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The map label for this gene is gcvPB

Identifier: 227827577

GI number: 227827577

Start: 1240468

End: 1241997

Strand: Direct

Name: gcvPB

Synonym: M1425_1304

Alternate gene names: 227827577

Gene position: 1240468-1241997 (Clockwise)

Preceding gene: 227827576

Following gene: 227827580

Centisome position: 47.55

GC content: 37.39

Gene sequence:

>1530_bases
ATGGTGTGGAGACAAGCTAAATGGGACGAGCCTTTAATATTTGAGCTAAACAATAGTGGTGCAAATAGACAAGGTCTCTT
GATAAATAAGGATGATGAGATAAGAAGCGAGATAAAGGAAATGAAAATACCTAAAAATCTACTGAGGGAGAATGGACCGA
ATCTGCCTAGTTTAAGCGAGCTAGAGGTAGTAAGGCACTTCATTAGATTATCTCAGATGAATTTTGGCGTAGATGTTGGA
ATTATGCCATTAGGTTCATGTACAATGAAATATAATCCAAAAATTGAGGAAAAAGCAACGGCGATTACGGAATCACATCA
CCCTTTAGAAGATGAGGATCATGTTCAAGGAATACTAGAGATGATTTACGAACTTCAGAATTGGTTTAGTGAAATAACTG
GTATGGATGAATGTAGCTTACAAGTACCTGCTGGATCTGCTGGTGAGTTCGCTGGAGTACTAATGATTAAAAAGTATCAT
GAGGATCACAATCGAAATTATAAAGATACAATGCTAGTTGCAGATACTGCTCACGGAACTAATCCCGCAAGTGCTGCAAT
GGCTGGATACAAGGTTATGTATGTGAAATCAAATGGAGAAGGGCTTGTGGATATGGATATCTTAAGAGAGATCGTAAATG
ATAAAACTGCAGGTTTTATGCTAACCAATCCAAATACGTTGGGATTATTTGAAGAGAATATCTTGGAAATCTCTAAGATA
ATACATTCTGCAAATGCAATACTATACTATGATGGAGCTAATTTAAATGGAGTATTAGGTATTGCGAGACCAGGGGATAT
GGGATTTGATATTGTGCATTTAAATCTACATAAGACATTCGCTGTTCCACATGGAGGAGGTGGACCTGGAGCTGGAGCAA
TTTGTGCAAAGGGTGAACTTGTTAATTACCTCCCATATCCAATGGTAGAGAAAGTAAATGGAAAGTATAGATTAAGTAAG
ATTCCGAAGAATAGTGTTGGTAAGATAGCTACATTTTACGGTAATGTGGGTAATTTAGCGCGTAGTTTCGCATACCTATT
AGGATTAGGACCCCAAGGTGTTCAAATGGTAGGCAAAATGAGCACTTTGGCAACCAATTATCTCATAGCTAAGTTAAGAG
ACATTAAAGAGCTGGAGCTAATTGCACCAAATAGACATAGAAAGCATGAGGTAGTATTCAGCGTGAAACAGTTAATGGAA
AATTATGGAGTAAGCGCTAACGATGTTGCAAAAGCCTTACTTGATAGCGGATTTTACGCTCCAACTATATACTTCCCACC
GATTATTGAAGAAGCGTTAATGATAGAACCCACGGAAACAGAGAGTAAAGAAACTTTAGATATGTTTGCTGAAGCTCTCA
AAAAGATCGTAGAGGATGCTAAAAGAAACCCAGAACAACTTCTAAAAAGTCCTAGTAATACAAGTATTGCAAGATTAGAT
CAAGCTTATGCTAATCACCCTTCTACTATAACGCCAACGTATAGAGTGTTAAAGCTGAGGAGGATGGGTAAAATAAATTA
CCTTAAATAA

Upstream 100 bases:

>100_bases
GGACTAAAATTGTCCGATTATACATCTCTCTTTTGCGTAACGGAAGTTCATGATAAGAAGTCAATAGATCTATTAGTATC
AACGATACAAGAGATGATAA

Downstream 100 bases:

>100_bases
TAGATGAGAAAAGTATGGATATGTATCCAAGATAAGGTATTGAAAATGTAAAATTACCAAACTCTATTATCTTCCCTACC
ACTAAATTTTTCGGTATACC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MVWRQAKWDEPLIFELNNSGANRQGLLINKDDEIRSEIKEMKIPKNLLRENGPNLPSLSELEVVRHFIRLSQMNFGVDVG
IMPLGSCTMKYNPKIEEKATAITESHHPLEDEDHVQGILEMIYELQNWFSEITGMDECSLQVPAGSAGEFAGVLMIKKYH
EDHNRNYKDTMLVADTAHGTNPASAAMAGYKVMYVKSNGEGLVDMDILREIVNDKTAGFMLTNPNTLGLFEENILEISKI
IHSANAILYYDGANLNGVLGIARPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGELVNYLPYPMVEKVNGKYRLSK
IPKNSVGKIATFYGNVGNLARSFAYLLGLGPQGVQMVGKMSTLATNYLIAKLRDIKELELIAPNRHRKHEVVFSVKQLME
NYGVSANDVAKALLDSGFYAPTIYFPPIIEEALMIEPTETESKETLDMFAEALKKIVEDAKRNPEQLLKSPSNTSIARLD
QAYANHPSTITPTYRVLKLRRMGKINYLK

Sequences:

>Translated_509_residues
MVWRQAKWDEPLIFELNNSGANRQGLLINKDDEIRSEIKEMKIPKNLLRENGPNLPSLSELEVVRHFIRLSQMNFGVDVG
IMPLGSCTMKYNPKIEEKATAITESHHPLEDEDHVQGILEMIYELQNWFSEITGMDECSLQVPAGSAGEFAGVLMIKKYH
EDHNRNYKDTMLVADTAHGTNPASAAMAGYKVMYVKSNGEGLVDMDILREIVNDKTAGFMLTNPNTLGLFEENILEISKI
IHSANAILYYDGANLNGVLGIARPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGELVNYLPYPMVEKVNGKYRLSK
IPKNSVGKIATFYGNVGNLARSFAYLLGLGPQGVQMVGKMSTLATNYLIAKLRDIKELELIAPNRHRKHEVVFSVKQLME
NYGVSANDVAKALLDSGFYAPTIYFPPIIEEALMIEPTETESKETLDMFAEALKKIVEDAKRNPEQLLKSPSNTSIARLD
QAYANHPSTITPTYRVLKLRRMGKINYLK
>Mature_509_residues
MVWRQAKWDEPLIFELNNSGANRQGLLINKDDEIRSEIKEMKIPKNLLRENGPNLPSLSELEVVRHFIRLSQMNFGVDVG
IMPLGSCTMKYNPKIEEKATAITESHHPLEDEDHVQGILEMIYELQNWFSEITGMDECSLQVPAGSAGEFAGVLMIKKYH
EDHNRNYKDTMLVADTAHGTNPASAAMAGYKVMYVKSNGEGLVDMDILREIVNDKTAGFMLTNPNTLGLFEENILEISKI
IHSANAILYYDGANLNGVLGIARPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGELVNYLPYPMVEKVNGKYRLSK
IPKNSVGKIATFYGNVGNLARSFAYLLGLGPQGVQMVGKMSTLATNYLIAKLRDIKELELIAPNRHRKHEVVFSVKQLME
NYGVSANDVAKALLDSGFYAPTIYFPPIIEEALMIEPTETESKETLDMFAEALKKIVEDAKRNPEQLLKSPSNTSIARLD
QAYANHPSTITPTYRVLKLRRMGKINYLK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=429, Percent_Identity=35.1981351981352, Blast_Score=231, Evalue=2e-60,
Organism=Escherichia coli, GI1789269, Length=403, Percent_Identity=37.2208436724566, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17535605, Length=410, Percent_Identity=36.5853658536585, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI32564013, Length=360, Percent_Identity=36.9444444444444, Blast_Score=212, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=410, Percent_Identity=38.5365853658537, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24645648, Length=409, Percent_Identity=38.1418092909535, Blast_Score=251, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_SULIA (C3N5G2)

Other databases:

- EMBL:   CP001401
- RefSeq:   YP_002843282.1
- GeneID:   7812565
- GenomeReviews:   CP001401_GR
- KEGG:   sim:M1627_1354
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 56585; Mature: 56585

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWRQAKWDEPLIFELNNSGANRQGLLINKDDEIRSEIKEMKIPKNLLRENGPNLPSLSE
CCCCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHCCCCCCCCHHH
LEVVRHFIRLSQMNFGVDVGIMPLGSCTMKYNPKIEEKATAITESHHPLEDEDHVQGILE
HHHHHHHHHHHHCCCCCEECEEECCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHH
MIYELQNWFSEITGMDECSLQVPAGSAGEFAGVLMIKKYHEDHNRNYKDTMLVADTAHGT
HHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
NPASAAMAGYKVMYVKSNGEGLVDMDILREIVNDKTAGFMLTNPNTLGLFEENILEISKI
CHHHHHHCCEEEEEEECCCCCEEEHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
IHSANAILYYDGANLNGVLGIARPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEL
HHCCCEEEEECCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCH
VNYLPYPMVEKVNGKYRLSKIPKNSVGKIATFYGNVGNLARSFAYLLGLGPQGVQMVGKM
HCCCCCCHHHHCCCCEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHH
STLATNYLIAKLRDIKELELIAPNRHRKHEVVFSVKQLMENYGVSANDVAKALLDSGFYA
HHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
PTIYFPPIIEEALMIEPTETESKETLDMFAEALKKIVEDAKRNPEQLLKSPSNTSIARLD
CEEECCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
QAYANHPSTITPTYRVLKLRRMGKINYLK
HHHHCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVWRQAKWDEPLIFELNNSGANRQGLLINKDDEIRSEIKEMKIPKNLLRENGPNLPSLSE
CCCCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCHHHHHCCCCCCCCHHH
LEVVRHFIRLSQMNFGVDVGIMPLGSCTMKYNPKIEEKATAITESHHPLEDEDHVQGILE
HHHHHHHHHHHHCCCCCEECEEECCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHH
MIYELQNWFSEITGMDECSLQVPAGSAGEFAGVLMIKKYHEDHNRNYKDTMLVADTAHGT
HHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
NPASAAMAGYKVMYVKSNGEGLVDMDILREIVNDKTAGFMLTNPNTLGLFEENILEISKI
CHHHHHHCCEEEEEEECCCCCEEEHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
IHSANAILYYDGANLNGVLGIARPGDMGFDIVHLNLHKTFAVPHGGGGPGAGAICAKGEL
HHCCCEEEEECCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCCCCCCCCEEECCCH
VNYLPYPMVEKVNGKYRLSKIPKNSVGKIATFYGNVGNLARSFAYLLGLGPQGVQMVGKM
HCCCCCCHHHHCCCCEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHH
STLATNYLIAKLRDIKELELIAPNRHRKHEVVFSVKQLMENYGVSANDVAKALLDSGFYA
HHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
PTIYFPPIIEEALMIEPTETESKETLDMFAEALKKIVEDAKRNPEQLLKSPSNTSIARLD
CEEECCHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
QAYANHPSTITPTYRVLKLRRMGKINYLK
HHHHCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA