Click here to switch to the map view.

The map label for this gene is pqqL [H]

Identifier: 227081858

GI number: 227081858

Start: 1787041

End: 1789809

Strand: Direct

Name: pqqL [H]

Synonym: VCM66_1649

Alternate gene names: 227081858

Gene position: 1787041-1789809 (Clockwise)

Preceding gene: 227081855

Following gene: 227081860

Centisome position: 61.78

GC content: 48.14

Gene sequence:

>2769_bases
ATGAAAATTCGATTATTAGTCAGCATTTTATGCATACTGTTCGCCGGTTGCGCCTTACAACAAACCAACCGCGCACTCCA
ACCCGACCAACGCTGGGTCACTCAAACACTGCCCAATGGCCTTACTTACCATCTCTACCCAGACAGTGAACAAGAAGTCT
CTATTCGTTTGTACGTTCACGCAGGTTCAATGCAAGAAACCGCGCAGCAAGCGGGTTACGCTCACTTCATCGAACATATG
GCGTTTAACGGAACCCGCCATTATCAGCACAACGATGTGATTCGTATGTTTGAGCAAAGTGGTGCCCAGTTTGGTGCGGA
CTTTAACGCTTTAACCGGCTACGACCGCACGGTTTATCAGCTCGACCTACCTAATGCGCAAAATATCGATAAAGCGCTAT
TGTGGTTTGCTGATATTGCTGACGGTTTAGCGTTTGACGCTGATGAAGTCGAAAAAGAGAAAGGGGTGATTTTGGGGGAG
TTTCGCGCCTCACGCACAGAAAACATGAGCTTAGAGCAGCAGTTTTATCTGCACCAGATCCAAGGAACCTCCTACGCGGA
TCGCGATCCCCTCGGTTCACGCGAGTTGGTGCAAGCCGCCACTCCAGACAGTTTGAAAGCCTTCTACCAACAGTGGTATC
AACCTCAATTAGCGGAACTGGTCATTACTGGTAACTTTACCCTTGAACAAGGCCAACAGTGGGTTGAGAACTATTTCTCC
TCATGGAAGAAAGGCTCCACCGAAAAGCCAGCTTCGATTTATCACCAAGCCCTGAATAACCAAGACCTAGTCGCTCCGGT
GACTGCAGGTGAATCGCCTAGCCTAACCTTGATCTTCCCCCAAGGCTCAGCAGCGATTAAAGACTATGCCAGCCAGCAAG
AGTTTTGGCGCGATGATGTCGGCGAACAACTCCTGCACACACGCCTAGTAGCGGCATTCAATGATGCAGCGCAGGCCATA
ACCGGCATTTACGCAACCCATTATGAAATCGAAGGTCAACGTTACACTCTCATTAGCGTCGGGTTTGCGGCCGAACAACG
AGAGAAAGTGCAAGCCTTGTTGCTGGAAACCCTCGCTTCAATGCGTGATTACGGGGTGACCAAAAATGAGTTGGATATCA
TTTTGCGCGGTTATCGTGAGCACTTAACCTTTTTGCAAGAAGATCGCGAAGCCATTACCCCAGCGAGCCATGCCAATCAA
AAAGTCTACTCGATTGTGTTTGATACACCGATCCAAGCGACGCTCGATTACCAAGCGAGCTTGAGCGAGTTTATTGCTTC
CGCGACACCAGAAATGATCAATCGTCATATCCAACAGCAATTGAGCCAAAACCCTGTCTGGGTTGTTGGCGTTGCGGCCA
CTGAAGATGCGCAAGCGTTGAACAAAGCCTTGCCACAATGGCGTAACGACCTAGCGCAACCTGGCAATCAGCCTATCGAT
CAACAAATCGATAGCCCATTCACCCAGCAATTTACTGCGGGCGAAGTGGTGAAACAACTCGATATCAATGACGATCCACA
GGTGACTTATTGGCAGCTTGATAACGGTATTGATGTCTATTATCTGCGCAATATTGAAGCCAAAGATCGCGTCTTTGTTC
AATACGCCAGTTCGGGTGGCCAATTCGCGTTACCTGCAGACCTACTCCCTGCAGCCGAGATTGCTACTGCAGTACAGACA
CGAAGTGGCCTCGATACGTTGAACGGCTCTCAGTTTGATCGCTACCTTCGTCAGAAAGACATTGGTTTCTATAGCTATAT
TGCATCGACCAGTCATGGTTTCGAAGCCAATAGTAAAGCGCAAGAGTTACCTGAGCTGTTGGAAATACTCCATTTATTGT
CAACTCAAGTCAAAGTCAGCCCTGATCAGCTCAATTCAGTGAAAACCGAATTTACTCAAAATCGTAGTGCGTACTTTGAT
TCCCCTATTGGCGCTTTCTTCCGTACGGTGACCAACCAAAGCTTTATCGAAACAAGTCCCTACAGAATTCGTACTCCAGA
GCAGATTGCTCAAGTCACGGCACAGCAAATTGAGCAGGTTCATCAGCGTCTCTTCAGTGAAGGACGCAATAATACGCTGG
TCATCGTCGGTGATATTGAGCGGTCTCAAATAACCCCGATGTTGCGTCAGTACGTAGCAAGTATACCTTTGAGCAAGGGA
ACGCTTTCCCCTATGACCAGCCAGTTGATCAAACCGGTTGCGCCACGCTTAGAGTTAGCACTTAACAATGAAAACTCGAC
CCAGTATTCCCTGCGCCTGATATCTGAAACGCAGCCGCGTACCGCAAAAACCGTCTTTATCGATGATATGTTGCAGCGTA
TTGCGACTCAGCGTTTACTGGCTGAAGTTCGCGAGCATCAAGGTTTAGACTACACGCCACAAGTGATCCCATACGTGGTC
GATGGAGACATTCTCAATGATTGGGTATTGTCAGCTTTAGTCGACCCCAAAAGTGAACCACAAGTGGCCAAAGTGATGCA
TGAGGTCGCGCGTGAGCTGGCTCAAGGTGTCACACAGCAAGAGTTGGATGTGGTGAAACAGAAGTTCTTGATTGATATGA
AACCGCTCAACAAATCACCGGAGCAGCAAGCTTACTTCATGTTGCGTTATGCGATTCATCACTATGGCGTTGAGACCATC
TACAAGGTTGAGGAGCTGACGAAATCCATCACTCTGGATGACATCAACCAACGTGCTCAAACGTTATTTGGCAAAGATAC
TATGTCACAAGAGCTGATCATGACACCTAAGGCTAATCCTAAAGGCTAA

Upstream 100 bases:

>100_bases
GATCGCAAAATGGCTAAAAGTGCAGCAAGCCAAACAAAAGTGAAGCGACAAAACATCACAATGCGTTATAGTTTCCGTCA
AACTATAACTAGAGAATGAT

Downstream 100 bases:

>100_bases
GCGCTGAGCGCACTCATCGAATCAATAATTCGTACAACACTCATTATTCAACCTAAACCAAGCCCGCCAAGCGGGCTTTT
TTATGAGTGGCGTTTTGGAG

Product: zinc protease, insulinase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 922; Mature: 922

Protein sequence:

>922_residues
MKIRLLVSILCILFAGCALQQTNRALQPDQRWVTQTLPNGLTYHLYPDSEQEVSIRLYVHAGSMQETAQQAGYAHFIEHM
AFNGTRHYQHNDVIRMFEQSGAQFGADFNALTGYDRTVYQLDLPNAQNIDKALLWFADIADGLAFDADEVEKEKGVILGE
FRASRTENMSLEQQFYLHQIQGTSYADRDPLGSRELVQAATPDSLKAFYQQWYQPQLAELVITGNFTLEQGQQWVENYFS
SWKKGSTEKPASIYHQALNNQDLVAPVTAGESPSLTLIFPQGSAAIKDYASQQEFWRDDVGEQLLHTRLVAAFNDAAQAI
TGIYATHYEIEGQRYTLISVGFAAEQREKVQALLLETLASMRDYGVTKNELDIILRGYREHLTFLQEDREAITPASHANQ
KVYSIVFDTPIQATLDYQASLSEFIASATPEMINRHIQQQLSQNPVWVVGVAATEDAQALNKALPQWRNDLAQPGNQPID
QQIDSPFTQQFTAGEVVKQLDINDDPQVTYWQLDNGIDVYYLRNIEAKDRVFVQYASSGGQFALPADLLPAAEIATAVQT
RSGLDTLNGSQFDRYLRQKDIGFYSYIASTSHGFEANSKAQELPELLEILHLLSTQVKVSPDQLNSVKTEFTQNRSAYFD
SPIGAFFRTVTNQSFIETSPYRIRTPEQIAQVTAQQIEQVHQRLFSEGRNNTLVIVGDIERSQITPMLRQYVASIPLSKG
TLSPMTSQLIKPVAPRLELALNNENSTQYSLRLISETQPRTAKTVFIDDMLQRIATQRLLAEVREHQGLDYTPQVIPYVV
DGDILNDWVLSALVDPKSEPQVAKVMHEVARELAQGVTQQELDVVKQKFLIDMKPLNKSPEQQAYFMLRYAIHHYGVETI
YKVEELTKSITLDDINQRAQTLFGKDTMSQELIMTPKANPKG

Sequences:

>Translated_922_residues
MKIRLLVSILCILFAGCALQQTNRALQPDQRWVTQTLPNGLTYHLYPDSEQEVSIRLYVHAGSMQETAQQAGYAHFIEHM
AFNGTRHYQHNDVIRMFEQSGAQFGADFNALTGYDRTVYQLDLPNAQNIDKALLWFADIADGLAFDADEVEKEKGVILGE
FRASRTENMSLEQQFYLHQIQGTSYADRDPLGSRELVQAATPDSLKAFYQQWYQPQLAELVITGNFTLEQGQQWVENYFS
SWKKGSTEKPASIYHQALNNQDLVAPVTAGESPSLTLIFPQGSAAIKDYASQQEFWRDDVGEQLLHTRLVAAFNDAAQAI
TGIYATHYEIEGQRYTLISVGFAAEQREKVQALLLETLASMRDYGVTKNELDIILRGYREHLTFLQEDREAITPASHANQ
KVYSIVFDTPIQATLDYQASLSEFIASATPEMINRHIQQQLSQNPVWVVGVAATEDAQALNKALPQWRNDLAQPGNQPID
QQIDSPFTQQFTAGEVVKQLDINDDPQVTYWQLDNGIDVYYLRNIEAKDRVFVQYASSGGQFALPADLLPAAEIATAVQT
RSGLDTLNGSQFDRYLRQKDIGFYSYIASTSHGFEANSKAQELPELLEILHLLSTQVKVSPDQLNSVKTEFTQNRSAYFD
SPIGAFFRTVTNQSFIETSPYRIRTPEQIAQVTAQQIEQVHQRLFSEGRNNTLVIVGDIERSQITPMLRQYVASIPLSKG
TLSPMTSQLIKPVAPRLELALNNENSTQYSLRLISETQPRTAKTVFIDDMLQRIATQRLLAEVREHQGLDYTPQVIPYVV
DGDILNDWVLSALVDPKSEPQVAKVMHEVARELAQGVTQQELDVVKQKFLIDMKPLNKSPEQQAYFMLRYAIHHYGVETI
YKVEELTKSITLDDINQRAQTLFGKDTMSQELIMTPKANPKG
>Mature_922_residues
MKIRLLVSILCILFAGCALQQTNRALQPDQRWVTQTLPNGLTYHLYPDSEQEVSIRLYVHAGSMQETAQQAGYAHFIEHM
AFNGTRHYQHNDVIRMFEQSGAQFGADFNALTGYDRTVYQLDLPNAQNIDKALLWFADIADGLAFDADEVEKEKGVILGE
FRASRTENMSLEQQFYLHQIQGTSYADRDPLGSRELVQAATPDSLKAFYQQWYQPQLAELVITGNFTLEQGQQWVENYFS
SWKKGSTEKPASIYHQALNNQDLVAPVTAGESPSLTLIFPQGSAAIKDYASQQEFWRDDVGEQLLHTRLVAAFNDAAQAI
TGIYATHYEIEGQRYTLISVGFAAEQREKVQALLLETLASMRDYGVTKNELDIILRGYREHLTFLQEDREAITPASHANQ
KVYSIVFDTPIQATLDYQASLSEFIASATPEMINRHIQQQLSQNPVWVVGVAATEDAQALNKALPQWRNDLAQPGNQPID
QQIDSPFTQQFTAGEVVKQLDINDDPQVTYWQLDNGIDVYYLRNIEAKDRVFVQYASSGGQFALPADLLPAAEIATAVQT
RSGLDTLNGSQFDRYLRQKDIGFYSYIASTSHGFEANSKAQELPELLEILHLLSTQVKVSPDQLNSVKTEFTQNRSAYFD
SPIGAFFRTVTNQSFIETSPYRIRTPEQIAQVTAQQIEQVHQRLFSEGRNNTLVIVGDIERSQITPMLRQYVASIPLSKG
TLSPMTSQLIKPVAPRLELALNNENSTQYSLRLISETQPRTAKTVFIDDMLQRIATQRLLAEVREHQGLDYTPQVIPYVV
DGDILNDWVLSALVDPKSEPQVAKVMHEVARELAQGVTQQELDVVKQKFLIDMKPLNKSPEQQAYFMLRYAIHHYGVETI
YKVEELTKSITLDDINQRAQTLFGKDTMSQELIMTPKANPKG

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=196, Percent_Identity=29.5918367346939, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1787770, Length=206, Percent_Identity=38.8349514563107, Blast_Score=159, Evalue=1e-39,
Organism=Escherichia coli, GI1789946, Length=456, Percent_Identity=23.2456140350877, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71999683, Length=230, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=228, Percent_Identity=29.3859649122807, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 104139; Mature: 104139

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRLLVSILCILFAGCALQQTNRALQPDQRWVTQTLPNGLTYHLYPDSEQEVSIRLYVH
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEE
AGSMQETAQQAGYAHFIEHMAFNGTRHYQHNDVIRMFEQSGAQFGADFNALTGYDRTVYQ
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
LDLPNAQNIDKALLWFADIADGLAFDADEVEKEKGVILGEFRASRTENMSLEQQFYLHQI
EECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
QGTSYADRDPLGSRELVQAATPDSLKAFYQQWYQPQLAELVITGNFTLEQGQQWVENYFS
CCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
SWKKGSTEKPASIYHQALNNQDLVAPVTAGESPSLTLIFPQGSAAIKDYASQQEFWRDDV
HHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GEQLLHTRLVAAFNDAAQAITGIYATHYEIEGQRYTLISVGFAAEQREKVQALLLETLAS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHH
MRDYGVTKNELDIILRGYREHLTFLQEDREAITPASHANQKVYSIVFDTPIQATLDYQAS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEECCCCCCHHCHHHH
LSEFIASATPEMINRHIQQQLSQNPVWVVGVAATEDAQALNKALPQWRNDLAQPGNQPID
HHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHH
QQIDSPFTQQFTAGEVVKQLDINDDPQVTYWQLDNGIDVYYLRNIEAKDRVFVQYASSGG
HHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEEECCCC
QFALPADLLPAAEIATAVQTRSGLDTLNGSQFDRYLRQKDIGFYSYIASTSHGFEANSKA
CEECCHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHH
QELPELLEILHLLSTQVKVSPDQLNSVKTEFTQNRSAYFDSPIGAFFRTVTNQSFIETSP
HHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEECCC
YRIRTPEQIAQVTAQQIEQVHQRLFSEGRNNTLVIVGDIERSQITPMLRQYVASIPLSKG
CEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC
TLSPMTSQLIKPVAPRLELALNNENSTQYSLRLISETQPRTAKTVFIDDMLQRIATQRLL
CCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEVREHQGLDYTPQVIPYVVDGDILNDWVLSALVDPKSEPQVAKVMHEVARELAQGVTQQ
HHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHH
ELDVVKQKFLIDMKPLNKSPEQQAYFMLRYAIHHYGVETIYKVEELTKSITLDDINQRAQ
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHH
TLFGKDTMSQELIMTPKANPKG
HHHCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MKIRLLVSILCILFAGCALQQTNRALQPDQRWVTQTLPNGLTYHLYPDSEQEVSIRLYVH
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEE
AGSMQETAQQAGYAHFIEHMAFNGTRHYQHNDVIRMFEQSGAQFGADFNALTGYDRTVYQ
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
LDLPNAQNIDKALLWFADIADGLAFDADEVEKEKGVILGEFRASRTENMSLEQQFYLHQI
EECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHH
QGTSYADRDPLGSRELVQAATPDSLKAFYQQWYQPQLAELVITGNFTLEQGQQWVENYFS
CCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
SWKKGSTEKPASIYHQALNNQDLVAPVTAGESPSLTLIFPQGSAAIKDYASQQEFWRDDV
HHCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GEQLLHTRLVAAFNDAAQAITGIYATHYEIEGQRYTLISVGFAAEQREKVQALLLETLAS
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHH
MRDYGVTKNELDIILRGYREHLTFLQEDREAITPASHANQKVYSIVFDTPIQATLDYQAS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEECCCCCCHHCHHHH
LSEFIASATPEMINRHIQQQLSQNPVWVVGVAATEDAQALNKALPQWRNDLAQPGNQPID
HHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHH
QQIDSPFTQQFTAGEVVKQLDINDDPQVTYWQLDNGIDVYYLRNIEAKDRVFVQYASSGG
HHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCCEEEEEEECCCC
QFALPADLLPAAEIATAVQTRSGLDTLNGSQFDRYLRQKDIGFYSYIASTSHGFEANSKA
CEECCHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHH
QELPELLEILHLLSTQVKVSPDQLNSVKTEFTQNRSAYFDSPIGAFFRTVTNQSFIETSP
HHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEECCC
YRIRTPEQIAQVTAQQIEQVHQRLFSEGRNNTLVIVGDIERSQITPMLRQYVASIPLSKG
CEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCC
TLSPMTSQLIKPVAPRLELALNNENSTQYSLRLISETQPRTAKTVFIDDMLQRIATQRLL
CCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AEVREHQGLDYTPQVIPYVVDGDILNDWVLSALVDPKSEPQVAKVMHEVARELAQGVTQQ
HHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHH
ELDVVKQKFLIDMKPLNKSPEQQAYFMLRYAIHHYGVETIYKVEELTKSITLDDINQRAQ
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHH
TLFGKDTMSQELIMTPKANPKG
HHHCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]