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The map label for this gene is glmU [H]

Identifier: 227827668

GI number: 227827668

Start: 1319477

End: 1320700

Strand: Direct

Name: glmU [H]

Synonym: M1425_1397

Alternate gene names: 227827668

Gene position: 1319477-1320700 (Clockwise)

Preceding gene: 227827667

Following gene: 227827670

Centisome position: 50.58

GC content: 35.7

Gene sequence:

>1224_bases
TTGAAAGCAGTAGTGTTAGCAGCGGGTAAAGGAGAGAGATTAGAACCAATAACTCATACAAGACCTAAACCTTTTGTTCC
TGTTCTTGATACTCCTTTAATTTTAAGAAATATTAGAATAGTTAAGAAATATGTTAATGATGCTGTAATTGTAATAAATT
CAAATCATAAGGAATATTTTAAACTTATTGAAGGAGTTAGCCTAGTTGAGCAGACTGAAGGGAAAGGTACTGCGGCAGCT
TTACTAGCAGTGGAAAAATATCTTGAGAGGGATGACGAATTTTTAGTTATATATGGGGATCTTCTTTTTGAAGAAGAAGC
AGTAGAGAAAATAGTTAACACTAACGGAGAAGCAATTCTAGCTACAGAATCTGACGATCCTAAAAAATATGGCGTTATAG
TTAAAGATTCGGAAAATAGACTAGTGAGAATAGTTGAAAAGCCCGAAAATCCTCCTTCGAAATTAATTAATGCAGGTATC
TATAAGCTTACCTATGATATTTTCTCATATATAGACAAAATAGGTTTATCAAGCAGAGGTGAACTTGAGCTTACAGATGC
TGTAAATCTTATCGGAAATAAGGTGAAGGTAGTTACATACAATGGGATATGGTTAGATATAGGAAGGCCTTGGGATTTAA
TAGAGGCTAATAAGGTCCTTTTAGATAGGGAGAAGGATAGAAATCTAGGTGTGATAGAGGAGAATGTCAAAATTAAAGGT
AAGGCAATTATTGAAGATGATGTTGTAATAAAATCTGGTACCTATATAGAGGGTCCCGTTTATATAGGCAAAAATTCTGT
TATCGGACCCAATGCCTATATAAGGCCATATAGCGTGATAGGAAGTAACGTTAAGGTGGGTGCGTTCAATGAGATAAAGG
AAAGTGTGATAATGGAAAATACAAAGATACCGCATTTAAGTTATGTCGGCGATAGTATAATCTGTGAAGATGTGAATTTT
GGGGCAGGAACGATAACAGCTAATCTACGATTTGATGAAAAGGAAGTTAAAGTCAATATAAAAAATGAAAGGGTAGGCAG
TGGAAGAAAGAAATTAGGTGCAATAGTAGGCGCTCATGTAAGAACTGGGATTAACGTATCCATATTGCCTGGAGTAAAGA
TTGGTGCATATGCTTGGATTTATCCAGGTGCTATCGTAGATAGGGATGTTGAGAAAGGCGAGAAATTCGTTCCATACTAC
TTAAGAAGGTCTAGCGGTACTTGA

Upstream 100 bases:

>100_bases
AATGAAATATTTGAGGCAACAAAGAAGATATACCCACTAAGGAAGGCTGAAATAGAAAAAACTAAAGTGCTAAAAGTGCC
AGAAAATTTAGGTAAACAAG

Downstream 100 bases:

>100_bases
CACAATCTTTATTACATCATTGTTCTGTAGTTGATAATTCTCTCCAACTCTCATTTTCCTCTTCACATCAATAGCGTATA
AGAAACCTTTTGCTAATTCC

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLDTPLILRNIRIVKKYVNDAVIVINSNHKEYFKLIEGVSLVEQTEGKGTAAA
LLAVEKYLERDDEFLVIYGDLLFEEEAVEKIVNTNGEAILATESDDPKKYGVIVKDSENRLVRIVEKPENPPSKLINAGI
YKLTYDIFSYIDKIGLSSRGELELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDREKDRNLGVIEENVKIKG
KAIIEDDVVIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENTKIPHLSYVGDSIICEDVNF
GAGTITANLRFDEKEVKVNIKNERVGSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAIVDRDVEKGEKFVPYY
LRRSSGT

Sequences:

>Translated_407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLDTPLILRNIRIVKKYVNDAVIVINSNHKEYFKLIEGVSLVEQTEGKGTAAA
LLAVEKYLERDDEFLVIYGDLLFEEEAVEKIVNTNGEAILATESDDPKKYGVIVKDSENRLVRIVEKPENPPSKLINAGI
YKLTYDIFSYIDKIGLSSRGELELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDREKDRNLGVIEENVKIKG
KAIIEDDVVIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENTKIPHLSYVGDSIICEDVNF
GAGTITANLRFDEKEVKVNIKNERVGSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAIVDRDVEKGEKFVPYY
LRRSSGT
>Mature_407_residues
MKAVVLAAGKGERLEPITHTRPKPFVPVLDTPLILRNIRIVKKYVNDAVIVINSNHKEYFKLIEGVSLVEQTEGKGTAAA
LLAVEKYLERDDEFLVIYGDLLFEEEAVEKIVNTNGEAILATESDDPKKYGVIVKDSENRLVRIVEKPENPPSKLINAGI
YKLTYDIFSYIDKIGLSSRGELELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDREKDRNLGVIEENVKIKG
KAIIEDDVVIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMENTKIPHLSYVGDSIICEDVNF
GAGTITANLRFDEKEVKVNIKNERVGSGRKKLGAIVGAHVRTGINVSILPGVKIGAYAWIYPGAIVDRDVEKGEKFVPYY
LRRSSGT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=329, Percent_Identity=26.4437689969605, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI11761621, Length=354, Percent_Identity=25.9887005649718, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790224, Length=248, Percent_Identity=27.4193548387097, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790168, Length=460, Percent_Identity=25.8695652173913, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788351, Length=248, Percent_Identity=27.0161290322581, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=337, Percent_Identity=29.3768545994065, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17509979, Length=340, Percent_Identity=25.2941176470588, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17509981, Length=329, Percent_Identity=24.0121580547112, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=330, Percent_Identity=30, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355443, Length=329, Percent_Identity=25.2279635258359, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644084, Length=329, Percent_Identity=25.2279635258359, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 45069; Mature: 45069

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVLAAGKGERLEPITHTRPKPFVPVLDTPLILRNIRIVKKYVNDAVIVINSNHKEYF
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHH
KLIEGVSLVEQTEGKGTAAALLAVEKYLERDDEFLVIYGDLLFEEEAVEKIVNTNGEAIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEE
ATESDDPKKYGVIVKDSENRLVRIVEKPENPPSKLINAGIYKLTYDIFSYIDKIGLSSRG
EECCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
ELELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDREKDRNLGVIEENVKIKG
CEEEHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCEEECCEEEEE
KAIIEDDVVIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMEN
EEEEECCEEEECCCEEECCEEECCCCEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHCC
TKIPHLSYVGDSIICEDVNFGAGTITANLRFDEKEVKVNIKNERVGSGRKKLGAIVGAHV
CCCCEEEECCCEEEEECCCCCCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHH
RTGINVSILPGVKIGAYAWIYPGAIVDRDVEKGEKFVPYYLRRSSGT
HCCCCEEEECCCEECEEEEECCCHHCCCCHHCCCCCCCEEEECCCCC
>Mature Secondary Structure
MKAVVLAAGKGERLEPITHTRPKPFVPVLDTPLILRNIRIVKKYVNDAVIVINSNHKEYF
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHH
KLIEGVSLVEQTEGKGTAAALLAVEKYLERDDEFLVIYGDLLFEEEAVEKIVNTNGEAIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEE
ATESDDPKKYGVIVKDSENRLVRIVEKPENPPSKLINAGIYKLTYDIFSYIDKIGLSSRG
EECCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
ELELTDAVNLIGNKVKVVTYNGIWLDIGRPWDLIEANKVLLDREKDRNLGVIEENVKIKG
CEEEHHHHHHCCCEEEEEEECCEEEECCCCCCCCCCCEEEEECCCCCCCCEEECCEEEEE
KAIIEDDVVIKSGTYIEGPVYIGKNSVIGPNAYIRPYSVIGSNVKVGAFNEIKESVIMEN
EEEEECCEEEECCCEEECCEEECCCCEECCCCCCCCHHHCCCCEEECCHHHHHHHHHHCC
TKIPHLSYVGDSIICEDVNFGAGTITANLRFDEKEVKVNIKNERVGSGRKKLGAIVGAHV
CCCCEEEECCCEEEEECCCCCCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHH
RTGINVSILPGVKIGAYAWIYPGAIVDRDVEKGEKFVPYYLRRSSGT
HCCCCEEEECCCEECEEEEECCCHHCCCCHHCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]