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The map label for this gene is mutL

Identifier: 227080557

GI number: 227080557

Start: 351799

End: 353760

Strand: Direct

Name: mutL

Synonym: VCM66_0329

Alternate gene names: 227080557

Gene position: 351799-353760 (Clockwise)

Preceding gene: 227080556

Following gene: 227080558

Centisome position: 12.16

GC content: 50.36

Gene sequence:

>1962_bases
ATGACGATTCGAATCCTACCCGCCCGTTTAGCCAACCAAATTGCAGCGGGTGAAGTTGTAGAAAGACCGGCTTCAGTAGT
CAAGGAGTTGGTGGAAAACAGTTTAGATGCTGGAGCCACTCGAATTGATATTGATCTCGAGAAGGGGGGCGCTAAGCTCA
TTCGTATTCGCGATAATGGTTCGGGTATTGATAAGGACGAACTAGGGCTTGCGCTGAGTCGTCACGCGACCTCTAAAATT
CACACCCTCGATGATCTGGAAGCGATCATGAGCCTTGGTTTTCGTGGCGAGGCCTTAGCCAGTATTAGCTCAGTCTCACG
CTTAACCCTTACTTCGCGCACGGTAGCTCAAGAAGAAGCGTGGTCTGCCTACAGTGAAGGCCGTGATATGGCGGTCAAGT
TACAGCCCGCGGCTCACCCCGTGGGTACGACTGTGGAAGTGCTGGATCTCTTTTTCAATACCCCGGCACGGCGTAAATTT
CTGCGCACCGAAAAAACCGAATTTACCCATATTGATGAGCTGCTCAAACGAATTGCTCTGAGCCGTTTTGATGTCAGCTT
TACTCTGCGCCATAACGGAAAAATCGTGCGTCAGTATCGCGCTGCAACGACTTTACCGCAGCAGGAAAAACGTTTAGCTG
CGGTGTGTGGCAACCCGTTTGTGCAACATATGTTACGCATTGAGTTAGAGCACCAAGGGCTTAAACTGCATGGCTGGATC
ACCACACCCGAAGGAGCGCGCCAGCAGAGCGATCTGCAATACTGTTACGTAAACGGCCGGATGATGCGTGATAAGCTGAT
CAATCATGCGATTCGCCAAAGCTACGAAACCAGCTTACGTGTCGATCAATTTGCTACCTATGTGCTGTTTATTGAACTCG
ATCCTCATCAAGTGGATGTCAACGTGCATCCAGCCAAGCATGAAGTGCGCTTCCATCAAGCTCGCCTCGTTCATGATTTC
ATCTATCAAGCCTTAAGCAGTGCGCTAGTACAAGGTGCGCAGGTGATGGCTCCGACCATTAATGAAGGGGCGTTTCATTT
ACCTCACTGCGCGGAAGAGGTGAATCCTCCGGTTGTGCCGATGATCGATACCACGCAACAAGAAAGAGTGTGGCAAGCGG
TGCAAAATACGCCAGATTATCCGCGCAAAGCTCCACGTGATAACGATAGGGATGAGAGCGATAATCCGCAGGTTAGAGAG
CGAGCGGTCAGTAATCCTTGGGTGGCTTCACCCAAGACTGCAAGTACTGGCAAAGAAAGATATGGTTCGGCATCCGTCAG
CAAAAAAGAGGCCGCGGTTTATCAAACCTTGATGCAAACTCCCGATTTATCGGATGAAGAACCGAGTACTGCCAGTACCA
TCGTCTCATCAATTGAAGCCGTCAAGGCTAATATTGCTATCGAAAAACTGGGTAAAGCGATCCAAGTGGTCGCGGGACAG
TACCTGTTGATGAGTAGCCCACAAGGCTGTGTGCTTATCTCGCTATACCAAGCTCAGCAACTCAAACTGCGTGGATTACT
CAATGCTCAGCATGGTGCGCTGAAAGCGCAGCCACTGCTGGTGCCACTCGCGCTAAAACTGAATGAATCTGAATGGCAAG
TGGCGCAGCGTCATTCATCGGCCCTGTTGCAACTGGGTATTGAGCTGAAATCGCGCACCAATCACAGCATTATGGTGATG
GCGGTTCCGCAGCCGCTGCGCCAGCAAAATTTACAGCAATTGCTGCCGGATCTGTTATCTTACGCGGCGAGTTGTTCGGA
AAGCCAAGCCTTGAGCCATCAAGCGTTGGCGGATTGGTTAACTCAACGCATCGTTGTAGAAAAAAGAGACTACACTTTAG
CCGAGGCGATCGGCTTGATCGCAGAGCTGGAGCAGCTCTGGCAAGGCAACTTGCCTTTGCAAGACCCGCATTTTATTACT
TTGGTGGATTTTTCCGCCTCAATTACAGCATTACACTCATGA

