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The map label for this gene is sdhA [H]

Identifier: 227826565

GI number: 227826565

Start: 135229

End: 136929

Strand: Direct

Name: sdhA [H]

Synonym: M1425_0155

Alternate gene names: 227826565

Gene position: 135229-136929 (Clockwise)

Preceding gene: 227826564

Following gene: 227826566

Centisome position: 5.18

GC content: 39.8

Gene sequence:

>1701_bases
ATGGAAAAGATCGAATACGATGCAGTTGTAATTGGAGGAGGACTAGCTGGCTTAATGAGTGCGCACGAGATAGCCTCTGC
TGGCTTTAAAGTTGCTGTTATTTCAAAGGTGTTTCCCACAAGGTCACACTCTGCTGCTGCAGAAGGTGGAATAGCTGCCT
ACATTCCCGGCAATTCAGATCCAAATGATAACCCAGATTATATGACATATGATACAGTTAAAGGAGGAGATTATTTAGTA
GATCAAGACGCGGCAGAGTTACTTTCTAACAAATCCGGAGAAATAGTAATGCTACTGGAAAGATGGGGGGCTCTATTCAA
TAGGCAACCTGATGGCAGAGTCGCAGTTAGATATTTTGGAGGACAGACCTATCCGAGGACTAGATTTGTGGGAGATAAAA
CAGGTATGGCGCTTTTGCATACGCTTTTTGAAAGGACTTCCGGTCTAAATGTGGATTTTTACAACGAGTGGTTCTCCTTA
GACTTAGTTACTGATAATAAAAAGGTAGTTGGTATAGTAGCAATGCAAATGAAGACGCTGACTCCATTCTTCTTTAAGAC
AAAGGCTGTCGTATTGGCAACTGGAGGAATGGGGATGCTGTATAGGCATACAACCAATAGTTACATTAACACTGGTGATG
GCTTCGGAATTGCATTAAGAGCGGGAGCTGCGTTAAAAGATCCAGAATTTGTGCAATTTCATCCCACAGCATTATACCCA
TCAGACGTTCTTATTAGTGAAGCCGCTAGAGGAGAAGGTGGGATACTGAAAAATGTTAAAGGAGAAAGATTTATGACGAA
ATATGCTCCCAAAAAGCTAGATCTAGCGCCTAGGGATATAGTTTCAAGAGCAATCATCACCGAGATAAGGGAAGGAAGAG
GGTTCCCTGGTGGATATGTTGGCTTAGATTTGACTCATTTAGGTGAAGAATATATTAAAGAAAGGTTAGCTTTAGCTGTA
GAAGCTGCAAAAAGTTTTGCAAGTGTTGATGCGTTTACTGAGCCTATTCCAGTCAGGCCCGCTCAGCATTATTATATGGG
AGGAATAGATGTGGATATAGATGGGAGGAATCCGGATATTGTGGGATTATTCTCTGCAGGTGAAGCAGCTTGTGTATCAG
TACATGGGGCTAATAGATTAGGCTCAAATTCACTTCTGGACACTTTAGTATTTGGCCAAGTTACAGGTAGAACTGTTGTA
CAATTTCTTAAGTCTAATCCAGGTAACCCCACATCAAATTATGAGAAAGAGGCTGAGAAAGTTGTTGATGACGCTTACAA
GTTCGTAAAGAGCGAGAGTGGTGTACATTTTGGCCAAATATTAGAAAAGCTAAGAGATACAATGTGGGATTATGTTGGAA
TATATAGAGATGAGGGTGGTCTACTAAATGCAATGTCCGAGATAAATAAATTAAGAGGTATGATTAGTAATATGTATGTT
ACAGATAAGAGTAAAGTCTATAATACAGAATTCTTTAACGCTCTTGAATTAAGGAATATGTTAGATTTAGCATTAACTAT
AACCAAGTCAGCTTTAGAGAGGAAAGAGTCAAGAGGGGCTCATTATAGGACGGATTATCCAGATAGAGATGATAATAATT
GGTTGAAACACACGATTGCGTATTTAAGGGGTAATACGGTTGAAGTCACATTTAAACCAGTTAAAATAACCAGATGGAAG
CCAGAACCTAGGGTGTATTAA

Upstream 100 bases:

>100_bases
GGAGTAGTGTTAAGCCGAAATACGTAGTAAATAGTTTATTAGACCTTTTATGAAATTGTAGAAAGAATACTTAAAAACTA
TTATGCAAATATAAACTTGT

Downstream 100 bases:

>100_bases
AATGACTCAGTCTCAAGAGGAAGAAGTTATATTAAAGGTAAAGAGATTCAATCCCGAAAGAGGATTCTGGTGGGCAGAAT
ATAAGCTGAAGGTTGATAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDNKKVVGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGGILKNVKGERFMTKYAPKKLDLAPRDIVSRAIITEIREGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFASVDAFTEPIPVRPAQHYYMGGIDVDIDGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVV
QFLKSNPGNPTSNYEKEAEKVVDDAYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLALTITKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY

Sequences:

>Translated_566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDNKKVVGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGGILKNVKGERFMTKYAPKKLDLAPRDIVSRAIITEIREGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFASVDAFTEPIPVRPAQHYYMGGIDVDIDGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVV
QFLKSNPGNPTSNYEKEAEKVVDDAYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLALTITKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY
>Mature_566_residues
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSDPNDNPDYMTYDTVKGGDYLV
DQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFGGQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSL
DLVTDNKKVVGIVAMQMKTLTPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
SDVLISEAARGEGGILKNVKGERFMTKYAPKKLDLAPRDIVSRAIITEIREGRGFPGGYVGLDLTHLGEEYIKERLALAV
EAAKSFASVDAFTEPIPVRPAQHYYMGGIDVDIDGRNPDIVGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVV
QFLKSNPGNPTSNYEKEAEKVVDDAYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
TDKSKVYNTEFFNALELRNMLDLALTITKSALERKESRGAHYRTDYPDRDDNNWLKHTIAYLRGNTVEVTFKPVKITRWK
PEPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=569, Percent_Identity=39.1915641476274, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=41.3265306122449, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=41.0810810810811, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=537, Percent_Identity=34.8230912476723, Blast_Score=257, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17505833, Length=592, Percent_Identity=39.527027027027, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17550100, Length=587, Percent_Identity=38.5008517887564, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71986328, Length=481, Percent_Identity=28.2744282744283, Blast_Score=102, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322416, Length=572, Percent_Identity=44.7552447552448, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322701, Length=572, Percent_Identity=44.2307692307692, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17137288, Length=583, Percent_Identity=39.2795883361921, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655642, Length=583, Percent_Identity=39.2795883361921, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655647, Length=583, Percent_Identity=39.2795883361921, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24663005, Length=610, Percent_Identity=37.2131147540984, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62590; Mature: 62590

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSD
CCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCCEEEEECCCCC
PNDNPDYMTYDTVKGGDYLVDQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSLDLVTDNKKVVGIVAMQMKTL
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCEEEEEEEEHHHHC
TPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
CCHHEECEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCCEEEECCCEECC
SDVLISEAARGEGGILKNVKGERFMTKYAPKKLDLAPRDIVSRAIITEIREGRGFPGGYV
CHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
GLDLTHLGEEYIKERLALAVEAAKSFASVDAFTEPIPVRPAQHYYMGGIDVDIDGRNPDI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEECCCCCCE
VGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVVQFLKSNPGNPTSNYEKEAEK
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHH
VVDDAYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCEE
TDKSKVYNTEFFNALELRNMLDLALTITKSALERKESRGAHYRTDYPDRDDNNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YLRGNTVEVTFKPVKITRWKPEPRVY
HHCCCEEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MEKIEYDAVVIGGGLAGLMSAHEIASAGFKVAVISKVFPTRSHSAAAEGGIAAYIPGNSD
CCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCCEEEEECCCCC
PNDNPDYMTYDTVKGGDYLVDQDAAELLSNKSGEIVMLLERWGALFNRQPDGRVAVRYFG
CCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEC
GQTYPRTRFVGDKTGMALLHTLFERTSGLNVDFYNEWFSLDLVTDNKKVVGIVAMQMKTL
CCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEECCEEEEEEEECCCEEEEEEEEHHHHC
TPFFFKTKAVVLATGGMGMLYRHTTNSYINTGDGFGIALRAGAALKDPEFVQFHPTALYP
CCHHEECEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCCCCEEEECCCEECC
SDVLISEAARGEGGILKNVKGERFMTKYAPKKLDLAPRDIVSRAIITEIREGRGFPGGYV
CHHHHHHHCCCCCCCEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
GLDLTHLGEEYIKERLALAVEAAKSFASVDAFTEPIPVRPAQHYYMGGIDVDIDGRNPDI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEECCCCCCE
VGLFSAGEAACVSVHGANRLGSNSLLDTLVFGQVTGRTVVQFLKSNPGNPTSNYEKEAEK
EEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHH
VVDDAYKFVKSESGVHFGQILEKLRDTMWDYVGIYRDEGGLLNAMSEINKLRGMISNMYV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCEE
TDKSKVYNTEFFNALELRNMLDLALTITKSALERKESRGAHYRTDYPDRDDNNWLKHTIA
ECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YLRGNTVEVTFKPVKITRWKPEPRVY
HHCCCEEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA