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The map label for this gene is tktA-1 [H]

Identifier: 227080683

GI number: 227080683

Start: 486374

End: 488458

Strand: Direct

Name: tktA-1 [H]

Synonym: VCM66_0458

Alternate gene names: 227080683

Gene position: 486374-488458 (Clockwise)

Preceding gene: 227080675

Following gene: 227080685

Centisome position: 16.81

GC content: 53.43

Gene sequence:

>2085_bases
TTGCAGCAGCAGGGGGGCTTTGCGACAATAGCCGCCACTGATTTTCCGCATCCATTCATTTCGCTTACTTCCCATTTAGG
AGTCGACATGTCTTCTCGCAAACAACTTGCCAATGCTATCCGCGCCCTGAGCATGGACGGCGTTCAAAAAGCTAACTCTG
GCCACCCGGGAGCCCCAATGGGCATGGCGGATATCGCCGAAGTGCTGTGGCGTTCACACTTAAACCACAACCCACAAAAC
CCAAACTGGGCTGACCGCGACCGTTTCGTACTGTCTAACGGCCACGGCTCTATGCTGATTTACTCGCTGCTACACCTGAG
CGGCTATGAGCTGTCGATTGACGATTTGAAAAACTTCCGTCAACTACACTCCAAAACACCGGGTCACCCAGAGTACGGTT
ATGCACCGGGCATCGAAACGACTACGGGCCCACTCGGCCAAGGCATCACCAATGCCGTAGGTATGGCGATTGCTGAGAAA
GCACTGGCGGCGCAGTTCAACAAACCGGGTCACGACATCGTTGACCACTTCACTTATGTGTTCATGGGTGACGGCTGTTT
GATGGAAGGTATCTCGCACGAAGCGTGTTCACTGGCGGGCACACTTGGCCTTGGCAAACTGATTGCGTTCTGGGATGACA
ACGGTATCTCTATCGACGGCCACGTGGAAGGCTGGTTCTCAGACGACACACCAAAACGTTTTGAAGCGTACGGCTGGCAC
GTAATCCCAGCGGTTGATGGTCACGATGCAGACGCGATTAATGCAGCAATTGAAGCGGCGAAAGCAGAAACCTCTCGCCC
AACGCTGATTTGTACCAAAACCATCATCGGTTTCGGCTCTCCAAACAAAGCGGGCTCACACGACTGTCACGGCGCGCCTC
TGGGCAACGATGAAATCAAAGCTGCACGTGAATTCTTGGGTTGGGAACACGCTCCGTTTGAAATCCCAGCGGACATCTAC
GCAGCGTGGGATGCAAAACAAGCAGGCGCAAGCAAAGAAGCCGCTTGGAATGAGAAATTCGCCGCTTACGCGAAAGCTTA
CCCAGCCGAAGCTGCTGAATACAAACGCCGCGTAGCGGGCGAGCTGCCAGCGAATTGGGAAGCCGCAACCAGCGAGATTA
TCGCTAACCTGCAAGCTAACCCTGCCAACATCGCATCGCGTAAAGCATCACAAAATGCGCTGGAAGCGTTCGGCAAACTG
CTGCCAGAATTTATGGGTGGTTCTGCTGACTTGGCGCCTTCTAACCTCACCATGTGGTCTGGCTCTAAGTCACTGACAGC
AGAAGATGCGTCAGGCAACTACATCCACTACGGTGTGCGTGAGTTTGGTATGACGGCCATCATCAACGGTATCGCGCTGC
ACGGCGGTTTTGTCCCTTACGGTGCAACCTTCCTGATGTTTATGGAATACGCGCGTAACGCGATGCGTATGGCAGCACTG
ATGAAAGTGCAAAATATCCAAGTGTACACGCATGACTCTATCGGTCTGGGTGAAGATGGCCCAACTCACCAACCAGTTGA
GCAAATCGCTTCTCTGCGTATGACACCAAACATGAGCACATGGCGCCCATGTGACCAAGTGGAATCGGCAGTGGCTTGGA
AACTGGCCATCGAGCGTAAAGATGCGCCATCTGCGCTGATTTTCTCGCGTCAAAACCTTGCGCAGCAACCACGCAGCGCA
GAGCAAGTCGCGAACATCGCTAAAGGCGGTTACATCCTGAAAGATTGTGCAGGCCAACCTGAGCTAATTCTGATTGCAAC
AGGCTCTGAAGTGGAACTGGCGGTTGCCGCTTACGAGCAACTGAGCGCCGAAGGTAAAGCGGTTCGCGTCGTTTCTATGC
CATCGACCGATGCGTTTGATAAGCAAGATGCGGCTTACCGTGAAGCCGTTCTGCCAGCCGCTGTGACTAAGCGTATCGCG
ATTGAAGCGGGCATTGCCGACTTCTGGTACAAGTACGTTGGCTTTGGTGGTCGCATCATCGGTATGACTAGCTTCGGTGA
ATCAGCACCAGCGGGTGAGCTGTTCAAACTGTTTGGTTTCACGACTGAAAACGTAGTGAAGCAAGCTAAAGAACTGCTGG
CGTAA

Upstream 100 bases:

>100_bases
GCATAACCAAACGTTTGCTTAAAAAAGTCAGCTTTGCCACTACAAAGCGAGAATGTGCTAAAAAGTGTGACAAAATCGGA
GCAAAGCACCAGTAAATCGT

Downstream 100 bases:

>100_bases
TTAAAAGCGATTTATTTCTTTGTTACGCAAAGAAAAATCGATGATAAAAAATCCCGCTGCGGCGGGATTTTTTATTGCCA
CTCATCGGGCCTTGCTTGGC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MQQQGGFATIAATDFPHPFISLTSHLGVDMSSRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQN
PNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEK
ALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWH
VIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEHAPFEIPADIY
AAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAGELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKL
LPEFMGGSADLAPSNLTMWSGSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAAL
MKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQPRSA
EQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQLSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIA
IEAGIADFWYKYVGFGGRIIGMTSFGESAPAGELFKLFGFTTENVVKQAKELLA

Sequences:

>Translated_694_residues
MQQQGGFATIAATDFPHPFISLTSHLGVDMSSRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQN
PNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEK
ALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWH
VIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEHAPFEIPADIY
AAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAGELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKL
LPEFMGGSADLAPSNLTMWSGSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAAL
MKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQPRSA
EQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQLSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIA
IEAGIADFWYKYVGFGGRIIGMTSFGESAPAGELFKLFGFTTENVVKQAKELLA
>Mature_694_residues
MQQQGGFATIAATDFPHPFISLTSHLGVDMSSRKQLANAIRALSMDGVQKANSGHPGAPMGMADIAEVLWRSHLNHNPQN
PNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFRQLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEK
ALAAQFNKPGHDIVDHFTYVFMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWH
VIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIKAAREFLGWEHAPFEIPADIY
AAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAGELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKL
LPEFMGGSADLAPSNLTMWSGSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAAL
MKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERKDAPSALIFSRQNLAQQPRSA
EQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQLSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIA
IEAGIADFWYKYVGFGGRIIGMTSFGESAPAGELFKLFGFTTENVVKQAKELLA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=694, Percent_Identity=26.5129682997118, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI4507521, Length=694, Percent_Identity=26.5129682997118, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI133778974, Length=274, Percent_Identity=31.021897810219, Blast_Score=116, Evalue=9e-26,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=78.9156626506024, Blast_Score=1122, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=70.392749244713, Blast_Score=1003, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=25.260029717682, Blast_Score=155, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=49.0312965722802, Blast_Score=607, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=44.4113263785395, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45551847, Length=688, Percent_Identity=25.5813953488372, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45550715, Length=688, Percent_Identity=25.5813953488372, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24645119, Length=654, Percent_Identity=25.2293577981651, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24666278, Length=682, Percent_Identity=23.3137829912023, Blast_Score=138, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74682; Mature: 74682

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQGGFATIAATDFPHPFISLTSHLGVDMSSRKQLANAIRALSMDGVQKANSGHPGAPM
CCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
GMADIAEVLWRSHLNHNPQNPNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFR
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHH
QLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEKALAAQFNKPGHDIVDHFTYV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEE
FMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWH
EECCCHHHHCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCHHHHCCCE
VIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIK
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHEECCCCCCCCCCCCCCCCCCCHHHH
AAREFLGWEHAPFEIPADIYAAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAG
HHHHHHCCCCCCCCCCHHHHEECCCHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
ELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKLLPEFMGGSADLAPSNLTMWS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAAL
CCCCCEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERK
HHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEECC
DAPSALIFSRQNLAQQPRSAEQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQ
CCCCCEEEEHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEHHHHHHH
LSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIAIEAGIADFWYKYVGFGGRII
HCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GMTSFGESAPAGELFKLFGFTTENVVKQAKELLA
EEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQQQGGFATIAATDFPHPFISLTSHLGVDMSSRKQLANAIRALSMDGVQKANSGHPGAPM
CCCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
GMADIAEVLWRSHLNHNPQNPNWADRDRFVLSNGHGSMLIYSLLHLSGYELSIDDLKNFR
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHH
QLHSKTPGHPEYGYAPGIETTTGPLGQGITNAVGMAIAEKALAAQFNKPGHDIVDHFTYV
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEE
FMGDGCLMEGISHEACSLAGTLGLGKLIAFWDDNGISIDGHVEGWFSDDTPKRFEAYGWH
EECCCHHHHCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCHHHHCCCE
VIPAVDGHDADAINAAIEAAKAETSRPTLICTKTIIGFGSPNKAGSHDCHGAPLGNDEIK
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHEECCCCCCCCCCCCCCCCCCCHHHH
AAREFLGWEHAPFEIPADIYAAWDAKQAGASKEAAWNEKFAAYAKAYPAEAAEYKRRVAG
HHHHHHCCCCCCCCCCHHHHEECCCHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
ELPANWEAATSEIIANLQANPANIASRKASQNALEAFGKLLPEFMGGSADLAPSNLTMWS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
GSKSLTAEDASGNYIHYGVREFGMTAIINGIALHGGFVPYGATFLMFMEYARNAMRMAAL
CCCCCEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
MKVQNIQVYTHDSIGLGEDGPTHQPVEQIASLRMTPNMSTWRPCDQVESAVAWKLAIERK
HHHHCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEEECC
DAPSALIFSRQNLAQQPRSAEQVANIAKGGYILKDCAGQPELILIATGSEVELAVAAYEQ
CCCCCEEEEHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCEEEHHHHHHH
LSAEGKAVRVVSMPSTDAFDKQDAAYREAVLPAAVTKRIAIEAGIADFWYKYVGFGGRII
HCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
GMTSFGESAPAGELFKLFGFTTENVVKQAKELLA
EEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]