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The map label for this gene is thrB [H]

Identifier: 227082487

GI number: 227082487

Start: 2455890

End: 2456846

Strand: Reverse

Name: thrB [H]

Synonym: VCM66_2286

Alternate gene names: 227082487

Gene position: 2456846-2455890 (Counterclockwise)

Preceding gene: 227082488

Following gene: 227082486

Centisome position: 84.94

GC content: 52.04

Gene sequence:

>957_bases
ATGAGTGTTGTGGTGTACGCACCCGCTTCCATTGGTAATGTCAGTGTCGGGTTTGATGTGTTGGGGGCCGCAGTGTCCCC
GATTGATGGCACGTTACTCGGCGATCGAGTGAAAGTGGAAGCTGGCGCAGAGGCTTTCACACTGAAAACGGCGGGGCGAT
TTGTCGATAAGCTTCCCGCTAATCCGCAAGAAAACATTGTGTATGACTGCTGGCAAGTATTCGCGCGTGAGCTAGAGAAA
AAGTCGGTGGTACTGAAGCCGCTGACCATGACGCTAGAAAAAAATATGCCGATTGGTTCAGGATTGGGCTCCAGTGCTTG
CTCGATTGTCGCGGCTCTGGATGCGTTGAATCAGTTTCACGCCAGTCCGCTTGATGAAACTGAGCTTCTGGCTCTGATGG
GGGAAATGGAAGGCAAGATCTCTGGCAGTATTCACTATGACAACGTTGCTCCCTGCTATTTAGGTGGTGTGCAGCTCATG
CTGGAAGAGCTTGGCATCATCAGTCAATCCGTACCGAGTTTTGATGACTGGTATTGGGTGATGGCCTATCCGGGGATCAA
GGTGTCCACGGCGGAAGCGCGTGCCATTTTGCCTGCGCAGTATCGCCGCCAAGATATCGTGGCGCATGGCCGCTATCTGG
CAGGATTTATTCACGCTTGCCATACTCAGCAGCCTGAATTAGCGGCAAAAATGATCAAAGACGTGATTGCCGAACCCTAT
CGTGAGAAACTGCTGCCGGGTTTTGCTAAAGCGCGCAACTACGCCGCTTCGGCTGGCGCACTGGCAACGGGCATTTCGGG
CAGTGGTCCGACTTTGTTTAGCGTGTGCAAAGAACAAGCAGTGGCTGAACGTGTGGCACGTTGGCTTGAGCAAAACTATG
TGCAAAATGAAGAAGGATTCGTCCACATTTGTCGTCTAGACAAGCAAGGTTCGAAAGTAACAGGAAGTGAGCTATGA

Upstream 100 bases:

>100_bases
ACGGCGCGGGTTCTGAAGTGACTGCTGCAGGCGTGTTCTCAGATGTGATGCGTACACTCGGTTGGAAATTAGGGGTTTAA
TAGAAATGAGTTCAGGTGAC

Downstream 100 bases:

>100_bases
AGCTGTACAACATAAAAGAAAATGATGAACAAGTCTCCTTTGGTCAAGCCGTTCGCCAAGGGTTAGGCCGCAATCAAGGC
CTGTTTTTTCCGGCACAATT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPANPQENIVYDCWQVFARELEK
KSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLM
LEELGIISQSVPSFDDWYWVMAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPY
REKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGFVHICRLDKQGSKVTGSEL

Sequences:

>Translated_318_residues
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPANPQENIVYDCWQVFARELEK
KSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLM
LEELGIISQSVPSFDDWYWVMAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPY
REKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGFVHICRLDKQGSKVTGSEL
>Mature_317_residues
SVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPANPQENIVYDCWQVFARELEKK
SVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFHASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLML
EELGIISQSVPSFDDWYWVMAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPYR
EKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGFVHICRLDKQGSKVTGSEL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=70.7395498392283, Blast_Score=464, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34296; Mature: 34165

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPA
CEEEEECCCCCCCCEECHHHHHHHCCCCCCCEECCEEEEECCCCEEEEHHHHHHHHHCCC
NPQENIVYDCWQVFARELEKKSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFH
CCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHC
ASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLMLEELGIISQSVPSFDDWYWV
CCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
MAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPY
EECCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHH
REKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGF
HHHHCCHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VHICRLDKQGSKVTGSEL
EEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVKVEAGAEAFTLKTAGRFVDKLPA
EEEEECCCCCCCCEECHHHHHHHCCCCCCCEECCEEEEECCCCEEEEHHHHHHHHHCCC
NPQENIVYDCWQVFARELEKKSVVLKPLTMTLEKNMPIGSGLGSSACSIVAALDALNQFH
CCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHC
ASPLDETELLALMGEMEGKISGSIHYDNVAPCYLGGVQLMLEELGIISQSVPSFDDWYWV
CCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
MAYPGIKVSTAEARAILPAQYRRQDIVAHGRYLAGFIHACHTQQPELAAKMIKDVIAEPY
EECCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHH
REKLLPGFAKARNYAASAGALATGISGSGPTLFSVCKEQAVAERVARWLEQNYVQNEEGF
HHHHCCHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VHICRLDKQGSKVTGSEL
EEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA