEKIINIVKIVWPGPLTFVLKKTDKVPKETTGGLDTIAVRMPAHPVALALINESDVPIAAPSANLATKPSPTKAEHVI
DDLFGKVDVVLDSGETFFGVESTVINVTVDPPVLLRPGPFSVEELERIFGKIIIPEQAKGTGEFSVALAPGMKYKHYAPT
KKFLVVENRGILRDVIKELREKGYRVVFLCAHEVCKQFQEEKIEIIELGSENNLYEISRNLFDSFRKLDKSNADIGIIHS
VSERGIGLAIMNRTRKASGFSSIYSIEDVWKYVGNKTQ

Sequences:

>Translated_358_residues
MTEVLKVDPLYPELDKIKKAASVIKAGGTVVFPTETVYGLGANALDAEAVKKIFIAKNRPMDNPLIVHISNIDQLYEVAK
DIPEKIINIVKIVWPGPLTFVLKKTDKVPKETTGGLDTIAVRMPAHPVALALINESDVPIAAPSANLATKPSPTKAEHVI
DDLFGKVDVVLDSGETFFGVESTVINVTVDPPVLLRPGPFSVEELERIFGKIIIPEQAKGTGEFSVALAPGMKYKHYAPT
KKFLVVENRGILRDVIKELREKGYRVVFLCAHEVCKQFQEEKIEIIELGSENNLYEISRNLFDSFRKLDKSNADIGIIHS
VSERGIGLAIMNRTRKASGFSSIYSIEDVWKYVGNKTQ
>Mature_357_residues
TEVLKVDPLYPELDKIKKAASVIKAGGTVVFPTETVYGLGANALDAEAVKKIFIAKNRPMDNPLIVHISNIDQLYEVAKD
IPEKIINIVKIVWPGPLTFVLKKTDKVPKETTGGLDTIAVRMPAHPVALALINESDVPIAAPSANLATKPSPTKAEHVID
DLFGKVDVVLDSGETFFGVESTVINVTVDPPVLLRPGPFSVEELERIFGKIIIPEQAKGTGEFSVALAPGMKYKHYAPTK
KFLVVENRGILRDVIKELREKGYRVVFLCAHEVCKQFQEEKIEIIELGSENNLYEISRNLFDSFRKLDKSNADIGIIHSV
SERGIGLAIMNRTRKASGFSSIYSIEDVWKYVGNKTQ

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=195, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI87081864, Length=203, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367210, Length=166, Percent_Identity=32.5301204819277, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537239, Length=179, Percent_Identity=27.3743016759777, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=409, Percent_Identity=38.1418092909535, Blast_Score=222, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 39522; Mature: 39391

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVLKVDPLYPELDKIKKAASVIKAGGTVVFPTETVYGLGANALDAEAVKKIFIAKNRP
CCCEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCHHHHHHHHHCCCCC
MDNPLIVHISNIDQLYEVAKDIPEKIINIVKIVWPGPLTFVLKKTDKVPKETTGGLDTIA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCEEEE
VRMPAHPVALALINESDVPIAAPSANLATKPSPTKAEHVIDDLFGKVDVVLDSGETFFGV
EECCCCCEEEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEEEEE
ESTVINVTVDPPVLLRPGPFSVEELERIFGKIIIPEQAKGTGEFSVALAPGMKYKHYAPT
EEEEEEEEECCCEEECCCCCCHHHHHHHHCEEECCCCCCCCCCEEEEECCCCCCCCCCCC
KKFLVVENRGILRDVIKELREKGYRVVFLCAHEVCKQFQEEKIEIIELGSENNLYEISRN
CEEEEEECCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
LFDSFRKLDKSNADIGIIHSVSERGIGLAIMNRTRKASGFSSIYSIEDVWKYVGNKTQ
HHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TEVLKVDPLYPELDKIKKAASVIKAGGTVVFPTETVYGLGANALDAEAVKKIFIAKNRP
CCEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCHHHHHHHHHCCCCC
MDNPLIVHISNIDQLYEVAKDIPEKIINIVKIVWPGPLTFVLKKTDKVPKETTGGLDTIA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCEEEE
VRMPAHPVALALINESDVPIAAPSANLATKPSPTKAEHVIDDLFGKVDVVLDSGETFFGV
EECCCCCEEEEEECCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEEEEE
ESTVINVTVDPPVLLRPGPFSVEELERIFGKIIIPEQAKGTGEFSVALAPGMKYKHYAPT
EEEEEEEEECCCEEECCCCCCHHHHHHHHCEEECCCCCCCCCCEEEEECCCCCCCCCCCC
KKFLVVENRGILRDVIKELREKGYRVVFLCAHEVCKQFQEEKIEIIELGSENNLYEISRN
CEEEEEECCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHH
LFDSFRKLDKSNADIGIIHSVSERGIGLAIMNRTRKASGFSSIYSIEDVWKYVGNKTQ
HHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]