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The map label for this gene is nanK

Identifier: 227081927

GI number: 227081927

Start: 1878016

End: 1878879

Strand: Direct

Name: nanK

Synonym: VCM66_1720

Alternate gene names: 227081927

Gene position: 1878016-1878879 (Clockwise)

Preceding gene: 227081926

Following gene: 227081928

Centisome position: 64.93

GC content: 45.02

Gene sequence:

>864_bases
ATGCGCACACTAGCCATCGATATCGGCGGAACAAAAATAGCATTAGCGATTGTAGAAGAAGGTACGATCATACAGCGTTA
CCAGATAGCAACGCCTGTGGTGCAGGACGTCACCAAGTTTGTTCAAGCGATTCTCGAAAAGGTCACTGAATGGCTCCCTT
CTATCGATTATGTAGGCGTATCAACAACAGGTTATGTAACGCCAGAAGGCATCACATCGATAAATCCAGAGACTCTTAAT
TTCCCTGTACCTTTTCCATTAGCTCAAACGCTAGAACAACTCACTAATAAACCAGTCTCCATTCTTAATGATGCACAGGC
CGCGGCATGGTTTGAATTTGTGCAGTTAAAAAATCCTAGCTTAAATATGGCTTTTATTACGGTTTCAACAGGGGTTGGTG
GCGGAATCATCATTGATGGCAAGCTTCACAAAGGAAACAGCGGTTTAGCGGGACACATAGGTCACATGTCGGTGGCCATT
GAAGGTCCATTATGCGGATGTGGTCAGCGAGGTTGTGTTGAGTCCATGGCTTCAGGTAACGCGATTCAAAAAGAGAGCGA
AGCCACTTTTACCGAGACAATGAGCAATGTTGAGTTATTTAAGCAAGCAGCGTTCAACCCGAAAGCAGAAGCGATCATCA
ATCGCAGTGTGCAAGCAGTAGCCACATTATGCTGTAATCTTAAAGCATGCTTAGATCTGGATATTATTGTTTTGGGTGGT
GGAATTGGTCTCGCAGAGGGCTACCTTGAACGCCTCAACAAAGCTATTCAATCTAGGCCATCCGTATTTCACATCCCTGT
CACTCCTGCTCATGGCGATTATGATGCTTGCCTACTCGGAGCAGCATTTCAGTTTAAGGAGTAA

Upstream 100 bases:

>100_bases
AGTCTGGTGCGGTTGCCGTAACGGTTGGTTCTGCATTGACTCGATTAGAAGTGGTTACTCAATGGTTCAATAACGCAACC
CAAGCTGCGGGAGAAAGGAA

Downstream 100 bases:

>100_bases
ACGATGGCATTAAAGGCAATTTCAGCCACACGGCTTTTTGATGGAATTCAGTATTACGAGAATGCGGCAATGGTTTGGGA
AGGTTCACACATTCACTCCA

Product: N-acetylmannosamine kinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGVSTTGYVTPEGITSINPETLN
FPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPSLNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAI
EGPLCGCGQRGCVESMASGNAIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGG
GIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE

Sequences:

>Translated_287_residues
MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGVSTTGYVTPEGITSINPETLN
FPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPSLNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAI
EGPLCGCGQRGCVESMASGNAIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGG
GIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE
>Mature_287_residues
MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGVSTTGYVTPEGITSINPETLN
FPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPSLNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAI
EGPLCGCGQRGCVESMASGNAIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGG
GIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily

Homologues:

Organism=Homo sapiens, GI298566325, Length=287, Percent_Identity=31.0104529616725, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI298566315, Length=287, Percent_Identity=31.0104529616725, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4885285, Length=287, Percent_Identity=31.0104529616725, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI190014632, Length=287, Percent_Identity=31.0104529616725, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI87082230, Length=276, Percent_Identity=40.2173913043478, Blast_Score=185, Evalue=2e-48,
Organism=Escherichia coli, GI1787363, Length=262, Percent_Identity=30.5343511450382, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87081733, Length=309, Percent_Identity=25.5663430420712, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790522, Length=158, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082127, Length=238, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787878, Length=169, Percent_Identity=27.2189349112426, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NANK_VIBC3 (A5F7C0)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F7C0
- STRING:   A5F7C0
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1379
- eggNOG:   COG1940
- HOGENOM:   HBG730260
- OMA:   GVASNIP
- ProtClustDB:   PRK05082
- BioCyc:   VCHO345073:VC0395_A1379-MONOMER
- HAMAP:   MF_01234
- InterPro:   IPR000600

Pfam domain/function: PF00480 ROK

EC number: =2.7.1.60

Molecular weight: Translated: 30519; Mature: 30519

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGV
CEEEEEEECCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
STTGYVTPEGITSINPETLNFPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPS
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCC
LNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAIEGPLCGCGQRGCVESMASGN
CEEEEEEEECCCCCCEEEECEEECCCCCCEEECCEEEEEEECCCCCCCCHHHHHHHHCCC
AIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEEC
GIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCHHCCCC
>Mature Secondary Structure
MRTLAIDIGGTKIALAIVEEGTIIQRYQIATPVVQDVTKFVQAILEKVTEWLPSIDYVGV
CEEEEEEECCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
STTGYVTPEGITSINPETLNFPVPFPLAQTLEQLTNKPVSILNDAQAAAWFEFVQLKNPS
CCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCCC
LNMAFITVSTGVGGGIIIDGKLHKGNSGLAGHIGHMSVAIEGPLCGCGQRGCVESMASGN
CEEEEEEEECCCCCCEEEECEEECCCCCCEEECCEEEEEEECCCCCCCCHHHHHHHHCCC
AIQKESEATFTETMSNVELFKQAAFNPKAEAIINRSVQAVATLCCNLKACLDLDIIVLGG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEEC
GIGLAEGYLERLNKAIQSRPSVFHIPVTPAHGDYDACLLGAAFQFKE
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA