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The map label for this gene is lrp [H]

Identifier: 227081862

GI number: 227081862

Start: 1795788

End: 1796231

Strand: Direct

Name: lrp [H]

Synonym: VCM66_1653

Alternate gene names: 227081862

Gene position: 1795788-1796231 (Clockwise)

Preceding gene: 227081860

Following gene: 227081867

Centisome position: 62.08

GC content: 48.87

Gene sequence:

>444_bases
ATGGATAGGTTTGACGAAAGAATATTGCAAGAGCTGCAACTCGATGGCCGAGTTTCCAATGTGGAGTTGGCCGAGCGCGT
GGGGTTATCGCCCTCCGCCACCCTGCGTCGAGTGCAAGATTTAGAGCGTAAGAAAATTATCAAAGGCTATCGCGCGGTAT
TGGATAAAAACCAGCTTGAGGTCGGTTTTATCGCGTATGTGGCGATTGGCTTAAACAGCCATACCAAGCAATCACAGCTC
AGCTTTGAGCAGCATGTCCGCTTTGCTAAAGAAGTCGTGGAATGCCACAACATCACCGGCATGAACGAATACTTGCTGCG
CGTGGAAACCAAAGATCTGGTGGCTTATAAACGCTTCCATGCTGATGTACTCGGCGAATGTGCGGTAGTGAAATCCATTA
CTACCATGGTGGTGATGGATTCACCCAAAGATGAGCGACAGTAA

Upstream 100 bases:

>100_bases
TTCTCGATTAATGTCAGATGCAAAAATATTAATCGCTCCCTGACGCAATTTTGTGTTTATATGAGCGAACAAAACACTGA
ATGCACAACAAAAGAGAATC

Downstream 100 bases:

>100_bases
ACTCACCAACAAGCACAGCTGCAAAAAAAAAGCGCCTTCCATTTGAAAGGCGTTTTCATATCAAGCCCTGATGGGTCTCA
ACTATTCCGTCAACTCACCT

Product: transcriptional regulator, AsnC family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MDRFDERILQELQLDGRVSNVELAERVGLSPSATLRRVQDLERKKIIKGYRAVLDKNQLEVGFIAYVAIGLNSHTKQSQL
SFEQHVRFAKEVVECHNITGMNEYLLRVETKDLVAYKRFHADVLGECAVVKSITTMVVMDSPKDERQ

Sequences:

>Translated_147_residues
MDRFDERILQELQLDGRVSNVELAERVGLSPSATLRRVQDLERKKIIKGYRAVLDKNQLEVGFIAYVAIGLNSHTKQSQL
SFEQHVRFAKEVVECHNITGMNEYLLRVETKDLVAYKRFHADVLGECAVVKSITTMVVMDSPKDERQ
>Mature_147_residues
MDRFDERILQELQLDGRVSNVELAERVGLSPSATLRRVQDLERKKIIKGYRAVLDKNQLEVGFIAYVAIGLNSHTKQSQL
SFEQHVRFAKEVVECHNITGMNEYLLRVETKDLVAYKRFHADVLGECAVVKSITTMVVMDSPKDERQ

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=143, Percent_Identity=40.5594405594406, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=27.972027972028, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16864; Mature: 16864

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFDERILQELQLDGRVSNVELAERVGLSPSATLRRVQDLERKKIIKGYRAVLDKNQLE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VGFIAYVAIGLNSHTKQSQLSFEQHVRFAKEVVECHNITGMNEYLLRVETKDLVAYKRFH
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ADVLGECAVVKSITTMVVMDSPKDERQ
HHHHHHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure
MDRFDERILQELQLDGRVSNVELAERVGLSPSATLRRVQDLERKKIIKGYRAVLDKNQLE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VGFIAYVAIGLNSHTKQSQLSFEQHVRFAKEVVECHNITGMNEYLLRVETKDLVAYKRFH
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
ADVLGECAVVKSITTMVVMDSPKDERQ
HHHHHHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]