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The map label for this gene is purE

Identifier: 227080289

GI number: 227080289

Start: 49460

End: 49945

Strand: Reverse

Name: purE

Synonym: VCM66_0052

Alternate gene names: 227080289

Gene position: 49945-49460 (Counterclockwise)

Preceding gene: 227080295

Following gene: 227080288

Centisome position: 1.73

GC content: 52.88

Gene sequence:

>486_bases
ATGACAGTCGGTATTATCATGGGTTCCAAGTCAGACTGGCCAACCATGAAACACGCAGCAGAAATGCTTGACCAGTTTGG
TGTGGCTTACGAGACCAAAGTGGTTTCTGCGCACCGTACTCCTCATCTTTTGGCCGACTACGCCTCTAGCGCCAAAGAAC
GCGGTTTACAAGTGATCATCGCTGGAGCGGGCGGCGCTGCGCATCTTCCCGGAATGACCGCCGCATTCACTAGCTTGCCA
GTGTTAGGCGTGCCCGTTCAATCTCGCGCTCTGTCTGGGCTCGACTCGTTATACTCCATTGTGCAGATGCCAAAAGGCAT
TGCGGTGGGTACGCTCGCCATTGGTGAAGCTGGTGCAGCGAATGCAGGATTACTTGCCGCACAAATCATCGGCATTCATA
ACCCAGAAGTGATGAGTAAAGTGGAAGCTTTCCGCGCTAAGCAGACTCAATCTGTGTTGGATAACCCAAATCCGGCTGAG
GAGTAA

Upstream 100 bases:

>100_bases
TCAACCAGAAAAAGCAAACGTTTGCTTGAGAAAAAAATCCCCGTATAATGCGCCGCAAACGGGCTTGCTTGTCCGATAAA
TAACACTGAAGGAGTTTGAG

Downstream 100 bases:

>100_bases
CAGATGCGTGTGTTGGTTCTCGGCGCTGGTCAGCTGGCGCGCATGATGTCGCTCGCCGGAGCACCGCTCAATATTGAAAC
GATCGCTTTTGATGTGGGTA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MTVGIIMGSKSDWPTMKHAAEMLDQFGVAYETKVVSAHRTPHLLADYASSAKERGLQVIIAGAGGAAHLPGMTAAFTSLP
VLGVPVQSRALSGLDSLYSIVQMPKGIAVGTLAIGEAGAANAGLLAAQIIGIHNPEVMSKVEAFRAKQTQSVLDNPNPAE
E

Sequences:

>Translated_161_residues
MTVGIIMGSKSDWPTMKHAAEMLDQFGVAYETKVVSAHRTPHLLADYASSAKERGLQVIIAGAGGAAHLPGMTAAFTSLP
VLGVPVQSRALSGLDSLYSIVQMPKGIAVGTLAIGEAGAANAGLLAAQIIGIHNPEVMSKVEAFRAKQTQSVLDNPNPAE
E
>Mature_160_residues
TVGIIMGSKSDWPTMKHAAEMLDQFGVAYETKVVSAHRTPHLLADYASSAKERGLQVIIAGAGGAAHLPGMTAAFTSLPV
LGVPVQSRALSGLDSLYSIVQMPKGIAVGTLAIGEAGAANAGLLAAQIIGIHNPEVMSKVEAFRAKQTQSVLDNPNPAEE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=156, Percent_Identity=65.3846153846154, Blast_Score=170, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=55.6291390728477, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_VIBCH (Q9KVT7)

Other databases:

- EMBL:   AF459402
- EMBL:   AE003852
- PIR:   C82370
- RefSeq:   NP_229711.1
- ProteinModelPortal:   Q9KVT7
- SMR:   Q9KVT7
- GeneID:   2614427
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0052
- TIGR:   VC_0052
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- ProtClustDB:   CLSK2391028
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 16645; Mature: 16514

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 12-12 BINDING 39-39

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGIIMGSKSDWPTMKHAAEMLDQFGVAYETKVVSAHRTPHLLADYASSAKERGLQVII
CEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEE
AGAGGAAHLPGMTAAFTSLPVLGVPVQSRALSGLDSLYSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
NAGLLAAQIIGIHNPEVMSKVEAFRAKQTQSVLDNPNPAEE
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TVGIIMGSKSDWPTMKHAAEMLDQFGVAYETKVVSAHRTPHLLADYASSAKERGLQVII
EEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEE
AGAGGAAHLPGMTAAFTSLPVLGVPVQSRALSGLDSLYSIVQMPKGIAVGTLAIGEAGAA
ECCCCCCCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCC
NAGLLAAQIIGIHNPEVMSKVEAFRAKQTQSVLDNPNPAEE
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301