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The map label for this gene is sdaC-1 [H]

Identifier: 227081472

GI number: 227081472

Start: 1338920

End: 1340173

Strand: Reverse

Name: sdaC-1 [H]

Synonym: VCM66_1256

Alternate gene names: 227081472

Gene position: 1340173-1338920 (Counterclockwise)

Preceding gene: 227081473

Following gene: 227081471

Centisome position: 46.33

GC content: 47.05

Gene sequence:

>1254_bases
ATGAATACTACAACAGCGGCTACTTCTACAGCACGTTCTGCTAGCAAGTGGACCTACAAAGATTTCACCTGGGCTCTGTC
CCTTTTCGGTACAGCGGTTGGTGCAGGTGTCCTGTTCCTACCTATTAAAGCGGGTGCGGGTGGCTTCTGGCCATTAGTTC
TTCTCGCACTGATTGCCGCCCCAATGACTTGGTTTGCACACAAGTCTCTCGCTCGTTTCGTATTATCTGCAAAAAATCCT
GATGCAGACATCACTGACACGGTTGAAGAACATTTTGGTAAAGCTGGCGCTAACCTCATTACTTTTGCTTACTTTTTCGC
CATCTATCCTATCGTTCTGATCTACGGTGTGGGCATCACTAACACGGTGGATTCTTTCCTCGTTAACCAAATCGGCATGG
AATCGATTCCTCGCTGGTTACTATCTGGTGCACTGATCACGGCGATGACTGCTGGTGTGGTATTTGGTAAGGAGCTGATG
CTGAAAGCCACTTCTGCCATGGTTTACCCACTGGTATTCATTCTGCTGGCTCTCTCTTTCTATCTGATCCCTGATTGGAA
CACTTCCATGATGGAAGTCGCACCTGACTGGTCAGCAATGCCTGCTATCGTATGGCTTGCGATCCCAATCATCGTGTTCT
CTTTCAACCACAGCCCAATCATTTCTCAGTTCTCTAAAGAGCAACGCCAACAGTTTGGTGATAAAGCCGTACAAAAAACG
GACATGATTACTGGCGGTGCAGCGATGATGCTGATGGGCTTCGTGATGTTCTTCGTATTCTCGGTAGTTCTATCACTGTC
TCCTGCAGAGCTGGCGATGGCAAAAGAGCAAAACATCTCTGTTCTGTCTTACCTAGCTAATGAACACGCTTCACCGATCA
TCTCTTACTTAGGTCCAATCGTGGCATTTGCAGCGATCACCTCAAGCTACTTCGGTCACTTCTTAGGTGCTCATGAAGGT
CTAGTCGGTCTGGTGAAATCACGCAGCAACATGCAAGTCAGCAAGATTGAGAAAATCTCTCTGGGCTTCATCGTCATCAC
CACTTGGATTGTAGCAATTGTGAACCCAAGCATCCTAGGTATGATTGAAACCATGGGCGCACCAATGATTGCTGCTATCT
TGTTCCTGCTGCCTGTATTTGCAATGCACAAAGTGCCTGCAATGGCTAAGTTCAAGACTTCAGCACCTGTACAGATTTTT
ACAGTTATTTGTGGCTTGGCTGCGATTAGTTCTGTAATCTACGGCGCTCTTTAA

Upstream 100 bases:

>100_bases
TAAGTACAACCAATCATGATTTAGATCTAGTTTTCTTATGTGAAAAATGTGCAAAAATGCGCTCCGACTTATTTCCTGTT
CCCAAAATGAGTAAAAACAT

Downstream 100 bases:

>100_bases
TCTCTACCTCTGCGTATGAGCTTAAAACACAAAACATAACTATACCAAAAGCCTCCCTACCCTTAGGGGGGCTTAGTTTT
GAGGCATTCAAAATGATTAG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNTTTAATSTARSASKWTYKDFTWALSLFGTAVGAGVLFLPIKAGAGGFWPLVLLALIAAPMTWFAHKSLARFVLSAKNP
DADITDTVEEHFGKAGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQIGMESIPRWLLSGALITAMTAGVVFGKELM
LKATSAMVYPLVFILLALSFYLIPDWNTSMMEVAPDWSAMPAIVWLAIPIIVFSFNHSPIISQFSKEQRQQFGDKAVQKT
DMITGGAAMMLMGFVMFFVFSVVLSLSPAELAMAKEQNISVLSYLANEHASPIISYLGPIVAFAAITSSYFGHFLGAHEG
LVGLVKSRSNMQVSKIEKISLGFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLLPVFAMHKVPAMAKFKTSAPVQIF
TVICGLAAISSVIYGAL

Sequences:

>Translated_417_residues
MNTTTAATSTARSASKWTYKDFTWALSLFGTAVGAGVLFLPIKAGAGGFWPLVLLALIAAPMTWFAHKSLARFVLSAKNP
DADITDTVEEHFGKAGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQIGMESIPRWLLSGALITAMTAGVVFGKELM
LKATSAMVYPLVFILLALSFYLIPDWNTSMMEVAPDWSAMPAIVWLAIPIIVFSFNHSPIISQFSKEQRQQFGDKAVQKT
DMITGGAAMMLMGFVMFFVFSVVLSLSPAELAMAKEQNISVLSYLANEHASPIISYLGPIVAFAAITSSYFGHFLGAHEG
LVGLVKSRSNMQVSKIEKISLGFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLLPVFAMHKVPAMAKFKTSAPVQIF
TVICGLAAISSVIYGAL
>Mature_417_residues
MNTTTAATSTARSASKWTYKDFTWALSLFGTAVGAGVLFLPIKAGAGGFWPLVLLALIAAPMTWFAHKSLARFVLSAKNP
DADITDTVEEHFGKAGANLITFAYFFAIYPIVLIYGVGITNTVDSFLVNQIGMESIPRWLLSGALITAMTAGVVFGKELM
LKATSAMVYPLVFILLALSFYLIPDWNTSMMEVAPDWSAMPAIVWLAIPIIVFSFNHSPIISQFSKEQRQQFGDKAVQKT
DMITGGAAMMLMGFVMFFVFSVVLSLSPAELAMAKEQNISVLSYLANEHASPIISYLGPIVAFAAITSSYFGHFLGAHEG
LVGLVKSRSNMQVSKIEKISLGFIVITTWIVAIVNPSILGMIETMGAPMIAAILFLLPVFAMHKVPAMAKFKTSAPVQIF
TVICGLAAISSVIYGAL

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=425, Percent_Identity=52, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1789504, Length=441, Percent_Identity=42.6303854875283, Blast_Score=340, Evalue=7e-95,
Organism=Escherichia coli, GI1789211, Length=404, Percent_Identity=33.1683168316832, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI1789961, Length=392, Percent_Identity=27.8061224489796, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI145693183, Length=407, Percent_Identity=25.0614250614251, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44961; Mature: 44961

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTTAATSTARSASKWTYKDFTWALSLFGTAVGAGVLFLPIKAGAGGFWPLVLLALIAA
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
PMTWFAHKSLARFVLSAKNPDADITDTVEEHFGKAGANLITFAYFFAIYPIVLIYGVGIT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCH
NTVDSFLVNQIGMESIPRWLLSGALITAMTAGVVFGKELMLKATSAMVYPLVFILLALSF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIPDWNTSMMEVAPDWSAMPAIVWLAIPIIVFSFNHSPIISQFSKEQRQQFGDKAVQKT
HCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMITGGAAMMLMGFVMFFVFSVVLSLSPAELAMAKEQNISVLSYLANEHASPIISYLGPI
HHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAFAAITSSYFGHFLGAHEGLVGLVKSRSNMQVSKIEKISLGFIVITTWIVAIVNPSILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MIETMGAPMIAAILFLLPVFAMHKVPAMAKFKTSAPVQIFTVICGLAAISSVIYGAL
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTTTAATSTARSASKWTYKDFTWALSLFGTAVGAGVLFLPIKAGAGGFWPLVLLALIAA
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
PMTWFAHKSLARFVLSAKNPDADITDTVEEHFGKAGANLITFAYFFAIYPIVLIYGVGIT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCH
NTVDSFLVNQIGMESIPRWLLSGALITAMTAGVVFGKELMLKATSAMVYPLVFILLALSF
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIPDWNTSMMEVAPDWSAMPAIVWLAIPIIVFSFNHSPIISQFSKEQRQQFGDKAVQKT
HCCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DMITGGAAMMLMGFVMFFVFSVVLSLSPAELAMAKEQNISVLSYLANEHASPIISYLGPI
HHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VAFAAITSSYFGHFLGAHEGLVGLVKSRSNMQVSKIEKISLGFIVITTWIVAIVNPSILG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
MIETMGAPMIAAILFLLPVFAMHKVPAMAKFKTSAPVQIFTVICGLAAISSVIYGAL
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]