Upstream 100 bases:

>100_bases
ATACAATGTTAGCGTTGATAGCATTCGCCAAGCCAACCAGCTACGCACTGACCAATTGTTGGTTGGGCAGCAACTGATTA
TCCCGAATAAATAAGCGCTC

Downstream 100 bases:

>100_bases
CTCAAAAGTTACCTCTCGCCCTCTTCTTAATGGGCCCAACGGCCTCTGGCAAAACGGATTTAGCCATTCGCTTACGTCAG
AAATATCCGGTGGAGATCAT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MTIRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNGSGIDKDELGLALSRHATSKI
HTLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKF
LRTEKTEFTHIDELLKRIALSRFDVSFTLRHNGKIVRQYRAATTLPQQEKRLAAVCGNPFVQHMLRIELEHQGLKLHGWI
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQALSSALVQGAQVMAPTINEGAFHLPHCAEEVNPPVVPMIDTTQQERVWQAVQNTPDYPRKAPRDNDRDESDNPQVRE
RAVSNPWVASPKTASTGKERYGSASVSKKEAAVYQTLMQTPDLSDEEPSTASTIVSSIEAVKANIAIEKLGKAIQVVAGQ
YLLMSSPQGCVLISLYQAQQLKLRGLLNAQHGALKAQPLLVPLALKLNESEWQVAQRHSSALLQLGIELKSRTNHSIMVM
AVPQPLRQQNLQQLLPDLLSYAASCSESQALSHQALADWLTQRIVVEKRDYTLAEAIGLIAELEQLWQGNLPLQDPHFIT
LVDFSASITALHS

Sequences:

>Translated_653_residues
MTIRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNGSGIDKDELGLALSRHATSKI
HTLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKF
LRTEKTEFTHIDELLKRIALSRFDVSFTLRHNGKIVRQYRAATTLPQQEKRLAAVCGNPFVQHMLRIELEHQGLKLHGWI
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDF
IYQALSSALVQGAQVMAPTINEGAFHLPHCAEEVNPPVVPMIDTTQQERVWQAVQNTPDYPRKAPRDNDRDESDNPQVRE
RAVSNPWVASPKTASTGKERYGSASVSKKEAAVYQTLMQTPDLSDEEPSTASTIVSSIEAVKANIAIEKLGKAIQVVAGQ
YLLMSSPQGCVLISLYQAQQLKLRGLLNAQHGALKAQPLLVPLALKLNESEWQVAQRHSSALLQLGIELKSRTNHSIMVM
AVPQPLRQQNLQQLLPDLLSYAASCSESQALSHQALADWLTQRIVVEKRDYTLAEAIGLIAELEQLWQGNLPLQDPHFIT
LVDFSASITALHS
>Mature_652_residues
TIRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNGSGIDKDELGLALSRHATSKIH
TLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEAWSAYSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKFL
RTEKTEFTHIDELLKRIALSRFDVSFTLRHNGKIVRQYRAATTLPQQEKRLAAVCGNPFVQHMLRIELEHQGLKLHGWIT
TPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQVDVNVHPAKHEVRFHQARLVHDFI
YQALSSALVQGAQVMAPTINEGAFHLPHCAEEVNPPVVPMIDTTQQERVWQAVQNTPDYPRKAPRDNDRDESDNPQVRER
AVSNPWVASPKTASTGKERYGSASVSKKEAAVYQTLMQTPDLSDEEPSTASTIVSSIEAVKANIAIEKLGKAIQVVAGQY
LLMSSPQGCVLISLYQAQQLKLRGLLNAQHGALKAQPLLVPLALKLNESEWQVAQRHSSALLQLGIELKSRTNHSIMVMA
VPQPLRQQNLQQLLPDLLSYAASCSESQALSHQALADWLTQRIVVEKRDYTLAEAIGLIAELEQLWQGNLPLQDPHFITL
VDFSASITALHS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=333, Percent_Identity=35.7357357357357, Blast_Score=207, Evalue=4e-53,
Organism=Homo sapiens, GI4505911, Length=320, Percent_Identity=30.625, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI189458898, Length=320, Percent_Identity=30.625, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.6709265175719, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI4505913, Length=339, Percent_Identity=29.7935103244838, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI310128478, Length=339, Percent_Identity=29.7935103244838, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI263191589, Length=239, Percent_Identity=30.5439330543933, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI91992162, Length=342, Percent_Identity=26.0233918128655, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI91992160, Length=342, Percent_Identity=26.0233918128655, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=26.6891891891892, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=661, Percent_Identity=49.6217851739788, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI71991825, Length=324, Percent_Identity=34.5679012345679, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=28.1976744186047, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=318, Percent_Identity=36.1635220125786, Blast_Score=191, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=347, Percent_Identity=29.3948126801153, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=401, Percent_Identity=26.1845386533666, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=384, Percent_Identity=27.34375, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136968, Length=331, Percent_Identity=33.8368580060423, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI17136970, Length=443, Percent_Identity=26.86230248307, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_VIBC3 (A5F3L5)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F3L5
- STRING:   A5F3L5
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A2756
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   EGRDQAV
- ProtClustDB:   PRK00095
- BioCyc:   VCHO345073:VC0395_A2756-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72632; Mature: 72501

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIDKDELGLALSRHATSKIHTLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAYSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKFLRTEKTEFTHIDELLKRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SRFDVSFTLRHNGKIVRQYRAATTLPQQEKRLAAVCGNPFVQHMLRIELEHQGLKLHGWI
HHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEE
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQALSSALVQGAQVMAPTINEGAFHLPHCAEEVNPPVVP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHHHCCCCEEE
MIDTTQQERVWQAVQNTPDYPRKAPRDNDRDESDNPQVRERAVSNPWVASPKTASTGKER
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHH
YGSASVSKKEAAVYQTLMQTPDLSDEEPSTASTIVSSIEAVKANIAIEKLGKAIQVVAGQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YLLMSSPQGCVLISLYQAQQLKLRGLLNAQHGALKAQPLLVPLALKLNESEWQVAQRHSS
EEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHH
ALLQLGIELKSRTNHSIMVMAVPQPLRQQNLQQLLPDLLSYAASCSESQALSHQALADWL
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TQRIVVEKRDYTLAEAIGLIAELEQLWQGNLPLQDPHFITLVDFSASITALHS
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECC
>Mature Secondary Structure 
TIRILPARLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDLEKGGAKLIRIRDNG
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
SGIDKDELGLALSRHATSKIHTLDDLEAIMSLGFRGEALASISSVSRLTLTSRTVAQEEA
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WSAYSEGRDMAVKLQPAAHPVGTTVEVLDLFFNTPARRKFLRTEKTEFTHIDELLKRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHH
SRFDVSFTLRHNGKIVRQYRAATTLPQQEKRLAAVCGNPFVQHMLRIELEHQGLKLHGWI
HHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEEE
TTPEGARQQSDLQYCYVNGRMMRDKLINHAIRQSYETSLRVDQFATYVLFIELDPHQVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEEEE
NVHPAKHEVRFHQARLVHDFIYQALSSALVQGAQVMAPTINEGAFHLPHCAEEVNPPVVP
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCHHHHCCCCEEE
MIDTTQQERVWQAVQNTPDYPRKAPRDNDRDESDNPQVRERAVSNPWVASPKTASTGKER
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHH
YGSASVSKKEAAVYQTLMQTPDLSDEEPSTASTIVSSIEAVKANIAIEKLGKAIQVVAGQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
YLLMSSPQGCVLISLYQAQQLKLRGLLNAQHGALKAQPLLVPLALKLNESEWQVAQRHSS
EEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHH
ALLQLGIELKSRTNHSIMVMAVPQPLRQQNLQQLLPDLLSYAASCSESQALSHQALADWL
HHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TQRIVVEKRDYTLAEAIGLIAELEQLWQGNLPLQDPHFITLVDFSASITALHS
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA