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The map label for this gene is grxA [H]

Identifier: 227081319

GI number: 227081319

Start: 1174684

End: 1174962

Strand: Reverse

Name: grxA [H]

Synonym: VCM66_1102

Alternate gene names: 227081319

Gene position: 1174962-1174684 (Counterclockwise)

Preceding gene: 227081321

Following gene: 227081318

Centisome position: 40.62

GC content: 44.09

Gene sequence:

>279_bases
ATGAAGGAGAAAGATATGTTTGTGGTCATTTTTGGTCGTCCTGGCTGTCCTTACTGTGTTCGTGCCAAAGAGCATGCTGA
AACATTGAAAGCAAAGCGTGATGATTTTAACTATCGCTATGTTGATATCCACGCCGAAGGCATCACTAAAGCCGATCTAG
AAAAAACCATCGGCAAGCCAGTCGAAACCGTTCCACAGATTTTCATCGATGAACAACACATCGGCGGCTGCACAGACTTC
GAAGCGTACGCAAAAGAGAATCTAGGTCTATTTGACTAA

Upstream 100 bases:

>100_bases
GCGAAGCATAGAGTAAAACCATTGTTTTTATCTATTAAATCAAGAGGAAAAATCACGCTTTATTTCCCCCTTTGAATCGG
GCATAGTACCCGCAAACAAA

Downstream 100 bases:

>100_bases
TAAAATGATAAATCGAAAAAGCCTGTGAATATCGCAGGCTTTTTTGTTCGTACGAGATTCTGCAGACTTAGGATTTTTTA
GCTATTTCGCTCCAAATAAT

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: NA

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MKEKDMFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKPVETVPQIFIDEQHIGGCTDF
EAYAKENLGLFD

Sequences:

>Translated_92_residues
MKEKDMFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKPVETVPQIFIDEQHIGGCTDF
EAYAKENLGLFD
>Mature_92_residues
MKEKDMFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKPVETVPQIFIDEQHIGGCTDF
EAYAKENLGLFD

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=83, Percent_Identity=72.289156626506, Blast_Score=130, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 10513; Mature: 10513

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKDMFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKP
CCCCCEEEEEECCCCCCCEECCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCC
VETVPQIFIDEQHIGGCTDFEAYAKENLGLFD
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MKEKDMFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKP
CCCCCEEEEEECCCCCCCEECCHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCC
VETVPQIFIDEQHIGGCTDFEAYAKENLGLFD
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]