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The map label for this gene is frdB [H]

Identifier: 227826566

GI number: 227826566

Start: 136931

End: 137881

Strand: Direct

Name: frdB [H]

Synonym: M1425_0156

Alternate gene names: 227826566

Gene position: 136931-137881 (Clockwise)

Preceding gene: 227826565

Following gene: 227826567

Centisome position: 5.25

GC content: 36.91

Gene sequence:

>951_bases
ATGACTCAGTCTCAAGAGGAAGAAGTTATATTAAAGGTAAAGAGATTCAATCCCGAAAGAGGATTCTGGTGGGCAGAATA
TAAGCTGAAGGTTGATAGGTTTACACAATTTACGGAGGCCCTTAGGAGAATAAAGAGTGAACAAGATCCTACACTATCGT
ACAGAGCATCTTGTCATATGGCAGTATGTGGAAGTTGTGGAATGAAAATTAATGGTGAACCTAGACTGGCCTGTAAAACG
CTAGTTTTAGATGTCGCCAAAAAATATAACAGCCATGTGATAACAATTGAGCCAATGGATTATTTTAAATCAATCAAAGA
CTTAATAGTGGACTGGGATGAGTTTTACGAAAGGATGTTCAAGGTAAAACCAAGATTATATCAGGCTAAAGAGGTATTAG
AGGGTAAAGCTGAACATAGACTTAAACCCGAAGATCAGAAAGAGTTATGGAAATTCGCTCAATGCATATGGTGTGGATTA
TGTGTATCAGCTTGTCCAGCGGTTATAATAGATCAGCAATTTTTAGGACCAGCTGCTCATGCTAAAGGTTATAGGTTTTT
AGCTGATCCAAGGGATACAATAACCGAAGAGAGAATGAAAATATTAATTGATAGTTCATGGCGTTGTACTTATTGCTATC
AATGCTTTAATGTGTGTCCAAGAGATATAGAGCCAGTGACTGCAATAAAGAAAACTAGAAGCTTTACTAGAATGTACAAG
GCCAAATCAGAAGTAGCAGAAAGAGGCGAAAATCATGTTGAGGCTATTCGTGAATCTATATTTAAAACTGGAAAGCTCTC
TGAAGCACCAGTATATTTAAAGACCTACGGAGTGTTGCAATCCCTTATTGATCTAGTGTATATGTCGAGGGCAGGAAAGC
TTAAGTACATATTAGTTCAAGAGAAACCCGTACAAAATATAAACGAAATTAAAAAGATAATAGGTGAGTGA

Upstream 100 bases:

>100_bases
TTGAAACACACGATTGCGTATTTAAGGGGTAATACGGTTGAAGTCACATTTAAACCAGTTAAAATAACCAGATGGAAGCC
AGAACCTAGGGTGTATTAAA

Downstream 100 bases:

>100_bases
TAAGAATGAAAATAGCTTACTATCCTGGATGTGCAACTCATGGTTTATCTAAGGATGTAGATATAGCAACAAAAAAGGTA
GCAGAAGTACTTGGAGTTGA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTQSQEEEVILKVKRFNPERGFWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHMAVCGSCGMKINGEPRLACKT
LVLDVAKKYNSHVITIEPMDYFKSIKDLIVDWDEFYERMFKVKPRLYQAKEVLEGKAEHRLKPEDQKELWKFAQCIWCGL
CVSACPAVIIDQQFLGPAAHAKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTRMYK
AKSEVAERGENHVEAIRESIFKTGKLSEAPVYLKTYGVLQSLIDLVYMSRAGKLKYILVQEKPVQNINEIKKIIGE

Sequences:

>Translated_316_residues
MTQSQEEEVILKVKRFNPERGFWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHMAVCGSCGMKINGEPRLACKT
LVLDVAKKYNSHVITIEPMDYFKSIKDLIVDWDEFYERMFKVKPRLYQAKEVLEGKAEHRLKPEDQKELWKFAQCIWCGL
CVSACPAVIIDQQFLGPAAHAKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTRMYK
AKSEVAERGENHVEAIRESIFKTGKLSEAPVYLKTYGVLQSLIDLVYMSRAGKLKYILVQEKPVQNINEIKKIIGE
>Mature_315_residues
TQSQEEEVILKVKRFNPERGFWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHMAVCGSCGMKINGEPRLACKTL
VLDVAKKYNSHVITIEPMDYFKSIKDLIVDWDEFYERMFKVKPRLYQAKEVLEGKAEHRLKPEDQKELWKFAQCIWCGLC
VSACPAVIIDQQFLGPAAHAKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTRMYKA
KSEVAERGENHVEAIRESIFKTGKLSEAPVYLKTYGVLQSLIDLVYMSRAGKLKYILVQEKPVQNINEIKKIIGE

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=207, Percent_Identity=35.7487922705314, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1790596, Length=227, Percent_Identity=35.2422907488987, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=35.3448275862069, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17533915, Length=239, Percent_Identity=30.1255230125523, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322987, Length=235, Percent_Identity=33.1914893617021, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17137106, Length=202, Percent_Identity=34.1584158415842, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24643156, Length=196, Percent_Identity=34.6938775510204, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 36815; Mature: 36684

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00197 2FE2S_FER_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSQEEEVILKVKRFNPERGFWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHM
CCCCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
AVCGSCGMKINGEPRLACKTLVLDVAKKYNSHVITIEPMDYFKSIKDLIVDWDEFYERMF
HHHCCCCCEECCCCHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCHHHHHHHHH
KVKPRLYQAKEVLEGKAEHRLKPEDQKELWKFAQCIWCGLCVSACPAVIIDQQFLGPAAH
HHCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEECHHHCCCHHH
AKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTRMYK
CCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AKSEVAERGENHVEAIRESIFKTGKLSEAPVYLKTYGVLQSLIDLVYMSRAGKLKYILVQ
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EKPVQNINEIKKIIGE
CCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQSQEEEVILKVKRFNPERGFWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHM
CCCCCHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCEEHHHHHHH
AVCGSCGMKINGEPRLACKTLVLDVAKKYNSHVITIEPMDYFKSIKDLIVDWDEFYERMF
HHHCCCCCEECCCCHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCHHHHHHHHH
KVKPRLYQAKEVLEGKAEHRLKPEDQKELWKFAQCIWCGLCVSACPAVIIDQQFLGPAAH
HHCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEECHHHCCCHHH
AKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTRMYK
CCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AKSEVAERGENHVEAIRESIFKTGKLSEAPVYLKTYGVLQSLIDLVYMSRAGKLKYILVQ
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EKPVQNINEIKKIIGE
CCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]