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The map label for this gene is mtaD [H]

Identifier: 226949455

GI number: 226949455

Start: 2462890

End: 2464242

Strand: Reverse

Name: mtaD [H]

Synonym: CLM_2387

Alternate gene names: 226949455

Gene position: 2464242-2462890 (Counterclockwise)

Preceding gene: 226949456

Following gene: 226949454

Centisome position: 59.3

GC content: 32.59

Gene sequence:

>1353_bases
ATGAATCAAATTTTAATAAAAAATGGTTATATTATTACAATGGATTCTTCAAAGAAAATATTTGAGAAAAGTGATATTTT
AGTTGAGGATTCTAAAATTATTACTATAGGTAATGTGGAATCTGAATTAATTAAATCTAGCGTTGAAATTATAGATGCTA
ATGGAAAAATCATAATGCCTGGTTTAGTAAATACCCATGTACATTTATCCCAACAATTAGCTAGAGGATTAGCTGACGAT
GTAGATCTTTTAACTTGGCTTCGCAAACGTATATGGCCTTACGAAAGCAATATGGATTTAGAGGATTCTTATATTTCTTC
ATTAGCCTGTTGTACAGAACTAATACGTTCAGGTGTTACTACTTTTTGTGAAGCTGGTGGACAAGAAGTAGATGGCATGG
GAAAAGCTGTAGAACAAGCAGGACTTAGAGGTATTCTTTGTCGCTCTACTATGGACTGTGGTGATGGTTTACCATTAAAA
TGGCAAGAAACTACAGAGGAATCTTTAGAAAAACAAGTAGAGTTGCTTGAAAAGTGGAATGGTAAAGGAGATGGACGTAT
TAAGTATTGGTTTGGCTTAAGAACTATTTTTAATACTACGGATAAATTAATAACTAAAACTAAAGAACTAGCAGATAAAT
ATAAAGTAGGTATTCATATGCATGTTGCTGAAATAGAAGAGGAAGTTAGATATGCAGAAGCAACTCGTGGTGAAACTACT
GTTCAGCATTTAGCTAAATTAGGGGTATTAGATAAAAACTTTTTAGCTGTACATACAGTATGGCTTACAGAACAAGAAAT
TGATTTATTTAAGCTTCATAATGTAAAAGTATCCCATAATCCTGGTGCTGCAATGAAAGTTGTTTTAGGTTTTGCACGTA
TTCCAGAAATGCTTGAAAAGGGAATCAATGTTTCAATTGGAACTGATGGCGCTCCTTCTAATAATAGAATGGATATGTTT
GATGAAATGCATTTAACCTCATTAATACATAAAGGTAGAAGATTGAATCCAAAGGTTGTTCCTGCTGATGAAGTATTAGA
AATGGCTACAATGAATGGTGCTAAATGTGCCCTTTGGGAAGATGAAATAGGCTCTTTGGAGGTAGGAAAAAAAGCAGATT
TAATAATCATTAACCCTAAATCCATTGGCAGTCTTCCTATGCATGATCCAATTGGAAATATAGTATATTCAATGCACTCT
AGTGATGTAGAATCTTCTATGTGTAATGGTAAGTGGTTAATGAAGAATAAAGTATTATTAACTATAAATGAAGAGGACAT
TATTAGAGAAGTACAAGAAAGAGCAACAGCTTTAGTTAAAAAAGCAGGTATTGTCTTACCAAAACGTTTTTAA

Upstream 100 bases:

>100_bases
ACAAGAATATGAAGAGGCTGTGTAAAATTTTTATATTTAAGTTTTACTAAGTTTCATTGAATTATATATATAAATAGAGA
TAGATAAAGGAGAATATATT

Downstream 100 bases:

>100_bases
AATAGAAAGAATCATCTTTAATCTAGCAATTATAGTTTAAGGATGATTCTAATATTTTTTGATAAAATTTATATATTGAT
TAATATAGGTATAATTTATT

Product: amidohydrolase family protein

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNQILIKNGYIITMDSSKKIFEKSDILVEDSKIITIGNVESELIKSSVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEQAGLRGILCRSTMDCGDGLPLK
WQETTEESLEKQVELLEKWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFARIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTINEEDIIREVQERATALVKKAGIVLPKRF

Sequences:

>Translated_450_residues
MNQILIKNGYIITMDSSKKIFEKSDILVEDSKIITIGNVESELIKSSVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEQAGLRGILCRSTMDCGDGLPLK
WQETTEESLEKQVELLEKWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFARIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTINEEDIIREVQERATALVKKAGIVLPKRF
>Mature_450_residues
MNQILIKNGYIITMDSSKKIFEKSDILVEDSKIITIGNVESELIKSSVEIIDANGKIIMPGLVNTHVHLSQQLARGLADD
VDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVTTFCEAGGQEVDGMGKAVEQAGLRGILCRSTMDCGDGLPLK
WQETTEESLEKQVELLEKWNGKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFARIPEMLEKGINVSIGTDGAPSNNRMDMF
DEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWEDEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHS
SDVESSMCNGKWLMKNKVLLTINEEDIIREVQERATALVKKAGIVLPKRF

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=344, Percent_Identity=27.0348837209302, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082177, Length=449, Percent_Identity=24.7216035634744, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789249, Length=378, Percent_Identity=26.984126984127, Blast_Score=121, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6319963, Length=366, Percent_Identity=22.9508196721311, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643849, Length=390, Percent_Identity=22.0512820512821, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50246; Mature: 50246

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQILIKNGYIITMDSSKKIFEKSDILVEDSKIITIGNVESELIKSSVEIIDANGKIIMP
CCCEEEECCEEEEECCCCHHHHCCCEEEECCEEEEECCCHHHHHHHHHHEEECCCCEEEC
GLVNTHVHLSQQLARGLADDVDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
TFCEAGGQEVDGMGKAVEQAGLRGILCRSTMDCGDGLPLKWQETTEESLEKQVELLEKWN
HHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCHHH
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFARIPEMLEK
HHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GINVSIGTDGAPSNNRMDMFDEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWE
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
DEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHSSDVESSMCNGKWLMKNKVLL
CCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCEEEEECCEEE
TINEEDIIREVQERATALVKKAGIVLPKRF
EECHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNQILIKNGYIITMDSSKKIFEKSDILVEDSKIITIGNVESELIKSSVEIIDANGKIIMP
CCCEEEECCEEEEECCCCHHHHCCCEEEECCEEEEECCCHHHHHHHHHHEEECCCCEEEC
GLVNTHVHLSQQLARGLADDVDLLTWLRKRIWPYESNMDLEDSYISSLACCTELIRSGVT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHH
TFCEAGGQEVDGMGKAVEQAGLRGILCRSTMDCGDGLPLKWQETTEESLEKQVELLEKWN
HHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GKGDGRIKYWFGLRTIFNTTDKLITKTKELADKYKVGIHMHVAEIEEEVRYAEATRGETT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCHHH
VQHLAKLGVLDKNFLAVHTVWLTEQEIDLFKLHNVKVSHNPGAAMKVVLGFARIPEMLEK
HHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GINVSIGTDGAPSNNRMDMFDEMHLTSLIHKGRRLNPKVVPADEVLEMATMNGAKCALWE
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC
DEIGSLEVGKKADLIIINPKSIGSLPMHDPIGNIVYSMHSSDVESSMCNGKWLMKNKVLL
CCCCCEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCEEEEECCEEE
TINEEDIIREVQERATALVKKAGIVLPKRF
EECHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA