Click here to switch to the map view.

The map label for this gene is pabB [H]

Identifier: 227081474

GI number: 227081474

Start: 1341283

End: 1342659

Strand: Reverse

Name: pabB [H]

Synonym: VCM66_1258

Alternate gene names: 227081474

Gene position: 1342659-1341283 (Counterclockwise)

Preceding gene: 227081482

Following gene: 227081473

Centisome position: 46.42

GC content: 48.87

Gene sequence:

>1377_bases
ATGAATAACAACCAAACTTTGTCAATTGAACACAAAAAATTAACTTATCACCCTGATATTGCTAAACAATTTTTCACATC
CATTGAGCAGCAACCTTGGGCAATGCTGCTGCGCTCTGCGTCTACCACCCATATGGATAGCCGCTTTGATATTCTGGTCG
CCAATCCTTTCGCCACTTTAGTGACTTTTGGTGATGAAACTGAAATTCACGCCCAGAACGGCGTGACATTGTCACGAGAA
GATCCTTTTGCGCTTCTTGCTGACATCCAAGAGCAGTATCTTCCTCAAGTGACTGATGAGTCGGAGTTACCTTTTGTTGG
CGGTGCTCTGGGGTATTTTTCCTATGATTTAGGACGCCGAGTCGAAGTCCTCCCTAGCTTAGCAGAACAAGATATTGCTA
TGCCCGATATGGCCGTGGGCATCTATTCTTGGGCGCTCGTGGTCGATCACCAACAGCACACCGCGCAATTGGTCGGACAA
AATGTTGAAGACGCTTGGGGTTGGTTAAACCAACAAGAGGCGATAAAGCCAAGCGAAGTAACTGACTTTGCTCTCACATC
GCCTTGGCGATCCAATATGAGCTATACCGCCTATCAAGATAAATTTGCTCGTGTACAGGACTATTTACGCTCGGGAGACT
GTTACCAGATCAACCTCGCGCAGCGTTTTCAGGCTCACTACACTGGTAGTGAATGGCAAGCGTATTTGAAGCTGGAAAAA
GGTAATCAAGCGCCCTTCTCCGCCTTTTTGCGTTTGCCACAAGGCGCAATTTTGAGTGTTTCTCCAGAACGTTTTCTGCA
AGTTTGTGATCGAGTGATTGAAACCAAACCGATCAAAGGCACACGTCCACGCCATGCCGACAAGCAACAAGATGCCCTAC
TCAAGCAAGATTTAGTCAGCGCAGAAAAAGATCAGGCCGAGAATTTAATGATTGTCGATCTGCTGCGTAATGATATTGGT
CGTGTGGCAAAGCCGGGTAGCGTGCATGTACCTAAGTTGTTTGATGTCGAAAGCTTTCCCGCCGTGCACCATCTGGTGAG
CACGATTCGCGCAACACTGGATGAGCAATACCAAGCCGCCGATCTGTTACGCGCCTGTTTTCCCGGCGGTTCGATTACGG
GAGCGCCCAAAGTGCGGGCAATGGAAATCATTGAGGAGCTCGAGCCGCATCGCCGTAGCGCTTATTGTGGCTCAATTGGC
TATCTCAGCCGTCATGGAAAAATGGATACCAGCATCACGATCCGCACTTTAGTGGCCTATCAGCAGCAGCTTTACGCTTG
GGCGGGTGGCGGCTTGGTGGCTGACAGCGAAGGCGCTGCGGAGTATCAAGAAACGCTAGATAAGTTAAGCCGAATTCTTC
CAACCCTAGAATCCTAA

Upstream 100 bases:

>100_bases
CTCACTCTTTAAGTAGCAGCTTTGTATGAGATTTTTATGATACTCTTGCTTTCCCTGCGATGCTACGCAATGAACGGTTT
CTCTGTCACAAATTACACAA

Downstream 100 bases:

>100_bases
CTCTCAGTTTGAACCACCGTCAGCACCGCCTATGCTCGCTGGCGGTTTTCTTCTCAAGCCATCCCCTTCCTACGTACAGC
GTCAAGTCGGTAGAAAGGGG

Product: para-aminobenzoate synthase, component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNNNQTLSIEHKKLTYHPDIAKQFFTSIEQQPWAMLLRSASTTHMDSRFDILVANPFATLVTFGDETEIHAQNGVTLSRE
DPFALLADIQEQYLPQVTDESELPFVGGALGYFSYDLGRRVEVLPSLAEQDIAMPDMAVGIYSWALVVDHQQHTAQLVGQ
NVEDAWGWLNQQEAIKPSEVTDFALTSPWRSNMSYTAYQDKFARVQDYLRSGDCYQINLAQRFQAHYTGSEWQAYLKLEK
GNQAPFSAFLRLPQGAILSVSPERFLQVCDRVIETKPIKGTRPRHADKQQDALLKQDLVSAEKDQAENLMIVDLLRNDIG
RVAKPGSVHVPKLFDVESFPAVHHLVSTIRATLDEQYQAADLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIG
YLSRHGKMDTSITIRTLVAYQQQLYAWAGGGLVADSEGAAEYQETLDKLSRILPTLES

Sequences:

>Translated_458_residues
MNNNQTLSIEHKKLTYHPDIAKQFFTSIEQQPWAMLLRSASTTHMDSRFDILVANPFATLVTFGDETEIHAQNGVTLSRE
DPFALLADIQEQYLPQVTDESELPFVGGALGYFSYDLGRRVEVLPSLAEQDIAMPDMAVGIYSWALVVDHQQHTAQLVGQ
NVEDAWGWLNQQEAIKPSEVTDFALTSPWRSNMSYTAYQDKFARVQDYLRSGDCYQINLAQRFQAHYTGSEWQAYLKLEK
GNQAPFSAFLRLPQGAILSVSPERFLQVCDRVIETKPIKGTRPRHADKQQDALLKQDLVSAEKDQAENLMIVDLLRNDIG
RVAKPGSVHVPKLFDVESFPAVHHLVSTIRATLDEQYQAADLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIG
YLSRHGKMDTSITIRTLVAYQQQLYAWAGGGLVADSEGAAEYQETLDKLSRILPTLES
>Mature_458_residues
MNNNQTLSIEHKKLTYHPDIAKQFFTSIEQQPWAMLLRSASTTHMDSRFDILVANPFATLVTFGDETEIHAQNGVTLSRE
DPFALLADIQEQYLPQVTDESELPFVGGALGYFSYDLGRRVEVLPSLAEQDIAMPDMAVGIYSWALVVDHQQHTAQLVGQ
NVEDAWGWLNQQEAIKPSEVTDFALTSPWRSNMSYTAYQDKFARVQDYLRSGDCYQINLAQRFQAHYTGSEWQAYLKLEK
GNQAPFSAFLRLPQGAILSVSPERFLQVCDRVIETKPIKGTRPRHADKQQDALLKQDLVSAEKDQAENLMIVDLLRNDIG
RVAKPGSVHVPKLFDVESFPAVHHLVSTIRATLDEQYQAADLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIG
YLSRHGKMDTSITIRTLVAYQQQLYAWAGGGLVADSEGAAEYQETLDKLSRILPTLES

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=454, Percent_Identity=59.4713656387665, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1787518, Length=399, Percent_Identity=33.3333333333333, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786809, Length=214, Percent_Identity=27.1028037383178, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082077, Length=199, Percent_Identity=27.1356783919598, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=442, Percent_Identity=30.7692307692308, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324361, Length=402, Percent_Identity=26.865671641791, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 51381; Mature: 51381

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNQTLSIEHKKLTYHPDIAKQFFTSIEQQPWAMLLRSASTTHMDSRFDILVANPFATL
CCCCCEEEEEECEEEECHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEE
VTFGDETEIHAQNGVTLSREDPFALLADIQEQYLPQVTDESELPFVGGALGYFSYDLGRR
EECCCCCEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCH
VEVLPSLAEQDIAMPDMAVGIYSWALVVDHQQHTAQLVGQNVEDAWGWLNQQEAIKPSEV
HHHHHHHHHHCCCCCHHHHHHHHEEEEEECHHHHHHHHCCCHHHHHCCCCHHHCCCCCCC
TDFALTSPWRSNMSYTAYQDKFARVQDYLRSGDCYQINLAQRFQAHYTGSEWQAYLKLEK
CCHHCCCCHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCCEEEEEEEEC
GNQAPFSAFLRLPQGAILSVSPERFLQVCDRVIETKPIKGTRPRHADKQQDALLKQDLVS
CCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
AEKDQAENLMIVDLLRNDIGRVAKPGSVHVPKLFDVESFPAVHHLVSTIRATLDEQYQAA
HHHHHHCCEEHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIGYLSRHGKMDTSITIRTLVAY
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHH
QQQLYAWAGGGLVADSEGAAEYQETLDKLSRILPTLES
HHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNNNQTLSIEHKKLTYHPDIAKQFFTSIEQQPWAMLLRSASTTHMDSRFDILVANPFATL
CCCCCEEEEEECEEEECHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEE
VTFGDETEIHAQNGVTLSREDPFALLADIQEQYLPQVTDESELPFVGGALGYFSYDLGRR
EECCCCCEEECCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCH
VEVLPSLAEQDIAMPDMAVGIYSWALVVDHQQHTAQLVGQNVEDAWGWLNQQEAIKPSEV
HHHHHHHHHHCCCCCHHHHHHHHEEEEEECHHHHHHHHCCCHHHHHCCCCHHHCCCCCCC
TDFALTSPWRSNMSYTAYQDKFARVQDYLRSGDCYQINLAQRFQAHYTGSEWQAYLKLEK
CCHHCCCCHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHCCCCCEEEEEEEEC
GNQAPFSAFLRLPQGAILSVSPERFLQVCDRVIETKPIKGTRPRHADKQQDALLKQDLVS
CCCCHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
AEKDQAENLMIVDLLRNDIGRVAKPGSVHVPKLFDVESFPAVHHLVSTIRATLDEQYQAA
HHHHHHCCEEHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
DLLRACFPGGSITGAPKVRAMEIIEELEPHRRSAYCGSIGYLSRHGKMDTSITIRTLVAY
HHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHH
QQQLYAWAGGGLVADSEGAAEYQETLDKLSRILPTLES
HHHHHHEECCCEEECCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6330050; 9097040; 9278503; 7896119; 2251281; 7592344 [H]