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The map label for this gene is gcvPA [H]

Identifier: 227827576

GI number: 227827576

Start: 1239120

End: 1240487

Strand: Direct

Name: gcvPA [H]

Synonym: M1425_1303

Alternate gene names: 227827576

Gene position: 1239120-1240487 (Clockwise)

Preceding gene: 227827564

Following gene: 227827577

Centisome position: 47.5

GC content: 35.96

Gene sequence:

>1368_bases
ATGTATAAGCATCCTTGGCTTCCAAACCTAGACCTAATAGATGAGATGCTGAAAGAGATAGGGGTAAACTCCCTTGACGA
GTTGTTTAATGATATACCGGCTGAAATCAAAATAAATAGATTATTGAACGTAGCAAAAGGCAAACCACTATCAGAATATG
AAATTGAAAAAGAAATCAATGAAAAAGTGAAGAAAAACGTAGAGCTACAAGCGCCACCTTTTATTGGAGCTGGTATTTGT
CCCCATTACATCCCTAATGTAGTGAAATTTATCATAGGTAGATCAGAGTTTTATACATCATATACTCCGTATCAACCAGA
AATTTCTCAAGGCCTATTACAAGCATTGTTTGAATATCAAAGTTTAATGGCTGAGCTACTAGACATGGATGTAGTTAACG
CTTCGATGTATGATTGGGGTTCAGCTTTAGCTGAGGCCGTACTGATGGCTAATAGAATAAATGGGAAAAAGACTGTATTG
GTTCCTGAAAATGCTAACCCATTTCATAAAGAAGTAGTAAGAACATGGATTGGAGGAAAGGGGATAAAAATAGAGGAAGT
TAAATATGATAAGAATTCTGGCGAACTTGATTTAGAGGATCTGGAGAAGAAATCTAATATCGATGACATATCTGCAATAT
ATATACAACAACCAAATTTCTTTGGGATCTTTGAAAGTAATATTGAACATGTAATTGATGTTGCCAAACATAAAAGAGCA
TTAAGTATTGTGGGAGTTAACCCACTTTCACTTGGTCTAATAAAGCCACCTGGAAGCTACGAAGCTGATATAGTTGTGGG
TGATGGTCAAGAATTAGGGCTTCCATTGAATTTTGGAGGACCTTTAATGGGAGTATTTGCAGTAAGATGGGATATGAGTT
TGGTAAGACAAATGCCAGGTAGAATAGTGGGAATTACAAAAGACACAAATGGCAAAATGGGATTTACGCTAATTCTTCAA
ACTAGGGAACAATTCATCAAGAGGGAAAAGGCAACATCTAACATAACTACAAACGAAGCCTTACTTGCTATAGCTAATGC
CGTCTATTTAAGCTTGTTAGGAAAAGAGGGAATGAGAGAGCTTGCAGAGGAGATTTACTTCAGAAGCCACTACGCTGCTA
AAAAGTTGACTGAAATAGATAACGTAAGCATGCCATTTAGGTCGGACTTTTTTGAGGAATTTGCAATTAGATTTCCTATA
GAATATGATAAAATAAGTAACAAACTAAAAGAAAGAAAACTACAAGGGGGACTAAAATTGTCCGATTATACATCTCTCTT
TTGCGTAACGGAAGTTCATGATAAGAAGTCAATAGATCTATTAGTATCAACGATACAAGAGATGATAAATGGTGTGGAGA
CAAGCTAA

Upstream 100 bases:

>100_bases
GCCAGCGAATTCTCCAAAATTAGCTCCCAACTTTTCCTCAAGGTCATGGAAAGGTGAAACAAACATATATTAAAAATGTC
TTAAAGTTGTATTAAGGCTT

Downstream 100 bases:

>100_bases
ATGGGACGAGCCTTTAATATTTGAGCTAAACAATAGTGGTGCAAATAGACAAGGTCTCTTGATAAATAAGGATGATGAGA
TAAGAAGCGAGATAAAGGAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEINEKVKKNVELQAPPFIGAGIC
PHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQSLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVVRTWIGGKGIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRA
LSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPGRIVGITKDTNGKMGFTLILQ
TREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRELAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPI
EYDKISNKLKERKLQGGLKLSDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS

Sequences:

>Translated_455_residues
MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEINEKVKKNVELQAPPFIGAGIC
PHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQSLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVVRTWIGGKGIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRA
LSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPGRIVGITKDTNGKMGFTLILQ
TREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRELAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPI
EYDKISNKLKERKLQGGLKLSDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS
>Mature_455_residues
MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEINEKVKKNVELQAPPFIGAGIC
PHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQSLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVVRTWIGGKGIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRA
LSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPGRIVGITKDTNGKMGFTLILQ
TREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRELAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPI
EYDKISNKLKERKLQGGLKLSDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=445, Percent_Identity=33.9325842696629, Blast_Score=218, Evalue=9e-57,
Organism=Escherichia coli, GI1789269, Length=364, Percent_Identity=32.4175824175824, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17535605, Length=389, Percent_Identity=34.9614395886889, Blast_Score=197, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=404, Percent_Identity=33.9108910891089, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24645648, Length=353, Percent_Identity=37.6770538243626, Blast_Score=228, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 51277; Mature: 51277

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEIN
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHH
EKVKKNVELQAPPFIGAGICPHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHH
SLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVVRTWIGGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
GIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRA
CCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHCE
LSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPG
EEEEECCCCEEEEECCCCCCCEEEEEECCCHHCEEECCCCHHHHHHHHHHHHHHHHHCCC
RIVGITKDTNGKMGFTLILQTREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRE
EEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPIEYDKISNKLKERKLQGGLKL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEE
SDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYKHPWLPNLDLIDEMLKEIGVNSLDELFNDIPAEIKINRLLNVAKGKPLSEYEIEKEIN
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHH
EKVKKNVELQAPPFIGAGICPHYIPNVVKFIIGRSEFYTSYTPYQPEISQGLLQALFEYQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHH
SLMAELLDMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVVRTWIGGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
GIKIEEVKYDKNSGELDLEDLEKKSNIDDISAIYIQQPNFFGIFESNIEHVIDVAKHKRA
CCEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHHHHHHCE
LSIVGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGVFAVRWDMSLVRQMPG
EEEEECCCCEEEEECCCCCCCEEEEEECCCHHCEEECCCCHHHHHHHHHHHHHHHHHCCC
RIVGITKDTNGKMGFTLILQTREQFIKREKATSNITTNEALLAIANAVYLSLLGKEGMRE
EEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEEIYFRSHYAAKKLTEIDNVSMPFRSDFFEEFAIRFPIEYDKISNKLKERKLQGGLKL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEE
SDYTSLFCVTEVHDKKSIDLLVSTIQEMINGVETS
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA