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The map label for this gene is cpx [H]

Identifier: 226949456

GI number: 226949456

Start: 2464318

End: 2465661

Strand: Reverse

Name: cpx [H]

Synonym: CLM_2388

Alternate gene names: 226949456

Gene position: 2465661-2464318 (Counterclockwise)

Preceding gene: 226949459

Following gene: 226949455

Centisome position: 59.34

GC content: 34.08

Gene sequence:

>1344_bases
ATGAAAAACACTAAAGATACTAATTTAATTGTTGGAATTGATGAAAAAATTAGCTTAAGATACGCCTTTTTTCTAGGTTT
ACAACATGTTTTTGCTATGGATTTATACATAGTTCCTATAATATTGGCAGGTATTTTATCTCTTGATGCCCAAAATACAG
CCTATTTTATACAAATGAGTTTTATAGCCGCTGGAATTGCTACACTAATACAAACTGGTTTATGCATGCGATTACCTATT
ATGCAGGGACCTTCCTATATTCCTATAGGTGCCTTAGCTGCCATCGGAAGTAAGTTAGGACTACAAGCTATGGTTGGCAG
TTTAATTCCAGGTTCACTATTTTTAATGATACTTGGTTATCCATTACGTTTTCTCTCAAAAATAATTTCTAAATTTATTC
CACATATTGTTGGAGGTACTGTTATTGTCATAGTAGGAATATCCTTAATGCCTGTGGCTATGACTAATATTTTTACTGCA
CCGGGTAATTTAAAAATAAATTGTATCCTTGCTCTTATTTCATCAGCTTTATTAGTTAGCTGTATGATGATAGGACGTAA
ATCCAATAAGTTTGGTAAAGCTGTTCGACTTACATCTGTAATGATTTCATTAATTGGTGGTACTATAGCAGCTTCATTAT
TAGGGGTCGTAGATTTTACGCCTGTTACAAAGGCAGCTTGGTTTTCATTCCCTAAATTATTACCCTTCGGAAAACCAGTA
TTTGATTTAAAAGCAATTTTAACTATGTTATTTATTTATGCAGTTATTTTAGTTGAAACCTCAGGAACTTGGTTTGCAGT
TTCTGCTGTTACAGGAAGCGAATTAACAGATGAAGGTTTAAATAGAGGTGCTGTGGGCGAGGGAATTGGCTGTTTTGTAG
GTGCATTGTTTGGTGGTACTCCAATGACAGGCTATTCCACAAATGCAGGTATTATTGCGGTAACAGGTGTTGGTAGTAGA
ATGGCTATTATTGCTGGAGGAATCATATTAGTTGCCCTTGGTATGTTACCTAAATTAATGAATGTAATTGCTTGTATACC
TAGCGCAGTTGTTAGTGGAGTTTTTGCAGTAGTTTGTGTAATTATTGCTATGAACGGCTTTAAATCAATTCAACATGAAG
AATTTGATGAAAGAAATATGTTATTAATTGGACTACCTATTCTTTTAGCACTTGGAACTACTGTTTTACCTAAAGATATC
TTAAATAGTTTGCCAAGTCTTGCAAATTATATTTTTTCCTCTGGAATTACAGTAGGGGTTTTGGCTGCAGTAATATTGAA
TATACTTTTACCTAAGGCACCCGTAGAAGTATCTAAATCACAAGAATATGAAGAGGCTGTGTAA

Upstream 100 bases:

>100_bases
TTATCTAAAATAATGAGCGATAAGGTTTTCATTTATAGTGTGAATACCTTATGGCTTTTTTTATTATTATGAGCATGAAT
TTTACTAGGAGGACTTTACA

Downstream 100 bases:

>100_bases
AATTTTTATATTTAAGTTTTACTAAGTTTCATTGAATTATATATATAAATAGAGATAGATAAAGGAGAATATATTATGAA
TCAAATTTTAATAAAAAATG

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKNTKDTNLIVGIDEKISLRYAFFLGLQHVFAMDLYIVPIILAGILSLDAQNTAYFIQMSFIAAGIATLIQTGLCMRLPI
MQGPSYIPIGALAAIGSKLGLQAMVGSLIPGSLFLMILGYPLRFLSKIISKFIPHIVGGTVIVIVGISLMPVAMTNIFTA
PGNLKINCILALISSALLVSCMMIGRKSNKFGKAVRLTSVMISLIGGTIAASLLGVVDFTPVTKAAWFSFPKLLPFGKPV
FDLKAILTMLFIYAVILVETSGTWFAVSAVTGSELTDEGLNRGAVGEGIGCFVGALFGGTPMTGYSTNAGIIAVTGVGSR
MAIIAGGIILVALGMLPKLMNVIACIPSAVVSGVFAVVCVIIAMNGFKSIQHEEFDERNMLLIGLPILLALGTTVLPKDI
LNSLPSLANYIFSSGITVGVLAAVILNILLPKAPVEVSKSQEYEEAV

Sequences:

>Translated_447_residues
MKNTKDTNLIVGIDEKISLRYAFFLGLQHVFAMDLYIVPIILAGILSLDAQNTAYFIQMSFIAAGIATLIQTGLCMRLPI
MQGPSYIPIGALAAIGSKLGLQAMVGSLIPGSLFLMILGYPLRFLSKIISKFIPHIVGGTVIVIVGISLMPVAMTNIFTA
PGNLKINCILALISSALLVSCMMIGRKSNKFGKAVRLTSVMISLIGGTIAASLLGVVDFTPVTKAAWFSFPKLLPFGKPV
FDLKAILTMLFIYAVILVETSGTWFAVSAVTGSELTDEGLNRGAVGEGIGCFVGALFGGTPMTGYSTNAGIIAVTGVGSR
MAIIAGGIILVALGMLPKLMNVIACIPSAVVSGVFAVVCVIIAMNGFKSIQHEEFDERNMLLIGLPILLALGTTVLPKDI
LNSLPSLANYIFSSGITVGVLAAVILNILLPKAPVEVSKSQEYEEAV
>Mature_447_residues
MKNTKDTNLIVGIDEKISLRYAFFLGLQHVFAMDLYIVPIILAGILSLDAQNTAYFIQMSFIAAGIATLIQTGLCMRLPI
MQGPSYIPIGALAAIGSKLGLQAMVGSLIPGSLFLMILGYPLRFLSKIISKFIPHIVGGTVIVIVGISLMPVAMTNIFTA
PGNLKINCILALISSALLVSCMMIGRKSNKFGKAVRLTSVMISLIGGTIAASLLGVVDFTPVTKAAWFSFPKLLPFGKPV
FDLKAILTMLFIYAVILVETSGTWFAVSAVTGSELTDEGLNRGAVGEGIGCFVGALFGGTPMTGYSTNAGIIAVTGVGSR
MAIIAGGIILVALGMLPKLMNVIACIPSAVVSGVFAVVCVIIAMNGFKSIQHEEFDERNMLLIGLPILLALGTTVLPKDI
LNSLPSLANYIFSSGITVGVLAAVILNILLPKAPVEVSKSQEYEEAV

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=223, Percent_Identity=26.9058295964126, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI40316845, Length=223, Percent_Identity=26.9058295964126, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI44680145, Length=226, Percent_Identity=26.9911504424779, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI44680143, Length=226, Percent_Identity=26.9911504424779, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082181, Length=429, Percent_Identity=28.6713286713287, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790087, Length=465, Percent_Identity=26.2365591397849, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081818, Length=476, Percent_Identity=24.7899159663866, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082178, Length=451, Percent_Identity=26.1640798226164, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788843, Length=388, Percent_Identity=25.5154639175258, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17541904, Length=444, Percent_Identity=24.5495495495495, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17542262, Length=456, Percent_Identity=24.1228070175439, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17558856, Length=426, Percent_Identity=24.4131455399061, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17542260, Length=246, Percent_Identity=29.6747967479675, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71993493, Length=177, Percent_Identity=32.7683615819209, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356175, Length=491, Percent_Identity=24.847250509165, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47006; Mature: 47006

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTKDTNLIVGIDEKISLRYAFFLGLQHVFAMDLYIVPIILAGILSLDAQNTAYFIQMS
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
FIAAGIATLIQTGLCMRLPIMQGPSYIPIGALAAIGSKLGLQAMVGSLIPGSLFLMILGY
HHHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
PLRFLSKIISKFIPHIVGGTVIVIVGISLMPVAMTNIFTAPGNLKINCILALISSALLVS
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
CMMIGRKSNKFGKAVRLTSVMISLIGGTIAASLLGVVDFTPVTKAAWFSFPKLLPFGKPV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCH
FDLKAILTMLFIYAVILVETSGTWFAVSAVTGSELTDEGLNRGAVGEGIGCFVGALFGGT
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHCCC
PMTGYSTNAGIIAVTGVGSRMAIIAGGIILVALGMLPKLMNVIACIPSAVVSGVFAVVCV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIAMNGFKSIQHEEFDERNMLLIGLPILLALGTTVLPKDILNSLPSLANYIFSSGITVGV
HHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
LAAVILNILLPKAPVEVSKSQEYEEAV
HHHHHHHHHCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MKNTKDTNLIVGIDEKISLRYAFFLGLQHVFAMDLYIVPIILAGILSLDAQNTAYFIQMS
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
FIAAGIATLIQTGLCMRLPIMQGPSYIPIGALAAIGSKLGLQAMVGSLIPGSLFLMILGY
HHHHHHHHHHHCCCHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
PLRFLSKIISKFIPHIVGGTVIVIVGISLMPVAMTNIFTAPGNLKINCILALISSALLVS
HHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
CMMIGRKSNKFGKAVRLTSVMISLIGGTIAASLLGVVDFTPVTKAAWFSFPKLLPFGKPV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHCCCCCCH
FDLKAILTMLFIYAVILVETSGTWFAVSAVTGSELTDEGLNRGAVGEGIGCFVGALFGGT
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHCCC
PMTGYSTNAGIIAVTGVGSRMAIIAGGIILVALGMLPKLMNVIACIPSAVVSGVFAVVCV
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIAMNGFKSIQHEEFDERNMLLIGLPILLALGTTVLPKDILNSLPSLANYIFSSGITVGV
HHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
LAAVILNILLPKAPVEVSKSQEYEEAV
HHHHHHHHHCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]