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The map label for this gene is hemE [H]

Identifier: 227080544

GI number: 227080544

Start: 335237

End: 336316

Strand: Direct

Name: hemE [H]

Synonym: VCM66_0316

Alternate gene names: 227080544

Gene position: 335237-336316 (Clockwise)

Preceding gene: 227080543

Following gene: 227080545

Centisome position: 11.59

GC content: 50.56

Gene sequence:

>1080_bases
GTGGGAATCACCATGACTGAATTAAAAAATGATCGCTACCTGCGTGCTTTGCTCAAGCAGCCAGTCGATTACACTCCTGT
ATGGATGATGCGCCAAGCGGGGCGTTATCTCCCTGAATACCGTGCCACTCGTGCTCAAGCGGGTGATTTTATGGCGCTGT
GCAAGAATGCAGAGTTGGCTTCAGAAGTGACTTTACAGCCGCTGCGACGTTTTCCGCTTGATGCTGCGATCCTGTTTTCT
GATATTTTGACGATTCCTGATGCGATGGGACTTGGGCTGCGTTTTGCGGCGGGCGAAGGACCGGTCTTTGAGCGTCCCAT
CACCTGCAAAGCCGATGTCGATAAGATTGGTATTCCCGATCCTGAAGGGGAATTGCAGTATGTGATGAACGCGGTGCGTC
AAATTCGCAAAGATCTGCAAGGTGAAGTGCCGCTGATTGGTTTCTCTGGCAGTCCTTGGACGCTCGCCACTTATATGGTT
GAAGGTGGCAGTTCAAAAGCCTTCACCAAAATCAAAAAGATGATGTACAGCGAGCCTACCGTGCTGCATGCGCTGTTAGA
TAAATTAGCTGACAGTGTGATCAGCTACCTGAATGCTCAGATTAAAGCCGGCGCACAAGCGGTGATGGTATTTGATACTT
GGGGCGGCGTGTTAACACCGCGTGATTATCAACAGTTCTCTTTGCAATACATGCACAAGATTGTCGATGGCTTGATTCGT
GAAAACGAAGGCCGCCGTGTACCAGTCACGCTGTTTACCAAAAATGGTGGCATGTGGCTGGAGCAGATCGCGGCTACAGG
TTGTGATGCTGTGGGTTTAGATTGGACGATCAATATCGCCGACGCTAAAGCGCGTGTGGGAGATAAAGTGGCACTGCAAG
GCAATATGGATCCTTCTATTCTGTATGCTCCTGCCCCACGAATTCGTGAAGAGGTGGCGAGTATTTTGGCTGGATTTGGC
CAAGGTGGCACAGGCCACGTGTTCAACTTGGGGCATGGTATTCATTTGGACGTGCCGCCTGAAAATGCCGGTGTGTTTGT
TGAAGCGGTGCATGAGCTTTCGAAGCCGTACCATCCATAG

Upstream 100 bases:

>100_bases
ATTGATTTAAAAGTTAATAACTTGATCCCGCTTGCAAAGCCAACCGCTTTTGTGGGACAAACGATGTTAGAATACGCGCC
AAAGTAAAGAAGCCGAAAAA

Downstream 100 bases:

>100_bases
TAAACGTGAAAAGCGTCTGCAGGTCAGACGCTTTTCACATCTTGAGCCCGACTGTTTTATACTTCGGTAATCCAGACAGA
AAGACGAAGCGAATCATGAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MGITMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYRATRAQAGDFMALCKNAELASEVTLQPLRRFPLDAAILFS
DILTIPDAMGLGLRFAAGEGPVFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLQGEVPLIGFSGSPWTLATYMV
EGGSSKAFTKIKKMMYSEPTVLHALLDKLADSVISYLNAQIKAGAQAVMVFDTWGGVLTPRDYQQFSLQYMHKIVDGLIR
ENEGRRVPVTLFTKNGGMWLEQIAATGCDAVGLDWTINIADAKARVGDKVALQGNMDPSILYAPAPRIREEVASILAGFG
QGGTGHVFNLGHGIHLDVPPENAGVFVEAVHELSKPYHP

Sequences:

>Translated_359_residues
MGITMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYRATRAQAGDFMALCKNAELASEVTLQPLRRFPLDAAILFS
DILTIPDAMGLGLRFAAGEGPVFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLQGEVPLIGFSGSPWTLATYMV
EGGSSKAFTKIKKMMYSEPTVLHALLDKLADSVISYLNAQIKAGAQAVMVFDTWGGVLTPRDYQQFSLQYMHKIVDGLIR
ENEGRRVPVTLFTKNGGMWLEQIAATGCDAVGLDWTINIADAKARVGDKVALQGNMDPSILYAPAPRIREEVASILAGFG
QGGTGHVFNLGHGIHLDVPPENAGVFVEAVHELSKPYHP
>Mature_358_residues
GITMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYRATRAQAGDFMALCKNAELASEVTLQPLRRFPLDAAILFSD
ILTIPDAMGLGLRFAAGEGPVFERPITCKADVDKIGIPDPEGELQYVMNAVRQIRKDLQGEVPLIGFSGSPWTLATYMVE
GGSSKAFTKIKKMMYSEPTVLHALLDKLADSVISYLNAQIKAGAQAVMVFDTWGGVLTPRDYQQFSLQYMHKIVDGLIRE
NEGRRVPVTLFTKNGGMWLEQIAATGCDAVGLDWTINIADAKARVGDKVALQGNMDPSILYAPAPRIREEVASILAGFGQ
GGTGHVFNLGHGIHLDVPPENAGVFVEAVHELSKPYHP

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=355, Percent_Identity=47.0422535211268, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=83.6158192090395, Blast_Score=615, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=38.5269121813031, Blast_Score=266, Evalue=4e-72,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=42.5287356321839, Blast_Score=285, Evalue=2e-77,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=42.5287356321839, Blast_Score=285, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39451; Mature: 39320

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYRATRAQAGDFMALCKNAELA
CCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCHHH
SEVTLQPLRRFPLDAAILFSDILTIPDAMGLGLRFAAGEGPVFERPITCKADVDKIGIPD
HHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCEECCCCCCCCCCCC
PEGELQYVMNAVRQIRKDLQGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYSEPT
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCH
VLHALLDKLADSVISYLNAQIKAGAQAVMVFDTWGGVLTPRDYQQFSLQYMHKIVDGLIR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENEGRRVPVTLFTKNGGMWLEQIAATGCDAVGLDWTINIADAKARVGDKVALQGNMDPSI
CCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEECCCHHHCCCEEEEECCCCCCE
LYAPAPRIREEVASILAGFGQGGTGHVFNLGHGIHLDVPPENAGVFVEAVHELSKPYHP
EECCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GITMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYRATRAQAGDFMALCKNAELA
CCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCHHH
SEVTLQPLRRFPLDAAILFSDILTIPDAMGLGLRFAAGEGPVFERPITCKADVDKIGIPD
HHHHHHHHHHCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCCCEECCCCCCCCCCCC
PEGELQYVMNAVRQIRKDLQGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYSEPT
CCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHCCCH
VLHALLDKLADSVISYLNAQIKAGAQAVMVFDTWGGVLTPRDYQQFSLQYMHKIVDGLIR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENEGRRVPVTLFTKNGGMWLEQIAATGCDAVGLDWTINIADAKARVGDKVALQGNMDPSI
CCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEECCCHHHCCCEEEEECCCCCCE
LYAPAPRIREEVASILAGFGQGGTGHVFNLGHGIHLDVPPENAGVFVEAVHELSKPYHP
EECCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA