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The map label for this gene is disA [H]

Identifier: 226950961

GI number: 226950961

Start: 4003629

End: 4004690

Strand: Reverse

Name: disA [H]

Synonym: CLM_3978

Alternate gene names: 226950961

Gene position: 4004690-4003629 (Counterclockwise)

Preceding gene: 226950962

Following gene: 226950959

Centisome position: 96.38

GC content: 30.32

Gene sequence:

>1062_bases
GTGAGAATAGAAAAAGATAAAGAATTAATGAATATACTTAAAATAATGGCCCCAGGAACACCCCTAAGAGAGGGGTTAGA
GAATATATTAAGAGCTAAAACCGGTGGATTATTAATTCTAGGGGATAGTGACCAGATATTAAAGTTAGTAGACGGTGGAT
TTAAAATTAATTCGGAATATAGTCCATCTTATGTTTATGAATTAGCTAAAATGGATGGTTCAATTGTGTTAAGCAGCGAT
TTAAAGAAGATATTATGTGCTAATGCTCAACTAATACCAGATTCATCTATACCTACTTTTGAAACAGGAACAAGACATAG
AACTGCTGATAGAGTAGCAAAACAAACAGGGGCTATAGTAATAGCTATTTCTCAAAGGAGAAATATAATAACTGTTTATA
AGGGTGGAATAAAGTATGTATTAAGAGATAGTAGCATAATATTGGCAAGAGCTAATCAGGCTCTGCAAACTTTAGAAAAG
TATGTAGCTGTTTTAGACAGAGTAGTAAATAATTTAAATATACTAGAATTTAAGGATATAGCAACTTTATTTGATGTAGT
AACTGCTGTTCAAAGATCCGAAATGGTTATGAGAATAGTTAGTGAAATAGAAAGATATATATGTGAATTAGGTAATGAAG
GAAGACTAATTGATATGCAATTAAGTGAATTAATAAAAAGTGTAGAAGAAGATGGTATTCTGCTTATAAGAGACTATTGT
AGAAGTAATATGGAATATGAAGATATATACAAACAGATACAAGGACTTTCATCAGAAGAACTTTTAAATTTAGATGGATT
ATCAAAAATTATAGGATATACAGGAGTACCTTTGGTAGATACACTTATTTCACCTCGAGGATATAGGATGATTAATAAAA
TACCGAGGATACCAAGTAATGTAATAGAAAATTTAGTAGCTAATTTTAATCAATTAAAATGTGTAATGGAAGCATCCTAT
GAGCAATTAGATAATGTAGAAGGGATTGGAGAAGCTAGAGCTAAAGCTATAAAAAACGGATTAAGAAGACTTAGAGAACA
AATAATGCTAGATAAAGTATAG

Upstream 100 bases:

>100_bases
TAAAGACAAAATTTCTGTTAAAAATAATGTTAACCTAATTGGTATATCTTCTTTAAGAGAAGGTATTAATAAAGTATTTT
AATTGTGTAGGGTGAGAGAA

Downstream 100 bases:

>100_bases
CACAAAGTATTTTAATACTTTGTGCTATACTTTATCTCATACTATATTTGCCTAATGTATTTATCTTATTATATTCTTTT
AACAATATATCATATAAGTT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV

Sequences:

>Translated_353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
>Mature_353_residues
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSD
LKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEK
YVAVLDRVVNNLNILEFKDIATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASY
EQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 39642; Mature: 39642

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEY
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEECCCC
SPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIV
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
IAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDI
EEEECCCCEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHH
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSN
CCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCHHH
VIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEY
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCEEECCCC
SPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGAIV
CHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
IAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDI
EEEECCCCEEEEEECCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ATLFDVVTAVQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHH
RSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSN
CCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHCCCCHHH
VIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA